Crossref journal-article
Elsevier BV
Neoplasia (78)
Bibliography

Vajkoczy, P., Menger, M. D., Vollmar, B., Schilling, L., Schmiedek, P., Hirth, K. P., Ullrich, A., & Fong, T. A. T. (1999). Inhibition of Tumor Growth, Angiogenesis, and Microcirculation by the Novel Flk-1 Inhibitor SU5416 as Assessed by Intravital Multi-fluorescence Videomicroscopy. Neoplasia, 1(1), 31–41.

Authors 8
  1. Peter Vajkoczy (first)
  2. Michael D. Menger (additional)
  3. Brigitte Vollmar (additional)
  4. Lothar Schilling (additional)
  5. Peter Schmiedek (additional)
  6. K. Peter Hirth (additional)
  7. Axel Ullrich (additional)
  8. T.Annie T. Fong (additional)
References 53 Referenced 119
  1. 10.1093/jnci/82.1.4 / J Natl Cancer Inst / What is the evidence that tumors are angiogenesis-dependent? by Folkman (1990)
  2. 10.1126/science.2432664 / Science, / Angiogenic factors by Folkman (1987)
  3. {'key': '10.1038/sj.neo.7900006_bib3', 'first-page': '347', 'article-title': 'Tumor angiogenesis: A quantitative method for histological grading', 'volume': '48', 'author': 'Brem', 'year': '1972', 'journal-title': 'J Natl Cancer Inst'} / J Natl Cancer Inst / Tumor angiogenesis: A quantitative method for histological grading by Brem (1972)
  4. 10.1172/JCI114322 / J Clin Invest / Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis by Connolly (1989)
  5. 10.1210/edrv-13-1-18 / Endocr Rev / Molecular and biological properties of the vascular endothelial growth factor family of proteins by Ferrara (1992)
  6. 10.1126/science.2479987 / Science / Vascular permeability factor, an endothelial cell mitogen related to PDGF by Keck (1989)
  7. 10.1073/pnas.88.20.9267 / Proc Natl Acad Sci USA / Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor by Maglione (1991)
  8. 10.1126/science.1312256 / Science / The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor by DeVries (1992)
  9. 10.1016/0092-8674(93)90573-9 / Cell / High affinity VEGF binding and development expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis by Millauer (1993)
  10. 10.1016/S0021-9258(18)47116-5 / J Biol Chem / Different signal transduction properties of KDR and FLT1, two receptors for vascular endothelial growth factor by Waltenberger (1994)
  11. 10.1038/376066a0 / Nature / Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium by Fong (1995)
  12. 10.1074/jbc.271.30.17629 / J Biol Chem / The vascular endothelial growth factor receptor flt-1 mediates biological activities by Clauss (1996)
  13. 10.1002/ijc.2910590415 / Int J Cancer / Vascular endothelial growth factor and glioma angiogenesis: Coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms by Plate (1994)
  14. {'key': '10.1038/sj.neo.7900006_bib14', 'first-page': '1189', 'article-title': 'Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors', 'volume': '55', 'author': 'Samoto', 'year': '1995', 'journal-title': 'Cancer Res'} / Cancer Res / Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors by Samoto (1995)
  15. 10.1038/362841a0 / Nature / Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo by Kim (1993)
  16. 10.1038/367576a0 / Nature / Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant by Millauer (1994)
  17. {'key': '10.1038/sj.neo.7900006_bib17', 'first-page': '3540', 'article-title': 'Flk-1 as a target for tumor growth inhibition', 'volume': '56', 'author': 'Strawn', 'year': '1996', 'journal-title': 'Cancer Res'} / Cancer Res / Flk-1 as a target for tumor growth inhibition by Strawn (1996)
  18. {'key': '10.1038/sj.neo.7900006_bib18', 'first-page': '99', 'article-title': 'SU5416 is a potent and selective inhibitor of the VEGF receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, growth of multiple tumor types', 'volume': '59', 'author': 'Fong', 'year': '1999', 'journal-title': 'Cancer Res'} / Cancer Res / SU5416 is a potent and selective inhibitor of the VEGF receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, growth of multiple tumor types by Fong (1999)
  19. 10.1126/science.276.5314.955 / Science / Structures of the tyrosine kinase domain of fibroblast growth factor receptor on complex with inhibitors by Mohammadi (1997)
  20. 10.1097/00007890-199507000-00002 / Transplantation / Angiogenesis and vascularization of murine pancreatic islet isografts by Vajkoczy (1995)
  21. {'key': '10.1038/sj.neo.7900006_bib21', 'first-page': '1397', 'article-title': 'Histogenesis and ultrastructure of pancreatic islet graft microvasculature', 'volume': '146', 'author': 'Vajkoczy', 'year': '1995', 'journal-title': 'Evidence for graft revascularization by endothelial cells of host origin. Am J Pathol'} / Evidence for graft revascularization by endothelial cells of host origin. Am J Pathol / Histogenesis and ultrastructure of pancreatic islet graft microvasculature by Vajkoczy (1995)
  22. {'key': '10.1038/sj.neo.7900006_bib22', 'first-page': '1487', 'article-title': 'Prevention of pancreatic islet xenograft rejection by dietary vitamin E', 'volume': '150', 'author': 'Vajkoczy', 'year': '1997', 'journal-title': 'Am J Pathol'} / Am J Pathol / Prevention of pancreatic islet xenograft rejection by dietary vitamin E by Vajkoczy (1997)
  23. {'key': '10.1038/sj.neo.7900006_bib23', 'first-page': '6553', 'article-title': 'Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice', 'volume': '52', 'author': 'Leunig', 'year': '1992', 'journal-title': 'Cancer Res'} / Cancer Res / Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice by Leunig (1992)
  24. 10.1097/00004647-199805000-00006 / J Cereb Blood Flow Metab / Characterization of angiogenesis and microcirculation of high-grade glioma: An intravital multifluorescence microscopic approach in the athymic nude mouse by Vajkoczy (1998)
  25. {'key': '10.1038/sj.neo.7900006_bib25', 'first-page': '4032', 'article-title': 'Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy', 'volume': '56', 'author': 'Borgström', 'year': '1996', 'journal-title': 'Cancer Res'} / Cancer Res / Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy by Borgström (1996)
  26. 10.1016/0736-5748(93)90051-E / Int J Dev Neurosci / Grafting of fast blue labeled glial cells into neonatal rat brain: differential survival and migration among cell types by Espinosa de los Monteros (1993)
  27. 10.3171/jns.1995.82.4.0615 / J Neurosurg / Assessment of brain tumor cell motility in vivo and in vitro by Chicoine (1995)
  28. 10.3171/jns.1995.83.4.0665 / J Neurosurg / Invading C6 glioma cells maintaining tumorigenicity by Chicoine (1995)
  29. 10.1016/0026-2862(74)90043-0 / Microvasc Res / On-line volume flow rate and velocity profile measurement for blood in microvessels by Baker (1974)
  30. {'key': '10.1038/sj.neo.7900006_bib30', 'first-page': '7022', 'article-title': 'Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure', 'volume': '48', 'author': 'Jain', 'year': '1988', 'journal-title': 'Cancer Res'} / Cancer Res / Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure by Jain (1988)
  31. 10.1016/B978-0-12-005215-8.50011-5 / Adv Biol Med Phys / Microcirculatory basis of fluid exchange by Intaglietta (1974)
  32. 10.1097/00005072-198801000-00004 / J Neuropathol Exp Neurol / A quantitative assessment of microvessel ultrastructure in C6 astrocytoma spheroids transplanted to brain and to muscle by Coomber (1988)
  33. {'key': '10.1038/sj.neo.7900006_bib33', 'first-page': '1956', 'article-title': 'Neovascularization induced growth of implanted C6 glioma multicellular spheroids: Magnetic Resonance Microimaging', 'volume': '55', 'author': 'Abramovitch', 'year': '1995', 'journal-title': 'Cancer Res'} / Cancer Res / Neovascularization induced growth of implanted C6 glioma multicellular spheroids: Magnetic Resonance Microimaging by Abramovitch (1995)
  34. {'key': '10.1038/sj.neo.7900006_bib34', 'first-page': '55', 'article-title': 'The vasculature of experimental brain tumours', 'volume': '49', 'author': 'Deane', 'year': '1981', 'journal-title': 'Part 1. A sequential light and electron microscope study of angiogenesis. J Neurol Sci'} / Part 1. A sequential light and electron microscope study of angiogenesis. J Neurol Sci / The vasculature of experimental brain tumours by Deane (1981)
  35. {'key': '10.1038/sj.neo.7900006_bib35', 'first-page': '5822', 'article-title': 'Up-regulation of vascular endothelial growth factor and its cognate receptor in a rat glioma model of angiogenesis', 'volume': '53', 'author': 'Plate', 'year': '1993', 'journal-title': 'Cancer Res'} / Cancer Res / Up-regulation of vascular endothelial growth factor and its cognate receptor in a rat glioma model of angiogenesis by Plate (1993)
  36. 10.3171/jns.1994.81.6.0902 / J Neurosurg / Quantitative immunohistochemical analysis of the microvasculature in untreated human glioblastoma multiforme by Wesseling (1994)
  37. 10.1007/BF00687774 / Acta Neuropathol / The microvascular architecture of human malignant glioma by Orita (1988)
  38. 10.1038/bjc.1995.141 / Br J Cancer / Vascularity and perfusion of human gliomas xenografted in the athymic nude mouse by Bernsen (1995)
  39. 10.1007/BF01411266 / Acta Neurochir (Wien) / Nitric oxide synthase is expressed in experimental malignant glioma and influences tumour blood flow by Whittle (1996)
  40. 10.1111/j.1476-5381.1992.tb13412.x / Br J Pharmacol / Inhibitors of nitric oxide synthase selectively reduce flow in tumour-associated neovasculature by Andrade (1992)
  41. 10.1227/00006123-199505000-00014 / Neurosurgery / A pial window model for the intracranial study of human glioma microvascular function by Foltz (1995)
  42. 10.1038/nm1197-1203 / Nat Med / Quantitative angiogenesis assays: progress and problems by Jain (1997)
  43. 10.1073/pnas.93.16.8502 / Proc Natl Acad Sci USA / Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor by Cheng (1996)
  44. 10.1074/jbc.270.43.25915 / J Biol Chem / Both V-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells by Grugel (1995)
  45. {'key': '10.1038/sj.neo.7900006_bib45', 'first-page': '963', 'article-title': 'Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression', 'volume': '9', 'author': 'Kieser', 'year': '1994', 'journal-title': 'Oncogene'} / Oncogene / Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression by Kieser (1994)
  46. 10.1038/359843a0 / Nature / Vascular endothelial growth factor induced by hypoxia-initiated angiogenesis by Shweiki (1992)
  47. 10.1073/pnas.92.3.768 / Proc Natl Acad Sci USA / Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implications for tumor angiogenesis by Shweiki (1995)
  48. 10.1172/JCI118437 / J Clin Invest / Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression by Brogi (1996)
  49. 10.3171/jns.1995.82.5.0864 / J Neurosurg / Vascular endothelial growth factor in human glioma cell lines: Induced secretion by EGF, PDGF-BB, and bFGF by Tsai (1995)
  50. 10.1016/0092-8674(90)90801-K / Cell / Signal transduction by receptors with tyrosine kinase activity by Ullrich (1990)
  51. 10.1126/science.7892601 / Science / Tyrosine kinase inhibition: An approach to drug development by Levitzki (1995)
  52. 10.1038/nm0195-27 / Nature Med / Angiogenesis in cancer, vascular, rheumatoid and other disease by Folkman (1995)
  53. {'key': '10.1038/sj.neo.7900006_bib53', 'first-page': '4264', 'article-title': 'Tumor angiogenesis and interstitial hypertension', 'volume': '56', 'author': 'Boucher', 'year': '1996', 'journal-title': 'Cancer Res'} / Cancer Res / Tumor angiogenesis and interstitial hypertension by Boucher (1996)
Dates
Type When
Created 23 years ago (Sept. 4, 2002, 2:48 p.m.)
Deposited 4 years, 3 months ago (May 15, 2021, 12:56 p.m.)
Indexed 2 months, 3 weeks ago (June 11, 2025, 5:28 a.m.)
Issued 26 years, 5 months ago (April 1, 1999)
Published 26 years, 5 months ago (April 1, 1999)
Published Print 26 years, 5 months ago (April 1, 1999)
Funders 0

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@article{Vajkoczy_1999, title={Inhibition of Tumor Growth, Angiogenesis, and Microcirculation by the Novel Flk-1 Inhibitor SU5416 as Assessed by Intravital Multi-fluorescence Videomicroscopy}, volume={1}, ISSN={1476-5586}, url={http://dx.doi.org/10.1038/sj.neo.7900006}, DOI={10.1038/sj.neo.7900006}, number={1}, journal={Neoplasia}, publisher={Elsevier BV}, author={Vajkoczy, Peter and Menger, Michael D. and Vollmar, Brigitte and Schilling, Lothar and Schmiedek, Peter and Hirth, K. Peter and Ullrich, Axel and Fong, T.Annie T.}, year={1999}, month=apr, pages={31–41} }