Abstract
Sm and Lsm proteins are ubiquitous in eukaryotes and form complexes that interact with RNAs involved in almost every cellular process. My laboratory has studied the Lsm proteins in the yeast Saccharomyces cerevisiae, identifying in the nucleus and cytoplasm distinct complexes that affect pre-mRNA splicing and degradation, small nucleolar RNA, tRNA processing, rRNA processing and mRNA degradation. These activities suggest RNA chaperone-like roles for Lsm proteins, affecting RNA–RNA and/or RNA–protein interactions. This article reviews the properties of the Sm and Lsm proteins and structurally and functionally related proteins in archaea and eubacteria.
References
49
Referenced
97
10.1073/pnas.76.11.5495
/ Proc. Natl. Acad. Sci. U.S.A. by Lerner (1979)10.1016/0167-4781(90)90001-I
/ Biochim. Biophys. Acta by Lührmann (1990)10.1016/S0955-0674(00)00211-8
/ Curr. Opin. Cell Biol. by Will (2001)10.1016/S0092-8674(00)80550-4
/ Cell (Cambridge, Mass.) by Kambach (1999)10.1016/S0959-440X(99)80032-3
/ Curr. Opin. Struct. Biol. by Kambach (1999)10.1002/j.1460-2075.1995.tb07199.x
/ EMBO J. by Hermann (1995)10.1073/pnas.87.5.1710
/ Proc. Natl. Acad. Sci. U.S.A. by Kastner (1990)10.1038/35054102
/ Nature (London) by Stark (2001){'key': '2021111822211528500_B9', 'first-page': '273', 'volume': '1', 'author': 'Boelens', 'year': '1995', 'journal-title': 'RNA'}
/ RNA by Boelens (1995)10.1002/j.1460-2075.1995.tb07198.x
/ EMBO J. by Cooper (1995)10.1002/j.1460-2075.1995.tb07200.x
/ EMBO J. by Séraphin (1995)10.1038/ng0797-277
/ Nat. Genet. by Fromont-Racine (1997)10.1155/2000/919260
/ Yeast by Fromont-Racine (2000)10.1093/emboj/17.24.7442
/ EMBO J. by Pannone (1998)10.1093/emboj/18.15.4321
/ EMBO J. by Mayes (1999)10.1093/emboj/18.12.3451
/ EMBO J. by Salgado-Garrido (1999)10.1093/emboj/18.20.5789
/ EMBO J. by Achsel (1999)10.1093/emboj/18.16.4535
/ EMBO J. by Gottschalk (1999)10.1073/pnas.96.13.7226
/ Proc. Natl. Acad. Sci. U.S.A. by Stevens (1999)10.1017/S1355838299991355
/ RNA by Vidal (1999)10.1038/35006676
/ Nature (London) by Tharun (2000)10.1093/emboj/19.7.1661
/ EMBO J. by Bouveret (2000)10.1093/genetics/158.1.187
/ Genetics by Pannone (2001)10.1017/S1355838202021726
/ RNA by Ingelfinger (2002)10.1016/j.cub.2004.08.032
/ Curr. Biol. by Verdone (2004)10.1126/science.279.5352.857
/ Science by Raghunathan (1998)10.1128/MCB.22.14.5248-5256.2002
/ Mol. Cell. Biol. by Kufel (2002)10.1074/jbc.M208856200
/ J. Biol. Chem. by Kufel (2003)10.1093/nar/gkg904
/ Nucleic Acids Res. by Kufel (2003)10.1128/MCB.24.21.9646-9657.2004
/ Mol. Cell. Biol. by Kufel (2004)10.1016/S0092-8674(00)80220-2
/ Cell (Cambridge, Mass.) by Yoo (1997)10.1091/mbc.e04-02-0116
/ Mol. Biol. Cell by Fernandez (2004)10.1128/MCB.22.12.4101-4112.2002
/ Mol. Cell. Biol. by Tomasevic (2002)10.1093/emboj/20.19.5470
/ EMBO J. by Pillai (2001)10.1101/gad.274403
/ Genes Dev. by Pillai (2003)10.1073/pnas.080072997
/ Proc. Natl. Acad. Sci. U.S.A. by Diez (2000)10.1128/MCB.18.9.5062
/ Mol. Cell. Biol. by Boeck (1998)10.1126/science.1082320
/ Science by Sheth (2003)10.1093/genetics/158.4.1445
/ Genetics by He (2001)10.1073/pnas.071033998
/ Proc. Natl. Acad. Sci. U.S.A. by Achsel (2001)10.1093/emboj/20.9.2293
/ EMBO J. by Törö (2001)10.1016/S0022-2836(02)00406-0
/ J. Mol. Biol. by Törö (2002)10.1093/emboj/cdf322
/ EMBO J. by Schumacher (2002)10.1093/nar/gkg480
/ Nucleic Acids Res. by Sauter (2003)10.1016/j.mib.2004.02.015
/ Curr. Opin. Micro. by Storz (2004)10.1111/j.1365-2958.2003.03935.x
/ Mol. Microbiol. by Valentin-Hansen (2004)10.1038/nsmb858
/ Nat. Struct. Mol. Biol. by Mikulecky (2004)10.1038/sj.embor.embor772
/ EMBO Rep. by Moll (2003)10.1126/science.1086602
/ Science by Chan (2003)
Dates
Type | When |
---|---|
Created | 19 years ago (Aug. 16, 2006, 10:03 a.m.) |
Deposited | 2 years, 3 months ago (May 8, 2023, 10:51 a.m.) |
Indexed | 2 months ago (July 2, 2025, 1:52 p.m.) |
Issued | 20 years, 3 months ago (June 1, 2005) |
Published | 20 years, 3 months ago (June 1, 2005) |
Published Online | 20 years, 3 months ago (June 1, 2005) |
Published Print | 20 years, 3 months ago (June 1, 2005) |
@article{Beggs_2005, title={Lsm proteins and RNA processing}, volume={33}, ISSN={1470-8752}, url={http://dx.doi.org/10.1042/bst0330433}, DOI={10.1042/bst0330433}, number={3}, journal={Biochemical Society Transactions}, publisher={Portland Press Ltd.}, author={Beggs, J.D.}, year={2005}, month=jun, pages={433–438} }