DOI: 10.1042/bst0331544. Contrasting mechanisms of regulating translation of specific <i>Drosophila</i> germline mRNAs at the level of 5′-cap structure binding

Contrasting mechanisms of regulating translation of specific Drosophila germline mRNAs at the level of 5′-cap structure binding

10.1042/bst0331544

Crossref journal-article

Portland Press Ltd.

Biochemical Society Transactions (288)

Abstract

Translational control is a key genetic regulatory mechanism underlying the initial establishment of the major spatial axes of the Drosophila embryo. Many translational control mechanisms target eIF4E (eukaryotic initiation factor 4E), an initiation factor that recognizes the 5′-cap structure of the mRNA. Cap recognition by eIF4E, in complex with eIF4G, is essential for recruitment of the mRNA to the small ribosomal subunit. One established mechanism for repressing translation involves eIF4E-binding proteins, which competitively inhibit the eIF4E–eIF4G interaction. Our group has uncovered a novel mechanism for repression in which an eIF4E cognate protein called d4EHP, which cannot bind eIF4G, binds to the 5′-cap structure of cad mRNA thus rendering it translationally inactive. These two related, but distinct, mechanisms are discussed and contrasted in this review.

Bibliography

Lasko, P., Cho, P., Poulin, F., & Sonenberg, N. (2005). Contrasting mechanisms of regulating translation of specific Drosophila germline mRNAs at the level of 5â²-cap structure binding. Biochemical Society Transactions, 33(6), 1544â1546.

Authors 4

P. Lasko (first)
P. Cho (additional)
F. Poulin (additional)
N. Sonenberg (additional)

References 29 Referenced 3

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Dates

Type	When
Created	10 years ago (Aug. 11, 2015, 12:17 p.m.)
Deposited	3 years, 9 months ago (Nov. 17, 2021, 5:57 p.m.)
Indexed	1 year, 4 months ago (April 22, 2024, 2:38 p.m.)
Issued	19 years, 10 months ago (Oct. 26, 2005)
Published	19 years, 10 months ago (Oct. 26, 2005)
Published Online	19 years, 10 months ago (Oct. 26, 2005)
Published Print	19 years, 10 months ago (Oct. 26, 2005)

Funders 0

None

BibTeX

@article{Lasko_2005, title={Contrasting mechanisms of regulating translation of specific Drosophila germline mRNAs at the level of 5′-cap structure binding}, volume={33}, ISSN={1470-8752}, url={http://dx.doi.org/10.1042/bst0331544}, DOI={10.1042/bst0331544}, number={6}, journal={Biochemical Society Transactions}, publisher={Portland Press Ltd.}, author={Lasko, P. and Cho, P. and Poulin, F. and Sonenberg, N.}, year={2005}, month=oct, pages={1544–1546} }

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