DOI: 10.1038/sj.bjp.0702980. Functional group I metabotropic glutamate receptors in submucous plexus of guinea‐pig ileum

Functional group I metabotropic glutamate receptors in submucous plexus of guinea‐pig ileum

10.1038/sj.bjp.0702980

Crossref journal-article

Wiley

British Journal of Pharmacology (311)

Abstract

Intracellular recording methods and immunostaining revealed the existence of functional group I metabotropic glutamate receptors (mGluRs) in submucous plexus neurons of guinea‐pig ileum. Selective group I, but not groups II or III metabotropic glutamate receptor agonists induced concentration‐dependent, slowly‐activating depolarizing responses. Group I metabotropic glutamate receptor antagonism observed with (S)‐4‐carboxyphenylglycine (S‐4‐CPG) (100–600 μM) was competitive as determined by Schild analysis (pA2=3.81±0.02). Neither the group II and III metabotropic nor ionotropic glutamate receptor antagonists altered responses evoked by group I receptor agonists. Immunoreactivities for metabotropic glutamate 1α and 5 receptors were found to locate exclusively in neurons in the submucous plexus of guinea‐pig ileum with the highest density around the cell bodies. The results suggest that group I metabotropic glutamate receptors are functionally expressed in the submucous plexus of guinea‐pig small intestine.British Journal of Pharmacology (1999) 128, 1631–1635; doi:10.1038/sj.bjp.0702980

Bibliography

Hu, H., Ren, J., Liu, S., Gao, C., Xia, Y., & Wood, J. D. (1999). Functional group I metabotropic glutamate receptors in submucous plexus of guineaâpig ileum. British Journal of Pharmacology, 128(8), 1631â1635. Portico.

Authors 6

Hong‐Zhen Hu (first)
Jun Ren (additional)
Sumei Liu (additional)
Chuanyun Gao (additional)
Yun Xia (additional)
Jackie D Wood (additional)

References 12 Referenced 23

{'key': 'e_1_2_7_2_1', 'first-page': 'G414', 'article-title': 'Effects of PACAP on morphologically identified myenteric neurons in guinea‐pig small bowel', 'volume': '264', 'author': 'CHRISTOFI F.L.', 'year': '1993', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. / Effects of PACAP on morphologically identified myenteric neurons in guinea‐pig small bowel by CHRISTOFI F.L. (1993)
10.1523/JNEUROSCI.17-14-05366.1997
10.1146/annurev.pharmtox.37.1.205
10.1006/phrs.1998.0422
10.1523/JNEUROSCI.17-22-08804.1997
10.1523/JNEUROSCI.17-12-04764.1997 / J. Neurosci. / Glutamatergic enteric neurons by LIU M.‐T. (1997)
10.1002/(SICI)1097-4547(19960601)44:5<507::AID-JNR11>3.0.CO;2-Y
{'key': 'e_1_2_7_9_1', 'first-page': '404', 'article-title': 'Asparagine stimulates piglet intestinal Cl secretion by a mechanism requiring a submucosal glutamate receptor and nitric oxide', 'volume': '274', 'author': 'RHOADS J.M.', 'year': '1995', 'journal-title': 'J Pharmacol. Exp. Ther.'} / J Pharmacol. Exp. Ther. / Asparagine stimulates piglet intestinal Cl secretion by a mechanism requiring a submucosal glutamate receptor and nitric oxide by RHOADS J.M. (1995)
10.1113/jphysiol.1993.sp019565
10.1016/S0304-3940(98)00866-0
{'key': 'e_1_2_7_12_1', 'first-page': '423', 'volume-title': 'Physiology of the gastrointestinal tract', 'author': 'WOOD J.D.', 'year': '1994'} / Physiology of the gastrointestinal tract by WOOD J.D. (1994)
{'key': 'e_1_2_7_13_1', 'first-page': 'G442', 'article-title': 'Elevation of cAMP facilitates noradrenergic transmission in submucous neurons of guinea‐pig ileum', 'author': 'ZAFIROV D.H.', 'year': '1993', 'journal-title': 'Am. J. Physiol.'} / Am. J. Physiol. / Elevation of cAMP facilitates noradrenergic transmission in submucous neurons of guinea‐pig ileum by ZAFIROV D.H. (1993)

Dates

Type	When
Created	20 years, 7 months ago (Jan. 28, 2005, 3:29 p.m.)
Deposited	1 year, 10 months ago (Oct. 28, 2023, 5:27 p.m.)
Indexed	1 year ago (Aug. 24, 2024, 7:08 p.m.)
Issued	25 years, 9 months ago (Dec. 1, 1999)
Published	25 years, 9 months ago (Dec. 1, 1999)
Published Online	16 years, 7 months ago (Jan. 30, 2009)
Published Print	25 years, 9 months ago (Dec. 1, 1999)

Funders 0

None

BibTeX

@article{Hu_1999, title={Functional group I metabotropic glutamate receptors in submucous plexus of guinea‐pig ileum}, volume={128}, ISSN={1476-5381}, url={http://dx.doi.org/10.1038/sj.bjp.0702980}, DOI={10.1038/sj.bjp.0702980}, number={8}, journal={British Journal of Pharmacology}, publisher={Wiley}, author={Hu, Hong‐Zhen and Ren, Jun and Liu, Sumei and Gao, Chuanyun and Xia, Yun and Wood, Jackie D}, year={1999}, month=dec, pages={1631–1635} }

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