DOI: 10.1038/nsmb.2074. X-ray structure of a functional full-length dynein motor domain

X-ray structure of a functional full-length dynein motor domain

10.1038/nsmb.2074

Crossref journal-article

Springer Science and Business Media LLC

Nature Structural & Molecular Biology (297)

Bibliography

Kon, T., Sutoh, K., & Kurisu, G. (2011). X-ray structure of a functional full-length dynein motor domain. Nature Structural & Molecular Biology, 18(6), 638â642.

Authors 3

Takahide Kon (first)
Kazuo Sutoh (additional)
Genji Kurisu (additional)

References 47 Referenced 100

Gibbons, I.R. & Rowe, A.J. Dynein: a protein with adenosine triphosphatase activity from cilia. Science 149, 424–426 (1965). (10.1126/science.149.3682.424) / Science by IR Gibbons (1965)
Paschal, B.M. & Vallee, R.B. Retrograde transport by the microtubule-associated protein MAP 1C. Nature 330, 181–183 (1987). (10.1038/330181a0) / Nature by BM Paschal (1987)
Karki, S. & Holzbaur, E.L. Cytoplasmic dynein and dynactin in cell division and intracellular transport. Curr. Opin. Cell Biol. 11, 45–53 (1999). (10.1016/S0955-0674(99)80006-4) / Curr. Opin. Cell Biol. by S Karki (1999)
DiBella, L.M. & King, S.M. Dynein motors of the Chlamydomonas flagellum. Int. Rev. Cytol. 210, 227–268 (2001). (10.1016/S0074-7696(01)10007-0) / Int. Rev. Cytol. by LM DiBella (2001)
Vale, R.D. The molecular motor toolbox for intracellular transport. Cell 112, 467–480 (2003). (10.1016/S0092-8674(03)00111-9) / Cell by RD Vale (2003)
Vallee, R.B., Williams, J.C., Varma, D. & Barnhart, L.E. Dynein: an ancient motor protein involved in multiple modes of transport. J. Neurobiol. 58, 189–200 (2004). (10.1002/neu.10314) / J. Neurobiol. by RB Vallee (2004)
Sakato, M. & King, S.M. Design and regulation of the AAA+ microtubule motor dynein. J. Struct. Biol. 146, 58–71 (2004). (10.1016/j.jsb.2003.09.026) / J. Struct. Biol. by M Sakato (2004)
Pfister, K.K. et al. Genetic analysis of the cytoplasmic dynein subunit families. PLoS Genet. 2, e1 (2006). (10.1371/journal.pgen.0020001) / PLoS Genet. by KK Pfister (2006)
Neuwald, A.F., Aravind, L., Spouge, J.L. & Koonin, E.V. AAA+: a class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res. 9, 27–43 (1999). (10.1101/gr.9.1.27) / Genome Res. by AF Neuwald (1999)
Koonce, M.P. & Samso, M. Overexpression of cytoplasmic dynein's globular head causes a collapse of the interphase microtubule network in Dictyostelium. Mol. Biol. Cell 7, 935–948 (1996). (10.1091/mbc.7.6.935) / Mol. Biol. Cell by MP Koonce (1996)
Nishiura, M. et al. A single-headed recombinant fragment of Dictyostelium cytoplasmic dynein can drive the robust sliding of microtubules. J. Biol. Chem. 279, 22799–22802 (2004). (10.1074/jbc.M313362200) / J. Biol. Chem. by M Nishiura (2004)
Gee, M.A., Heuser, J.E. & Vallee, R.B. An extended microtubule-binding structure within the dynein motor domain. Nature 390, 636–639 (1997). (10.1038/37663) / Nature by MA Gee (1997)
Reck-Peterson, S.L. et al. Single-molecule analysis of dynein processivity and stepping behavior. Cell 126, 335–348 (2006). (10.1016/j.cell.2006.05.046) / Cell by SL Reck-Peterson (2006)
Carter, A.P., Cho, C., Jin, L. & Vale, R.D. Crystal structure of the dynein motor domain. Science 331, 1159–1165 (2011). (10.1126/science.1202393) / Science by AP Carter (2011)
Roberts, A.J. et al. AAA+ ring and linker swing mechanism in the dynein motor. Cell 136, 485–495 (2009). (10.1016/j.cell.2008.11.049) / Cell by AJ Roberts (2009)
Mocz, G. & Gibbons, I.R. Model for the motor component of dynein heavy chain based on homology to the AAA family of oligomeric ATPases. Structure 9, 93–103 (2001). (10.1016/S0969-2126(00)00557-8) / Structure by G Mocz (2001)
Hanson, P.I. & Whiteheart, S.W. AAA+ proteins: have engine, will work. Nat. Rev. Mol. Cell Biol. 6, 519–529 (2005). (10.1038/nrm1684) / Nat. Rev. Mol. Cell Biol. by PI Hanson (2005)
Erzberger, J.P. & Berger, J.M. Evolutionary relationships and structural mechanisms of AAA+ proteins. Annu. Rev. Biophys. Biomol. Struct. 35, 93–114 (2006). (10.1146/annurev.biophys.35.040405.101933) / Annu. Rev. Biophys. Biomol. Struct. by JP Erzberger (2006)
Burgess, S.A., Walker, M.L., Sakakibara, H., Knight, P.J. & Oiwa, K. Dynein structure and power stroke. Nature 421, 715–718 (2003). (10.1038/nature01377) / Nature by SA Burgess (2003)
Burgess, S.A. & Knight, P.J. Is the dynein motor a winch? Curr. Opin. Struct. Biol. 14, 138–146 (2004). (10.1016/j.sbi.2004.03.013) / Curr. Opin. Struct. Biol. by SA Burgess (2004)
Shima, T., Kon, T., Imamula, K., Ohkura, R. & Sutoh, K. Two modes of microtubule sliding driven by cytoplasmic dynein. Proc. Natl. Acad. Sci. USA 103, 17736–17740 (2006). (10.1073/pnas.0606794103) / Proc. Natl. Acad. Sci. USA by T Shima (2006)
Kon, T., Mogami, T., Ohkura, R., Nishiura, M. & Sutoh, K. ATP hydrolysis cycle-dependent tail motions in cytoplasmic dynein. Nat. Struct. Mol. Biol. 12, 513–519 (2005). (10.1038/nsmb930) / Nat. Struct. Mol. Biol. by T Kon (2005)
Asai, D.J. & Koonce, M.P. The dynein heavy chain: structure, mechanics and evolution. Trends Cell Biol. 11, 196–202 (2001). (10.1016/S0962-8924(01)01970-5) / Trends Cell Biol. by DJ Asai (2001)
Toba, S., Watanabe, T.M., Yamaguchi-Okimoto, L., Toyoshima, Y.Y. & Higuchi, H. Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein. Proc. Natl. Acad. Sci. USA 103, 5741–5745 (2006). (10.1073/pnas.0508511103) / Proc. Natl. Acad. Sci. USA by S Toba (2006)
Gennerich, A., Carter, A.P., Reck-Peterson, S.L. & Vale, R.D. Force-induced bidirectional stepping of cytoplasmic dynein. Cell 131, 952–965 (2007). (10.1016/j.cell.2007.10.016) / Cell by A Gennerich (2007)
Amos, L.A. Brain dynein crossbridges microtubules into bundles. J. Cell Sci. 93, 19–28 (1989). (10.1242/jcs.93.1.19) / J. Cell Sci. by LA Amos (1989)
Gibbons, I.R. et al. The affinity of the dynein microtubule-binding domain is modulated by the conformation of its coiled-coil stalk. J. Biol. Chem. 280, 23960–23965 (2005). (10.1074/jbc.M501636200) / J. Biol. Chem. by IR Gibbons (2005)
Carter, A.P. et al. Structure and functional role of dynein's microtubule-binding domain. Science 322, 1691–1695 (2008). (10.1126/science.1164424) / Science by AP Carter (2008)
Kon, T. et al. Helix sliding in the stalk coiled coil of dynein couples ATPase and microtubule binding. Nat. Struct. Mol. Biol. 16, 325–333 (2009). (10.1038/nsmb.1555) / Nat. Struct. Mol. Biol. by T Kon (2009)
Vale, R.D. AAA proteins. Lords of the ring. J. Cell Biol. 150, F13–F19 (2000). (10.1083/jcb.150.1.F13) / J. Cell Biol. by RD Vale (2000)
Samsó, M. & Koonce, M.P. 25 Angstrom resolution structure of a cytoplasmic dynein motor reveals a seven-member planar ring. J. Mol. Biol. 340, 1059–1072 (2004). (10.1016/j.jmb.2004.05.063) / J. Mol. Biol. by M Samsó (2004)
Höök, P. et al. Long range allosteric control of cytoplasmic dynein ATPase activity by the stalk and C-terminal domains. J. Biol. Chem. 280, 33045–33054 (2005). (10.1074/jbc.M504693200) / J. Biol. Chem. by P Höök (2005)
Numata, N. et al. Molecular mechanism of force generation by dynein, a molecular motor belonging to the AAA+ family. Biochem. Soc. Trans. 36, 131–135 (2008). (10.1042/BST0360131) / Biochem. Soc. Trans. by N Numata (2008)
Kon, T., Nishiura, M., Ohkura, R., Toyoshima, Y.Y. & Sutoh, K. Distinct functions of nucleotide-binding/hydrolysis sites in the four AAA modules of cytoplasmic dynein. Biochemistry 43, 11266–11274 (2004). (10.1021/bi048985a) / Biochemistry by T Kon (2004)
Imamula, K., Kon, T., Ohkura, R. & Sutoh, K. The coordination of cyclic microtubule association/dissociation and tail swing of cytoplasmic dynein. Proc. Natl. Acad. Sci. USA 104, 16134–16139 (2007). (10.1073/pnas.0702370104) / Proc. Natl. Acad. Sci. USA by K Imamula (2007)
Cho, C., Reck-Peterson, S.L. & Vale, R.D. Regulatory ATPase sites of cytoplasmic dynein affect processivity and force generation. J. Biol. Chem. 283, 25839–25845 (2008). (10.1074/jbc.M802951200) / J. Biol. Chem. by C Cho (2008)
Kon, T., Shima, T. & Sutoh, K. Protein engineering approaches to study the dynein mechanism using a Dictyostelium expression system. Methods Cell Biol. 92, 65–82 (2009). (10.1016/S0091-679X(08)92005-7) / Methods Cell Biol. by T Kon (2009)
Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307–326 (1997). (10.1016/S0076-6879(97)76066-X) / Methods Enzymol. by Z Otwinowski (1997)
Schneider, T.R. & Sheldrick, G.M. Substructure solution with SHELXD. Acta Crystallogr. D Biol. Crystallogr. 58, 1772–1779 (2002). (10.1107/S0907444902011678) / Acta Crystallogr. D Biol. Crystallogr. by TR Schneider (2002)
Bricogne, G., Vonrhein, C., Flensburg, C., Schiltz, M. & Paciorek, W. Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0. Acta Crystallogr. D Biol. Crystallogr. 59, 2023–2030 (2003). (10.1107/S0907444903017694) / Acta Crystallogr. D Biol. Crystallogr. by G Bricogne (2003)
Abrahams, J.P. & Leslie, A.G.W. Methods used in the structure determination of bovine mitochondrial F-1 ATPase. Acta Crystallogr. D Biol. Crystallogr. 52, 30–42 (1996). (10.1107/S0907444995008754) / Acta Crystallogr. D Biol. Crystallogr. by JP Abrahams (1996)
Cowtan, K. dm: an automated procedure for phase improvement by density modification. Joint CCP4 and ESF-EACBM Newslett. Protein Crystallogr. 31, 34–38 (1994). / Joint CCP4 and ESF-EACBM Newslett. Protein Crystallogr. by K Cowtan (1994)
CCP4. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50, 760–763 (1994). (10.1107/S0907444994003112)
Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 60, 2126–2132 (2004). (10.1107/S0907444904019158) / Acta Crystallogr. D Biol. Crystallogr. by P Emsley (2004)
Jones, T.A., Zou, J.Y., Cowan, S.W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110–119 (1991). (10.1107/S0108767390010224) / Acta Crystallogr. A by TA Jones (1991)
Esnouf, R.M. An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. J. Mol. Graph. Model. 15, 132–134 (1997). (10.1016/S1093-3263(97)00021-1) / J. Mol. Graph. Model. by RM Esnouf (1997)
Merritt, E.A. & Murphy, M.E. Raster3D Version 2.0. A program for photorealistic molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 50, 869–873 (1994). (10.1107/S0907444994006396) / Acta Crystallogr. D Biol. Crystallogr. by EA Merritt (1994)

Dates

Type	When
Created	14 years, 3 months ago (May 22, 2011, 2:26 p.m.)
Deposited	2 years, 3 months ago (May 19, 2023, 12:29 a.m.)
Indexed	9 months, 1 week ago (Nov. 19, 2024, 11:30 a.m.)
Issued	14 years, 3 months ago (May 22, 2011)
Published	14 years, 3 months ago (May 22, 2011)
Published Online	14 years, 3 months ago (May 22, 2011)
Published Print	14 years, 3 months ago (June 1, 2011)

Funders 0

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BibTeX

@article{Kon_2011, title={X-ray structure of a functional full-length dynein motor domain}, volume={18}, ISSN={1545-9985}, url={http://dx.doi.org/10.1038/nsmb.2074}, DOI={10.1038/nsmb.2074}, number={6}, journal={Nature Structural & Molecular Biology}, publisher={Springer Science and Business Media LLC}, author={Kon, Takahide and Sutoh, Kazuo and Kurisu, Genji}, year={2011}, month=may, pages={638–642} }

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