Recent developments in nitric oxide donor drugs
10.1038/sj.bjp.0707224
Crossref journal-article
Wiley
British Journal of Pharmacology (311)
Abstract

During the 1980s, the free radical, nitric oxide (NO), was discovered to be a crucial signalling molecule, with wide‐ranging functions in the cardiovascular, nervous and immune systems. Aside from providing a credible explanation for the actions of organic nitrates and sodium nitroprusside that have long been used in the treatment of angina and hypertensive crises respectively, the discovery generated great hopes for new NO‐based treatments for a wide variety of ailments. Decades later, however, we are still awaiting novel licensed agents in this arena, despite an enormous research effort to this end. This review explores some of the most promising recent advances in NO donor drug development and addresses the challenges associated with NO as a therapeutic agent.British Journal of Pharmacology(2007)151, 305–321; doi:10.1038/sj.bjp.0707224

Bibliography

Miller, M. R., & Megson, I. L. (2007). Recent developments in nitric oxide donor drugs. British Journal of Pharmacology, 151(3), 305–321. Portico.

Authors 2
  1. M R Miller (first)
  2. I L Megson (additional)
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Dates
Type When
Created 18 years, 5 months ago (April 2, 2007, 8 a.m.)
Deposited 7 months, 3 weeks ago (Jan. 15, 2025, 6:24 a.m.)
Indexed 11 hours, 9 minutes ago (Sept. 6, 2025, 3:49 p.m.)
Issued 18 years, 3 months ago (June 1, 2007)
Published 18 years, 3 months ago (June 1, 2007)
Published Online 16 years, 7 months ago (Jan. 29, 2009)
Published Print 18 years, 3 months ago (June 1, 2007)
Funders 0

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@article{Miller_2007, title={Recent developments in nitric oxide donor drugs}, volume={151}, ISSN={1476-5381}, url={http://dx.doi.org/10.1038/sj.bjp.0707224}, DOI={10.1038/sj.bjp.0707224}, number={3}, journal={British Journal of Pharmacology}, publisher={Wiley}, author={Miller, M R and Megson, I L}, year={2007}, month=jun, pages={305–321} }