DOI: 10.1042/bj1050779. Studies on the pathogenesis of liver necrosis by α-amanitin. Effect of α-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei

Studies on the pathogenesis of liver necrosis by α-amanitin. Effect of α-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei

10.1042/bj1050779

Crossref journal-article

Portland Press Ltd.

Biochemical Journal (288)

Abstract

1. Injection of α-amanitin to mice causes a decreased incorporation of [6−14C]-orotic acid into liver RNA in vivo. 2. The activity of RNA polymerase activated by Mn2+ and ammonium sulphate is greatly impaired in liver nuclei isolated from mice poisoned with α-amanitin, and is inhibited by the addition of the same toxin in vitro. 3. The activity of the Mg2+-activated RNA polymerase is only slightly affected by α-amanitin either administered to mice or added in vitro.

Bibliography

Stirpe, F., & Fiume, L. (1967). Studies on the pathogenesis of liver necrosis by Î±-amanitin. Effect of Î±-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei. Biochemical Journal, 105(2), 779â782.

Authors 2

F. Stirpe (first)
L. Fiume (additional)

References 0 Referenced 145

None

Dates

Type	When
Created	10 years ago (Aug. 13, 2015, 5:36 p.m.)
Deposited	3 years, 8 months ago (Nov. 29, 2021, 3:51 p.m.)
Indexed	1 month, 4 weeks ago (June 30, 2025, 6:01 p.m.)
Issued	57 years, 9 months ago (Nov. 1, 1967)
Published	57 years, 9 months ago (Nov. 1, 1967)
Published Print	57 years, 9 months ago (Nov. 1, 1967)

Funders 0

None

BibTeX

@article{Stirpe_1967, title={Studies on the pathogenesis of liver necrosis by α-amanitin. Effect of α-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei}, volume={105}, ISSN={0306-3283}, url={http://dx.doi.org/10.1042/bj1050779}, DOI={10.1042/bj1050779}, number={2}, journal={Biochemical Journal}, publisher={Portland Press Ltd.}, author={Stirpe, F. and Fiume, L.}, year={1967}, month=nov, pages={779–782} }

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