Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding
10.1038/nsmb.1503
Crossref journal-article
Springer Science and Business Media LLC
Nature Structural & Molecular Biology (297)
Bibliography

Martin, A., Baker, T. A., & Sauer, R. T. (2008). Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding. Nature Structural & Molecular Biology, 15(11), 1147–1151.

Authors 3
  1. Andreas Martin (first)
  2. Tania A Baker (additional)
  3. Robert T Sauer (additional)
References 32 Referenced 240
  1. Ogura, T. & Wilkinson, A.J. AAA+ superfamily ATPases: common structure—diverse function. Genes Cells 6, 575–597 (2001). (10.1046/j.1365-2443.2001.00447.x) / Genes Cells by T Ogura (2001)
  2. Hanson, P.I. & Whiteheart, S.W. AAA+ proteins: have engine, will work. Nat. Rev. Mol. Cell Biol. 6, 519–529 (2005). (10.1038/nrm1684) / Nat. Rev. Mol. Cell Biol. by PI Hanson (2005)
  3. Gottesman, S., Maurizi, M.R. & Wickner, S. Regulatory subunits of energy-dependent proteases. Cell 91, 435–438 (1997). (10.1016/S0092-8674(00)80428-6) / Cell by S Gottesman (1997)
  4. Neuwald, A.F., Aravind, L., Spouge, J.L. & Koonin, E.V. AAA+: a class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res. 9, 27–43 (1999). (10.1101/gr.9.1.27) / Genome Res. by AF Neuwald (1999)
  5. Sauer, R.T. et al. Sculpting the proteome with AAA+ proteases and disassembly machines. Cell 119, 9–18 (2004). (10.1016/j.cell.2004.09.020) / Cell by RT Sauer (2004)
  6. Wang, J. et al. Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism. Structure 9, 177–184 (2001). (10.1016/S0969-2126(01)00570-6) / Structure by J Wang (2001)
  7. Yamada-Inagawa, T., Okuno, T., Karata, K., Yamanaka, K. & Ogura, T. Conserved pore residues in the AAA protease FtsH are important for proteolysis and its coupling to ATP hydrolysis. J. Biol. Chem. 278, 50182–50187 (2003). (10.1074/jbc.M308327200) / J. Biol. Chem. by T Yamada-Inagawa (2003)
  8. Wang, J. et al. Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU. Structure 9, 1107–1116 (2001). (10.1016/S0969-2126(01)00670-0) / Structure by J Wang (2001)
  9. Song, H.K. et al. Mutational studies on HslU and its docking mode with HslV. Proc. Natl. Acad. Sci. USA 97, 14103–14108 (2000). (10.1073/pnas.250491797) / Proc. Natl. Acad. Sci. USA by HK Song (2000)
  10. Lum, R., Tkach, J.M., Vierling, E. & Glover, J.R. Evidence for an unfolding/threading mechanism for protein disaggregation by Saccharomyces cerevisiae Hsp104. J. Biol. Chem. 279, 29139–29146 (2004). (10.1074/jbc.M403777200) / J. Biol. Chem. by R Lum (2004)
  11. Schlieker, C. et al. Substrate recognition by the AAA+ chaperone ClpB. Nat. Struct. Mol. Biol. 11, 607–615 (2004). (10.1038/nsmb787) / Nat. Struct. Mol. Biol. by C Schlieker (2004)
  12. Siddiqui, S.M., Sauer, R.T. & Baker, T.A. Role of the protein-processing pore of ClpX, a AAA+ ATPase, in recognition and engagement of specific protein substrates. Genes Dev. 18, 369–374 (2004). (10.1101/gad.1170304) / Genes Dev. by SM Siddiqui (2004)
  13. Weibezahn, J. et al. Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB. Cell 119, 653–665 (2004). (10.1016/j.cell.2004.11.027) / Cell by J Weibezahn (2004)
  14. Park, E. et al. Role of the GYVG pore motif of HslU ATPase in protein unfolding and translocation for degradation by HslV peptidase. J. Biol. Chem. 280, 22892–22898 (2005). (10.1074/jbc.M500035200) / J. Biol. Chem. by E Park (2005)
  15. Hinnerwisch, J., Fenton, W.A., Furtak, K.J., Farr, G.W. & Horwich, A.L. Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation. Cell 121, 1029–1041 (2005). (10.1016/j.cell.2005.04.012) / Cell by J Hinnerwisch (2005)
  16. Okuno, T., Yamanaka, K. & Ogura, T. Characterization of mutants of the Escherichia coli AAA protease, FtsH, carrying a mutation in the central pore region. J. Struct. Biol. 156, 109–114 (2006). (10.1016/j.jsb.2006.02.003) / J. Struct. Biol. by T Okuno (2006)
  17. Graef, M. & Langer, T. Substrate specific consequences of central pore mutations in the i-AAA protease Yme1 on substrate engagement. J. Struct. Biol. 156, 101–108 (2006). (10.1016/j.jsb.2006.01.009) / J. Struct. Biol. by M Graef (2006)
  18. Kenniston, J.A., Baker, T.A., Fernandez, J.M. & Sauer, R.T. Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of a AAA+ degradation machine. Cell 114, 511–520 (2003). (10.1016/S0092-8674(03)00612-3) / Cell by JA Kenniston (2003)
  19. Singleton, M.R., Sawaya, M.R., Ellenberger, T. & Wigley, D.B. Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides. Cell 101, 589–600 (2000). (10.1016/S0092-8674(00)80871-5) / Cell by MR Singleton (2000)
  20. Hishida, T., Han, Y.W., Fujimoto, S., Iwasaki, H. & Shinagawa, H. Direct evidence that a conserved arginine in RuvB AAA+ ATPase acts as an allosteric effector for the ATPase activity of the adjacent subunit in a hexamer. Proc. Natl. Acad. Sci. USA 101, 9573–9577 (2004). (10.1073/pnas.0403584101) / Proc. Natl. Acad. Sci. USA by T Hishida (2004)
  21. Hersch, G.L., Burton, R.E., Bolon, D.N., Baker, T.A. & Sauer, R.T. Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine. Cell 121, 1017–1027 (2005). (10.1016/j.cell.2005.05.024) / Cell by GL Hersch (2005)
  22. Martin, A., Baker, T.A. & Sauer, R.T. Rebuilt AAA+ motors reveal operating principles for ATP-fueled machines. Nature 437, 1115–1120 (2005). (10.1038/nature04031) / Nature by A Martin (2005)
  23. Enemark, E.J. & Joshua-Tor, L. Mechanism of DNA translocation in a replicative hexameric helicase. Nature 442, 270–275 (2006). (10.1038/nature04943) / Nature by EJ Enemark (2006)
  24. Joshi, S.A., Hersch, G.L., Baker, T.A. & Sauer, R.T. Communication between ClpX and ClpP during substrate processing and degradation. Nat. Struct. Mol. Biol. 11, 404–411 (2004). (10.1038/nsmb752) / Nat. Struct. Mol. Biol. by SA Joshi (2004)
  25. Martin, A., Baker, T.A. & Sauer, R.T. Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates. Mol. Cell 29, 441–450 (2008). (10.1016/j.molcel.2008.02.002) / Mol. Cell by A Martin (2008)
  26. Kenniston, J.A., Baker, T.A. & Sauer, R.T. Partitioning between unfolding and release of native domains during ClpXP degradation determines substrate selectivity and partial processing. Proc. Natl. Acad. Sci. USA 102, 1390–1395 (2005). (10.1073/pnas.0409634102) / Proc. Natl. Acad. Sci. USA by JA Kenniston (2005)
  27. Martin, A., Baker, T.A. & Sauer, R.T. Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis rates and substrate energy landscapes. Nat. Struct. Mol. Biol. 15, 139–145 (2008). (10.1038/nsmb.1380) / Nat. Struct. Mol. Biol. by A Martin (2008)
  28. Thompson, M.W. & Maurizi, M.R. Activity and specificity of Escherichia coli ClpAP protease in cleaving model peptide substrates. J. Biol. Chem. 269, 18201–18208 (1994). (10.1016/S0021-9258(17)32435-3) / J. Biol. Chem. by MW Thompson (1994)
  29. Bochtler, M. et al. The structures of HsIU and the ATP-dependent protease HsIU-HsIV. Nature 403, 800–805 (2000). (10.1038/35001629) / Nature by M Bochtler (2000)
  30. Bieniossek, C. et al. The molecular architecture of the metalloprotease FtsH. Proc. Natl. Acad. Sci. USA 103, 3066–3071 (2006). (10.1073/pnas.0600031103) / Proc. Natl. Acad. Sci. USA by C Bieniossek (2006)
  31. Martin, A., Baker, T.A. & Sauer, R.T. Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease. Mol. Cell 27, 41–52 (2007). (10.1016/j.molcel.2007.05.024) / Mol. Cell by A Martin (2007)
  32. Burton, R.E., Baker, T.A. & Sauer, R.T. Energy-dependent degradation: linkage between ClpX-catalyzed nucleotide hydrolysis and protein-substrate processing. Protein Sci. 12, 893–902 (2003). (10.1110/ps.0237603) / Protein Sci. by RE Burton (2003)
Dates
Type When
Created 16 years, 10 months ago (Oct. 19, 2008, 2:14 p.m.)
Deposited 2 years, 3 months ago (May 20, 2023, 12:26 p.m.)
Indexed 1 month ago (July 20, 2025, 12:16 a.m.)
Issued 16 years, 10 months ago (Oct. 19, 2008)
Published 16 years, 10 months ago (Oct. 19, 2008)
Published Online 16 years, 10 months ago (Oct. 19, 2008)
Published Print 16 years, 9 months ago (Nov. 1, 2008)
Funders 0

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@article{Martin_2008, title={Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding}, volume={15}, ISSN={1545-9985}, url={http://dx.doi.org/10.1038/nsmb.1503}, DOI={10.1038/nsmb.1503}, number={11}, journal={Nature Structural & Molecular Biology}, publisher={Springer Science and Business Media LLC}, author={Martin, Andreas and Baker, Tania A and Sauer, Robert T}, year={2008}, month=oct, pages={1147–1151} }