DOI: 10.1038/sj.bjc.6601922. Phase I and pharmacokinetic (PK) study of MAG-CPT (PNU 166148): a polymeric derivative of camptothecin (CPT)

Phase I and pharmacokinetic (PK) study of MAG-CPT (PNU 166148): a polymeric derivative of camptothecin (CPT)

10.1038/sj.bjc.6601922

Crossref journal-article

Springer Science and Business Media LLC

British Journal of Cancer (297)

Bibliography

Bissett, D., Cassidy, J., de Bono, J. S., Muirhead, F., Main, M., Robson, L., Fraier, D., MagnÃ¨, M. L., Pellizzoni, C., Porro, M. G., Spinelli, R., Speed, W., & Twelves, C. (2004). Phase I and pharmacokinetic (PK) study of MAG-CPT (PNU 166148): a polymeric derivative of camptothecin (CPT). British Journal of Cancer, 91(1), 50â55.

Authors 13

D Bissett (first)
J Cassidy (additional)
J S de Bono (additional)
F Muirhead (additional)
M Main (additional)
L Robson (additional)
D Fraier (additional)
M L Magnè (additional)
C Pellizzoni (additional)
M G Porro (additional)
R Spinelli (additional)
W Speed (additional)
C Twelves (additional)

References 13 Referenced 104

Caiolfa VR, Zamai M, Fiorino A, Frigerio E, Pellizzoni C, D'Argy R, Ghiglieri A, Castelli MG, Farao M, Pesenti E, Gigli M, Angelucci F, Suarato A (2000) Polymer-bound camptothecin: initial biodistribution and antitumour activity studies. J Control Release 65: 105–119 (10.1016/S0168-3659(99)00243-6) / J Control Release by VR Caiolfa (2000)
Conover CD, Greenwald RB, Pendri A, Gilbert CW, Shum KL (1998) Camptothecin delivery systems: enhanced efficacy and tumor accumulation of camptothecin following its conjugation to polyethylene glycol via a glycine linker. Cancer Chemother Pharmacol 42: 407–414 (10.1007/s002800050837) / Cancer Chemother Pharmacol by CD Conover (1998)
Conover CD, Greenwald RB, Pendri A, Shum KL (1999) Camptothecin delivery systems: the utility of amino acid spacers for the conjugation of camptothecin with polyethylene glycol to create prodrugs. Anticancer Drug Des 14: 499–506 / Anticancer Drug Des by CD Conover (1999)
Duncan R, Gac-Breton S, Keane R, Musila R, Sat YN, Satchi R, Searle F (2001) Polymer-drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic. J Control Release 74: 135–146 (10.1016/S0168-3659(01)00328-5) / J Control Release by R Duncan (2001)
Gottlieb JA, Guarino AM, Call JB, Oliverio VT, Block JB (1970) Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880). Cancer Chemother Rep 54: 461–470 / Cancer Chemother Rep by JA Gottlieb (1970)
Matsumura Y, Maeda H (1986) A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 46: 6387–6392 / Cancer Res by Y Matsumura (1986)
Muggia FM, Creaven PJ, Hansen HH, Cohen MH, Selawry OS (1972) Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies. Cancer Chemother Rep 56: 515–521 / Cancer Chemother Rep by FM Muggia (1972)
Rivory LP, Robert J (1995) Molecular, cellular, and clinical aspects of the pharmacology of 20(S)camptothecin and its derivatives. Pharmacol Ther 68: 269–296 (10.1016/0163-7258(95)02009-8) / Pharmacol Ther by LP Rivory (1995)
Sarapa N, Brillo MR, Speed W, Jannuzzo M, Breda M, James CA, Porro M, Rocchetti M, Wanders A, Mahteme H, Nygren P (2003) Assessment of normal and tumor tissue uptake of MAC-CPT, a polymer-bound prodrug of camptothecin, in patients undergoing elective surgery for colorectal carcinoma. Cancer Chemother Pharmacol 52: 424–430 (10.1007/s00280-003-0685-x) / Cancer Chemother Pharmacol by N Sarapa (2003)
Schoemaker NE, Frigerio E, Fraier D, Schellens JH, Rosing H, Jansen S, Beijnen JH (2001) High-performance liquid chromatographic analysis for the determination of a novel polymer-bound camptothecin derivative (MAG-camptothecin) and free camptothecin in human plasma. J Chromatogr B 763: 173–183 (10.1016/S0378-4347(01)00391-7) / J Chromatogr B by NE Schoemaker (2001)
Schoemaker NE, van Kesteren C, Rosing H, Jansen S, Swart M, Lieverst J, Fraier D, Breda M, Pellizzoni C, Spinelli R, Grazia PM, Beijnen JH, Schellens JH, Bokkel Huinink WW (2002) A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin. Br J Cancer 87: 608–614 (10.1038/sj.bjc.6600516) / Br J Cancer by NE Schoemaker (2002)
Seymour LW (1992) Passive tumor targeting of soluble macromolecules and drug conjugates. Crit Rev Ther Drug Carrier Systems 9: 135–187 / Crit Rev Ther Drug Carrier Systems by LW Seymour (1992)
Vasey PA, Kaye SB, Morrison R, Twelves C, Wilson P, Duncan R, Thomson AH, Murray LS, Hilditch TE, Murray T, Burtles S, Fraier D, Frigerio E, Cassidy J (1999) Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee. Clin Cancer Res 5: 83–94 / Clin Cancer Res by PA Vasey (1999)

Dates

Type	When
Created	21 years, 2 months ago (June 9, 2004, 4:31 a.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 8:09 a.m.)
Indexed	6 days, 17 hours ago (Aug. 27, 2025, 11:45 a.m.)
Issued	21 years, 2 months ago (June 8, 2004)
Published	21 years, 2 months ago (June 8, 2004)
Published Online	21 years, 2 months ago (June 8, 2004)
Published Print	21 years, 2 months ago (July 1, 2004)

Funders 0

None

BibTeX

@article{Bissett_2004, title={Phase I and pharmacokinetic (PK) study of MAG-CPT (PNU 166148): a polymeric derivative of camptothecin (CPT)}, volume={91}, ISSN={1532-1827}, url={http://dx.doi.org/10.1038/sj.bjc.6601922}, DOI={10.1038/sj.bjc.6601922}, number={1}, journal={British Journal of Cancer}, publisher={Springer Science and Business Media LLC}, author={Bissett, D and Cassidy, J and de Bono, J S and Muirhead, F and Main, M and Robson, L and Fraier, D and Magnè, M L and Pellizzoni, C and Porro, M G and Spinelli, R and Speed, W and Twelves, C}, year={2004}, month=jun, pages={50–55} }

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