Active site remodeling switches HIV specificity of antiretroviral TRIMCyp
10.1038/nsmb.1667
Crossref journal-article
Springer Science and Business Media LLC
Nature Structural & Molecular Biology (297)
Bibliography

Price, A. J., Marzetta, F., Lammers, M., Ylinen, L. M. J., Schaller, T., Wilson, S. J., Towers, G. J., & James, L. C. (2009). Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. Nature Structural & Molecular Biology, 16(10), 1036–1042.

Authors 8
  1. Amanda J Price (first)
  2. Flavia Marzetta (additional)
  3. Michael Lammers (additional)
  4. Laura M J Ylinen (additional)
  5. Torsten Schaller (additional)
  6. Sam J Wilson (additional)
  7. Greg J Towers (additional)
  8. Leo C James (additional)
References 41 Referenced 91
  1. Ozato, K., Shin, D.M., Chang, T.H. & Morse, H.C. III. TRIM family proteins and their emerging roles in innate immunity. Nat. Rev. Immunol. 8, 849–860 (2008). (10.1038/nri2413) / Nat. Rev. Immunol. by K Ozato (2008)
  2. Langelier, C.R. et al. Biochemical characterization of a recombinant TRIM5α protein that restricts human immunodeficiency virus type 1 replication. J. Virol. 82, 11682–11694 (2008). (10.1128/JVI.01562-08) / J. Virol. by CR Langelier (2008)
  3. Stremlau, M. et al. The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys. Nature 427, 848–853 (2004). (10.1038/nature02343) / Nature by M Stremlau (2004)
  4. Stremlau, M., Perron, M.J., Welikala, S. & Sodroski, J. Species-specific variation in the B30.2(SPRY) domain of TRIM5α determines the potency of human immunodeficiency virus restriction. J. Virol. 79, 3139–3145 (2005). (10.1128/JVI.79.5.3139-3145.2005) / J. Virol. by M Stremlau (2005)
  5. Song, B. et al. The B30.2(SPRY) domain of the retroviral restriction factor TRIM5α exhibits lineage-specific length and sequence variation in primates. J. Virol. 79, 6111–6121 (2005). (10.1128/JVI.79.10.6111-6121.2005) / J. Virol. by B Song (2005)
  6. Perez-Caballero, D., Hatziioannou, T., Yang, A., Cowan, S. & Bieniasz, P.D. Human tripartite motif 5α domains responsible for retrovirus restriction activity and specificity. J. Virol. 79, 8969–8978 (2005). (10.1128/JVI.79.14.8969-8978.2005) / J. Virol. by D Perez-Caballero (2005)
  7. Stremlau, M. et al. Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor. Proc. Natl. Acad. Sci. USA 103, 5514–5519 (2006). (10.1073/pnas.0509996103) / Proc. Natl. Acad. Sci. USA by M Stremlau (2006)
  8. Sayah, D.M., Sokolskaja, E., Berthoux, L. & Luban, J. Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1. Nature 430, 569–573 (2004). (10.1038/nature02777) / Nature by DM Sayah (2004)
  9. Nisole, S., Lynch, C., Stoye, J.P. & Yap, M.W.A. Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1. Proc. Natl. Acad. Sci. USA 101, 13324–13328 (2004). (10.1073/pnas.0404640101) / Proc. Natl. Acad. Sci. USA by S Nisole (2004)
  10. Franke, E.K., Yuan, H.E. & Luban, J. Specific incorporation of cyclophilin A into HIV-1 virions. Nature 372, 359–362 (1994). (10.1038/372359a0) / Nature by EK Franke (1994)
  11. Luban, J., Bossolt, K.L., Franke, E.K., Kalpana, G.V. & Goff, S.P. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell 73, 1067–1078 (1993). (10.1016/0092-8674(93)90637-6) / Cell by J Luban (1993)
  12. Thali, M. et al. Functional association of cyclophilin A with HIV-1 virions. Nature 372, 363–365 (1994). (10.1038/372363a0) / Nature by M Thali (1994)
  13. Towers, G.J. et al. Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors. Nat. Med. 9, 1138–1143 (2003). (10.1038/nm910) / Nat. Med. by GJ Towers (2003)
  14. Brennan, G., Kozyrev, Y. & Hu, S.L. TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis. Proc. Natl. Acad. Sci. USA 105, 3569–3574 (2008). (10.1073/pnas.0709511105) / Proc. Natl. Acad. Sci. USA by G Brennan (2008)
  15. Virgen, C.A., Kratovac, Z., Bieniasz, P.D. & Hatziioannou, T. Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species. Proc. Natl. Acad. Sci. USA 105, 3563–3568 (2008). (10.1073/pnas.0709258105) / Proc. Natl. Acad. Sci. USA by CA Virgen (2008)
  16. Wilson, S.J. et al. Independent evolution of an antiviral TRIMCyp in rhesus macaques. Proc. Natl. Acad. Sci. USA 105, 3557–3562 (2008). (10.1073/pnas.0709003105) / Proc. Natl. Acad. Sci. USA by SJ Wilson (2008)
  17. Braaten, D., Franke, E.K. & Luban, J. Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses. J. Virol. 70, 4220–4227 (1996). (10.1128/JVI.70.7.4220-4227.1996) / J. Virol. by D Braaten (1996)
  18. Yoo, S. et al. Molecular recognition in the HIV-1 capsid/cyclophilin A complex. J. Mol. Biol. 269, 780–795 (1997). (10.1006/jmbi.1997.1051) / J. Mol. Biol. by S Yoo (1997)
  19. Besnier, C., Takeuchi, Y. & Towers, G. Restriction of lentivirus in monkeys. Proc. Natl. Acad. Sci. USA 99, 11920–11925 (2002). (10.1073/pnas.172384599) / Proc. Natl. Acad. Sci. USA by C Besnier (2002)
  20. Gamble, T.R. et al. Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid. Cell 87, 1285–1294 (1996). (10.1016/S0092-8674(00)81823-1) / Cell by TR Gamble (1996)
  21. Yoo, S. et al. Molecular recognition in the HIV-1 capsid/cyclophilin A complex. J. Mol. Biol. 269, 780–795 (1997). (10.1006/jmbi.1997.1051) / J. Mol. Biol. by S Yoo (1997)
  22. Tang, C., Ndassa, Y. & Summers, M.F. Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein. Nat. Struct. Biol. 9, 537–543 (2002). / Nat. Struct. Biol. by C Tang (2002)
  23. Lin, T.Y. & Emerman, M. Cyclophilin A interacts with diverse lentiviral capsids. Retrovirology 3, 70 (2006). (10.1186/1742-4690-3-70) / Retrovirology by TY Lin (2006)
  24. Ke, H.M., Zydowsky, L.D., Liu, J. & Walsh, C.T. Crystal structure of recombinant human T-cell cyclophilin A at 2.5 Å resolution. Proc. Natl. Acad. Sci. USA 88, 9483–9487 (1991). (10.1073/pnas.88.21.9483) / Proc. Natl. Acad. Sci. USA by HM Ke (1991)
  25. Howard, B.R., Vajdos, F.F., Li, S., Sundquist, W.I. & Hill, C.P. Structural insights into the catalytic mechanism of cyclophilin A. Nat. Struct. Biol. 10, 475–481 (2003). (10.1038/nsb927) / Nat. Struct. Biol. by BR Howard (2003)
  26. Ikeda, Y., Ylinen, L., Kahar-Bador, M. & Towers, G.J. The influence of gag on HIV-1 species specific tropism. J. Virol. 78, 11816–11822 (2004). (10.1128/JVI.78.21.11816-11822.2004) / J. Virol. by Y Ikeda (2004)
  27. Gao, F. et al. Human infection by genetically diverse SIVSM-related HIV-2 in west Africa. Nature 358, 495–499 (1992). (10.1038/358495a0) / Nature by F Gao (1992)
  28. Gao, F. et al. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature 397, 436–441 (1999). (10.1038/17130) / Nature by F Gao (1999)
  29. Roques, P. et al. Phylogenetic analysis of 49 newly derived HIV-1 group O strains: high viral diversity but no group M-like subtype structure. Virology 302, 259–273 (2002). (10.1006/viro.2002.1430) / Virology by P Roques (2002)
  30. Braaten, D. et al. Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A. J. Virol. 70, 5170–5176 (1996). (10.1128/JVI.70.8.5170-5176.1996) / J. Virol. by D Braaten (1996)
  31. Ylinen, L.M., Keckesova, Z., Wilson, S.J., Ranasinghe, S. & Towers, G.J. Differential restriction of HIV-2 and SIVmac by TRIM5α alleles. J. Virol. 79, 11580–11587 (2005). (10.1128/JVI.79.18.11580-11587.2005) / J. Virol. by LM Ylinen (2005)
  32. Van Valen, L. A new evolutonary law. Evol. Theory 1, 1–30 (1973). / Evol. Theory by L Van Valen (1973)
  33. Yap, M.W., Nisole, S. & Stoye, J.P. A single amino acid change in the SPRY domain of human TRIM5α leads to HIV-1 restriction. Curr. Biol. 15, 73–78 (2005). (10.1016/j.cub.2004.12.042) / Curr. Biol. by MW Yap (2005)
  34. Schröfelbauer, B., Chen, D. & Landau, N.R. A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif). Proc. Natl. Acad. Sci. USA 101, 3927–3932 (2004). (10.1073/pnas.0307132101) / Proc. Natl. Acad. Sci. USA by B Schröfelbauer (2004)
  35. Zufferey, R., Nagy, D., Mandel, R.J., Naldini, L. & Trono, D. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat. Biotechnol. 15, 871–875 (1997). (10.1038/nbt0997-871) / Nat. Biotechnol. by R Zufferey (1997)
  36. Griffin, S.D., Allen, J.F. & Lever, A.M. The major human immunodeficiency virus type 2 (HIV-2) packaging signal is present on all HIV-2 RNA species: cotranslational RNA encapsidation and limitation of Gag protein confer specificity. J. Virol. 75, 12058–12069 (2001). (10.1128/JVI.75.24.12058-12069.2001) / J. Virol. by SD Griffin (2001)
  37. Zheng, L., Baumann, U. & Reymond, J.L. An efficient one-step site-directed and site-saturation mutagenesis protocol. Nucleic Acids Res. 32, e115 (2004). (10.1093/nar/gnh110) / Nucleic Acids Res. by L Zheng (2004)
  38. Zhang, F., Hatziioannou, T., Perez-Caballero, D., Derse, D. & Bieniasz, P.D. Antiretroviral potential of human tripartite motif-5 and related proteins. Virology 353, 396–409 (2006). (10.1016/j.virol.2006.05.035) / Virology by F Zhang (2006)
  39. Passerini, L.D., Keckesova, Z. & Towers, G.J. Retroviral restriction factors Fv1 and TRIM5α act independently and can compete for incoming virus before reverse transcription. J. Virol. 80, 2100–2105 (2006). (10.1128/JVI.80.5.2100-2105.2006) / J. Virol. by LD Passerini (2006)
  40. Wiseman, T., Williston, S., Brandts, J.F. & Lin, L.N. Rapid measurement of binding constants and heats of binding using a new titration calorimeter. Anal. Biochem. 179, 131–137 (1989). (10.1016/0003-2697(89)90213-3) / Anal. Biochem. by T Wiseman (1989)
  41. Collaborative Computational Project, Number 4. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50, 760–763 (1994). (10.1107/S0907444994003112)
Dates
Type When
Created 15 years, 11 months ago (Sept. 20, 2009, 2:05 p.m.)
Deposited 2 years, 3 months ago (May 19, 2023, 12:25 a.m.)
Indexed 2 months ago (June 17, 2025, 6:29 a.m.)
Issued 15 years, 11 months ago (Sept. 20, 2009)
Published 15 years, 11 months ago (Sept. 20, 2009)
Published Online 15 years, 11 months ago (Sept. 20, 2009)
Published Print 15 years, 10 months ago (Oct. 1, 2009)
Funders 0

None

@article{Price_2009, title={Active site remodeling switches HIV specificity of antiretroviral TRIMCyp}, volume={16}, ISSN={1545-9985}, url={http://dx.doi.org/10.1038/nsmb.1667}, DOI={10.1038/nsmb.1667}, number={10}, journal={Nature Structural & Molecular Biology}, publisher={Springer Science and Business Media LLC}, author={Price, Amanda J and Marzetta, Flavia and Lammers, Michael and Ylinen, Laura M J and Schaller, Torsten and Wilson, Sam J and Towers, Greg J and James, Leo C}, year={2009}, month=sep, pages={1036–1042} }