DOI: 10.1038/sj.embor.7400052. Roles of G‐protein‐coupled receptor dimerization

Roles of G‐protein‐coupled receptor dimerization

10.1038/sj.embor.7400052

Crossref journal-article

Springer Science and Business Media LLC

EMBO reports (297)

Abstract

The classical idea that G‐protein‐coupled receptors (GPCRs) function as monomeric entities has been unsettled by the emerging concept of GPCR dimerization. Recent findings have indicated not only that many GPCRs exist as homodimers and heterodimers, but also that their oligomeric assembly could have important functional roles. Several studies have shown that dimerization occurs early after biosynthesis, suggesting that it has a primary role in receptor maturation. G‐protein coupling, downstream signalling and regulatory processes such as internalization have also been shown to be influenced by the dimeric nature of the receptors. In addition to raising fundamental questions about GPCR function, the concept of dimerization could be important in the development and screening of drugs that act through this receptor class. In particular, the changes in ligand‐binding and signalling properties that accompany heterodimerization could give rise to an unexpected pharmacological diversity that would need to be considered.

Bibliography

Terrillon, S., & Bouvier, M. (2004). Roles of Gâproteinâcoupled receptor dimerization. EMBO Reports, 5(1), 30â34. Portico.

Authors 2

Sonia Terrillon (first)
Michel Bouvier (additional)

References 65 Referenced 531

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10.1021/bi981162z

Dates

Type	When
Created	21 years, 7 months ago (Jan. 7, 2004, 7:34 a.m.)
Deposited	1 year, 8 months ago (Dec. 18, 2023, 3:57 p.m.)
Indexed	1 month ago (July 26, 2025, 5:33 a.m.)
Issued	21 years, 7 months ago (Jan. 1, 2004)
Published	21 years, 7 months ago (Jan. 1, 2004)
Published Online	21 years, 7 months ago (Jan. 1, 2004)
Published Print	21 years, 7 months ago (Jan. 1, 2004)

Funders 0

None

BibTeX

@article{Terrillon_2004, title={Roles of G‐protein‐coupled receptor dimerization: From ontogeny to signalling regulation}, volume={5}, ISSN={1469-3178}, url={http://dx.doi.org/10.1038/sj.embor.7400052}, DOI={10.1038/sj.embor.7400052}, number={1}, journal={EMBO reports}, publisher={Springer Science and Business Media LLC}, author={Terrillon, Sonia and Bouvier, Michel}, year={2004}, month=jan, pages={30–34} }

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        "name": "publication_history",
        "label": "Publication History"
      }
    }
  ]
}