The molecular basis of water transport in the brain
10.1038/nrn1252
Crossref journal-article
Springer Science and Business Media LLC
Nature Reviews Neuroscience (297)
Bibliography

Amiry-Moghaddam, M., & Ottersen, O. P. (2003). The molecular basis of water transport in the brain. Nature Reviews Neuroscience, 4(12), 991–1001.

Authors 2
  1. Mahmood Amiry-Moghaddam (first)
  2. Ole P. Ottersen (additional)
References 129 Referenced 601
  1. Preston, G. M., Carroll, T. P., Guggino, W. B. & Agre, P. Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science 256, 385–387 (1992). Identification of the first member of the aquaporin family (Chip28, later renamed Aqp1). (10.1126/science.256.5055.385) / Science by GM Preston (1992)
  2. Agre, P. et al. Aquaporin water channels — from atomic structure to clinical medicine. J. Physiol. (Lond.) 542, 3–16 (2002). (10.1113/jphysiol.2002.020818) / J. Physiol. (Lond.) by P Agre (2002)
  3. Johansson, I., Karlsson, M., Johanson, U., Larsson, C. & Kjellbom, P. The role of aquaporins in cellular and whole plant water balance. Biochim. Biophys. Acta 1465, 324–342 (2000). (10.1016/S0005-2736(00)00147-4) / Biochim. Biophys. Acta by I Johansson (2000)
  4. Santoni, V., Gerbeau, P., Javot, H. & Maurel, C. The high diversity of aquaporins reveals novel facets of plant membrane functions. Curr. Opin. Plant Biol. 3, 476–481 (2000). (10.1016/S1369-5266(00)00116-3) / Curr. Opin. Plant Biol. by V Santoni (2000)
  5. Marples, D., Knepper, M. A., Christensen, E. I. & Nielsen, S. Redistribution of aquaporin-2 water channels induced by vasopressin in rat kidney inner medullary collecting duct. Am. J. Physiol. 269, C655–C664 (1995). (10.1152/ajpcell.1995.269.3.C655) / Am. J. Physiol. by D Marples (1995)
  6. Agre, P. et al. Aquaporin CHIP: the archetypal molecular water channel. Am. J. Physiol. 265, F463–F476 (1993). / Am. J. Physiol. by P Agre (1993)
  7. Nielsen, S., Smith, B. L., Christensen, E. I., Knepper, M. A. & Agre, P. CHIP28 water channels are localized in constitutively water-permeable segments of the nephron. J. Cell Biol. 120, 371–383 (1993). (10.1083/jcb.120.2.371) / J. Cell Biol. by S Nielsen (1993)
  8. Nielsen, S., Smith, B. L., Christensen, E. I. & Agre, P. Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc. Natl Acad. Sci. USA 90, 7275–7279 (1993). (10.1073/pnas.90.15.7275) / Proc. Natl Acad. Sci. USA by S Nielsen (1993)
  9. Hasegawa, H., Ma, T., Skach, W., Matthay, M. A. & Verkman, A. S. Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. J. Biol. Chem. 269, 5497–5500 (1994). A member of the aquaporin family was cloned that was later named Aqp4. (10.1016/S0021-9258(17)37486-0) / J. Biol. Chem. by H Hasegawa (1994)
  10. Jung, J. S. et al. Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. Proc. Natl Acad. Sci. USA 91, 13052–13056 (1994). (10.1073/pnas.91.26.13052) / Proc. Natl Acad. Sci. USA by JS Jung (1994)
  11. Nielsen, S. et al. Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J. Neurosci. 17, 171–180 (1997). High resolution immunogold analysis revealed a concentration of Aqp4 in subpial and perivascular endfeet, and in ependymal cells, that is, at the interfaces between brain and extracerebral liquids (blood and CSF). (10.1523/JNEUROSCI.17-01-00171.1997) / J. Neurosci. by S Nielsen (1997)
  12. Solenov, E., Watanabe, H., Manley, G. T. & Verkman A. S. Seven-fold reduced osmotic water permeability in primary astrocyte cultures from aquaporin-4 deficient mice measured by a calcein quenching method. Am. J. Physiol. Cell Physiol. (2003). (10.1152/ajpcell.00298.2003)
  13. Bai, L., Fushimi, K., Sasaki, S. & Marumo, F. Structure of aquaporin-2 vasopressin water channel. J. Biol. Chem. 271, 5171–5176 (1996). (10.1074/jbc.271.9.5171) / J. Biol. Chem. by L Bai (1996)
  14. Shi, L. B., Skach, W. R. & Verkman, A. S. Functional independence of monomeric CHIP28 water channels revealed by expression of wild-type mutant heterodimers. J. Biol. Chem. 269, 10417–10422 (1994). (10.1016/S0021-9258(17)34076-0) / J. Biol. Chem. by LB Shi (1994)
  15. Skach, W. R. et al. Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum. J. Cell Biol. 125, 803–815 (1994). (10.1083/jcb.125.4.803) / J. Cell Biol. by WR Skach (1994)
  16. Preston, G. M., Jung, J. S., Guggino, W. B. & Agre, P. Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis. J. Biol. Chem. 269, 1668–1673 (1994). (10.1016/S0021-9258(17)42079-5) / J. Biol. Chem. by GM Preston (1994)
  17. Chandy, G., Zampighi, G. A., Kreman, M. & Hall, J. E. Comparison of the water transporting properties of MIP and Aqp1. J. Membr. Biol. 159, 29–39 (1997). (10.1007/s002329900266) / J. Membr. Biol. by G Chandy (1997)
  18. Zhang, R., Van Hoek, A. N., Biwersi, J. & Verkman, A. S. A point mutation at cysteine 189 blocks the water permeability of rat kidney water channel CHIP28k. Biochemistry 32, 2938–2941 (1993). (10.1021/bi00063a002) / Biochemistry by R Zhang (1993)
  19. Farinas, J., Van Hoek, A. N., Shi, L. B., Erickson, C. & Verkman, A. S. Nonpolar environment of tryptophans in erythrocyte water channel CHIP28 determined by fluorescence quenching. Biochemistry 32, 11857–11864 (1993). (10.1021/bi00095a014) / Biochemistry by J Farinas (1993)
  20. Van Hoek, A. N. & Verkman, A. S. Functional reconstitution of the isolated erythrocyte water channel CHIP28. J. Biol. Chem. 267, 18267–18269 (1992). (10.1016/S0021-9258(19)36953-4) / J. Biol. Chem. by AN Van Hoek (1992)
  21. Zeidel, M. L., Ambudkar, S. V., Smith, B. L. & Agre, P. Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. Biochemistry 31, 7436–7440 (1992). (10.1021/bi00148a002) / Biochemistry by ML Zeidel (1992)
  22. Yang, B. & Verkman, A. S. Water and glycerol permeabilities of aquaporins 1–5 and MIP determined quantitatively by expression of epitope-tagged constructs in Xenopus oocytes. J. Biol. Chem. 272, 16140–16146 (1997). (10.1074/jbc.272.26.16140) / J. Biol. Chem. by B Yang (1997)
  23. Tsukaguchi, H. et al. Molecular characterization of a broad selectivity neutral solute channel. J. Biol. Chem. 273, 24737–24743 (1998). (10.1074/jbc.273.38.24737) / J. Biol. Chem. by H Tsukaguchi (1998)
  24. de Groot, B. L. & Grubmuller, H. Water permeation across biological membranes: mechanism and dynamics of aquaporin-1 and GlpF. Science 294, 2353–2357 (2001). (10.1126/science.1062459) / Science by BL de Groot (2001)
  25. Murata, K. et al. Structural determinants of water permeation through aquaporin-1. Nature 407, 599–605 (2000). (10.1038/35036519) / Nature by K Murata (2000)
  26. Sui, H., Han, B. G., Lee, J. K., Walian, P. & Jap, B. K. Structural basis of water-specific transport through the Aqp1 water channel. Nature 414, 872–878 (2001). This study describes an atomic model for Aqp1, revealing the three-dimensional structure of aqueous pore and providing an explanation of the water selectivity. (10.1038/414872a) / Nature by H Sui (2001)
  27. Fu, D. et al. Structure of a glycerol-conducting channel and the basis for its selectivity. Science 290, 481–486 (2000). (10.1126/science.290.5491.481) / Science by D Fu (2000)
  28. Thomas, D. et al. Aquaglyceroporins, one channel for two molecules. Biochim. Biophys. Acta 1555, 181–186 (2002). (10.1016/S0005-2728(02)00275-X) / Biochim. Biophys. Acta by D Thomas (2002)
  29. Preston, G. M., Jung, J. S., Guggino, W. B. & Agre, P. The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel. J. Biol. Chem. 268, 17–20 (1993). (10.1016/S0021-9258(18)54108-9) / J. Biol. Chem. by GM Preston (1993)
  30. Yasui, M. et al. Rapid gating and anion permeability of an intracellular aquaporin. Nature 402, 184–187 (1999). (10.1038/46045) / Nature by M Yasui (1999)
  31. Hazama, A., Kozono, D., Guggino, W. B., Agre, P. & Yasui, M. Ion permeation of Aqp6 water channel protein. Single channel recordings after Hg2+ activation. J. Biol. Chem. 277, 29224–29230 (2002). (10.1074/jbc.M204258200) / J. Biol. Chem. by A Hazama (2002)
  32. Katsura, T., Gustafson, C. E., Ausiello, D. A. & Brown, D. Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells. Am. J. Physiol. 272, F817–F822 (1997). / Am. J. Physiol. by T Katsura (1997)
  33. Fushimi, K., Sasaki, S. & Marumo, F. Phosphorylation of serine 256 is required for cAMP-dependent regulatory exocytosis of the aquaporin-2 water channel. J. Biol. Chem. 272, 14800–14804 (1997). (10.1074/jbc.272.23.14800) / J. Biol. Chem. by K Fushimi (1997)
  34. Brown, D. The ins and outs of aquaporin-2 trafficking. Am. J. Physiol. Renal Physiol. 284, F893–F901 (2003). (10.1152/ajprenal.00387.2002) / Am. J. Physiol. Renal Physiol. by D Brown (2003)
  35. Xu, D. L. et al. Upregulation of aquaporin-2 water channel expression in chronic heart failure rat. J. Clin. Invest 99, 1500–1505 (1997). (10.1172/JCI119312) / J. Clin. Invest by DL Xu (1997)
  36. Han, Z., Wax, M. B. & Patil, R. V. Regulation of aquaporin-4 water channels by phorbol ester-dependent protein phosphorylation. J. Biol. Chem. 273, 6001–6004 (1998). (10.1074/jbc.273.11.6001) / J. Biol. Chem. by Z Han (1998)
  37. Niermann, H., Amiry-Moghaddam, M., Holthoff, K., Witte, O. W. & Ottersen, O. P. A novel role of vasopressin in the brain: modulation of activity-dependent water flux in the neocortex. J. Neurosci. 21, 3045–3051 (2001). (10.1523/JNEUROSCI.21-09-03045.2001) / J. Neurosci. by H Niermann (2001)
  38. Rash, J. E., Yasumura, T., Hudson, C. S., Agre, P. & Nielsen, S. Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proc. Natl Acad. Sci. USA 95, 11981–11986 (1998). (10.1073/pnas.95.20.11981) / Proc. Natl Acad. Sci. USA by JE Rash (1998)
  39. Carmosino, M. et al. Histamine treatment induces rearrangements of orthogonal arrays of particles (OAPs) in human Aqp4-expressing gastric cells. J. Cell Biol. 154, 1235–1243 (2001). (10.1083/jcb.200103010) / J. Cell Biol. by M Carmosino (2001)
  40. Ke, C., Poon, W. S., Ng, H. K., Pang, J. C. & Chan, Y. Heterogeneous responses of aquaporin-4 in oedema formation in a replicated severe traumatic brain injury model in rats. Neurosci. Lett. 301, 21–24 (2001). (10.1016/S0304-3940(01)01589-0) / Neurosci. Lett. by C Ke (2001)
  41. Kiening, K. L. et al. Decreased hemispheric aquaporin-4 is linked to evolving brain edema following controlled cortical impact injury in rats. Neurosci. Lett. 324, 105–108 (2002). (10.1016/S0304-3940(02)00180-5) / Neurosci. Lett. by KL Kiening (2002)
  42. Saadoun, S., Papadopoulos, M. C., Davies, D. C., Krishna, S. & Bell, B. A. Aquaporin-4 expression is increased in oedematous human brain tumours. J. Neurol. Neurosurg. Psychiatry 72, 262–265 (2002). (10.1136/jnnp.72.2.262) / J. Neurol. Neurosurg. Psychiatry by S Saadoun (2002)
  43. Sato, S. et al. Expression of water channel mRNA following cerebral ischemia. Acta Neurochir. Suppl 76, 239–241 (2000). (10.1007/978-3-7091-6346-7_48) / Acta Neurochir. Suppl by S Sato (2000)
  44. Taniguchi, M. et al. Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat. Brain Res. Mol. Brain Res. 78, 131–137 (2000). (10.1016/S0169-328X(00)00084-X) / Brain Res. Mol. Brain Res. by M Taniguchi (2000)
  45. Vizuete. M. L. et al. Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: potential role in brain edema. Neurobiol. Dis. 6, 245–258 (1999). (10.1006/nbdi.1999.0246) / Neurobiol. Dis. by ML Vizuete. (1999)
  46. Nakahama, K., Nagano, M., Fujioka, A., Shinoda, K. & Sasaki, H. Effect of TPA on aquaporin 4 mRNA expression in cultured rat astrocytes. Glia 25, 240–246 (1999). (10.1002/(SICI)1098-1136(19990201)25:3<240::AID-GLIA4>3.0.CO;2-C) / Glia by K Nakahama (1999)
  47. Yamamoto, N. et al. Differential regulation of aquaporin expression in astrocytes by protein kinase C. Brain Res. Mol. Brain Res. 95, 110–116 (2001). (10.1016/S0169-328X(01)00254-6) / Brain Res. Mol. Brain Res. by N Yamamoto (2001)
  48. Arima, H. et al. Hyperosmolar mannitol stimulates expression of aquaporin 4 and 9 through a p38 mitogen activated protein kinase-dependent pathway in rat astrocytes. J. Biol. Chem. (2003). (10.1074/jbc.M304368200)
  49. Wu, Q., Delpire, E., Hebert, S. C. & Strange, K. Functional demonstration of Na+-K+-2Cl− cotransporter activity in isolated, polarized choroid plexus cells. Am. J. Physiol. 275, C1565–C1572 (1998). (10.1152/ajpcell.1998.275.6.C1565) / Am. J. Physiol. by Q Wu (1998)
  50. Speake, T., Freeman, L. J. & Brown, P. D. Expression of aquaporin 1 and aquaporin 4 water channels in rat choroid plexus. Biochim. Biophys. Acta 1609, 80–86 (2003). (10.1016/S0005-2736(02)00658-2) / Biochim. Biophys. Acta by T Speake (2003)
  51. Nejsum, L. N. et al. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Proc. Natl Acad. Sci. USA 99, 511–516 (2002). (10.1073/pnas.012588099) / Proc. Natl Acad. Sci. USA by LN Nejsum (2002)
  52. Ma, T. et al. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J. Biol. Chem. 273, 4296–4299 (1998). (10.1074/jbc.273.8.4296) / J. Biol. Chem. by T Ma (1998)
  53. Davson, H. & Bradbury, M. The fluid exchange of the central nervous system. Symp. Soc. Exp. Biol. 19, 349–364 (1965). / Symp. Soc. Exp. Biol. by H Davson (1965)
  54. Zeuthen, T. & Wright, E. M. An electrogenic Na+/K+ pump in the choroid plexus. Biochim. Biophys. Acta 511, 517–522 (1978). (10.1016/0005-2736(78)90287-0) / Biochim. Biophys. Acta by T Zeuthen (1978)
  55. Wright, E. M. Transport processes in the formation of the cerebrospinal fluid. Rev. Physiol Biochem. Pharmacol. 83, 3–34 (1978). / Rev. Physiol Biochem. Pharmacol. by EM Wright (1978)
  56. Keep, R. F., Xiang, J. & Betz, A. L. Potassium cotransport at the rat choroid plexus. Am. J. Physiol. 267, C1616–C1622 (1994). (10.1152/ajpcell.1994.267.6.C1616) / Am. J. Physiol. by RF Keep (1994)
  57. Plotkin, M. D. et al. Expression of the Na+-K+-2Cl− cotransporter BSC2 in the nervous system. Am. J. Physiol. 272, C173–C183 (1997). (10.1152/ajpcell.1997.272.1.C173) / Am. J. Physiol. by MD Plotkin (1997)
  58. Nakamura, N. et al. Inwardly rectifying K+ channel Kir7.1 is highly expressed in thyroid follicular cells, intestinal epithelial cells and choroid plexus epithelial cells: implication for a functional coupling with Na+,K+-ATPase. Biochem. J. 342, 329–336 (1999). (10.1042/bj3420329) / Biochem. J. by N Nakamura (1999)
  59. Lindsey, A. E. et al. Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus. Proc. Natl Acad. Sci. USA 87, 5278–5282 (1990). (10.1073/pnas.87.14.5278) / Proc. Natl Acad. Sci. USA by AE Lindsey (1990)
  60. Alper, S. L., Stuart-Tilley, A., Simmons, C. F., Brown, D. & Drenckhahn, D. The fodrin-ankyrin cytoskeleton of choroid plexus preferentially colocalizes with apical Na+K+-ATPase rather than with basolateral anion exchanger AE2. J. Clin. Invest. 93, 1430–1438 (1994). (10.1172/JCI117120) / J. Clin. Invest. by SL Alper (1994)
  61. Frigeri, A. et al. Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues. J. Cell Sci. 108, 2993–3002 (1995). (10.1242/jcs.108.9.2993) / J. Cell Sci. by A Frigeri (1995)
  62. Frigeri, A., Nicchia, G. P., Verbavatz, J. M., Valenti, G. & Svelto, M. Expression of aquaporin-4 in fast-twitch fibers of mammalian skeletal muscle. J. Clin. Invest. 102, 695–703 (1998). (10.1172/JCI2545) / J. Clin. Invest. by A Frigeri (1998)
  63. Takumi, Y. et al. Select types of supporting cell in the inner ear express aquaporin-4 water channel protein. Eur. J. Neurosci. 10, 3584–3595 (1998). (10.1046/j.1460-9568.1998.00360.x) / Eur. J. Neurosci. by Y Takumi (1998)
  64. Nagelhus, E. A. et al. Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Muller cells is mediated by a coenrichment of Kir4.1 and Aqp4 in specific membrane domains. Glia 26, 47–54 (1999). This study showed that Kir4.1, a K+ channel known to be involved in K+ clearance, is strictly co-localized with Aqp4, indicating that the two membrane molecules act in concert. (10.1002/(SICI)1098-1136(199903)26:1<47::AID-GLIA5>3.0.CO;2-5) / Glia by EA Nagelhus (1999)
  65. Kobayashi, H. et al. Aquaporin subtypes in rat cerebral microvessels. Neurosci. Lett. 297, 163–166 (2001). (10.1016/S0304-3940(00)01705-5) / Neurosci. Lett. by H Kobayashi (2001)
  66. Amiry-Moghaddam, M. Molecular basis of water homeostasis in brain. Thesis, Univ. Oslo. (2003). (10.1038/nrn1252)
  67. Adams, M. E., Mueller, H. A. & Froehner, S. C. In vivo requirement of the α-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4. J. Cell Biol. 155, 113–122 (2001). (10.1083/jcb.200106158) / J. Cell Biol. by ME Adams (2001)
  68. Peters, M. F., Adams, M. E. & Froehner, S. C. Differential association of syntrophin pairs with the dystrophin complex. J. Cell Biol. 138, 81–93 (1997). (10.1083/jcb.138.1.81) / J. Cell Biol. by MF Peters (1997)
  69. Adams, M. E. et al. Absence of α-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin. J. Cell Biol. 150, 1385–1398 (2000). (10.1083/jcb.150.6.1385) / J. Cell Biol. by ME Adams (2000)
  70. Albrecht, D. E. & Froehner, S. C. Syntrophins and dystrobrevins: defining the dystrophin scaffold at synapses. Neurosignals 11, 123–129 (2002). (10.1159/000065053) / Neurosignals by DE Albrecht (2002)
  71. Froehner, S. C., Adams, M. E., Peters, M. F. & Gee, S. H. Syntrophins: modular adapter proteins at the neuromuscular junction and the sarcolemma. Soc. Gen. Physiol Ser. 52, 197–207 (1997). / Soc. Gen. Physiol Ser. by SC Froehner (1997)
  72. Wertz, K. & Fuchtbauer, E. M. Dmdmdx-βgeo: A new allele for the mouse dystrophin gene. Dev. Dyn. 212, 229–241 (1998). (10.1002/(SICI)1097-0177(199806)212:2<229::AID-AJA7>3.0.CO;2-J) / Dev. Dyn. by K Wertz (1998)
  73. Frigeri, A. et al. Aquaporin-4 deficiency in skeletal muscle and brain of dystrophic mdx mice. FASEB J. 15, 90–98 (2001). (10.1096/fj.00-0260com) / FASEB J. by A Frigeri (2001)
  74. Amiry-Moghaddam, M. et al. An α-syntrophin-dependent pool of Aqp4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proc. Natl Acad. Sci. USA 100, 2106–2111 (2003). This study showed that selective removal of perivascular Aqp4 by α-Syn deletion reduced the extent of post-ischaemic oedema and that the binding between Aqp4 and α-Syn is sensitive to ischaemia. (10.1073/pnas.0437946100) / Proc. Natl Acad. Sci. USA by M Amiry-Moghaddam (2003)
  75. Neely, J. D. et al. Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein. Proc. Natl Acad. Sci. USA 98, 14108–14113 (2001). (10.1073/pnas.241508198) / Proc. Natl Acad. Sci. USA by JD Neely (2001)
  76. Wen, H. et al. Ontogeny of water transport in rat brain: postnatal expression of the aquaporin-4 water channel. Eur. J. Neurosci. 11, 935–945 (1999). (10.1046/j.1460-9568.1999.00502.x) / Eur. J. Neurosci. by H Wen (1999)
  77. Nico, B. et al. Role of aquaporin-4 water channel in the development and integrity of the blood-brain barrier. J. Cell Sci. 114, 1297–1307 (2001). (10.1242/jcs.114.7.1297) / J. Cell Sci. by B Nico (2001)
  78. Newman, E. A., Frambach, D. A. & Odette, L. L. Control of extracellular potassium levels by retinal glial cell K+ siphoning. Science 225, 1174–1175 (1984). (10.1126/science.6474173) / Science by EA Newman (1984)
  79. Newman, E. A. Regional specialization of the membrane of retinal glial cells and its importance to K+ spatial buffering. Ann. NY Acad. Sci. 481, 273–286 (1986). (10.1111/j.1749-6632.1986.tb27158.x) / Ann. NY Acad. Sci. by EA Newman (1986)
  80. Gardner-Medwin, A. R., Coles, J. A. & Tsacopoulos, M. Clearance of extracellular potassium: evidence for spatial buffering by glial cells in the retina of the drone. Brain Res. 209, 452–457 (1981). (10.1016/0006-8993(81)90169-4) / Brain Res. by AR Gardner-Medwin (1981)
  81. Dietzel, I., Heinemann, U., Hofmeier, G. & Lux, H. D. Transient changes in the size of the extracellular space in the sensorimotor cortex of cats in relation to stimulus-induced changes in potassium concentration. Exp. Brain Res. 40, 432–439 (1980). (10.1007/BF00236151) / Exp. Brain Res. by I Dietzel (1980)
  82. Lux, H. D., Heinemann, U. & Dietzel, I. Ionic changes and alterations in the size of the extracellular space during epileptic activity. Adv. Neurol. 44, 619–639 (1986). / Adv. Neurol. by HD Lux (1986)
  83. Holthoff, K. & Witte, O. W. Directed spatial potassium redistribution in rat neocortex. Glia 29, 288–292 (2000). (10.1002/(SICI)1098-1136(20000201)29:3<288::AID-GLIA10>3.0.CO;2-8) / Glia by K Holthoff (2000)
  84. Sarfaraz, D. & Fraser, C. L. Effects of arginine vasopressin on cell volume regulation in brain astrocyte in culture. Am. J. Physiol. 276, E596–E601 (1999). / Am. J. Physiol. by D Sarfaraz (1999)
  85. Sykova, E., Vargova, L., Prokopova, S. & Simonova, Z. Glial swelling and astrogliosis produce diffusion barriers in the rat spinal cord. Glia 25, 56–70 (1999). (10.1002/(SICI)1098-1136(19990101)25:1<56::AID-GLIA6>3.0.CO;2-4) / Glia by E Sykova (1999)
  86. Sykova, E. & Chvatal, A. Extracellular ionic and volume changes: the role in glia-neuron interaction. J. Chem. Neuroanat. 6, 247–260 (1993). (10.1016/0891-0618(93)90046-7) / J. Chem. Neuroanat. by E Sykova (1993)
  87. Sykova, E. Modulation of spinal cord transmission by changes in extracellular K+ activity and extracellular volume. Can. J. Physiol. Pharmacol. 65, 1058–1066 (1987). (10.1139/y87-167) / Can. J. Physiol. Pharmacol. by E Sykova (1987)
  88. Amiry-Moghaddam, M. et al. Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of α-syntrophin-null mice. Proc. Natl Acad. Sci. USA 100, 13615–13620 (2003). (10.1073/pnas.2336064100) / Proc. Natl Acad. Sci. USA by M Amiry-Moghaddam (2003)
  89. Lehninger, A. L. Biochemistry, The Molecular Base of Cell Structure and Function (Worth, New York, 1970). / Biochemistry, The Molecular Base of Cell Structure and Function by AL Lehninger (1970)
  90. Manley, G. T. et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nature Med. 6, 159–163 (2000). This is the first study suggesting that Aqp4 has a role in the development of brain oedema. (10.1038/72256) / Nature Med. by GT Manley (2000)
  91. Deleuze, C., Duvoid, A. & Hussy, N. Properties and glial origin of osmotic-dependent release of taurine from the rat supraoptic nucleus. J. Physiol. (Lond.) 507, 463–471 (1998). (10.1111/j.1469-7793.1998.463bt.x) / J. Physiol. (Lond.) by C Deleuze (1998)
  92. Hussy, N., Deleuze, C., Pantaloni, A., Desarmenien, M. G. & Moos, F. Agonist action of taurine on glycine receptors in rat supraoptic magnocellular neurones: possible role in osmoregulation. J. Physiol. (Lond.) 502, 609–621 (1997). (10.1111/j.1469-7793.1997.609bj.x) / J. Physiol. (Lond.) by N Hussy (1997)
  93. Hussy, N., Deleuze, C., Desarmenien, M. G. & Moos, F. C. Osmotic regulation of neuronal activity: a new role for taurine and glial cells in a hypothalamic neuroendocrine structure. Prog. Neurobiol. 62, 113–134 (2000). (10.1016/S0301-0082(99)00071-4) / Prog. Neurobiol. by N Hussy (2000)
  94. Elkjaer, M. et al. Immunolocalization of Aqp9 in liver, epididymis, testis, spleen, and brain. Biochem. Biophys. Res. Commun. 276, 1118–1128 (2000). (10.1006/bbrc.2000.3505) / Biochem. Biophys. Res. Commun. by M Elkjaer (2000)
  95. Carbrey, J. M. et al. Aquaglyceroporin Aqp9: solute permeation and metabolic control of expression in liver. Proc. Natl Acad. Sci. USA 100, 2945–2950 (2003). (10.1073/pnas.0437994100) / Proc. Natl Acad. Sci. USA by JM Carbrey (2003)
  96. Ishibashi, K. et al. Cloning and functional expression of a new aquaporin (Aqp9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. Biochem. Biophys. Res. Commun. 244, 268–274 (1998). (10.1006/bbrc.1998.8252) / Biochem. Biophys. Res. Commun. by K Ishibashi (1998)
  97. Venero, J. L., Vizuete, M. L., Machado, A. & Cano, J. Aquaporins in the central nervous system. Prog. Neurobiol. 63, 321–336 (2001). (10.1016/S0301-0082(00)00035-6) / Prog. Neurobiol. by JL Venero (2001)
  98. Vajda, Z. et al. Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice. Proc. Natl Acad. Sci. USA 99, 13131–13136 (2002). Mdx mice that lacked Aqp4 at the interfaces between brain and blood/CSF showed a delayed development of hyponatremic oedema, compared with wild-type mice. (10.1073/pnas.192457099) / Proc. Natl Acad. Sci. USA by Z Vajda (2002)
  99. Cadnapaphornchai, M. A. & Schrier, R. W. Pathogenesis and management of hyponatremia. Am. J. Med. 109, 688–692 (2000). (10.1016/S0002-9343(00)00622-7) / Am. J. Med. by MA Cadnapaphornchai (2000)
  100. Hise, M. A. & Johanson, C. E. The sink action of cerebrospinal fluid in uremia. Eur. Neurol. 18, 328–337 (1979). (10.1159/000115097) / Eur. Neurol. by MA Hise (1979)
  101. Klatzo, I., Chui, E., Fujiwara, K. & Spatz, M. Resolution of vasogenic brain edema. Adv. Neurol. 28, 359–373 (1980). / Adv. Neurol. by I Klatzo (1980)
  102. Wolburg, H. Orthogonal arrays of intramembranous particles: a review with special reference to astrocytes. J. Hirnforsch. 36, 239–258 (1995). / J. Hirnforsch. by H Wolburg (1995)
  103. Loo, D. D. F., Wright, E. M. & Zeuthen, T. Water pumps. J. Physiol. (Lond.) 542, 53–60 (2002). (10.1113/jphysiol.2002.018713) / J. Physiol. (Lond.) by DDF Loo (2002)
  104. Yan, Y., Dempsey, R. J. & Sun, D. Expression of Na+-K+-Cl− cotransporter in rat brain during development and its localization in mature astrocytes. Brain Res. 911, 43–55 (2001). (10.1016/S0006-8993(01)02649-X) / Brain Res. by Y Yan (2001)
  105. Nitta, T. et al. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J. Cell Biol. 161, 653–660 (2003). (10.1083/jcb.200302070) / J. Cell Biol. by T Nitta (2003)
  106. Hamann, S., Kiilgaard, J. F., la Cour, M., Prause, J. U. & Zeuthen, T. Cotransport of H+, lactate, and H2O in porcine retinal pigment epithelial cells. Exp. Eye Res. 76, 493–504 (2003). (10.1016/S0014-4835(02)00329-9) / Exp. Eye Res. by S Hamann (2003)
  107. Zeuthen, T. & MacAulay, N. Cotransporters as molecular water pumps. Int. Rev. Cytol. 215, 259–284 (2002). (10.1016/S0074-7696(02)15012-1) / Int. Rev. Cytol. by T Zeuthen (2002)
  108. MacAulay, N., Gether, U., Klaerke, D. A. & Zeuthen, T. Water transport by the human Na+-coupled glutamate cotransporter expressed in Xenopus oocytes. J. Physiol. (Lond.) 530, 367–378 (2001). (10.1111/j.1469-7793.2001.0367k.x) / J. Physiol. (Lond.) by N MacAulay (2001)
  109. Zeuthen, T. Molecular water pumps. Rev. Physiol Biochem. Pharmacol. 141, 97–151 (2000). (10.1007/BFb0119578) / Rev. Physiol Biochem. Pharmacol. by T Zeuthen (2000)
  110. Zeuthen, T. et al. Water transport by the Na+/glucose cotransporter under isotonic conditions. Biol. Cell 89, 307–312 (1997). / Biol. Cell by T Zeuthen (1997)
  111. MacAulay, N., Gether, U., Klaeke, D. A. & Zeuthen, T. Passive water and urea permeability of a human Na+-glutamate cotransporter expressed in Xenopus oocytes. J. Physiol. (Lond.) 542, 817–828 (2002). (10.1113/jphysiol.2002.020586) / J. Physiol. (Lond.) by N MacAulay (2002)
  112. Gerhart, D. Z., Enerson, B. E., Zhdankina, O. Y., Leino, R. L. & Drewes, L. R. Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats. Am. J. Physiol. (Lond.) 273, E207–E213 (1997). / Am. J. Physiol. (Lond.) by DZ Gerhart (1997)
  113. Yu, S. & Ding, W. G. The 45 kDa form of glucose transporter 1 (GLUT1) is localized in oligodendrocyte and astrocyte but not in microglia in the rat brain. Brain Res. 797, 65–72 (1998). (10.1016/S0006-8993(98)00372-2) / Brain Res. by S Yu (1998)
  114. Kacem, K., Lacombe, P., Seylaz, J. & Bonvento, G. Structural organization of the perivascular astrocyte endfeet and their relationship with the endothelial glucose transporter: a confocal microscopy study. Glia 23, 1–10 (1998). (10.1002/(SICI)1098-1136(199805)23:1<1::AID-GLIA1>3.0.CO;2-B) / Glia by K Kacem (1998)
  115. McCall, A. L. et al. Forebrain ischemia increases GLUT1 protein in brain microvessels and parenchyma. J. Cereb. Blood Flow Metab. 16, 69–76 (1996). (10.1097/00004647-199601000-00008) / J. Cereb. Blood Flow Metab. by AL McCall (1996)
  116. Takakura, Y. et al. Hexose uptake in primary cultures of bovine brain microvessel endothelial cells. II. Effects of conditioned media from astroglial and glioma cells. Biochim. Biophys. Acta 1070, 11–19 (1991). (10.1016/0005-2736(91)90140-4) / Biochim. Biophys. Acta by Y Takakura (1991)
  117. Bergersen, L., Rafiki, A. & Ottersen, O. P. Immunogold cytochemistry identifies specialized membrane domains for monocarboxylate transport in the central nervous system. Neurochem. Res. 27, 89–96 (2002). (10.1023/A:1014806723147) / Neurochem. Res. by L Bergersen (2002)
  118. Danbolt, N. C. et al. Properties and localization of glutamate transporters. Prog. Brain Res. 116, 23–43 (1998). (10.1016/S0079-6123(08)60428-8) / Prog. Brain Res. by NC Danbolt (1998)
  119. Pellerin, L. & Magistretti, P. J. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc. Natl Acad. Sci. USA 91, 10625–10629 (1994). (10.1073/pnas.91.22.10625) / Proc. Natl Acad. Sci. USA by L Pellerin (1994)
  120. Weed, L. H. & McKibben, P. S. Experimental alteration of brain bulk. Am. J. Physiol. 48, 531–558 (1919). (10.1152/ajplegacy.1919.48.4.531) / Am. J. Physiol. by LH Weed (1919)
  121. Li, J. & Verkman, A. S. Impaired hearing in mice lacking aquaporin-4 water channels. J. Biol. Chem. 276, 31233–31237 (2001). (10.1074/jbc.M104368200) / J. Biol. Chem. by J Li (2001)
  122. Li, J., Patil, R. V. & Verkman, A. S. Mildly abnormal retinal function in transgenic mice without Muller cell aquaporin-4 water channels. Invest. Ophthalmol. Vis. Sci. 43, 573–579 (2002). / Invest. Ophthalmol. Vis. Sci. by J Li (2002)
  123. Worton, R. Muscular dystrophies: diseases of the dystrophin-glycoprotein complex. Science 270, 755–756 (1995). (10.1126/science.270.5237.755) / Science by R Worton (1995)
  124. Blake, D. J., Hawkes, R., Benson, M. A. & Beesley, P. W. Different dystrophin-like complexes are expressed in neurons and glia. J. Cell Biol. 147, 645–658 (1999). (10.1083/jcb.147.3.645) / J. Cell Biol. by DJ Blake (1999)
  125. Austin, R. C., Morris, G. E., Howard, P. L., Klamut, H. J. & Ray, P. N. Expression and synthesis of alternatively spliced variants of Dp71 in adult human brain. Neuromuscul. Disord. 10, 187–193 (2000). (10.1016/S0960-8966(99)00105-4) / Neuromuscul. Disord. by RC Austin (2000)
  126. Chelly, J. et al. Dystrophin gene transcribed from different promoters in neuronal and glial cells. Nature 344, 64–65 (1990). (10.1038/344064a0) / Nature by J Chelly (1990)
  127. Newey, S. E., Benson, M. A., Ponting, C. P., Davies, K. E. & Blake, D. J. Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex. Curr. Biol. 10, 1295–1298 (2000). (10.1016/S0960-9822(00)00760-0) / Curr. Biol. by SE Newey (2000)
  128. Kachinsky, A. M., Froehner, S. C. & Milgram, S. L. A PDZ-containing scaffold related to the dystrophin complex at the basolateral membrane of epithelial cells. J. Cell Biol. 145, 391–402 (1999). (10.1083/jcb.145.2.391) / J. Cell Biol. by AM Kachinsky (1999)
  129. Kozono, D., Yasui, M., King, L. S. & Agre, P. Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine. J. Clin. Invest. 109, 1395–1399 (2002). (10.1172/JCI0215851) / J. Clin. Invest. by D Kozono (2002)
Dates
Type When
Created 16 years, 8 months ago (Nov. 28, 2008, 2:24 a.m.)
Deposited 2 years, 3 months ago (May 19, 2023, 12:51 a.m.)
Indexed 19 hours, 3 minutes ago (Aug. 26, 2025, 3:05 a.m.)
Issued 21 years, 8 months ago (Dec. 1, 2003)
Published 21 years, 8 months ago (Dec. 1, 2003)
Published Print 21 years, 8 months ago (Dec. 1, 2003)
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@article{Amiry_Moghaddam_2003, title={The molecular basis of water transport in the brain}, volume={4}, ISSN={1471-0048}, url={http://dx.doi.org/10.1038/nrn1252}, DOI={10.1038/nrn1252}, number={12}, journal={Nature Reviews Neuroscience}, publisher={Springer Science and Business Media LLC}, author={Amiry-Moghaddam, Mahmood and Ottersen, Ole P.}, year={2003}, month=dec, pages={991–1001} }