DOI: 10.1042/bst0290377. Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides [Penn]

Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides

10.1042/bst0290377

Crossref journal-article

Portland Press Ltd.

Biochemical Society Transactions (288)

Abstract

More than 250 pleckstrin homology (PH) domains have been identified in the human proteome. All PH domains studied to date appear to bind phosphoinositides, most binding only weakly and non-specifically. Members of a small subclass of PH domains show both high affinity and specificity for particular phosphoinositides, and recent structural studies have provided detailed views of these specific interactions. We discuss the architecture of the specific phosphoinositide-binding sites of PH domains, and how selectivity can be modulated by sequence changes.

Bibliography

Lemmon, M. A., & Ferguson, K. M. (2001). Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides. Biochemical Society Transactions, 29(4), 377â384.

Authors 2

M. A. Lemmon (first)
K. M. Ferguson (additional)

References 0 Referenced 89

None

Dates

Type	When
Created	20 years, 7 months ago (Jan. 31, 2005, 7:49 a.m.)
Deposited	3 years, 9 months ago (Nov. 17, 2021, 2:54 p.m.)
Indexed	4 months, 2 weeks ago (April 16, 2025, 11:45 a.m.)
Issued	24 years, 1 month ago (Aug. 1, 2001)
Published	24 years, 1 month ago (Aug. 1, 2001)
Published Print	24 years, 1 month ago (Aug. 1, 2001)

Funders 0

None

BibTeX

@article{Lemmon_2001, title={Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides}, volume={29}, ISSN={1470-8752}, url={http://dx.doi.org/10.1042/bst0290377}, DOI={10.1042/bst0290377}, number={4}, journal={Biochemical Society Transactions}, publisher={Portland Press Ltd.}, author={Lemmon, M. A. and Ferguson, K. M.}, year={2001}, month=aug, pages={377–384} }

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