DOI: 10.1042/bj1440361. Hormonal control of liver regeneration

10.1042/bj1440361

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

Two peaks in cyclic AMP production in rat livers 4 and 12h after partial hepatectomy (MacManus et al., 1972) were confirmed and a third peak established at 22h, which is the peak of DNA synthesis. The increases in cyclic AMP were prevented by β-adrenergic blocking agents, propranolol and pindolol, without affecting ornithine decarboxylase induction or DNA synthesis. The α-blocking agents, phenoxybenzamine and phentolamine, given at the time of partial hepatectomy, delayed the rise in ornithine decarboxylase normally found 4h after operation, but did not affect DNA synthesis. If the α-blocking agents were given at 9–12h or 18h, the onset of DNA synthesis was delayed. Phenoxybenzamine did not affect the induction of ornithine decarboxylase in intact rat livers by glucagon or growth hormone, but did inhibit induction by dexamethasone. The induction of ornithine decarboxylase produced by dexamethasone was inhibited by 17α-hydroxy-progesterone; this compound also blocked the induction of ornithine decarboxylase in livers of partially hepatectomized rats.

Bibliography

Thrower, S., & Ord, M. G. (1974). Hormonal control of liver regeneration. Biochemical Journal, 144(2), 361â369.

Authors 2

S Thrower (first)
M G Ord (additional)

References 0 Referenced 78

None

Dates

Type	When
Created	10 years ago (Aug. 10, 2015, 3:56 p.m.)
Deposited	3 years, 9 months ago (Nov. 26, 2021, 11:18 a.m.)
Indexed	1 year, 7 months ago (Jan. 11, 2024, 10:06 p.m.)
Issued	50 years, 9 months ago (Nov. 15, 1974)
Published	50 years, 9 months ago (Nov. 15, 1974)
Published Print	50 years, 9 months ago (Nov. 15, 1974)

Funders 0

None

BibTeX

@article{Thrower_1974, title={Hormonal control of liver regeneration}, volume={144}, ISSN={0306-3283}, url={http://dx.doi.org/10.1042/bj1440361}, DOI={10.1042/bj1440361}, number={2}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={Thrower, S and Ord, M G}, year={1974}, month=nov, pages={361–369} }

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