DOI: 10.1038/nrd3181. Personalized medicine in oncology: the future is now

Personalized medicine in oncology: the future is now

10.1038/nrd3181

Crossref journal-article

Springer Science and Business Media LLC

Nature Reviews Drug Discovery (297)

Bibliography

Schilsky, R. L. (2010). Personalized medicine in oncology: the future is now. Nature Reviews Drug Discovery, 9(5), 363â366.

Authors 1

Richard L. Schilsky (first)

References 36 Referenced 259

Peppercorn, J., Perou, C. M. & Carey, L. A. Molecular subtypes in breast cancer evaluation and management: divide and conquer. Cancer Invest. 26, 1–10 (2008). (10.1080/07357900701784238) / Cancer Invest. by J Peppercorn (2008)
van de Vijver, M. J. et al. A gene expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347, 1999–2009 (2002). (10.1056/NEJMoa021967) / N. Engl. J. Med. by MJ van de Vijver (2002)
Rosenwald, A. et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large B cell lymphoma. N. Engl. J. Med. 346, 1937–1947 (2002). (10.1056/NEJMoa012914) / N. Engl. J. Med. by A Rosenwald (2002)
Potti, A. et al. A genomic strategy to refine prognosis in early stage non small cell lung cancer. N. Engl. J. Med. 355, 570–580 (2006). (10.1056/NEJMoa060467) / N. Engl. J. Med. by A Potti (2006)
Slamon, D. J. et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344, 783–792 (2001). (10.1056/NEJM200103153441101) / N. Engl. J. Med. by DJ Slamon (2001)
Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129–2139 (2004). (10.1056/NEJMoa040938) / N. Engl. J. Med. by TJ Lynch (2004)
Amado, R. G. et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J. Clin. Oncol. 26, 1626–1634 (2008). (10.1200/JCO.2007.14.7116) / J. Clin. Oncol. by RG Amado (2008)
Hegi, M. E. et al. MGMT gene silencing and benefit from temozolomide in gliobalstoma. N. Engl. J. Med. 352, 997–1003 (2005). (10.1056/NEJMoa043331) / N. Engl. J. Med. by ME Hegi (2005)
O'Brien, S. G. et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 348, 994–1004 (2003). (10.1056/NEJMoa022457) / N. Engl. J. Med. by SG O'Brien (2003)
Demetri, G. D. et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N. Engl. J. Med. 347, 472–480 (2002). (10.1056/NEJMoa020461) / N. Engl. J. Med. by GD Demetri (2002)
Paik, S. et al. A multi-gene assay to predict recurrence of tamoxifen-treated, node negative breast cancer. N. Engl. J. Med. 351, 2817–2826 (2004). (10.1056/NEJMoa041588) / N. Engl. J. Med. by S Paik (2004)
Hayes, D. F. et al. Her2 and response to paclitaxel in node positive breast cancer. N. Engl. J. Med. 357, 1496–1506 (2007). (10.1056/NEJMoa071167) / N. Engl. J. Med. by DF Hayes (2007)
Olaussen, K. A. et al. DNA repair by ERCC1 in non small cell lung cancer and cisplatin-based adjuvant chemotherapy. N. Engl. J. Med. 355, 983–991 (2006). (10.1056/NEJMoa060570) / N. Engl. J. Med. by KA Olaussen (2006)
Schuster, S. J. et al. Idiotype vaccine therapy (Biovax ID) in follicular lymphoma in first complete remission: phase III clinical trial results. J. Clin. Oncol. 27 (Jun 20 Suppl.), 2 (2009). (10.1200/jco.2009.27.18_suppl.2) / J. Clin. Oncol. by SJ Schuster (2009)
Innocenti, F. et al. Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics. J. Clin. Oncol. 27, 2604–2614 (2009). (10.1200/JCO.2008.20.6300) / J. Clin. Oncol. by F Innocenti (2009)
Dezentjé, V. O., Guchelaar, H. -J., Nortier, J. W., van de Velde, C. J. & Gelderblom, H. Clinical implications of CYP2D6 genotyping in tamoxifen treatment for breast cancer. Clin. Cancer Res. 15, 15–21 (2009). (10.1158/1078-0432.CCR-08-2006) / Clin. Cancer Res. by VO Dezentjé (2009)
Schroth, W. et al. Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. J. Clin. Oncol. 25, 5187–5193 (2007). (10.1200/JCO.2007.12.2705) / J. Clin. Oncol. by W Schroth (2007)
Kris, M. et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor tyrosine kinase, in symptomatic patients with non small cell lung cancer. JAMA 290, 2149–2158 (2003). (10.1001/jama.290.16.2149) / JAMA by M Kris (2003)
Giaccone, G. et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a Phase III trial — INTACT 1. J. Clin. Oncol. 22, 777–784 (2004). (10.1200/JCO.2004.08.001) / J. Clin. Oncol. by G Giaccone (2004)
Herbst, R. S. et al. Gefitinibin combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a Phase III trial — INTACT 2. J. Clin. Oncol. 22, 785–794 (2004). (10.1200/JCO.2004.07.215) / J. Clin. Oncol. by RS Herbst (2004)
Mok, T. S. et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N. Engl. J. Med. 361, 947–957 (2009). (10.1056/NEJMoa0810699) / N. Engl. J. Med. by TS Mok (2009)
Kobayashi, S. et al. EGFR mutation and resistance of non small cell lung cancer to gefitinib. N. Engl. J. Med. 352, 786–792 (2005). (10.1056/NEJMoa044238) / N. Engl. J. Med. by S Kobayashi (2005)
Engelman, J. A. & Janne, P. A. Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non small cell lung cancer. Clin. Cancer Res. 14, 2895–2899 (2008). (10.1158/1078-0432.CCR-07-2248) / Clin. Cancer Res. by JA Engelman (2008)
Engelman, J. A. et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316, 1039–1043 (2007). (10.1126/science.1141478) / Science by JA Engelman (2007)
O'Reilly, K. E. et al. mTor inhibition induces upstream receptor tyrosine kinase signaling and activates AKT. Cancer Res. 66, 1500–1508 (2006). (10.1158/0008-5472.CAN-05-2925) / Cancer Res. by KE O'Reilly (2006)
Mandrekar, S. J. & Sargent, D. J. Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges. J. Clin. Oncol. 27, 4027–4034 (2009). (10.1200/JCO.2009.22.3701) / J. Clin. Oncol. by SJ Mandrekar (2009)
Shepherd, F. A. et al. Erlotinib in previously treated non small cell lung cancer. N. Engl. J. Med. 353, 123–132 (2005). (10.1056/NEJMoa050753) / N. Engl. J. Med. by FA Shepherd (2005)
Bradbury, P. A. et al. Economic analysis: randomized placebo-controlled clinical trial of erlotinib in advanced non-small cell lung cancer. J. Natl Cancer Inst. 102, 1–9 (2010). (10.1093/jnci/djp518) / J. Natl Cancer Inst. by PA Bradbury (2010)
Karapetis, C. S. et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N. Engl. J. Med. 359, 1757–1765 (2008). (10.1056/NEJMoa0804385) / N. Engl. J. Med. by CS Karapetis (2008)
Di Fiore, F. et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by cetuximab plus chemotherapy. Br. J. Cancer 96, 1166–1169 (2007). (10.1038/sj.bjc.6603685) / Br. J. Cancer by F Di Fiore (2007)
Lievre, A. et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J. Clin. Oncol. 26, 374–379 (2008). (10.1200/JCO.2007.12.5906) / J. Clin. Oncol. by A Lievre (2008)
Van Cutsem, E. et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N. Engl. J. Med. 360, 1408–1417 (2009). (10.1056/NEJMoa0805019) / N. Engl. J. Med. by E Van Cutsem (2009)
Allegra, C. J. et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J. Clin. Oncol. 27, 2091–2096 (2009). (10.1200/JCO.2009.21.9170) / J. Clin. Oncol. by CJ Allegra (2009)
Shankaran, V., Bentrem, D. J., Mulcahy, M. F., Bennett, C. L. & Benson, A. B. III. Economic implications of kras testing in metastatic colorectal cancer (mCRC). American Association of Clincal Oncology website [online] , (2009). / American Association of Clincal Oncology website by V Shankaran (2009)
Mittmann, N. et al. Prospective cost-effectiveness analysis of cetuximab in metastatic colorectal cancer: evaluation of National Cancer Institute of Canada Clinical Trials Group CO.17 trial. J. Natl Cancer Inst. 101, 1182–1192 (2009). (10.1093/jnci/djp232) / J. Natl Cancer Inst. by N Mittmann (2009)
Sartore-Bianchi, A. et al. Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer. PLOS One 4, e7287 (2009). (10.1371/journal.pone.0007287) / PLOS One by A Sartore-Bianchi (2009)

Dates

Type	When
Created	15 years, 4 months ago (April 30, 2010, 1:05 a.m.)
Deposited	2 years, 3 months ago (May 19, 2023, 12:04 a.m.)
Indexed	1 month, 1 week ago (July 28, 2025, 6:08 p.m.)
Issued	15 years, 4 months ago (May 1, 2010)
Published	15 years, 4 months ago (May 1, 2010)
Published Print	15 years, 4 months ago (May 1, 2010)

Funders 0

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BibTeX

@article{Schilsky_2010, title={Personalized medicine in oncology: the future is now}, volume={9}, ISSN={1474-1784}, url={http://dx.doi.org/10.1038/nrd3181}, DOI={10.1038/nrd3181}, number={5}, journal={Nature Reviews Drug Discovery}, publisher={Springer Science and Business Media LLC}, author={Schilsky, Richard L.}, year={2010}, month=may, pages={363–366} }

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