DOI: 10.1038/sj.embor.embor854. The role of the death‐domain kinase RIP in tumour‐necrosis‐factor‐induced activation of mitogen‐activated protein kinases

The role of the death‐domain kinase RIP in tumour‐necrosis‐factor‐induced activation of mitogen‐activated protein kinases

10.1038/sj.embor.embor854

Crossref journal-article

Springer Science and Business Media LLC

EMBO reports (297)

Abstract

The death‐domain kinase RIP (receptor‐interacting protein) is an important effector of tumour necrosis factor (TNF) signalling and is essential for TNF‐induced nuclear factor‐κB activation. However, the function of RIP in the TNF‐induced activation of mitogen‐activated protein kinases (MAPKs) has not been fully investigated. In this report, using Rip null (Rip−/−) mouse fibroblast cells, we investigated whether RIP is required for TNF‐induced activation of the MAPKs extracellular‐signal‐related kinase (ERK), p38 and c‐Jun amino‐terminal kinase (JNK). We found that TNF‐induced activation of ERK, p38 and JNK is decreased in Rip−/− cells. The activation of these kinases by interleukin‐1 is normal in Rip−/− cells. More importantly, we showed that the kinase activity of RIP is needed for ERK activation.

Bibliography

Devin, A., Lin, Y., & Liu, Z. (2003). The role of the deathâdomain kinase RIP in tumourânecrosisâfactorâinduced activation of mitogenâactivated protein kinases. EMBO Reports, 4(6), 623â627. Portico.

Authors 3

Anne Devin (first)
Yong Lin (additional)
Zheng‐gang Liu (additional)

References 24 Referenced 109

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Dates

Type	When
Created	22 years, 3 months ago (May 16, 2003, 9:32 a.m.)
Deposited	1 year, 8 months ago (Dec. 18, 2023, 3:56 p.m.)
Indexed	3 weeks, 1 day ago (Aug. 6, 2025, 8:14 a.m.)
Issued	22 years, 3 months ago (May 16, 2003)
Published	22 years, 3 months ago (May 16, 2003)
Published Online	22 years, 3 months ago (May 16, 2003)
Published Print	22 years, 2 months ago (June 1, 2003)

Funders 0

None

BibTeX

@article{Devin_2003, title={The role of the death‐domain kinase RIP in tumour‐necrosis‐factor‐induced activation of mitogen‐activated protein kinases}, volume={4}, ISSN={1469-3178}, url={http://dx.doi.org/10.1038/sj.embor.embor854}, DOI={10.1038/sj.embor.embor854}, number={6}, journal={EMBO reports}, publisher={Springer Science and Business Media LLC}, author={Devin, Anne and Lin, Yong and Liu, Zheng‐gang}, year={2003}, month=may, pages={623–627} }

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