DOI: 10.1038/sj.onc.1204090. Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging

Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging
10.1038/sj.onc.1204090
Crossref journal-article
Springer Science and Business Media LLC
Oncogene (297)
Bibliography
Blyth, K., Terry, A., Mackay, N., Vaillant, F., Bell, M., Cameron, E. R., Neil, J. C., & Stewart, M. (2001). Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging. Oncogene, 20(3), 295â302.
Authors 8
Karen Blyth (first)
Anne Terry (additional)
Nancy Mackay (additional)
François Vaillant (additional)
Margaret Bell (additional)
Ewan R Cameron (additional)
James C Neil (additional)
Monica Stewart (additional)
References 50 Referenced 91
Dates
Type	When
Created	22 years, 11 months ago (Sept. 20, 2002, 2:48 p.m.)
Deposited	3 years, 5 months ago (March 21, 2022, 9:48 p.m.)
Indexed	1 month, 1 week ago (July 26, 2025, 4:41 a.m.)
Issued	24 years, 7 months ago (Jan. 18, 2001)
Published	24 years, 7 months ago (Jan. 18, 2001)
Published Online	24 years, 5 months ago (March 12, 2001)
Published Print	24 years, 7 months ago (Jan. 18, 2001)
Funders 0
None
BibTeX
@article{Blyth_2001, title={Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging}, volume={20}, ISSN={1476-5594}, url={http://dx.doi.org/10.1038/sj.onc.1204090}, DOI={10.1038/sj.onc.1204090}, number={3}, journal={Oncogene}, publisher={Springer Science and Business Media LLC}, author={Blyth, Karen and Terry, Anne and Mackay, Nancy and Vaillant, François and Bell, Margaret and Cameron, Ewan R and Neil, James C and Stewart, Monica}, year={2001}, month=jan, pages={295–302} }
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    {
      "key": "BF1204090_CR4",
      "unstructured": "Berns A, Mikkers H, Krimpenfort P, Allen J, Scheijen B and Jonkers J. . 1999 Cancer Res. 59: 1773s\u20131777s."
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      "unstructured": "Blyth K, Terry A, O'Hara M, Baxter EW, Campbell M, Stewart M, Donehower L, Onions DE, Neil JC and Cameron ER. . 1995 Oncogene 10: 1717\u20131723."
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    },
    {
      "key": "BF1204090_CR8",
      "doi-asserted-by": "crossref",
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      "key": "BF1204090_CR9",
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