Abstract
AbstractWe used soft X-ray three-dimensional imaging to quantify the mass of superparamagnetic iron oxide nanoparticles (SPION) within whole cells, by exploiting the iron oxide differential absorption contrast. Near-edge absorption soft X-ray nanotomography (NEASXT) combines whole-cell 3D structure determination at 50 nm resolution, with 3D elemental mapping and high throughput. We detected three-dimensional distribution of SPIONs within cells with 0.3 g/cm3 sensitivity, sufficient for detecting the density corresponding to a single nanoparticle.
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Dates
Type | When |
---|---|
Created | 9 years, 5 months ago (March 10, 2016, 5:02 a.m.) |
Deposited | 2 years, 7 months ago (Jan. 4, 2023, 8:13 a.m.) |
Indexed | 1 month ago (July 16, 2025, 9:35 a.m.) |
Issued | 9 years, 5 months ago (March 10, 2016) |
Published | 9 years, 5 months ago (March 10, 2016) |
Published Online | 9 years, 5 months ago (March 10, 2016) |
@article{Conesa_2016, title={Intracellular nanoparticles mass quantification by near-edge absorption soft X-ray nanotomography}, volume={6}, ISSN={2045-2322}, url={http://dx.doi.org/10.1038/srep22354}, DOI={10.1038/srep22354}, number={1}, journal={Scientific Reports}, publisher={Springer Science and Business Media LLC}, author={Conesa, Jose Javier and Otón, Joaquín and Chiappi, Michele and Carazo, Jose María and Pereiro, Eva and Chichón, Francisco Javier and Carrascosa, José L.}, year={2016}, month=mar }