Crossref journal-article
Portland Press Ltd.
Biochemical Society Transactions (288)
Abstract

Recent advances in the structural biology of GPCRs (G-protein-coupled receptors) have provided insights into their structure and function. Comparisons of the visual and ligand-activated receptors highlight the unique elements of rhodopsin that allow it to function as a highly sensitive dim-light photoreceptor in vertebrates, as well as the common elements that it shares with the large class A GPCR family. However, despite progress, a number of questions remain unanswered about how these receptors are activated.

Bibliography

Smith, S. O. (2012). Insights into the activation mechanism of the visual receptor rhodopsin. Biochemical Society Transactions, 40(2), 389–393.

Authors 1
  1. Steven O. Smith (first)
References 41 Referenced 13
  1. 10.1146/annurev-biophys-101209-104901 / Annu. Rev. Biophys. / Structure and activation of the visual pigment rhodopsin by Smith (2010)
  2. 10.1146/annurev.biophys.31.082901.134348 / Annu. Rev. Biophys. Biomol. Struct. / Rhodopsin: insights from recent structural studies by Sakmar (2002)
  3. 10.1146/annurev.biochem.75.103004.142743 / Annu. Rev. Biochem. / G-protein-coupled receptor rhodopsin by Palczewski (2006)
  4. 10.1126/science.111.2877.179 / Science / The light reaction in the bleaching of rhodopsin by Wald (1950)
  5. 10.1038/321075a0 / Nature / Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin by Dixon (1986)
  6. 10.1021/bi00074a024 / Biochemistry / Constitutive activation of opsin: influence of charge at position 134 and size at position 296 by Cohen (1993)
  7. 10.1074/jbc.M105423200 / J. Biol. Chem. / Conformations of the active and inactive states of opsin by Vogel (2001)
  8. 10.1126/science.1925597 / Science / The first step in vision: femtosecond isomerization of rhodopsin by Schoenlein (1991)
  9. 10.1126/science.274.5288.768 / Science / Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin by Farrens (1996)
  10. 10.1126/science.289.5480.739 / Science / Crystal structure of rhodopsin: a G protein-coupled receptor by Palczewski (2000)
  11. 10.1038/nature06325 / Nature / Crystal structure of the human β2 adrenergic G-protein-coupled receptor by Rasmussen (2007)
  12. 10.1038/nature07101 / Nature / Structure of a β1-adrenergic G-protein-coupled receptor by Warne (2008)
  13. 10.1126/science.1197410 / Science / Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist by Chien (2010)
  14. 10.1038/nature10236 / Nature / Structure of the human histamine H1 receptor complex with doxepin by Shimamura (2011)
  15. 10.1126/science.1194396 / Science / Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists by Wu (2010)
  16. 10.1126/science.1202793 / Science / Structure of an agonist-bound human A2A adenosine receptor by Xu (2011)
  17. 10.1006/jsbi.1999.4209 / J. Struct. Biol. / X-ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles by Okada (2000)
  18. 10.1073/pnas.0608022103 / Proc. Natl. Acad. Sci. U.S.A. / Crystal structure of a photoactivated deprotonated intermediate of rhodopsin by Salom (2006)
  19. 10.1038/nature07330 / Nature / Crystal structure of opsin in its G-protein-interacting conformation by Scheerer (2008)
  20. 10.1038/nature07063 / Nature / Crystal structure of the ligand-free G-protein-coupled receptor opsin by Park (2008)
  21. 10.1016/j.pnmrs.2010.04.004 / Prog. Nucl. Magn. Reson. Spectrosc. / Structure and function of G protein-coupled receptors using NMR spectroscopy by Goncalves (2010)
  22. 10.1016/j.jmb.2005.01.069 / J. Mol. Biol. / Changes in interhelical hydrogen bonding upon rhodopsin activation by Patel (2005)
  23. 10.1016/j.jmb.2005.12.046 / J. Mol. Biol. / Location of Trp265 in metarhodopsin II: implications for the activation mechanism of the visual receptor rhodopsin by Crocker (2006)
  24. 10.1038/nsmb.1549 / Nat. Struct. Mol. Biol. / Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation by Ahuja (2009)
  25. 10.1074/jbc.M805725200 / J. Biol. Chem. / Location of the retinal chromophore in the activated state of rhodopsin by Ahuja (2009)
  26. 10.1038/nature09648 / Nature / Structure of a nanobody-stabilized active state of the β2 adrenoceptor by Rasmussen (2011)
  27. 10.1038/nature10361 / Nature / Crystal structure of the β2 adrenergic receptor–Gs protein complex by Rasmussen (2011)
  28. 10.1038/nature09746 / Nature / The structural basis for agonist and partial agonist action on a β1-adrenergic receptor by Warne (2011)
  29. 10.1152/physiol.00002.2010 / Physiology / Energy landscapes as a tool to integrate GPCR structure, dynamics, and function by Deupi (2010)
  30. 10.1038/nature09789 / Nature / Crystal structure of metarhodopsin II by Choe (2011)
  31. 10.1038/nature09795 / Nature / The structural basis of agonist-induced activation in constitutively active rhodopsin by Standfuss (2011)
  32. 10.1021/bi00189a045 / Biochemistry / Interactions of the β-ionone ring with the protein in the visual pigment rhodopsin control the activation mechanism: an FTIR and fluorescence study on artificial vertebrate rhodopsins by Jäger (1994)
  33. 10.1021/bi0508587 / Biochemistry / Agonists and partial agonists of rhodopsin: retinals with ring modifications by Vogel (2005)
  34. 10.1073/pnas.91.15.6958 / Proc. Natl. Acad. Sci. U.S.A. / Relief of opsin desensitization and prolonged excitation of rod photoreceptors by 9-desmethylretinal by Corson (1994)
  35. 10.1073/pnas.94.25.13442 / Proc. Natl. Acad. Sci. U.S.A. / The C9 methyl group of retinal interacts with glycine-121 in rhodopsin by Han (1997)
  36. 10.1073/pnas.83.12.4209 / Proc. Natl. Acad. Sci. U.S.A. / Deprotonation of the Schiff base of rhodopsin is obligate in the activation of the G-protein by Longstaff (1986)
  37. 10.1021/bi00165a008 / Biochemistry / Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296 by Cohen (1992)
  38. 10.1038/nature08650 / Nature / Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor by Bokoch (2010)
  39. 10.1016/j.jmb.2009.12.003 / J. Mol. Biol. / Light activation of rhodopsin: insights from molecular dynamics simulations guided by solid-state NMR distance restraints by Hornak (2010)
  40. 10.1016/j.jmb.2004.02.001 / J. Mol. Biol. / Helix packing moments reveal diversity and conservation in membrane protein structure by Liu (2004)
  41. 10.1016/S0006-3495(02)75613-0 / Biophys. J. / Comparison of helix interactions in membrane and soluble α-bundle proteins by Eilers (2002)
Dates
Type When
Created 13 years, 4 months ago (April 19, 2012, 5:03 a.m.)
Deposited 3 years, 9 months ago (Nov. 17, 2021, 4:39 p.m.)
Indexed 1 year, 5 months ago (March 5, 2024, 5:06 p.m.)
Issued 13 years, 5 months ago (March 21, 2012)
Published 13 years, 5 months ago (March 21, 2012)
Published Online 13 years, 5 months ago (March 21, 2012)
Published Print 13 years, 4 months ago (April 1, 2012)
Funders 0

None

@article{Smith_2012, title={Insights into the activation mechanism of the visual receptor rhodopsin}, volume={40}, ISSN={1470-8752}, url={http://dx.doi.org/10.1042/bst20110751}, DOI={10.1042/bst20110751}, number={2}, journal={Biochemical Society Transactions}, publisher={Portland Press Ltd.}, author={Smith, Steven O.}, year={2012}, month=mar, pages={389–393} }