DOI: 10.1038/sj.gt.3301678. Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle

Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle

10.1038/sj.gt.3301678

Crossref journal-article

Springer Science and Business Media LLC

Gene Therapy (297)

Bibliography

Taniyama, Y., Tachibana, K., Hiraoka, K., Aoki, M., Yamamoto, S., Matsumoto, K., Nakamura, T., Ogihara, T., Kaneda, Y., & Morishita, R. (2002). Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Therapy, 9(6), 372â380.

Authors 10

Y Taniyama (first)
K Tachibana (additional)
K Hiraoka (additional)
M Aoki (additional)
S Yamamoto (additional)
K Matsumoto (additional)
T Nakamura (additional)
T Ogihara (additional)
Y Kaneda (additional)
R Morishita (additional)

References 43 Referenced 331

Second European Consensus Document on Chronic Critical Leg Ischemia. Circulation 1991; 84 (4 Suppl.): 1–26
Dormandy J. et al. Fate of the patient with chronic leg ischaemia. A review article J Cardiovasc Surg Torino 1989 30: 50 50 / J Cardiovasc Surg Torino by J Dormandy (1989)
Rutherford R.B. et al. Suggested standards for reports dealing with lower extremity ischemia. Ad Hoc Committee on Reporting Standards. Society for Vascular Surgery/North American Chapter, International Society for Cardiovascular Surgery J Vasc Surg 1986 4: 80 80 (10.1016/0741-5214(86)90326-5) / J Vasc Surg by RB Rutherford (1986)
Isner J.M. et al. Clinical evidence of angiogenesis after arterial gene transfer of ph VEGF165 in patient with ischaemic limb Lancet 1996 348: 370 370 (10.1016/S0140-6736(96)03361-2) / Lancet by JM Isner (1996)
Baumgartner I. et al. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia Circulation 1998 97: 1114 1114 (10.1161/01.CIR.97.12.1114) / Circulation by I Baumgartner (1998)
Isner J.M. et al. Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: preliminary clinical results J Vasc Surg 1998 28: 964 964 (10.1016/S0741-5214(98)70022-9) / J Vasc Surg by JM Isner (1998)
Baumgartner I. et al. Lower-extremity edema associated with gene transfer of naked DNA encoding vascular endothelial growth factor Ann Intern Med 2000 132: 880 880 (10.7326/0003-4819-132-11-200006060-00005) / Ann Intern Med by I Baumgartner (2000)
Losordo D.W. et al. Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia Circulation 1998 98: 2800 2800 (10.1161/01.CIR.98.25.2800) / Circulation by DW Losordo (1998)
Vale P.R. et al. Left ventricular electromechanical mapping to assess efficacy of phVEGF165 gene transfer for therapeutic angiogenesis in chronic myocardial ischemia Circulation 2000 102: 965 965 (10.1161/01.CIR.102.9.965) / Circulation by PR Vale (2000)
Rosengart T.K. et al. Angiogenesis gene therapy: phase 1 assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease Circulation 1999 100: 468 468 (10.1161/01.CIR.100.5.468) / Circulation by TK Rosengart (1999)
Rosengart T.K. et al. Six-month assessment of a phase 1 trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA Ann Surg 1999 230: 466 466 (10.1097/00000658-199910000-00002) / Ann Surg by TK Rosengart (1999)
Taniyama Y. et al. Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hind limb ischemia models: preclinical study for treatment of peripheral arterial disease Gene Therapy 2000 8: 181 181 (10.1038/sj.gt.3301379) / Gene Therapy by Y Taniyama (2000)
Tabata H., Silver M., Isner J.M. . Arterial gene transfer of acidic fibroblast growth factor for therapeutic angiogenesis in vivo: critical role of secretion signal in use of naked DNA Cardiovasc Res 1997 35: 470 470 (10.1016/S0008-6363(97)00152-1) / Cardiovasc Res by H Tabata (1997)
Ueno H. et al. Adenovirus-mediated expression of the secreted form of basic fibroblast growth factor (FGF-2) induces cellular proliferation and angiogenesis in vivo Arterioscler Thromb Vasc Biol 1997 17: 2453 2453 (10.1161/01.ATV.17.11.2453) / Arterioscler Thromb Vasc Biol by H Ueno (1997)
Takahashi J.C. et al. Adenovirus-mediated gene transfer of basic fibroblast growth factor induces in vitro angiogenesis Atherosclerosis 1997 132: 199 199 (10.1016/S0021-9150(97)00102-0) / Atherosclerosis by JC Takahashi (1997)
Vincent K.A. et al. Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor Circulation 2000 102: 2255 2255 (10.1161/01.CIR.102.18.2255) / Circulation by KA Vincent (2000)
Giordano F.J. et al. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart Nat Med 1996 2: 534 534 (10.1038/nm0596-534) / Nat Med by FJ Giordano (1996)
Aoki M. et al. Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: up-regulation of essential transcription factor for angiogenesis, ets Gene Therapy 2000 7: 417 417 (10.1038/sj.gt.3301104) / Gene Therapy by M Aoki (2000)
Ueda H. et al. Gene transfection of hepatocyte growth factor attenuates reperfusion injury in the heart Ann Thorac Surg 1999 67: 1726 1726 (10.1016/S0003-4975(99)00279-9) / Ann Thorac Surg by H Ueda (1999)
Safi J. Jr. et al. Adenovirus-mediated acidic fibroblast growth factor gene transfer induces angiogenesis in the nonischemic rabbit heart Microvasc Res 1999 58: 238 238 (10.1006/mvre.1999.2165) / Microvasc Res by J Safi Jr. (1999)
Schwarz E.R. et al. Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat – angiogenesis and angioma formation J Am Coll Cardiol 2000 35: 1323 1323 (10.1016/S0735-1097(00)00522-2) / J Am Coll Cardiol by ER Schwarz (2000)
Lazarous D.F. et al. Adenoviral-mediated gene transfer induces sustained pericardial VEGF expression in dogs: effect on myocardial angiogenesis Cardiovasc Res 1999 44: 294 294 (10.1016/S0008-6363(99)00203-5) / Cardiovasc Res by DF Lazarous (1999)
Lee L.Y. et al. Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor 121 Ann Thorac Surg 2000 69: 14 14 (10.1016/S0003-4975(99)01102-9) / Ann Thorac Surg by LY Lee (2000)
Gowdak L.H. et al. Adenovirus-mediated VEGF(121) gene transfer stimulates angiogenesis in normoperfused skeletal muscle and preserves tissue perfusion after induction of ischemia Circulation 2000 102: 565 565 (10.1161/01.CIR.102.5.565) / Circulation by LH Gowdak (2000)
Varenne O. et al. Percutaneous adenoviral gene transfer into porcine coronary arteries: is catheter-based gene delivery adapted to coronary circulation? Hum Gene Ther 1999 10: 1105 1105 (10.1089/10430349950018102) / Hum Gene Ther by O Varenne (1999)
Barr E. et al. Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus Gene Therapy 1994 1: 51 51 / Gene Therapy by E Barr (1994)
Dzau V.J., Mann M.J., Morishita R., Kaneda Y. . Fusigenic viral liposome for gene therapy in cardiovascular diseases Proc Natl Acad Sci USA 1996 93: 11421 11421 (10.1073/pnas.93.21.11421) / Proc Natl Acad Sci USA by VJ Dzau (1996)
Marshall E. . Gene therapy death prompts review of adenovirus vector Science 1999 286: 2244 2244 (10.1126/science.286.5448.2244) / Science by E Marshall (1999)
Aoki M. et al. Survival of grafts of genetically modified cardiac myocytes transfected with FITC-labeled oligodeoxynucleotides and β-galactosidase gene in non-infarcted area, but not myocardial infarcted area Gene Therapy 1997 4: 120 120 (10.1038/sj.gt.3300361) / Gene Therapy by M Aoki (1997)
Tyrrell M.R., Wolfe J.H. . Critical leg ischaemia: an appraisal of clinical definitions. Joint Vascular Research Group Br J Surg 1993 80: 177 177 (10.1002/bjs.1800800214) / Br J Surg by MR Tyrrell (1993)
Eneroth M., Persson B.M. . Amputation for occlusive arterial disease. A prospective multicentre study of 177 amputees Int Orthop 1992 16: 383 383 (10.1007/BF00189624) / Int Orthop by M Eneroth (1992)
Dawson I. et al. Late outcomes of limb loss after failed infrainguinal bypass J Vasc Surg 1995 21: 613 613 (10.1016/S0741-5214(95)70193-1) / J Vasc Surg by I Dawson (1995)
Losordo D.W. et al. Use of the rabbit ear artery to serially assess foreign protein secretion after site specific arterial gene transfer in vivo: evidence that anatomic identification of successful gene transfer may underestimate the potential magnitude of transgene expression Circulation 1994 89: 785 785 (10.1161/01.CIR.89.2.785) / Circulation by DW Losordo (1994)
Huber P.E., Pfisterer P. . In vitro and in vivo transfection of plasmid DNA in the Dunning prostate tumor R3327-AT1 is enhanced by focused ultrasound Gene Therapy 2000 7: 1516 1516 (10.1038/sj.gt.3301242) / Gene Therapy by PE Huber (2000)
Greenleaf W.J. et al. Artificial cavitation nuclei significantly enhance acoustically induced cell transfection Ultrasound Med Biol 1998 24: 587 587 (10.1016/S0301-5629(98)00003-9) / Ultrasound Med Biol by WJ Greenleaf (1998)
Manome Y., Nakamura M., Ohno T., Furuhata H. . Ultrasound facilitates transduction of naked plasmid DNA into colon carcinoma cells in vitro and in vivo Hum Gene Ther 2000 11: 1521 1521 (10.1089/10430340050083252) / Hum Gene Ther by Y Manome (2000)
Tachibana K. et al. Induction of cell-membrane porosity by ultrasound Lancet 1999 353: 1409 1409 (10.1016/S0140-6736(99)01244-1) / Lancet by K Tachibana (1999)
Lawrie A. et al. Microbubble-enhanced ultrasound for vascular gene delivery Gene Therapy 2000 7: 2023 2023 (10.1038/sj.gt.3301339) / Gene Therapy by A Lawrie (2000)
Tachibana K., Tachibana S. . Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis Circulation 1995 92: 1148 1148 (10.1161/01.CIR.92.5.1148) / Circulation by K Tachibana (1995)
Podell S. et al. Physical and biochemical stability of Optison, an injectable ultrasound contrast agent Biotechnol Appl Biochem 1999 30: 213 213 (10.1111/j.1470-8744.1999.tb00773.x) / Biotechnol Appl Biochem by S Podell (1999)
Aoki M. et al. Efficient in vivo gene transfer into heart in rat myocardial infarction model using HVJ (hemagglutinating virus of Japan)–liposome method J Mol Cell Cardiol 1997 29: 949 949 (10.1006/jmcc.1996.0337) / J Mol Cell Cardiol by M Aoki (1997)
Morishita R. et al. Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as ‘cytokine supplement therapy’ Hypertension 1999 33: 1379 1379 (10.1161/01.HYP.33.6.1379) / Hypertension by R Morishita (1999)
Hayashi S. et al. Potential role of hepatocyte growth factor, a novel angiogenic growth factor, in peripheral arterial disease: down-regulation of HGF in response to hypoxia in vascular cells Circulation 1999 100: II301 II301 (10.1161/01.CIR.100.suppl_2.II-301) / Circulation by S Hayashi (1999)

Dates

Type	When
Created	22 years, 11 months ago (Sept. 5, 2002, 2:32 p.m.)
Deposited	1 year, 7 months ago (Jan. 3, 2024, 7:34 a.m.)
Indexed	4 minutes ago (Aug. 31, 2025, 2:20 p.m.)
Issued	23 years, 5 months ago (March 1, 2002)
Published	23 years, 5 months ago (March 1, 2002)
Published Online	23 years, 4 months ago (April 2, 2002)
Published Print	23 years, 5 months ago (March 1, 2002)

Funders 0

None

BibTeX

@article{Taniyama_2002, title={Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle}, volume={9}, ISSN={1476-5462}, url={http://dx.doi.org/10.1038/sj.gt.3301678}, DOI={10.1038/sj.gt.3301678}, number={6}, journal={Gene Therapy}, publisher={Springer Science and Business Media LLC}, author={Taniyama, Y and Tachibana, K and Hiraoka, K and Aoki, M and Yamamoto, S and Matsumoto, K and Nakamura, T and Ogihara, T and Kaneda, Y and Morishita, R}, year={2002}, month=mar, pages={372–380} }

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