DOI: 10.1038/sj.leu.2402157. Improved prognostic significance of cytokine-induced proliferation in vitro in patients with de novo acute myeloid leukemia of intermediate risk: impact of internal tandem duplications in the Flt3 gene

Improved prognostic significance of cytokine-induced proliferation in vitro in patients with de novo acute myeloid leukemia of intermediate risk: impact of internal tandem duplications in the Flt3 gene

10.1038/sj.leu.2402157

Crossref journal-article

Springer Science and Business Media LLC

Leukemia (297)

Bibliography

Rombouts, W., LÃ¶wenberg, B., van Putten, W., & Ploemacher, R. (2001). Improved prognostic significance of cytokine-induced proliferation in vitro in patients with de novo acute myeloid leukemia of intermediate risk: impact of internal tandem duplications in the Flt3 gene. Leukemia, 15(7), 1046â1053.

Authors 4

WJC Rombouts (first)
B Löwenberg (additional)
WLJ van Putten (additional)
RE Ploemacher (additional)

References 30 Referenced 13

Lowenberg B, Downing JR, Burnett A . Acute myeloid leukemia N Engl J Med 1999 341: 1051–62 (10.1056/NEJM199909303411407) / N Engl J Med by B Lowenberg (1999)
van Putten W, Lowenbreg B . Prognostic factors in adult AML Blood 1997 90 (Suppl. 1): 65a (Abstr.) / Blood by W van Putten (1997)
Rosnet O, Mattei MG, Marchetto S, Birnbaum D . Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene Genomics 1991 9: 380–385 (10.1016/0888-7543(91)90270-O) / Genomics by O Rosnet (1991)
Lyman SD, James L, Zappone J, Sleath PR, Beckmann MP, Bird T . Characterization of the protein encoded by the flt3 (flk2) receptor-like tyrosine kinase gene Oncogene 1993 8: 815–822 / Oncogene by SD Lyman (1993)
Lyman SD, James L, Johnson L, Brasel K, de Vries P, Escobar SS, Downey H, Splett RR, Beckmann MP, McKenna HJ . Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells Blood 1994 83: 2795–2801 (10.1182/blood.V83.10.2795.2795) / Blood by SD Lyman (1994)
Agnes F, Shamoon B, Dina C, Rosnet O, Birnbaum D, Galibert F . Genomic structure of the downstream part of the human FLT3 gene: exon/intron structure conservation among genes encoding receptor tyrosine kinases (RTK) of subclass III Gene 1994 145: 283–288 (10.1016/0378-1119(94)90021-3) / Gene by F Agnes (1994)
Zola H, Siderius N, Flego L, Beckman I, Seshadri R . Cytokine receptor expression in leukaemic cells Leuk Res 1994 18: 347–355 (10.1016/0145-2126(94)90018-3) / Leuk Res by H Zola (1994)
Escribano L, Ocqueteau M, Almeida J, Orfao A, San Miguel JF . Expression of the c-kit (CD117) molecule in normal and malignant hematopoiesis Leuk Lymphoma 1998 30: 459–466 (10.3109/10428199809057558) / Leuk Lymphoma by L Escribano (1998)
Dubreuil P, Torres H, Courcoul MA, Birg F, Mannoni P . c-fms expression is a marker of human acute myeloid leukemias Blood 1988 72: 1081–1085 (10.1182/blood.V72.3.1081.bloodjournal7231081) / Blood by P Dubreuil (1988)
Birg F, Rosnet O, Carbuccia N, Birnbaum D . The expression of FMS, KIT and FLT3 in hematopoietic malignancies Leuk Lymphoma 1994 13: 223–227 (10.3109/10428199409056285) / Leuk Lymphoma by F Birg (1994)
Rombouts WJC, Blokland I, Lowenberg B, Ploemacher RE . Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene Leukemia 2000 14: 675–683 (10.1038/sj.leu.2401731) / Leukemia by WJC Rombouts (2000)
Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, Asou N, Kuriyama K, Jinnai I, Shimazaki C, Akiyama H, Saito K, Oh H, Motoji T, Omoto E, Saito H, Ohno R, Ueda R . Prognostic implication of Flt3 and N-Ras gene mutations in acute myeloid leukemia Blood 1999 93: 3074–3080 / Blood by H Kiyoi (1999)
Kondo M, Horibe K, Takahashi Y, Matsumoto K, Fukuda M, Inaba J, Kato K, Kojima S, Matsuyama T . Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia Med Pediatr Oncol 1999 33: 525–529 (10.1002/(SICI)1096-911X(199912)33:6<525::AID-MPO1>3.0.CO;2-8) / Med Pediatr Oncol by M Kondo (1999)
Horiike S, Yokota S, Nakao M, Iwai T, Sasai Y, Kaneko H, Taniwaki M, Kashima K, Fujii H, Abe T, Misawa S . Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia Leukemia 1997 11: 1442–1446 (10.1038/sj.leu.2400770) / Leukemia by S Horiike (1997)
Rombouts WJC, Broyl A, Martens ACM, Slater R, Ploemacher RE . Reduced proliferative ability of human acute myeloid leukemia cells with internal tandem duplications in the Flt3 gene in stroma supported long term cultures Leukemia 1999 13: 1071–1078 (10.1038/sj.leu.2401446) / Leukemia by WJC Rombouts (1999)
French-American-British (FAB) Cooperative group . Proposed revised criteria for the classification of acute myeloid leukemia Ann Intern Med 1985 103: 620–685 (10.7326/0003-4819-103-4-620) / Ann Intern Med by group French-American-British (FAB) Coope (1985)
Vellenga E, van Putten WL, Boogaerts MA, Daenen SM, Verhoef GE, Hagenbeek A, Jonkhoff AR, Huijgens PC, Verdonck LF, van der Lelie J, Schouten HC, Gmur J, Wijermans P, Gratwohl A, Hess U, Fey MF, Lowenberg B . Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia? Bone Marrow Transplant 1999 23: 1279–1282 (10.1038/sj.bmt.1701799) / Bone Marrow Transplant by E Vellenga (1999)
Lowenberg B, Boogaerts MA, Daenen SM, Verhoef GE, Hagenbeek A, Vellenga E, Ossenkoppele GJ, Huijgens PC, Verdonck LF, van der Lelie J, Wielenga JJ, Schouten HC, Gmur J, Gratwohl A, Hess U, Fey MF, van Putten WL . Value of different modalities of granulocyte–macrophage colony-stimulating factor applied during or after induction therapy of acute myeloid leukemia J Clin Oncol 1997 15: 3496–3506 (10.1200/JCO.1997.15.12.3496) / J Clin Oncol by B Lowenberg (1997)
Lowenberg B, Suciu S, Archimbaud E, Ossenkoppele G, Verhoef GE, Vellenga E, Wijermans P, Berneman Z, Dekker AW, Stryckmans P, Schouten H, Jehn U, Muus P, Sonneveld P, Dardenne M, Zittoun R . Use of recombinant GM-CSF during and after remission induction chemotherapy in patients aged 61 years and older with acute myeloid leukemia: final report of AML-11, a phase III randomized study of the Leukemia Cooperative Group of European Organisation for the Research and Treatment of Cancer and the Dutch Belgian Hemato–Oncology Cooperative Group Blood 1997 90: 2952–2961 / Blood by B Lowenberg (1997)
Mrozek K, Heinonen K, de la Chapelle A, Bloomfield CD . Clinical significance of cytogenetics in acute myeloid leukemia Semin Oncol 1997 24: 17–31 / Semin Oncol by K Mrozek (1997)
Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G, Rees J, Hann I, Stevens R, Burnett A, Goldstone A . The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties Blood 1998 92: 2322–2333 (10.1182/blood.V92.7.2322) / Blood by D Grimwade (1998)
Nakao M, Yokota S, Iwai T, Kaneko H, Horiike S, Kashima K, Sonoda Y, Fujimoto T, Misawa S . Internal tandem duplication of the flt3 gene found in acute myeloid leukemia Leukemia 1996 10: 1911–1918 / Leukemia by M Nakao (1996)
Yokota S, Hansen-Hagge TE, Ludwig WD, Reiter A, Raghavachar A, Kleihauer E, Bertram CR . The use of polymerase chain reaction to monitor minimal residual disease in acute myeloid leukemia patients Blood 1991 77: 331–339 (10.1182/blood.V77.2.331.331) / Blood by S Yokota (1991)
Delwel R, Salem M, Pellens C, Dorrsers L, Wagemaker G, Clark S, Lowenberg B . Growth regulation of human acute myeloid leykemia: effects of five recombinant hematopoietic factors in a serum-free culture system Blood 1988 72: 1944–1949 (10.1182/blood.V72.6.1944.1944) / Blood by R Delwel (1988)
Yokota S, Kiyoi H, Nakao M, Iwai T, Misawa S, Okuda T, Sonoda Y, Abe T, Kahsima K, Matsuo Y, Naoe T . Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines Leukemia 1997 11: 1605–1609 (10.1038/sj.leu.2400812) / Leukemia by S Yokota (1997)
Delwel R, Salem M, Pellens C, Dorssers L, Wagemaker G, Clark S, Lowenberg B . Growth regulation of human acute myeloid leukemia: effects of five recombinant hematopoietic factors in a serum-free culture system Blood 1988 72: 1944–1949 (10.1182/blood.V72.6.1944.1944) / Blood by R Delwel (1988)
Cannistra SA . Growth regulation of malignant clonogenic cells in acute myeloid leukemia Curr Opin Oncol 1991 3: 4–12 (10.1097/00001622-199102000-00002) / Curr Opin Oncol by SA Cannistra (1991)
Tsuzuki M, Ezaki K, Maruyama F, Ino T, Kojima H, Okamoto M, Yamaguchi T, Nomura T, Miyazaki H, Wakita M, Matsui T, Hirano M . Proliferative effects of several hematopoietic growth factors on acute myelogenous leukemia cells and correlation with treatment outcome Leukemia 1997 11: 2125–2130 (10.1038/sj.leu.2400870) / Leukemia by M Tsuzuki (1997)
Lowenberg B, van Putten LJ, Touw IP, Delwel R, Santini V . Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis an adult acute myeloid leukemia N Engl J Med 1993 328: 614–619 (10.1056/NEJM199303043280904) / N Engl J Med by B Lowenberg (1993)
Hunter AE, Rogers SY, Roberts IA, Barrett AJ, Russell N . Autonomous growth of blast cells is associated with reduced survival in acute myeloblastic leukemia Blood 1993 82: 899–903 (10.1182/blood.V82.3.899.899) / Blood by AE Hunter (1993)

Dates

Type	When
Created	22 years, 11 months ago (Sept. 19, 2002, 5:05 p.m.)
Deposited	3 years, 5 months ago (March 31, 2022, 5:10 p.m.)
Indexed	3 months, 1 week ago (May 25, 2025, 9:44 p.m.)
Issued	24 years, 2 months ago (July 1, 2001)
Published	24 years, 2 months ago (July 1, 2001)
Published Online	24 years, 1 month ago (July 19, 2001)
Published Print	24 years, 2 months ago (July 1, 2001)

Funders 0

None

BibTeX

@article{Rombouts_2001, title={Improved prognostic significance of cytokine-induced proliferation in vitro in patients with de novo acute myeloid leukemia of intermediate risk: impact of internal tandem duplications in the Flt3 gene}, volume={15}, ISSN={1476-5551}, url={http://dx.doi.org/10.1038/sj.leu.2402157}, DOI={10.1038/sj.leu.2402157}, number={7}, journal={Leukemia}, publisher={Springer Science and Business Media LLC}, author={Rombouts, WJC and Löwenberg, B and van Putten, WLJ and Ploemacher, RE}, year={2001}, month=jul, pages={1046–1053} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        5,
        26
      ]
    ],
    "date-time": "2025-05-26T01:44:49Z",
    "timestamp": 1748223889330
  },
  "reference-count": 30,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "7",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2001,
            7,
            1
          ]
        ],
        "date-time": "2001-07-01T00:00:00Z",
        "timestamp": 993945600000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "https://www.springer.com/tdm"
    },
    {
      "start": {
        "date-parts": [
          [
            2001,
            7,
            1
          ]
        ],
        "date-time": "2001-07-01T00:00:00Z",
        "timestamp": 993945600000
      },
      "content-version": "vor",
      "delay-in-days": 0,
      "URL": "https://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [
      "link.springer.com"
    ],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2001,
        7,
        1
      ]
    ]
  },
  "DOI": "10.1038/sj.leu.2402157",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2002,
        9,
        19
      ]
    ],
    "date-time": "2002-09-19T21:05:45Z",
    "timestamp": 1032469545000
  },
  "page": "1046-1053",
  "update-policy": "http://dx.doi.org/10.1007/springer_crossmark_policy",
  "source": "Crossref",
  "is-referenced-by-count": 13,
  "title": "Improved prognostic significance of cytokine-induced proliferation in vitro in patients with de novo acute myeloid leukemia of intermediate risk: impact of internal tandem duplications in the Flt3 gene",
  "prefix": "10.1038",
  "volume": "15",
  "author": [
    {
      "given": "WJC",
      "family": "Rombouts",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "B",
      "family": "L\u00f6wenberg",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "WLJ",
      "family": "van Putten",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "RE",
      "family": "Ploemacher",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "published-online": {
    "date-parts": [
      [
        2001,
        7,
        19
      ]
    ]
  },
  "reference": [
    {
      "key": "BF2402157_CR1",
      "doi-asserted-by": "publisher",
      "first-page": "1051",
      "DOI": "10.1056/NEJM199909303411407",
      "volume": "341",
      "author": "B Lowenberg",
      "year": "1999",
      "unstructured": "Lowenberg B, Downing JR, Burnett A . Acute myeloid leukemia N Engl J Med 1999 341: 1051\u201362",
      "journal-title": "N Engl J Med"
    },
    {
      "key": "BF2402157_CR2",
      "first-page": "65a (Abstr.)",
      "volume": "90 (Suppl. 1)",
      "author": "W van Putten",
      "year": "1997",
      "unstructured": "van Putten W, Lowenbreg B . Prognostic factors in adult AML Blood 1997 90 (Suppl. 1): 65a (Abstr.)",
      "journal-title": "Blood"
    },
    {
      "key": "BF2402157_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "380",
      "DOI": "10.1016/0888-7543(91)90270-O",
      "volume": "9",
      "author": "O Rosnet",
      "year": "1991",
      "unstructured": "Rosnet O, Mattei MG, Marchetto S, Birnbaum D . Isolation and chromosomal localization of a novel FMS-like tyrosine kinase gene Genomics 1991 9: 380\u2013385",
      "journal-title": "Genomics"
    },
    {
      "key": "BF2402157_CR4",
      "first-page": "815",
      "volume": "8",
      "author": "SD Lyman",
      "year": "1993",
      "unstructured": "Lyman SD, James L, Zappone J, Sleath PR, Beckmann MP, Bird T . Characterization of the protein encoded by the flt3 (flk2) receptor-like tyrosine kinase gene Oncogene 1993 8: 815\u2013822",
      "journal-title": "Oncogene"
    },
    {
      "key": "BF2402157_CR5",
      "doi-asserted-by": "crossref",
      "first-page": "2795",
      "DOI": "10.1182/blood.V83.10.2795.2795",
      "volume": "83",
      "author": "SD Lyman",
      "year": "1994",
      "unstructured": "Lyman SD, James L, Johnson L, Brasel K, de Vries P, Escobar SS, Downey H, Splett RR, Beckmann MP, McKenna HJ . Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells Blood 1994 83: 2795\u20132801",
      "journal-title": "Blood"
    },
    {
      "key": "BF2402157_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "283",
      "DOI": "10.1016/0378-1119(94)90021-3",
      "volume": "145",
      "author": "F Agnes",
      "year": "1994",
      "unstructured": "Agnes F, Shamoon B, Dina C, Rosnet O, Birnbaum D, Galibert F . Genomic structure of the downstream part of the human FLT3 gene: exon/intron structure conservation among genes encoding receptor tyrosine kinases (RTK) of subclass III Gene 1994 145: 283\u2013288",
      "journal-title": "Gene"
    },
    {
      "key": "BF2402157_CR7",
      "doi-asserted-by": "publisher",
      "first-page": "347",
      "DOI": "10.1016/0145-2126(94)90018-3",
      "volume": "18",
      "author": "H Zola",
      "year": "1994",
      "unstructured": "Zola H, Siderius N, Flego L, Beckman I, Seshadri R . Cytokine receptor expression in leukaemic cells Leuk Res 1994 18: 347\u2013355",
      "journal-title": "Leuk Res"
    },
    {
      "key": "BF2402157_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "459",
      "DOI": "10.3109/10428199809057558",
      "volume": "30",
      "author": "L Escribano",
      "year": "1998",
      "unstructured": "Escribano L, Ocqueteau M, Almeida J, Orfao A, San Miguel JF . Expression of the c-kit (CD117) molecule in normal and malignant hematopoiesis Leuk Lymphoma 1998 30: 459\u2013466",
      "journal-title": "Leuk Lymphoma"
    },
    {
      "key": "BF2402157_CR9",
      "doi-asserted-by": "crossref",
      "first-page": "1081",
      "DOI": "10.1182/blood.V72.3.1081.bloodjournal7231081",
      "volume": "72",
      "author": "P Dubreuil",
      "year": "1988",
      "unstructured": "Dubreuil P, Torres H, Courcoul MA, Birg F, Mannoni P . c-fms expression is a marker of human acute myeloid leukemias Blood 1988 72: 1081\u20131085",
      "journal-title": "Blood"
    },
    {
      "key": "BF2402157_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "223",
      "DOI": "10.3109/10428199409056285",
      "volume": "13",
      "author": "F Birg",
      "year": "1994",
      "unstructured": "Birg F, Rosnet O, Carbuccia N, Birnbaum D . The expression of FMS, KIT and FLT3 in hematopoietic malignancies Leuk Lymphoma 1994 13: 223\u2013227",
      "journal-title": "Leuk Lymphoma"
    },
    {
      "key": "BF2402157_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "675",
      "DOI": "10.1038/sj.leu.2401731",
      "volume": "14",
      "author": "WJC Rombouts",
      "year": "2000",
      "unstructured": "Rombouts WJC, Blokland I, Lowenberg B, Ploemacher RE . Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene Leukemia 2000 14: 675\u2013683",
      "journal-title": "Leukemia"
    },
    {
      "key": "BF2402157_CR12",
      "first-page": "3074",
      "volume": "93",
      "author": "H Kiyoi",
      "year": "1999",
      "unstructured": "Kiyoi H, Naoe T, Nakano Y, Yokota S, Minami S, Miyawaki S, Asou N, Kuriyama K, Jinnai I, Shimazaki C, Akiyama H, Saito K, Oh H, Motoji T, Omoto E, Saito H, Ohno R, Ueda R . Prognostic implication of Flt3 and N-Ras gene mutations in acute myeloid leukemia Blood 1999 93: 3074\u20133080",
      "journal-title": "Blood"
    },
    {
      "key": "BF2402157_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "525",
      "DOI": "10.1002/(SICI)1096-911X(199912)33:6<525::AID-MPO1>3.0.CO;2-8",
      "volume": "33",
      "author": "M Kondo",
      "year": "1999",
      "unstructured": "Kondo M, Horibe K, Takahashi Y, Matsumoto K, Fukuda M, Inaba J, Kato K, Kojima S, Matsuyama T . Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia Med Pediatr Oncol 1999 33: 525\u2013529",
      "journal-title": "Med Pediatr Oncol"
    },
    {
      "key": "BF2402157_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "1442",
      "DOI": "10.1038/sj.leu.2400770",
      "volume": "11",
      "author": "S Horiike",
      "year": "1997",
      "unstructured": "Horiike S, Yokota S, Nakao M, Iwai T, Sasai Y, Kaneko H, Taniwaki M, Kashima K, Fujii H, Abe T, Misawa S . Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia Leukemia 1997 11: 1442\u20131446",
      "journal-title": "Leukemia"
    },
    {
      "key": "BF2402157_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "1071",
      "DOI": "10.1038/sj.leu.2401446",
      "volume": "13",
      "author": "WJC Rombouts",
      "year": "1999",
      "unstructured": "Rombouts WJC, Broyl A, Martens ACM, Slater R, Ploemacher RE . Reduced proliferative ability of human acute myeloid leukemia cells with internal tandem duplications in the Flt3 gene in stroma supported long term cultures Leukemia 1999 13: 1071\u20131078",
      "journal-title": "Leukemia"
    },
    {
      "key": "BF2402157_CR16",
      "doi-asserted-by": "publisher",
      "first-page": "620",
      "DOI": "10.7326/0003-4819-103-4-620",
      "volume": "103",
      "author": "group French-American-British (FAB) Coope",
      "year": "1985",
      "unstructured": "French-American-British (FAB) Cooperative group . Proposed revised criteria for the classification of acute myeloid leukemia Ann Intern Med 1985 103: 620\u2013685",
      "journal-title": "Ann Intern Med"
    },
    {
      "key": "BF2402157_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "1279",
      "DOI": "10.1038/sj.bmt.1701799",
      "volume": "23",
      "author": "E Vellenga",
      "year": "1999",
      "unstructured": "Vellenga E, van Putten WL, Boogaerts MA, Daenen SM, Verhoef GE, Hagenbeek A, Jonkhoff AR, Huijgens PC, Verdonck LF, van der Lelie J, Schouten HC, Gmur J, Wijermans P, Gratwohl A, Hess U, Fey MF, Lowenberg B . Peripheral blood stem cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia? Bone Marrow Transplant 1999 23: 1279\u20131282",
      "journal-title": "Bone Marrow Transplant"
    },
    {
      "key": "BF2402157_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "3496",
      "DOI": "10.1200/JCO.1997.15.12.3496",
      "volume": "15",
      "author": "B Lowenberg",
      "year": "1997",
      "unstructured": "Lowenberg B, Boogaerts MA, Daenen SM, Verhoef GE, Hagenbeek A, Vellenga E, Ossenkoppele GJ, Huijgens PC, Verdonck LF, van der Lelie J, Wielenga JJ, Schouten HC, Gmur J, Gratwohl A, Hess U, Fey MF, van Putten WL . Value of different modalities of granulocyte\u2013macrophage colony-stimulating factor applied during or after induction therapy of acute myeloid leukemia J Clin Oncol 1997 15: 3496\u20133506",
      "journal-title": "J Clin Oncol"
    },
    {
      "key": "BF2402157_CR19",
      "first-page": "2952",
      "volume": "90",
      "author": "B Lowenberg",
      "year": "1997",
      "unstructured": "Lowenberg B, Suciu S, Archimbaud E, Ossenkoppele G, Verhoef GE, Vellenga E, Wijermans P, Berneman Z, Dekker AW, Stryckmans P, Schouten H, Jehn U, Muus P, Sonneveld P, Dardenne M, Zittoun R . Use of recombinant GM-CSF during and after remission induction chemotherapy in patients aged 61 years and older with acute myeloid leukemia: final report of AML-11, a phase III randomized study of the Leukemia Cooperative Group of European Organisation for the Research and Treatment of Cancer and the Dutch Belgian Hemato\u2013Oncology Cooperative Group Blood 1997 90: 2952\u20132961",
      "journal-title": "Blood"
    },
    {
      "key": "BF2402157_CR20",
      "first-page": "17",
      "volume": "24",
      "author": "K Mrozek",
      "year": "1997",
      "unstructured": "Mrozek K, Heinonen K, de la Chapelle A, Bloomfield CD . Clinical significance of cytogenetics in acute myeloid leukemia Semin Oncol 1997 24: 17\u201331",
      "journal-title": "Semin Oncol"
    },
    {
      "key": "BF2402157_CR21",
      "doi-asserted-by": "crossref",
      "first-page": "2322",
      "DOI": "10.1182/blood.V92.7.2322",
      "volume": "92",
      "author": "D Grimwade",
      "year": "1998",
      "unstructured": "Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G, Rees J, Hann I, Stevens R, Burnett A, Goldstone A . The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties Blood 1998 92: 2322\u20132333",
      "journal-title": "Blood"
    },
    {
      "key": "BF2402157_CR22",
      "first-page": "1911",
      "volume": "10",
      "author": "M Nakao",
      "year": "1996",
      "unstructured": "Nakao M, Yokota S, Iwai T, Kaneko H, Horiike S, Kashima K, Sonoda Y, Fujimoto T, Misawa S . Internal tandem duplication of the flt3 gene found in acute myeloid leukemia Leukemia 1996 10: 1911\u20131918",
      "journal-title": "Leukemia"
    },
    {
      "key": "BF2402157_CR23",
      "doi-asserted-by": "crossref",
      "first-page": "331",
      "DOI": "10.1182/blood.V77.2.331.331",
      "volume": "77",
      "author": "S Yokota",
      "year": "1991",
      "unstructured": "Yokota S, Hansen-Hagge TE, Ludwig WD, Reiter A, Raghavachar A, Kleihauer E, Bertram CR . The use of polymerase chain reaction to monitor minimal residual disease in acute myeloid leukemia patients Blood 1991 77: 331\u2013339",
      "journal-title": "Blood"
    },
    {
      "key": "BF2402157_CR24",
      "doi-asserted-by": "crossref",
      "first-page": "1944",
      "DOI": "10.1182/blood.V72.6.1944.1944",
      "volume": "72",
      "author": "R Delwel",
      "year": "1988",
      "unstructured": "Delwel R, Salem M, Pellens C, Dorrsers L, Wagemaker G, Clark S, Lowenberg B . Growth regulation of human acute myeloid leykemia: effects of five recombinant hematopoietic factors in a serum-free culture system Blood 1988 72: 1944\u20131949",
      "journal-title": "Blood"
    },
    {
      "key": "BF2402157_CR25",
      "doi-asserted-by": "publisher",
      "first-page": "1605",
      "DOI": "10.1038/sj.leu.2400812",
      "volume": "11",
      "author": "S Yokota",
      "year": "1997",
      "unstructured": "Yokota S, Kiyoi H, Nakao M, Iwai T, Misawa S, Okuda T, Sonoda Y, Abe T, Kahsima K, Matsuo Y, Naoe T . Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines Leukemia 1997 11: 1605\u20131609",
      "journal-title": "Leukemia"
    },
    {
      "key": "BF2402157_CR26",
      "doi-asserted-by": "crossref",
      "first-page": "1944",
      "DOI": "10.1182/blood.V72.6.1944.1944",
      "volume": "72",
      "author": "R Delwel",
      "year": "1988",
      "unstructured": "Delwel R, Salem M, Pellens C, Dorssers L, Wagemaker G, Clark S, Lowenberg B . Growth regulation of human acute myeloid leukemia: effects of five recombinant hematopoietic factors in a serum-free culture system Blood 1988 72: 1944\u20131949",
      "journal-title": "Blood"
    },
    {
      "key": "BF2402157_CR27",
      "doi-asserted-by": "publisher",
      "first-page": "4",
      "DOI": "10.1097/00001622-199102000-00002",
      "volume": "3",
      "author": "SA Cannistra",
      "year": "1991",
      "unstructured": "Cannistra SA . Growth regulation of malignant clonogenic cells in acute myeloid leukemia Curr Opin Oncol 1991 3: 4\u201312",
      "journal-title": "Curr Opin Oncol"
    },
    {
      "key": "BF2402157_CR28",
      "doi-asserted-by": "publisher",
      "first-page": "2125",
      "DOI": "10.1038/sj.leu.2400870",
      "volume": "11",
      "author": "M Tsuzuki",
      "year": "1997",
      "unstructured": "Tsuzuki M, Ezaki K, Maruyama F, Ino T, Kojima H, Okamoto M, Yamaguchi T, Nomura T, Miyazaki H, Wakita M, Matsui T, Hirano M . Proliferative effects of several hematopoietic growth factors on acute myelogenous leukemia cells and correlation with treatment outcome Leukemia 1997 11: 2125\u20132130",
      "journal-title": "Leukemia"
    },
    {
      "key": "BF2402157_CR29",
      "doi-asserted-by": "publisher",
      "first-page": "614",
      "DOI": "10.1056/NEJM199303043280904",
      "volume": "328",
      "author": "B Lowenberg",
      "year": "1993",
      "unstructured": "Lowenberg B, van Putten LJ, Touw IP, Delwel R, Santini V . Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis an adult acute myeloid leukemia N Engl J Med 1993 328: 614\u2013619",
      "journal-title": "N Engl J Med"
    },
    {
      "key": "BF2402157_CR30",
      "doi-asserted-by": "crossref",
      "first-page": "899",
      "DOI": "10.1182/blood.V82.3.899.899",
      "volume": "82",
      "author": "AE Hunter",
      "year": "1993",
      "unstructured": "Hunter AE, Rogers SY, Roberts IA, Barrett AJ, Russell N . Autonomous growth of blast cells is associated with reduced survival in acute myeloblastic leukemia Blood 1993 82: 899\u2013903",
      "journal-title": "Blood"
    }
  ],
  "container-title": "Leukemia",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://www.nature.com/articles/2402157.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://www.nature.com/articles/2402157",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "https://www.nature.com/articles/2402157.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2022,
        3,
        31
      ]
    ],
    "date-time": "2022-03-31T21:10:24Z",
    "timestamp": 1648761024000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/2402157"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2001,
        7,
        1
      ]
    ]
  },
  "references-count": 30,
  "journal-issue": {
    "issue": "7",
    "published-print": {
      "date-parts": [
        [
          2001,
          7,
          1
        ]
      ]
    }
  },
  "alternative-id": [
    "BF2402157"
  ],
  "URL": "http://dx.doi.org/10.1038/sj.leu.2402157",
  "relation": {},
  "ISSN": [
    "0887-6924",
    "1476-5551"
  ],
  "subject": [],
  "container-title-short": "Leukemia",
  "published": {
    "date-parts": [
      [
        2001,
        7,
        1
      ]
    ]
  },
  "assertion": [
    {
      "value": "25 September 2000",
      "order": 1,
      "name": "received",
      "label": "Received",
      "group": {
        "name": "ArticleHistory",
        "label": "Article History"
      }
    },
    {
      "value": "16 March 2001",
      "order": 2,
      "name": "accepted",
      "label": "Accepted",
      "group": {
        "name": "ArticleHistory",
        "label": "Article History"
      }
    },
    {
      "value": "19 July 2001",
      "order": 3,
      "name": "first_online",
      "label": "First Online",
      "group": {
        "name": "ArticleHistory",
        "label": "Article History"
      }
    }
  ]
}