DOI: 10.1042/bst0350532. Synthetic <i>de novo</i> designed polypeptides for control of nanoparticle assembly and biosensing

Synthetic de novo designed polypeptides for control of nanoparticle assembly and biosensing

10.1042/bst0350532

Crossref journal-article

Portland Press Ltd.

Biochemical Society Transactions (288)

Abstract

This contribution describes how de novo designed synthetic helix–loop–helix polypeptides are utilized to control the assembly of gold nanoparticles and as scaffolds for biosensing. The synthetic polypeptides are designed to fold into a four-helix bundle upon dimerization. When immobilized on gold nanoparticles, dimerization and folding occur between peptides on neighbouring particles as an effect of particle aggregation and the folded polypeptides are rigid enough to keep the particles separated at a distance corresponding to the size of the four-helix bundle. Moreover, peptide dimerization offers a convenient route to assemble nanoparticles into hybrid multilayers on planar substrates. The drastic change in the resonance conditions of the localized nanoparticle surface plasmon upon particle aggregation is shown to be useful for optical detection of biomolecular interactions.

Bibliography

Aili, D., Enander, K., Baltzer, L., & Liedberg, B. (2007). Synthetic de novo designed polypeptides for control of nanoparticle assembly and biosensing. Biochemical Society Transactions, 35(3), 532â534.

Authors 4

D. Aili (first)
K. Enander (additional)
L. Baltzer (additional)
B. Liedberg (additional)

References 8 Referenced 12

10.1021/cr030698+ / Chem. Rev. by Daniel (2004)
10.1002/1521-3773(20011119)40:22<4128::AID-ANIE4128>3.0.CO;2-S / Angew. Chem. Int. Ed. by Niemeyer (2001)
10.1039/P29950002047 / J. Chem. Soc. Perkin Trans. by Olofsson (1995)
10.1021/nl034197f / Nano Lett. by Su (2003)
10.1021/la0470232 / Langmuir by Guarise (2005)
10.1021/la048029u / Langmuir by Enander (2005)
10.1021/ja057056j / J. Am. Chem. Soc. by Aili (2006)
10.1021/ja038799c / J. Am. Chem. Soc. by Enander (2004)

Dates

Type	When
Created	18 years, 3 months ago (May 24, 2007, 4:55 a.m.)
Deposited	3 years, 9 months ago (Nov. 17, 2021, 4:09 p.m.)
Indexed	1 year, 10 months ago (Oct. 17, 2023, 3:49 a.m.)
Issued	18 years, 3 months ago (May 22, 2007)
Published	18 years, 3 months ago (May 22, 2007)
Published Online	18 years, 3 months ago (May 22, 2007)
Published Print	18 years, 3 months ago (June 1, 2007)

Funders 0

None

BibTeX

@article{Aili_2007, title={Synthetic de novo designed polypeptides for control of nanoparticle assembly and biosensing}, volume={35}, ISSN={1470-8752}, url={http://dx.doi.org/10.1042/bst0350532}, DOI={10.1042/bst0350532}, number={3}, journal={Biochemical Society Transactions}, publisher={Portland Press Ltd.}, author={Aili, D. and Enander, K. and Baltzer, L. and Liedberg, B.}, year={2007}, month=may, pages={532–534} }

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