DOI: 10.1038/sj.embor.7400146. Structures of protein domains that create or recognize histone modifications

Structures of protein domains that create or recognize histone modifications

10.1038/sj.embor.7400146

Crossref journal-article

Springer Science and Business Media LLC

EMBO reports (297)

Abstract

DNA is packed together with histone proteins in cell nuclei to form a compact structure called chromatin. Chromatin represents a scaffold for many genetic events and shows varying degrees of condensation, including a relatively open form (euchromatin) and a highly condensed form (heterochromatin). Enzymes such as histone acetyltransferases (HATs) and methylases covalently label the amino‐termini of histones, thereby creating a ‘histone code’ of modifications that is interpreted by the recruitment of other proteins through recognition domains. Ultimately, this network of interacting proteins is thought to control the degree of chromatin condensation so that DNA is available when it is required for genomic processes. Reviewed here are the structures of HAT and SET domains, which mediate the acetylation and methylation of histones, respectively, and bromodomains and chromodomains, which recognize the modified histones. How these structures have increased our understanding of DNA regulation is also discussed.

Bibliography

Bottomley, M. J. (2004). Structures of protein domains that create or recognize histone modifications. EMBO Reports, 5(5), 464â469. Portico.

Authors 1

Matthew J Bottomley (first)

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{'key': 'e_1_2_7_34_1', 'first-page': '217', 'article-title': 'The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA‐binding folds', 'volume': '9', 'author': 'Qiu C', 'year': '2002', 'journal-title': 'Nat Struct Biol'} / Nat Struct Biol / The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA‐binding folds by Qiu C (2002)
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Dates

Type	When
Created	21 years, 1 month ago (July 30, 2004, 1:24 a.m.)
Deposited	1 year, 8 months ago (Dec. 18, 2023, 3:57 p.m.)
Indexed	3 months ago (May 28, 2025, 5:46 p.m.)
Issued	21 years, 4 months ago (May 1, 2004)
Published	21 years, 4 months ago (May 1, 2004)
Published Online	21 years, 4 months ago (May 1, 2004)
Published Print	21 years, 4 months ago (May 1, 2004)

Funders 0

None

BibTeX

@article{Bottomley_2004, title={Structures of protein domains that create or recognize histone modifications}, volume={5}, ISSN={1469-3178}, url={http://dx.doi.org/10.1038/sj.embor.7400146}, DOI={10.1038/sj.embor.7400146}, number={5}, journal={EMBO reports}, publisher={Springer Science and Business Media LLC}, author={Bottomley, Matthew J}, year={2004}, month=may, pages={464–469} }

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