DOI: 10.1038/nsmb1026. RNA emerging from the active site of RNA polymerase II interacts with the Rpb7 subunit

RNA emerging from the active site of RNA polymerase II interacts with the Rpb7 subunit

10.1038/nsmb1026

Crossref journal-article

Springer Science and Business Media LLC

Nature Structural & Molecular Biology (297)

Bibliography

ÃjvÃ¡ri, A., & Luse, D. S. (2005). RNA emerging from the active site of RNA polymerase II interacts with the Rpb7 subunit. Nature Structural & Molecular Biology, 13(1), 49â54.

Authors 2

Andrea Újvári (first)
Donal S Luse (additional)

References 38 Referenced 91

Cramer, P. RNA polymerase II structure: from core to functional complexes. Curr. Opin. Genet. Dev. 14, 218–226 (2004). (10.1016/j.gde.2004.01.003) / Curr. Opin. Genet. Dev. by P Cramer (2004)
Kettenberger, H., Armache, K.-J. & Cramer, P. Complete RNA polymerase II elongation complex structure and its interaction with NTPs and TFIIS. Mol. Cell 16, 955–965 (2004). (10.1016/j.molcel.2004.11.040) / Mol. Cell by H Kettenberger (2004)
Gu, W., Wind, M. & Reines, D. Increased accommodation of nascent RNA in a product site on RNA polymerase II during arrest. Proc. Natl. Acad. Sci. USA 93, 6935–6940 (1996). (10.1073/pnas.93.14.6935) / Proc. Natl. Acad. Sci. USA by W Gu (1996)
Reeder, T.C. & Hawley, D.K. Promoter proximal sequences modulate RNA polymerase II elongation by a novel mechanism. Cell 87, 767–777 (1996). (10.1016/S0092-8674(00)81395-1) / Cell by TC Reeder (1996)
Cramer, P. et al. Architecture of RNA polymerase II and implications for the transcription mechanism. Science 288, 640–649 (2000). (10.1126/science.288.5466.640) / Science by P Cramer (2000)
Cramer, P., Bushnell, D.A. & Kornberg, R.D. Structural basis of transcription: RNA polymerase II at 2.8 Å resolution. Science 292, 1863–1876 (2001). (10.1126/science.1059493) / Science by P Cramer (2001)
Gnatt, A.L., Cramer, P., Fu, J., Bushnell, D.A. & Kornberg, R.D. Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 Å resolution. Science 292, 1876–1882 (2001). (10.1126/science.1059495) / Science by AL Gnatt (2001)
Westover, K.D., Bushnell, D.A. & Kornberg, R.D. Structural basis of transcription: separation of RNA from DNA by RNA polymerase II. Science 303, 1014–1016 (2004). (10.1126/science.1090839) / Science by KD Westover (2004)
Todone, F., Brick, P., Werner, F., Weinzierl, R.O. & Onesti, S. Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex. Mol. Cell 8, 1137–1143 (2001). (10.1016/S1097-2765(01)00379-3) / Mol. Cell by F Todone (2001)
Orlicky, S.M., Tran, P.T., Sayre, M.H. & Edwards, A.M. Dissociable Rpb4-Rpb7 subassembly of RNA polymerase II binds to single-strand nucleic acid and mediates a post-recruitment step in transcription initiation. J. Biol. Chem. 276, 10097–10102 (2001). (10.1074/jbc.M003165200) / J. Biol. Chem. by SM Orlicky (2001)
Ebright, R.H. RNA polymerase: structural similarities between bacterial RNA polymerase and eukaryotic RNA polymerase II. J. Mol. Biol. 304, 687–698 (2000). (10.1006/jmbi.2000.4309) / J. Mol. Biol. by RH Ebright (2000)
Proudfoot, N.J., Furger, A. & Dye, M.J. Integrating rnRNA processing with transcription. Cell 108, 501–512 (2002). (10.1016/S0092-8674(02)00617-7) / Cell by NJ Proudfoot (2002)
Maniatis, T. & Reed, R. An extensive network of coupling among gene expression machines. Nature 416, 499–506 (2002). (10.1038/416499a) / Nature by T Maniatis (2002)
Howe, K.J. RNA polymerase II conducts a symphony of pre-mRNA processing activities. Biochim. Biophys. Acta 1577, 308–324 (2002). (10.1016/S0167-4781(02)00460-8) / Biochim. Biophys. Acta by KJ Howe (2002)
Zorio, D.A. & Bentley, D.L. The link between mRNA processing and transcription: communication works both ways. Exp. Cell Res. 296, 91–97 (2004). (10.1016/j.yexcr.2004.03.019) / Exp. Cell Res. by DA Zorio (2004)
Újvári, A. & Luse, D.S. Newly initiated RNA encounters a factor involved in splicing immediately upon emerging from within RNA polymerase II. J. Biol. Chem. 279, 49773–49779 (2004). (10.1074/jbc.M409087200) / J. Biol. Chem. by A Újvári (2004)
Choder, M. Rpb4 and Rpb7: subunits of RNA polymerase II and beyond. Trends Biochem. Sci. 29, 674–681 (2004). (10.1016/j.tibs.2004.10.007) / Trends Biochem. Sci. by M Choder (2004)
Bushnell, D.A. & Kornberg, R.D. Complete, 12-subunit RNA polymerase II at 4.1-Å resolution: implications for the initiation of transcription. Proc. Natl. Acad. Sci. USA 100, 6969–6973 (2003). (10.1073/pnas.1130601100) / Proc. Natl. Acad. Sci. USA by DA Bushnell (2003)
Meisenheimer, K.M., Meisenheimer, P.L. & Koch, T.H. Nucleoprotein photo-cross-linking using halopyrimidine-substituted RNAs. Methods Enzymol. 318, 88–104 (2000). (10.1016/S0076-6879(00)18046-2) / Methods Enzymol. by KM Meisenheimer (2000)
Armache, K.-J., Kettenberger, H. & Cramer, P. Architecture of initiation-competent 12-subunit RNA polymerase II. Proc. Natl. Acad. Sci. USA 100, 6964–6968 (2003). (10.1073/pnas.1030608100) / Proc. Natl. Acad. Sci. USA by K-J Armache (2003)
Edwards, A.M., Kane, C.M., Young, R.A. & Kornberg, R.D. Two dissociable subunits of yeast RNA polymerase II stimulate the initiation of transcription at a promoter in vitro. J. Biol. Chem. 266, 71–75 (1991). (10.1016/S0021-9258(18)52403-0) / J. Biol. Chem. by AM Edwards (1991)
Chung, W.H. et al. RNA polymerase II/TFIIF structure and conserved organization of the initiation complex. Mol. Cell 12, 1003–1013 (2003). (10.1016/S1097-2765(03)00387-3) / Mol. Cell by WH Chung (2003)
Kimura, M., Suzuki, H. & Ishihama, A. Formation of a carboxy-terminal domain phosphatase (Fcp1)/TFIIF/RNA polymerase II (pol II) complex in Schizosaccharomyces pombe involves direct interaction between Fcp1 and the Rpb4 subunit of pol II. Mol. Cell. Biol. 22, 1577–1588 (2002). (10.1128/MCB.22.5.1577-1588.2002) / Mol. Cell. Biol. by M Kimura (2002)
Kamenski, T., Heilmeier, S., Meinhart, A. & Cramer, P. Structure and mechanism of RNA polymerase II CTD phosphatases. Mol. Cell 15, 399–407 (2004). (10.1016/j.molcel.2004.06.035) / Mol. Cell by T Kamenski (2004)
Moore, M.J. Intron recognition comes of AGe. Nat. Struct. Biol. 7, 14–16 (2000). (10.1038/71207) / Nat. Struct. Biol. by MJ Moore (2000)
Zolotukhin, A.S., Tan, W., Bear, J., Smulevitch, S. & Felber, B.K. U2AF participates in the binding of TAP (NXF1) to mRNA. J. Biol. Chem. 277, 3935–3942 (2002). (10.1074/jbc.M107598200) / J. Biol. Chem. by AS Zolotukhin (2002)
Blanchette, M., Labourier, E., Green, R.E., Brenner, S.E. & Rio, D.C. Genome-wide analysis reveals an unexpected function for the Drosophila splicing factor U2AF(50) in the nuclear export of intronless mRNAs. Mol. Cell 14, 775–786 (2004). (10.1016/j.molcel.2004.06.012) / Mol. Cell by M Blanchette (2004)
Robert, F., Blanchette, M., Maes, O., Chabot, B. & Coulombe, B. A human RNA polymerase II-containing complex associated with factors necessary for spliceosome assembly. J. Biol. Chem. 277, 9302–9306 (2002). (10.1074/jbc.M110516200) / J. Biol. Chem. by F Robert (2002)
Samkurashvili, I. & Luse, D.S. Structural changes in the RNA polymerase II transcription complex during transition from initiation to elongation. Mol. Cell. Biol. 18, 5343–5354 (1998). (10.1128/MCB.18.9.5343) / Mol. Cell. Biol. by I Samkurashvili (1998)
Újvári, A., Pal, M. & Luse, D.S. RNA polymerase II transcription complexes may become arrested if the nascent RNA is shortened to less than 50 nucleotides. J. Biol. Chem. 277, 32527–32537 (2002). (10.1074/jbc.M201145200) / J. Biol. Chem. by A Újvári (2002)
Pal, M., McKean, D. & Luse, D.S. Promoter clearance by RNA polymerase II is an extended, multistep process strongly affected by sequence. Mol. Cell. Biol. 21, 5815–5825 (2001). (10.1128/MCB.21.17.5815-5825.2001) / Mol. Cell. Biol. by M Pal (2001)
Pal, M. & Luse, D.S. The initiation-elongation transition: lateral mobility of RNA in RNA polymerase II complexes is greatly reduced at +8/+9 and absent by +23. Proc. Natl. Acad. Sci. USA 100, 5700–5705 (2003). (10.1073/pnas.1037057100) / Proc. Natl. Acad. Sci. USA by M Pal (2003)
Pal, M. & Luse, D.S. Strong natural pausing by RNA polymerase II within 10 bases of transcription start may result in repeated slippage and reextension of the nascent RNA. Mol. Cell. Biol. 22, 30–40 (2002). (10.1128/MCB.22.1.30-40.2002) / Mol. Cell. Biol. by M Pal (2002)
Werner, F., Eloranta, J.J. & Weinzierl, R.O. Archaeal RNA polymerase subunits F and P are bona fide homologs of eukaryotic RPB4 and RPB12. Nucleic Acids Res. 28, 4299–4305 (2000). (10.1093/nar/28.21.4299) / Nucleic Acids Res. by F Werner (2000)
Eloranta, J.J., Kato, A., Teng, M.S. & Weinzierl, R.O. In vitro assembly of an archaeal D-L-N RNA polymerase subunit complex reveals a eukaryote-like structural arrangement. Nucleic Acids Res. 26, 5562–5567 (1998). (10.1093/nar/26.24.5562) / Nucleic Acids Res. by JJ Eloranta (1998)
Pal, M., Ponticelli, A.S. & Luse, D.S. The role of the transcription bubble and TFIIB in promoter clearance by RNA polymerase II. Mol. Cell 19, 101–110 (2005). (10.1016/j.molcel.2005.05.024) / Mol. Cell by M Pal (2005)
Maldonado, E., Drapkin, R. & Reinberg, D. Purification of human RNA polymerase II and general transcription factors. Methods Enzymol. 274, 72–100 (1996). (10.1016/S0076-6879(96)74009-0) / Methods Enzymol. by E Maldonado (1996)
Komissarova, N. & Kashlev, M. Functional topography of nascent RNA in elongation intermediates of RNA polymerase. Proc. Natl. Acad. Sci. USA 95, 14699–14704 (1998). (10.1073/pnas.95.25.14699) / Proc. Natl. Acad. Sci. USA by N Komissarova (1998)

Dates

Type	When
Created	19 years, 8 months ago (Dec. 4, 2005, 3:19 p.m.)
Deposited	2 years, 3 months ago (May 19, 2023, 12:47 a.m.)
Indexed	2 months, 2 weeks ago (June 10, 2025, 5:30 a.m.)
Issued	19 years, 8 months ago (Dec. 4, 2005)
Published	19 years, 8 months ago (Dec. 4, 2005)
Published Online	19 years, 8 months ago (Dec. 4, 2005)
Published Print	19 years, 7 months ago (Jan. 1, 2006)

Funders 0

None

BibTeX

@article{_jv_ri_2005, title={RNA emerging from the active site of RNA polymerase II interacts with the Rpb7 subunit}, volume={13}, ISSN={1545-9985}, url={http://dx.doi.org/10.1038/nsmb1026}, DOI={10.1038/nsmb1026}, number={1}, journal={Nature Structural & Molecular Biology}, publisher={Springer Science and Business Media LLC}, author={Újvári, Andrea and Luse, Donal S}, year={2005}, month=dec, pages={49–54} }

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