DOI: 10.1042/bst0360126. Role(s) of Cdc48/p97 in mitosis

10.1042/bst0360126

Crossref journal-article

Portland Press Ltd.

Biochemical Society Transactions (288)

Abstract

The ubiquitin-dependent chaperone Cdc48 (cell divison cycle 48)/p97 is involved in a variety of degradative and regulatory processes during interphase that help to maintain cellular homoeostasis. The results available so far suggest that its basic activity is to mobilize ubiquitinated substrate proteins from cellular structures or segregate them from binding partners, and then hand them over for degradation or recycling. Several studies in different organisms show that Cdc48/p97 also has critical roles in mitosis. However, many important aspects of these functions and the general perspective have remained unclear.

Bibliography

Meyer, H., & Popp, O. (2008). Role(s) of Cdc48/p97 in mitosis. Biochemical Society Transactions, 36(1), 126â130.

Authors 2

Hemmo Meyer (first)
Oliver Popp (additional)

References 36 Referenced 29

10.1002/j.1460-2075.1990.tb08300.x / EMBO J. / An abundant and ubiquitous homo-oligomeric ring-shaped ATPase particle related to the putative vesicle fusion proteins, Sec18p and NSF by Peters (1990)
10.1242/jcs.00817 / J. Cell Sci. / p97, a protein coping with multiple identities by Woodman (2003)
10.1093/genetics/100.4.547 / Genetics / Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies by Moir (1982)
10.1083/jcb.114.3.443 / J. Cell Biol. / Yeast cell cycle protein cdc48p shows full-length homology to the mammalian protein VCP and is a member of a protein family involved in secretion, peroxisome formation, and gene expression by Frohlich (1991)
10.1016/j.jsb.2006.01.005 / J. Struct. Biol. / Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase by Ye (2006)
10.1093/emboj/19.10.2181 / EMBO J. / A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways by Meyer (2000)
10.1038/sj.embor.7400203 / EMBO Rep. / Shp1 and Ubx2 are adaptors of Cdc48 involved in ubiquitin-dependent protein degradation by Schuberth (2004)
10.1016/j.cub.2004.04.029 / Curr. Biol. / The Ubx2 and Ubx3 cofactors direct Cdc48 activity to proteolytic and nonproteolytic ubiquitin-dependent processes by Hartmann-Petersen (2004)
10.1093/emboj/cdf579 / EMBO J. / Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1–Npl4 by Meyer (2002)
10.1016/j.tibs.2006.11.005 / Trends Biochem. Sci. / Cdc48 (p97): a “molecular gearbox” in the ubiquitin pathway? by Jentsch (2007)
10.1038/ncb0805-766 / Nat. Cell Biol. / ERAD: the long road to destruction by Meusser (2005)
10.1016/S0955-0674(00)00218-0 / Curr. Opin. Cell Biol. / Membrane-bound transcription factors: regulated release by RIP or RUP by Hoppe (2001)
10.1242/jcs.00841 / J. Cell Sci. / RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis by Wojcik (2004)
10.1016/j.cell.2005.03.006 / Cell / How do so few control so many? by Nasmyth (2005)
10.1038/nrm1988 / Nat. Rev. Mol. Cell Biol. / The anaphase promoting complex/cyclosome: a machine designed to destroy by Peters (2006)
10.1016/j.tcb.2005.11.006 / Trends Cell Biol. / Mitosis: a matter of getting rid of the right protein at the right time by Pines (2006)
10.1038/ncb0805-731 / Nat. Cell Biol. / Proteolysis: anytime, any place, anywhere? by Pines (2005)
10.1091/mbc.7.11.1835 / Mol. Biol. Cell. / Nuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene by DeHoratius (1996)
10.1074/jbc.270.29.17442 / J. Biol. Chem. / A proteolytic pathway that recognizes ubiquitin as a degradation signal by Johnson (1995)
10.1016/S0092-8674(03)00815-8 / Cell / The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis by Cao (2003)
10.1111/j.1365-2443.2004.00790.x / Genes Cells / An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation by Yuasa (2004)
10.1016/j.jsb.2006.04.003 / J. Struct. Biol. / Cdc48 is required for the stability of Cut1/separase in mitotic anaphase by Ikai (2006)
10.1242/jcs.006924 / J. Cell Sci. / The AAA-ATPase p97–Ufd1–Npl4 is required for ERAD but not for spindle disassembly in Xenopus egg extracts by Heubes (2007)
10.1038/ncb1201-1086 / Nat. Cell Biol. / Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly by Hetzer (2001)
10.1242/jcs.010181 / J. Cell Sci. / NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extracts by Baur (2007)
10.1016/j.bbrc.2007.05.022 / Biochem. Biophys. Res. Commun. / Caenorhabditis elegans p97/CDC-48 is crucial for progression of meiosis I by Sasagawa (2007)
10.1126/science.1120160 / Science / Chromosome alignment and segregation regulated by ubiquitination of survivin by Vong (2005)
10.1007/s00412-004-0307-3 / Chromosoma / Chromosomal passengers: the four-dimensional regulation of mitotic events by Vagnarelli (2004)
10.1074/jbc.M408695200 / J. Biol. Chem. / The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1–Npl4 and p47, through a common bipartite binding mechanism by Bruderer (2004)
10.1093/jb/mvi028 / J. Biochem. / p97/p47-mediated biogenesis of Golgi and ER by Uchiyama (2005)
10.1016/S0092-8674(00)81128-9 / Cell / Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro by Rabouille (1998)
10.1083/jcb.200401010 / J. Cell Biol. / VCIP135 acts as a deubiquitinating enzyme during p97–p47-mediated reassembly of mitotic Golgi fragments by Wang (2004)
10.1016/j.bbamcr.2005.03.011 / Biochim. Biophys. Acta / Golgi reassembly after mitosis: the AAA family meets the ubiquitin family by Meyer (2005)
10.1083/jcb.200303048 / J. Cell Biol. / The localization and phosphorylation of p47 are important for Golgi disassembly–assembly during the cell cycle by Uchiyama (2003)
10.1038/40411 / Nature / p47 is a cofactor for p97-mediated membrane fusion by Kondo (1997)
10.1083/jcb.200208112 / J. Cell Biol. / VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo by Uchiyama (2002)

Dates

Type	When
Created	17 years, 5 months ago (March 17, 2008, 2:25 p.m.)
Deposited	3 years, 9 months ago (Nov. 18, 2021, 6:01 p.m.)
Indexed	1 month, 3 weeks ago (July 2, 2025, 2:33 p.m.)
Issued	17 years, 7 months ago (Jan. 22, 2008)
Published	17 years, 7 months ago (Jan. 22, 2008)
Published Online	17 years, 7 months ago (Jan. 22, 2008)
Published Print	17 years, 6 months ago (Feb. 1, 2008)

Funders 0

None

BibTeX

@article{Meyer_2008, title={Role(s) of Cdc48/p97 in mitosis}, volume={36}, ISSN={1470-8752}, url={http://dx.doi.org/10.1042/bst0360126}, DOI={10.1042/bst0360126}, number={1}, journal={Biochemical Society Transactions}, publisher={Portland Press Ltd.}, author={Meyer, Hemmo and Popp, Oliver}, year={2008}, month=jan, pages={126–130} }

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      "author": "Frohlich",
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      "volume": "156",
      "author": "Ye",
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      "doi-asserted-by": "crossref",
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      "volume": "19",
      "author": "Meyer",
      "year": "2000",
      "journal-title": "EMBO J."
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      "first-page": "818",
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      "volume": "5",
      "author": "Schuberth",
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      "volume": "14",
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      "volume": "21",
      "author": "Meyer",
      "year": "2002",
      "journal-title": "EMBO J."
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    },
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      "key": "2021111823011134400_B11",
      "doi-asserted-by": "crossref",
      "first-page": "766",
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    {
      "key": "2021111823011134400_B12",
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      "doi-asserted-by": "crossref",
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      "author": "Wojcik",
      "year": "2004",
      "journal-title": "J. Cell Sci."
    },
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      "author": "Nasmyth",
      "year": "2005",
      "journal-title": "Cell"
    },
    {
      "key": "2021111823011134400_B15",
      "doi-asserted-by": "crossref",
      "first-page": "644",
      "DOI": "10.1038/nrm1988",
      "article-title": "The anaphase promoting complex/cyclosome: a machine designed to destroy",
      "volume": "7",
      "author": "Peters",
      "year": "2006",
      "journal-title": "Nat. Rev. Mol. Cell Biol."
    },
    {
      "key": "2021111823011134400_B16",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "DOI": "10.1016/j.tcb.2005.11.006",
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      "volume": "16",
      "author": "Pines",
      "year": "2006",
      "journal-title": "Trends Cell Biol."
    },
    {
      "key": "2021111823011134400_B17",
      "doi-asserted-by": "crossref",
      "first-page": "731",
      "DOI": "10.1038/ncb0805-731",
      "article-title": "Proteolysis: anytime, any place, anywhere?",
      "volume": "7",
      "author": "Pines",
      "year": "2005",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "2021111823011134400_B18",
      "doi-asserted-by": "crossref",
      "first-page": "1835",
      "DOI": "10.1091/mbc.7.11.1835",
      "article-title": "Nuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene",
      "volume": "7",
      "author": "DeHoratius",
      "year": "1996",
      "journal-title": "Mol. Biol. Cell."
    },
    {
      "key": "2021111823011134400_B19",
      "doi-asserted-by": "crossref",
      "first-page": "17442",
      "DOI": "10.1074/jbc.270.29.17442",
      "article-title": "A proteolytic pathway that recognizes ubiquitin as a degradation signal",
      "volume": "270",
      "author": "Johnson",
      "year": "1995",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "2021111823011134400_B20",
      "doi-asserted-by": "crossref",
      "first-page": "355",
      "DOI": "10.1016/S0092-8674(03)00815-8",
      "article-title": "The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis",
      "volume": "115",
      "author": "Cao",
      "year": "2003",
      "journal-title": "Cell"
    },
    {
      "key": "2021111823011134400_B21",
      "doi-asserted-by": "crossref",
      "first-page": "1069",
      "DOI": "10.1111/j.1365-2443.2004.00790.x",
      "article-title": "An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation",
      "volume": "9",
      "author": "Yuasa",
      "year": "2004",
      "journal-title": "Genes Cells"
    },
    {
      "key": "2021111823011134400_B22",
      "doi-asserted-by": "crossref",
      "first-page": "50",
      "DOI": "10.1016/j.jsb.2006.04.003",
      "article-title": "Cdc48 is required for the stability of Cut1/separase in mitotic anaphase",
      "volume": "156",
      "author": "Ikai",
      "year": "2006",
      "journal-title": "J. Struct. Biol."
    },
    {
      "key": "2021111823011134400_B23",
      "doi-asserted-by": "crossref",
      "first-page": "1325",
      "DOI": "10.1242/jcs.006924",
      "article-title": "The AAA-ATPase p97\u2013Ufd1\u2013Npl4 is required for ERAD but not for spindle disassembly in Xenopus egg extracts",
      "volume": "120",
      "author": "Heubes",
      "year": "2007",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "2021111823011134400_B24",
      "doi-asserted-by": "crossref",
      "first-page": "1086",
      "DOI": "10.1038/ncb1201-1086",
      "article-title": "Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly",
      "volume": "3",
      "author": "Hetzer",
      "year": "2001",
      "journal-title": "Nat. Cell Biol."
    },
    {
      "key": "2021111823011134400_B25",
      "doi-asserted-by": "crossref",
      "first-page": "2895",
      "DOI": "10.1242/jcs.010181",
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      "volume": "120",
      "author": "Baur",
      "year": "2007",
      "journal-title": "J. Cell Sci."
    },
    {
      "key": "2021111823011134400_B26",
      "doi-asserted-by": "crossref",
      "first-page": "920",
      "DOI": "10.1016/j.bbrc.2007.05.022",
      "article-title": "Caenorhabditis elegans p97/CDC-48 is crucial for progression of meiosis I",
      "volume": "358",
      "author": "Sasagawa",
      "year": "2007",
      "journal-title": "Biochem. Biophys. Res. Commun."
    },
    {
      "key": "2021111823011134400_B27",
      "doi-asserted-by": "crossref",
      "first-page": "1499",
      "DOI": "10.1126/science.1120160",
      "article-title": "Chromosome alignment and segregation regulated by ubiquitination of survivin",
      "volume": "310",
      "author": "Vong",
      "year": "2005",
      "journal-title": "Science"
    },
    {
      "key": "2021111823011134400_B28",
      "doi-asserted-by": "crossref",
      "first-page": "211",
      "DOI": "10.1007/s00412-004-0307-3",
      "article-title": "Chromosomal passengers: the four-dimensional regulation of mitotic events",
      "volume": "113",
      "author": "Vagnarelli",
      "year": "2004",
      "journal-title": "Chromosoma"
    },
    {
      "key": "2021111823011134400_B29",
      "doi-asserted-by": "crossref",
      "first-page": "49609",
      "DOI": "10.1074/jbc.M408695200",
      "article-title": "The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1\u2013Npl4 and p47, through a common bipartite binding mechanism",
      "volume": "279",
      "author": "Bruderer",
      "year": "2004",
      "journal-title": "J. Biol. Chem."
    },
    {
      "key": "2021111823011134400_B30",
      "doi-asserted-by": "crossref",
      "first-page": "115",
      "DOI": "10.1093/jb/mvi028",
      "article-title": "p97/p47-mediated biogenesis of Golgi and ER",
      "volume": "137",
      "author": "Uchiyama",
      "year": "2005",
      "journal-title": "J. Biochem."
    },
    {
      "key": "2021111823011134400_B31",
      "doi-asserted-by": "crossref",
      "first-page": "603",
      "DOI": "10.1016/S0092-8674(00)81128-9",
      "article-title": "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro",
      "volume": "92",
      "author": "Rabouille",
      "year": "1998",
      "journal-title": "Cell"
    },
    {
      "key": "2021111823011134400_B32",
      "doi-asserted-by": "crossref",
      "first-page": "973",
      "DOI": "10.1083/jcb.200401010",
      "article-title": "VCIP135 acts as a deubiquitinating enzyme during p97\u2013p47-mediated reassembly of mitotic Golgi fragments",
      "volume": "164",
      "author": "Wang",
      "year": "2004",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "2021111823011134400_B33",
      "doi-asserted-by": "crossref",
      "first-page": "108",
      "DOI": "10.1016/j.bbamcr.2005.03.011",
      "article-title": "Golgi reassembly after mitosis: the AAA family meets the ubiquitin family",
      "volume": "1744",
      "author": "Meyer",
      "year": "2005",
      "journal-title": "Biochim. Biophys. Acta"
    },
    {
      "key": "2021111823011134400_B34",
      "doi-asserted-by": "crossref",
      "first-page": "1067",
      "DOI": "10.1083/jcb.200303048",
      "article-title": "The localization and phosphorylation of p47 are important for Golgi disassembly\u2013assembly during the cell cycle",
      "volume": "161",
      "author": "Uchiyama",
      "year": "2003",
      "journal-title": "J. Cell Biol."
    },
    {
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