DOI: 10.1042/bst0381105. Brr2p RNA helicase with a split personality: insights into structure and function

Brr2p RNA helicase with a split personality: insights into structure and function

10.1042/bst0381105

Crossref journal-article

Portland Press Ltd.

Biochemical Society Transactions (288)

Abstract

RNA helicases are involved in many cellular processes. Pre-mRNA splicing requires eight different DExD/H-box RNA helicases, which facilitate spliceosome assembly and remodelling of the intricate network of RNA rearrangements that are central to the splicing process. Brr2p, one of the spliceosomal RNA helicases, stands out through its unusual domain architecture. In the present review we highlight the advances made by recent structural and biochemical studies that have important implications for the mechanism and regulation of Brr2p activity. We also discuss the involvement of human Brr2 in retinitis pigmentosa, a degenerative eye disease, and how its functions in splicing might connect to the molecular pathology of the disease.

Bibliography

Hahn, D., & Beggs, J. D. (2010). Brr2p RNA helicase with a split personality: insights into structure and function. Biochemical Society Transactions, 38(4), 1105â1109.

Authors 2

Daniela Hahn (first)
Jean D. Beggs (additional)

References 32 Referenced 25

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Dates

Type	When
Created	15 years, 1 month ago (July 27, 2010, 5:48 a.m.)
Deposited	3 years, 9 months ago (Nov. 17, 2021, 6:18 p.m.)
Indexed	1 year, 7 months ago (Jan. 15, 2024, 11:31 a.m.)
Issued	15 years, 1 month ago (July 26, 2010)
Published	15 years, 1 month ago (July 26, 2010)
Published Online	15 years, 1 month ago (July 26, 2010)
Published Print	15 years, 1 month ago (Aug. 1, 2010)

Funders 0

None

BibTeX

@article{Hahn_2010, title={Brr2p RNA helicase with a split personality: insights into structure and function}, volume={38}, ISSN={1470-8752}, url={http://dx.doi.org/10.1042/bst0381105}, DOI={10.1042/bst0381105}, number={4}, journal={Biochemical Society Transactions}, publisher={Portland Press Ltd.}, author={Hahn, Daniela and Beggs, Jean D.}, year={2010}, month=jul, pages={1105–1109} }

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