DOI: 10.1038/sj.embor.embor861. MYC recruits the TIP60 histone acetyltransferase complex to chromatin

MYC recruits the TIP60 histone acetyltransferase complex to chromatin

10.1038/sj.embor.embor861

Crossref journal-article

Springer Science and Business Media LLC

EMBO reports (297)

Abstract

The transcription factor MYC binds specific DNA sites in cellular chromatin and induces the acetylation of histones H3 and H4. However, the histone acetyltransferases (HATs) that are responsible for these modifications have not yet been identified. MYC associates with TRRAP, a subunit of distinct macromolecular complexes that contain the HATs GCN5/PCAF or TIP60. Although the association of MYC with GCN5 has been shown, its interaction with TIP60 has never been analysed. Here, we show that MYC associates with TIP60 and recruits it to chromatin in vivo with four other components of the TIP60 complex: TRRAP, p400, TIP48 and TIP49. Overexpression of enzymatically inactive TIP60 delays the MYC‐induced acetylation of histone H4, and also reduces the level of MYC binding to chromatin. Thus, the TIP60 HAT complex is recruited to MYC‐target genes and, probably with other other HATs, contributes to histone acetylation in response to mitogenic signals.

Bibliography

Frank, S. R., Parisi, T., Taubert, S., Fernandez, P., Fuchs, M., Chan, H., Livingston, D. M., & Amati, B. (2003). MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Reports, 4(6), 575â580. Portico.

Authors 8

Scott R Frank (first)
Tiziana Parisi (additional)
Stefan Taubert (additional)
Paula Fernandez (additional)
Miriam Fuchs (additional)
Ho‐Man Chan (additional)
David M Livingston (additional)
Bruno Amati (additional)

References 27 Referenced 304

Dates

Type	When
Created	22 years, 2 months ago (May 30, 2003, 9:16 a.m.)
Deposited	1 year, 8 months ago (Dec. 18, 2023, 3:56 p.m.)
Indexed	3 weeks, 1 day ago (Aug. 7, 2025, 5 p.m.)
Issued	22 years, 2 months ago (June 1, 2003)
Published	22 years, 2 months ago (June 1, 2003)
Published Online	22 years, 2 months ago (June 1, 2003)
Published Print	22 years, 2 months ago (June 1, 2003)

Funders 0

None

BibTeX

@article{Frank_2003, title={MYC recruits the TIP60 histone acetyltransferase complex to chromatin}, volume={4}, ISSN={1469-3178}, url={http://dx.doi.org/10.1038/sj.embor.embor861}, DOI={10.1038/sj.embor.embor861}, number={6}, journal={EMBO reports}, publisher={Springer Science and Business Media LLC}, author={Frank, Scott R and Parisi, Tiziana and Taubert, Stefan and Fernandez, Paula and Fuchs, Miriam and Chan, Ho‐Man and Livingston, David M and Amati, Bruno}, year={2003}, month=jun, pages={575–580} }

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