Crossref
journal-article
Springer Science and Business Media LLC
Nature Reviews Cancer (297)
References
154
Referenced
595
-
Cerwenka, A. & Lanier, L. L. Natural killer cells, viruses and cancer. Nature Rev. Immunol. 1, 41–49 (2001).
(
10.1038/35095564
) / Nature Rev. Immunol. by A Cerwenka (2001) -
Wiltrout, R. H. et al. Augmentation of organ-associated natural killer activity by biological response modifiers. Isolation and characterization of large granular lymphocytes from the liver. J. Exp. Med. 160, 1431–1449 (1984).
(
10.1084/jem.160.5.1431
) / J. Exp. Med. by RH Wiltrout (1984) -
Fogler, W. E. et al. NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J. Immunol. 156, 4707–4714 (1996).
(
10.4049/jimmunol.156.12.4707
) / J. Immunol. by WE Fogler (1996) -
Biron, C. A. Activation and function of natural killer cell responses during viral infections. Curr. Opin. Immunol. 9, 24–34 (1997).
(
10.1016/S0952-7915(97)80155-0
) / Curr. Opin. Immunol. by CA Biron (1997) -
Glas, R. et al. Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype. An adaptive component of NK cell-mediated responses. J. Exp. Med. 191, 129–138 (2000).
(
10.1084/jem.191.1.129
) / J. Exp. Med. by R Glas (2000) -
Cooper, M. A., Fehniger, T. A. & Caligiuri, M. A. The biology of human natural killer-cell subsets. Trends Immunol. 22, 633–640 (2001).
(
10.1016/S1471-4906(01)02060-9
) / Trends Immunol. by MA Cooper (2001) -
Colucci, F., Di Santo, J. P. & Leibson, P. J. Natural killer cell activation in mice and men: different triggers for similar weapons? Nature Immunol. 3, 807–813 (2002).
(
10.1038/ni0902-807
) / Nature Immunol. by F Colucci (2002) -
Cooper, M. A. et al. Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset. Blood 97, 3146–3151 (2001).
(
10.1182/blood.V97.10.3146
) / Blood by MA Cooper (2001) -
Koo, G. C., Dumont, F. J., Tutt, M., Hackett, J. Jr & Kumar, V. The NK-1.1(−) mouse: a model to study differentiation of murine NK cells. J. Immunol. 137, 3742–3747 (1986).
(
10.4049/jimmunol.137.12.3742
) / J. Immunol. by GC Koo (1986) -
Smyth, M. J., Crowe, N. Y. & Godfrey, D. I. NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma. Int. Immunol. 13, 459–463 (2001).
(
10.1093/intimm/13.4.459
) / Int. Immunol. by MJ Smyth (2001) -
Riccardi, C., Santoni, A., Barlozzari, T., Puccetti, P. & Herberman, R. B. In vivo natural reactivity of mice against tumor cells. Int. J. Cancer 25, 475–486 (1980).An early and clear description of the natural activity of NK cells against tumour cells in vivo.
(
10.1002/ijc.2910250409
) / Int. J. Cancer by C Riccardi (1980) - Gorelik, E., Rosen, B., Copeland, D., Weatherly, B. & Herberman, R. B. Evaluation of role of natural killer cells in radiation-induced leukemogenesis in mice. J. Natl Cancer Inst. 72, 1397–1403 (1984). / J. Natl Cancer Inst. by E Gorelik (1984)
-
Barlozzari, T., Reynolds, C. W. & Herberman, R. B. In vivo role of natural killer cells: involvement of large granular lymphocytes in the clearance of tumor cells in anti-asialo GM1-treated rats. J. Immunol. 131, 1024–1027 (1983).
(
10.4049/jimmunol.131.2.1024
) / J. Immunol. by T Barlozzari (1983) -
Ljunggren, H. G. & Karre, K. Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism. J. Exp. Med. 162, 1745–1759 (1985).A selection of mouse lymphoma variants that lacked H-2 first illustrated the concept of NK cells recognizing 'missing-self' in vivo.
(
10.1084/jem.162.6.1745
) / J. Exp. Med. by HG Ljunggren (1985) -
Karre, K., Ljunggren, H. G., Piontek, G. & Kiessling, R. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319, 675–678 (1986).
(
10.1038/319675a0
) / Nature by K Karre (1986) -
van den Broek, M. F., Kagi, D., Zinkernagel, R. M. & Hengartner, H. Perforin dependence of natural killer cell-mediated tumor control in vivo. Eur. J. Immunol. 25, 3514–3516 (1995).The first demonstration that perforin is a major effector pathway used by NK cells to eliminate MHC class-I-deficient tumours in vivo.
(
10.1002/eji.1830251246
) / Eur. J. Immunol. by MF van den Broek (1995) -
Smyth, M. J., Kelly, J. M., Baxter, A. G., Korner, H. & Sedgwick, J. D. An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum. J. Exp. Med. 188, 1611–1619 (1998).
(
10.1084/jem.188.9.1611
) / J. Exp. Med. by MJ Smyth (1998) -
Smyth, M. J. et al. Perforin is a major contributor to NK cell control of tumor metastasis. J. Immunol. 162, 6658–6662 (1999).
(
10.4049/jimmunol.162.11.6658
) / J. Immunol. by MJ Smyth (1999) - Talmadge, J. E., Phillips, H., Schindler, J., Tribble, H. & Pennington, R. Systematic preclinical study on the therapeutic properties of recombinant human interleukin 2 for the treatment of metastatic disease. Cancer Res. 47, 5725–5732 (1987). / Cancer Res. by JE Talmadge (1987)
-
Trinchieri, G. Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv. Immunol. 70, 83–243 (1998).
(
10.1016/S0065-2776(08)60387-9
) / Adv. Immunol. by G Trinchieri (1998) -
Wiltrout, R. H. et al. Role of organ-associated NK cells in decreased formation of experimental metastases in lung and liver. J. Immunol. 134, 4267–4275 (1985).
(
10.4049/jimmunol.134.6.4267
) / J. Immunol. by RH Wiltrout (1985) -
McClain, K. L. Immunodeficiency states and related malignancies. Cancer Treat. Res. 92, 39–61 (1997).
(
10.1007/978-1-4615-5767-8_2
) / Cancer Treat. Res. by KL McClain (1997) -
Smyth, M. J. et al. Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma. J. Exp. Med. 192, 755–760 (2000).
(
10.1084/jem.192.5.755
) / J. Exp. Med. by MJ Smyth (2000) -
Shankaran, V. et al. IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410, 1107–1111 (2001).
(
10.1038/35074122
) / Nature by V Shankaran (2001) -
Smyth, M. J. et al. Differential tumor surveillance by natural killer (NK) and NKT cells. J. Exp. Med. 191, 661–668 (2000).Striking demonstration of the role of NK1.1+ cells in natural protection from chemical carcinogen-induced tumour initiation.
(
10.1084/jem.191.4.661
) / J. Exp. Med. by MJ Smyth (2000) -
Haliotis, T., Ball, J. K., Dexter, D. & Roder, J. C. Spontaneous and induced primary oncogenesis in natural killer (NK)-cell-deficient beige mutant mice. Int. J. Cancer 35, 505–513 (1985).
(
10.1002/ijc.2910350414
) / Int. J. Cancer by T Haliotis (1985) -
Erianne, G. S. et al. B cell lymphomas of C57L/J mice; the role of natural killer cells and T helper cells in lymphoma development and growth. Leuk. Res. 24, 705–718 (2000).
(
10.1016/S0145-2126(00)00027-8
) / Leuk. Res. by GS Erianne (2000) -
Miyauchi-Hashimoto, H., Okamoto, H., Tanaka, K. & Horio, T. Ultraviolet radiation-induced suppression of natural killer cell activity is enhanced in xeroderma pigmentosum group A (XPA) model mice. J. Invest. Dermatol. 112, 965–970 (1999).
(
10.1046/j.1523-1747.1999.00597.x
) / J. Invest. Dermatol. by H Miyauchi-Hashimoto (1999) -
Norris, P. G., Limb, G. A., Hamblin, A. S. & Hawk, J. L. Impairment of natural-killer-cell activity in xeroderma pigmentosum. N. Engl. J. Med. 319, 1668–1669 (1988).
(
10.1056/NEJM198812223192512
) / N. Engl. J. Med. by PG Norris (1988) -
Gaspari, A. A., Fleisher, T. A. & Kraemer, K. H. Impaired interferon production and natural killer cell activation in patients with the skin cancer-prone disorder, xeroderma pigmentosum. J. Clin. Invest. 92, 1135–1142 (1993).
(
10.1172/JCI116682
) / J. Clin. Invest. by AA Gaspari (1993) -
Whiteside, T. L. & Herberman, R. B. Role of human natural killer cells in health and disease. Clin. Diagn. Lab. Immunol. 1, 125–133 (1994).
(
10.1128/cdli.1.2.125-133.1994
) / Clin. Diagn. Lab. Immunol. by TL Whiteside (1994) - Whiteside, T. L., Vujanovic, N. L. & Herberman, R. B. Natural killer cells and tumor therapy. Curr. Top. Microbiol. Immunol. 230, 221–244 (1998). / Curr. Top. Microbiol. Immunol. by TL Whiteside (1998)
-
Trapani, J. A., Davis, J., Sutton, V. R. & Smyth, M. J. Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo. Curr. Opin. Immunol. 12, 323–329 (2000).
(
10.1016/S0952-7915(00)00094-7
) / Curr. Opin. Immunol. by JA Trapani (2000) -
Kagi, D. et al. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369, 31–37 (1994).Landmark paper that first described perforin-deficient mice and their lack of NK-cell-mediated cytolysis.
(
10.1038/369031a0
) / Nature by D Kagi (1994) -
Smyth, M. J. et al. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis. J. Exp. Med. 193, 661–670 (2001).
(
10.1084/jem.193.6.661
) / J. Exp. Med. by MJ Smyth (2001) -
Kodama, T. et al. Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12. Eur. J. Immunol. 29, 1390–1396 (1999).
(
10.1002/(SICI)1521-4141(199904)29:04<1390::AID-IMMU1390>3.0.CO;2-C
) / Eur. J. Immunol. by T Kodama (1999) - Brandau, S. et al. Perforin-mediated lysis of tumor cells by Mycobacterium bovis Bacillus Calmette–Guerin-activated killer cells. Clin. Cancer Res. 6, 3729–3738 (2000). / Clin. Cancer Res. by S Brandau (2000)
-
van den Broek, M. E. et al. Decreased tumor surveillance in perforin-deficient mice. J. Exp. Med. 184, 1781–1790 (1996).
(
10.1084/jem.184.5.1781
) / J. Exp. Med. by ME van den Broek (1996) -
Street, S. E., Trapani, J. A., MacGregor, D. & Smyth, M. J. Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J. Exp. Med. 196, 129–134 (2002).
(
10.1084/jem.20020063
) / J. Exp. Med. by SE Street (2002) -
Davis, J. E., Smyth, M. J. & Trapani, J. A. Granzyme A- and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity. Eur. J. Immunol. 31, 39–47 (2001).
(
10.1002/1521-4141(200101)31:1<39::AID-IMMU39>3.0.CO;2-1
) / Eur. J. Immunol. by JE Davis (2001) -
Ashkenazi, A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nature Rev. Cancer 2, 420–430 (2002).
(
10.1038/nrc821
) / Nature Rev. Cancer by A Ashkenazi (2002) -
Kayagaki, N. et al. Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells. J. Immunol. 163, 1906–1913 (1999).
(
10.4049/jimmunol.163.4.1906
) / J. Immunol. by N Kayagaki (1999) -
Takeda, K. et al. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nature Med. 7, 94–100 (2001).The first demonstration that NK-cell TRAIL has a physiological function as a tumour suppressor.
(
10.1038/83416
) / Nature Med. by K Takeda (2001) -
Cretney, E. et al. Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J. Immunol. 168, 1356–1361 (2002).
(
10.4049/jimmunol.168.3.1356
) / J. Immunol. by E Cretney (2002) -
Takeda, K. et al. Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. J. Exp. Med. 195, 161–169 (2002).
(
10.1084/jem.20011171
) / J. Exp. Med. by K Takeda (2002) -
Kronenberg, M. & Gapin, L. The unconventional lifestyle of NKT cells. Nature Rev. Immunol. 2, 557–568 (2002).
(
10.1038/nri854
) / Nature Rev. Immunol. by M Kronenberg (2002) -
Bradley, M., Zeytun, A., Rafi-Janajreh, A., Nagarkatti, P. S. & Nagarkatti, M. Role of spontaneous and interleukin-2-induced natural killer cell activity in the cytotoxicity and rejection of Fas+ and Fas− tumor cells. Blood 92, 4248–4255 (1998).
(
10.1182/blood.V92.11.4248
) / Blood by M Bradley (1998) -
Screpanti, V., Wallin, R. P., Ljunggren, H. G. & Grandien, A. A central role for death receptor-mediated apoptosis in the rejection of tumors by NK cells. J. Immunol. 167, 2068–2073 (2001).
(
10.4049/jimmunol.167.4.2068
) / J. Immunol. by V Screpanti (2001) -
Loza, M. J., Zamai, L., Azzoni, L., Rosati, E. & Perussia, B. Expression of type 1 (interferon gamma) and type 2 (interleukin-13, interleukin-5) cytokines at distinct stages of natural killer cell differentiation from progenitor cells. Blood 99, 1273–1281 (2002).
(
10.1182/blood.V99.4.1273
) / Blood by MJ Loza (2002) -
Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P. & Salazar-Mather, T. P. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17, 189–220 (1999).
(
10.1146/annurev.immunol.17.1.189
) / Annu. Rev. Immunol. by CA Biron (1999) -
Street, S. E., Cretney, E. & Smyth, M. J. Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood 97, 192–197 (2001).
(
10.1182/blood.V97.1.192
) / Blood by SE Street (2001) -
Yao, L. et al. Contribution of natural killer cells to inhibition of angiogenesis by interleukin-12. Blood 93, 1612–1621 (1999).
(
10.1182/blood.V93.5.1612
) / Blood by L Yao (1999) -
Smyth, M. J. et al. Sequential production of interferon-gamma by NK1.1(+) T cells and natural killer cells is essential for the antimetastatic effect of alpha-galactosylceramide. Blood 99, 1259–1266 (2002).
(
10.1182/blood.V99.4.1259
) / Blood by MJ Smyth (2002) - Hayakawa, Y. et al. IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide. Blood 100, 1728–1733 (2002). / Blood by Y Hayakawa (2002)
-
Cifone, M. G. et al. Interleukin-2-activated rat natural killer cells express inducible nitric oxide synthase that contributes to cytotoxic function and interferon-gamma production. Blood 93, 3876–3884 (1999).
(
10.1182/blood.V93.11.3876.411k25_3876_3884
) / Blood by MG Cifone (1999) -
Furuke, K. et al. Human NK cells express endothelial nitric oxide synthase, and nitric oxide protects them from activation-induced cell death by regulating expression of TNF-alpha. J. Immunol. 163, 1473–1480 (1999).
(
10.4049/jimmunol.163.3.1473
) / J. Immunol. by K Furuke (1999) -
Leibson, P. J. Signal transduction during natural killer cell activation: inside the mind of a killer. Immunity 6, 655–661 (1997).
(
10.1016/S1074-7613(00)80441-0
) / Immunity by PJ Leibson (1997) -
Yokoyama, W. M. et al. A family of murine NK cell receptors specific for target cell MHC class I molecules. Semin. Immunol. 7, 89–101 (1995).
(
10.1006/smim.1995.0013
) / Semin. Immunol. by WM Yokoyama (1995) -
Takei, F., Brennan, J. & Mager, D. L. The Ly-49 family: genes, proteins and recognition of class I MHC. Immunol. Rev. 155, 67–77 (1997).
(
10.1111/j.1600-065X.1997.tb00940.x
) / Immunol. Rev. by F Takei (1997) -
Lanier, L. L. NK cell receptors. Annu. Rev. Immunol. 16, 359–393 (1998).
(
10.1146/annurev.immunol.16.1.359
) / Annu. Rev. Immunol. by LL Lanier (1998) -
Long, E. O. et al. Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158). Immunol. Rev. 181, 223–233 (2001).
(
10.1034/j.1600-065X.2001.1810119.x
) / Immunol. Rev. by EO Long (2001) -
O'Callaghan, C. A. Molecular basis of human natural killer cell recognition of HLA-E (human leucocyte antigen-E) and its relevance to clearance of pathogen-infected and tumour cells. Clin. Sci. 99, 9–17 (2000).
(
10.1042/cs0990009
) / Clin. Sci. by CA O'Callaghan (2000) -
Liao, N. S., Bix, M., Zijlstra, M., Jaenisch, R. & Raulet, D. MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. Science 253, 199–202 (1991).
(
10.1126/science.1853205
) / Science by NS Liao (1991) -
Ruggeri, L., Capanni, M., Martelli, M. F. & Velardi, A. Cellular therapy: exploiting NK cell alloreactivity in transplantation. Curr. Opin. Hematol. 8, 355–359 (2001).
(
10.1097/00062752-200111000-00007
) / Curr. Opin. Hematol. by L Ruggeri (2001) -
Ruggeri, L. et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295, 2097–2100 (2002).Recipients of MHC-mismatched transplants display NK-cell alloreactivity that eliminates leukaemia relapse, prevents graft rejection and protects patients against graft versus host disease. A beautiful demonstration of how new knowledge about NK-cell receptors for MHC class I can pave the way for effective immunotherapy using NK cells.
(
10.1126/science.1068440
) / Science by L Ruggeri (2002) -
Bakker, A. B., Phillips, J. H., Figdor, C. G. & Lanier, L. L. Killer cell inhibitory receptors for MHC class I molecules regulate lysis of melanoma cells mediated by NK cells, gamma delta T cells, and antigen-specific CTL. J. Immunol. 160, 5239–5245 (1998).
(
10.4049/jimmunol.160.11.5239
) / J. Immunol. by AB Bakker (1998) -
Koh, C. Y. et al. Augmentation of antitumor effects by NK cell inhibitory receptor blockade in vitro and in vivo. Blood 97, 3132–3137 (2001).
(
10.1182/blood.V97.10.3132
) / Blood by CY Koh (2001) -
Smith, K. M., Wu, J., Bakker, A. B., Phillips, J. H. & Lanier, L. L. Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J. Immunol. 161, 7–10 (1998).
(
10.4049/jimmunol.161.1.7
) / J. Immunol. by KM Smith (1998) -
Idris, A. H., Iizuka, K., Smith, H. R., Scalzo, A. A. & Yokoyama, W. M. Genetic control of natural killing and in vivo tumor elimination by the Chok locus. J. Exp. Med. 188, 2243–2256 (1998).
(
10.1084/jem.188.12.2243
) / J. Exp. Med. by AH Idris (1998) -
Idris, A. H. et al. The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing. Proc. Natl Acad. Sci. USA 96, 6330–6335 (1999).
(
10.1073/pnas.96.11.6330
) / Proc. Natl Acad. Sci. USA by AH Idris (1999) -
Kubota, A., Lian, R. H., Lohwasser, S., Salcedo, M. & Takei, F. IFN-gamma production and cytotoxicity of IL-2-activated murine NK cells are differentially regulated by MHC class I molecules. J. Immunol. 163, 6488–6493 (1999).
(
10.4049/jimmunol.163.12.6488
) / J. Immunol. by A Kubota (1999) -
Le Drean, E. et al. Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. Eur. J. Immunol. 28, 264–276 (1998).
(
10.1002/(SICI)1521-4141(199801)28:01<264::AID-IMMU264>3.0.CO;2-O
) / Eur. J. Immunol. by E Le Drean (1998) -
Moser, J. M., Gibbs, J., Jensen, P. E. & Lukacher, A. E. CD94-NKG2A receptors regulate antiviral CD8(+) T cell responses. Nature Immunol. 3, 189–195 (2002).
(
10.1038/ni757
) / Nature Immunol. by JM Moser (2002) -
Jia, S. H., Kurepa, Z., Bai, A. & Forman, J. Comparative ability of Qdm/Qa-1b, kb, and Db to protect class Ilow cells from NK-mediated lysis in vivo. J. Immunol. 165, 6142–6147 (2000).
(
10.4049/jimmunol.165.11.6142
) / J. Immunol. by SH Jia (2000) -
Moretta, A. et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19, 197–223 (2001).
(
10.1146/annurev.immunol.19.1.197
) / Annu. Rev. Immunol. by A Moretta (2001) -
Lanier, L. L. On guard: activating NK cell receptors. Nature Immunol. 2, 23–27 (2001).
(
10.1038/83130
) / Nature Immunol. by LL Lanier (2001) -
Sivori, S. et al. p46, a novel natural killer cell-specific surface molecule that mediates cell activation. J. Exp. Med. 186, 1129–1136 (1997).First decription of a new family of natural cytotoxicity receptors on NK cells that have a key role in non-MHC-restricted cytolysis.
(
10.1084/jem.186.7.1129
) / J. Exp. Med. by S Sivori (1997) -
Vitale, M. et al. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J. Exp. Med. 187, 2065–2072 (1998).
(
10.1084/jem.187.12.2065
) / J. Exp. Med. by M Vitale (1998) -
Moretta, A., Biassoni, R., Bottino, C., Mingari, M. C. & Moretta, L. Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis. Immunol. Today 21, 228–234 (2000).
(
10.1016/S0167-5699(00)01596-6
) / Immunol. Today by A Moretta (2000) -
Tomasello, E. et al. Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Immunity 13, 355–364 (2000).
(
10.1016/S1074-7613(00)00035-2
) / Immunity by E Tomasello (2000) -
Bauer, S. et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285, 727–729 (1999).Demonstration that NKG2D recognizes stress-inducible MICA, a distant homologue of MHC class I, and previously shown to function as an antigen for γδ T cells and frequently expressed in epithelial tumours. These data first indicated an activating-immunoreceptor–MHC-ligand interaction that might promote antitumour NK- and T-cell responses.
(
10.1126/science.285.5428.727
) / Science by S Bauer (1999) -
Wu, J. et al. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285, 730–732 (1999).
(
10.1126/science.285.5428.730
) / Science by J Wu (1999) -
Groh, V. et al. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. Proc. Natl Acad. Sci. USA 93, 12445–12450 (1996).
(
10.1073/pnas.93.22.12445
) / Proc. Natl Acad. Sci. USA by V Groh (1996) -
Groh, V. et al. Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc. Natl Acad. Sci. USA 96, 6879–6884 (1999).
(
10.1073/pnas.96.12.6879
) / Proc. Natl Acad. Sci. USA by V Groh (1999) -
Cosman, D. et al. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14, 123–133 (2001).
(
10.1016/S1074-7613(01)00095-4
) / Immunity by D Cosman (2001) -
Malarkannan, S. et al. The molecular and functional characterization of a dominant minor H antigen, H60. J. Immunol. 161, 3501–3509 (1998).
(
10.4049/jimmunol.161.7.3501
) / J. Immunol. by S Malarkannan (1998) -
Cerwenka, A. et al. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity 12, 721–727 (2000).First description of mouse GPI-anchored cell-surface proteins that function as ligands for the activating NKG2D receptor and confer target susceptibility to NK-cell attack.
(
10.1016/S1074-7613(00)80222-8
) / Immunity by A Cerwenka (2000) -
Diefenbach, A., Jamieson, A. M., Liu, S. D., Shastri, N. & Raulet, D. H. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nature Immunol. 1, 119–126 (2000).
(
10.1038/77793
) / Nature Immunol. by A Diefenbach (2000) -
Groh, V., Steinle, A., Bauer, S. & Spies, T. Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science 279, 1737–1740 (1998).
(
10.1126/science.279.5357.1737
) / Science by V Groh (1998) -
Vetter, C. S. et al. Expression of stress-induced MHC class I related chain molecules on human melanoma. J. Invest. Dermatol. 118, 600–605 (2002).
(
10.1046/j.1523-1747.2002.01700.x
) / J. Invest. Dermatol. by CS Vetter (2002) -
Diefenbach, A., Jensen, E. R., Jamieson, A. M. & Raulet, D. H. Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature 413, 165–171 (2001).First direct evidence in the mouse that linked the expression of stress-induced ligands with tumour-cell rejection by NK cells and CD8+ T cells in vivo.
(
10.1038/35093109
) / Nature by A Diefenbach (2001) -
Cerwenka, A., Baron, J. L. & Lanier, L. L. Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc. Natl Acad. Sci. USA 98, 11521–11526 (2001).
(
10.1073/pnas.201238598
) / Proc. Natl Acad. Sci. USA by A Cerwenka (2001) -
Girardi, M. et al. Regulation of cutaneous malignancy by γδ T cells. Science 294, 605–609 (2001).
(
10.1126/science.1063916
) / Science by M Girardi (2001) -
Kennedy, C. et al. MICA gene polymorphism is not associated with an increased risk for skin cancer. J. Invest. Dermatol. 118, 686–691 (2002).
(
10.1046/j.1523-1747.2002.01712.x
) / J. Invest. Dermatol. by C Kennedy (2002) -
Ghaderi, M. et al. Tumor necrosis factor A and MHC class I chain related gene A (MIC-A) polymorphisms in Swedish patients with cervical cancer. Hum. Immunol. 62, 1153–1158 (2001).
(
10.1016/S0198-8859(01)00306-8
) / Hum. Immunol. by M Ghaderi (2001) -
Pende, D. et al. Role of NKG2D in tumor cell lysis mediated by human NK cells: cooperation with natural cytotoxicity receptors and capability of recognizing tumors of nonepithelial origin. Eur. J. Immunol. 31, 1076–1086 (2001).
(
10.1002/1521-4141(200104)31:4<1076::AID-IMMU1076>3.0.CO;2-Y
) / Eur. J. Immunol. by D Pende (2001) -
Clynes, R. A., Towers, T. L., Presta, L. G. & Ravetch, J. V. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nature Med. 6, 443–446 (2000).
(
10.1038/74704
) / Nature Med. by RA Clynes (2000) -
Wilson, J. L. et al. NK cell triggering by the human costimulatory molecules CD80 and CD86. J. Immunol. 163, 4207–4212 (1999).
(
10.4049/jimmunol.163.8.4207
) / J. Immunol. by JL Wilson (1999) -
Galea-Lauri, J. et al. Expression of a variant of CD28 on a subpopulation of human NK cells: implications for B7-mediated stimulation of NK cells. J. Immunol. 163, 62–70 (1999).
(
10.4049/jimmunol.163.1.62
) / J. Immunol. by J Galea-Lauri (1999) - Geldhof, A. B. et al. Expression of B7-1 by highly metastatic mouse T lymphomas induces optimal natural killer cell-mediated cytotoxicity. Cancer Res. 55, 2730–2733 (1995). / Cancer Res. by AB Geldhof (1995)
-
Kelly, J. M., Takeda, K., Darcy, P. K., Yagita, H. & Smyth, M. J. A role for IFN-gamma in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo. J. Immunol. 168, 4472–4479 (2002).Direct demonstration that NK-cell-mediated rejection of tumours via CD27–CD70 co-stimulatory interactions subsequently evoke the development of tumour-specific cytotoxic and T helper type 1 responses, providing a key link between innate NK-cell responses and adaptive T-cell immunity.
(
10.4049/jimmunol.168.9.4472
) / J. Immunol. by JM Kelly (2002) -
LaBelle, J. L., Hanke, C. A., Blazar, B. R. & Truitt, R. L. Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia. Blood 99, 2146–2153 (2002).
(
10.1182/blood.V99.6.2146
) / Blood by JL LaBelle (2002) -
Lang, S., Vujanovic, N. L., Wollenberg, B. & Whiteside, T. L. Absence of B7.1-CD28/CTLA-4-mediated co-stimulation in human NK cells. Eur. J. Immunol. 28, 780–786 (1998).
(
10.1002/(SICI)1521-4141(199803)28:03<780::AID-IMMU780>3.0.CO;2-8
) / Eur. J. Immunol. by S Lang (1998) -
Sugita, K. et al. Participation of the CD27 antigen in the regulation of IL-2-activated human natural killer cells. J. Immunol. 149, 1199–1203 (1992).
(
10.4049/jimmunol.149.4.1199
) / J. Immunol. by K Sugita (1992) -
Takeda, K. et al. CD27-mediated activation of murine NK cells. J. Immunol. 164, 1741–1745 (2000).
(
10.4049/jimmunol.164.4.1741
) / J. Immunol. by K Takeda (2000) -
Kelly, J. M. et al. Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection. Nature Immunol. 3, 83–90 (2002).
(
10.1038/ni746
) / Nature Immunol. by JM Kelly (2002) -
Sivori, S. et al. 2B4 functions as a co-receptor in human NK cell activation. Eur. J. Immunol. 30, 787–793 (2000).
(
10.1002/1521-4141(200003)30:3<787::AID-IMMU787>3.0.CO;2-I
) / Eur. J. Immunol. by S Sivori (2000) -
Sivori, S. et al. Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. Proc. Natl Acad. Sci. USA 99, 4526–4531 (2002).
(
10.1073/pnas.072065999
) / Proc. Natl Acad. Sci. USA by S Sivori (2002) -
Tangye, S. G., Phillips, J. H., Lanier, L. L. & Nichols, K. E. Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. J. Immunol. 165, 2932–2936 (2000).
(
10.4049/jimmunol.165.6.2932
) / J. Immunol. by SG Tangye (2000) -
Nakajima, A. et al. Antitumor effect of CD40 ligand: elicitation of local and systemic antitumor responses by IL-12 and B7. J. Immunol. 161, 1901–1907 (1998).
(
10.4049/jimmunol.161.4.1901
) / J. Immunol. by A Nakajima (1998) -
Takeda, K. et al. Relative contribution of NK and NKT cells to the anti-metastatic activities of IL-12. Int. Immunol. 12, 909–914 (2000).
(
10.1093/intimm/12.6.909
) / Int. Immunol. by K Takeda (2000) - Duda, D. G. et al. Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12. Cancer Res. 60, 1111–1116 (2000). / Cancer Res. by DG Duda (2000)
-
Smyth, M. J., Taniguchi, M. & Street, S. E. The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent. J. Immunol. 165, 2665–2670 (2000).
(
10.4049/jimmunol.165.5.2665
) / J. Immunol. by MJ Smyth (2000) -
Fernandez, N. C. et al. Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo. Nature Med. 5, 405–411 (1999).Milestone paper illustrating that dendritic cells can trigger the innate, NK-cell-mediated antitumour immunity.
(
10.1038/7403
) / Nature Med. by NC Fernandez (1999) - Waldmann, T. A., Dubois, S. & Tagaya, Y. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: implications for immunotherapy. Immunity 14, 105–110 (2001). / Immunity by TA Waldmann (2001)
-
Fehniger, T. A. & Caligiuri, M. A. Interleukin 15: biology and relevance to human disease. Blood 97, 14–32 (2001).
(
10.1182/blood.V97.1.14
) / Blood by TA Fehniger (2001) -
Yajima, T. et al. Overexpression of interleukin-15 in vivo enhances antitumor activity against MHC class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response. Int. J. Cancer 99, 573–578 (2002).
(
10.1002/ijc.10395
) / Int. J. Cancer by T Yajima (2002) -
Lynch, D. H. et al. Flt3 ligand induces tumor regression and antitumor immune responses in vivo. Nature Med. 3, 625–631 (1997).
(
10.1038/nm0697-625
) / Nature Med. by DH Lynch (1997) -
Peron, J. M. et al. FLT3-ligand administration inhibits liver metastases: role of NK cells. J. Immunol. 161, 6164–6170 (1998).
(
10.4049/jimmunol.161.11.6164
) / J. Immunol. by JM Peron (1998) -
Pawlowska, A. B. et al. In vitro tumor-pulsed or in vivo Flt3 ligand-generated dendritic cells provide protection against acute myelogenous leukemia in nontransplanted or syngeneic bone marrow-transplanted mice. Blood 97, 1474–1482 (2001).
(
10.1182/blood.V97.5.1474
) / Blood by AB Pawlowska (2001) -
Zheng, L. M. et al. Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism. J. Exp. Med. 184, 579–584 (1996).
(
10.1084/jem.184.2.579
) / J. Exp. Med. by LM Zheng (1996) -
Moore, R. J. et al. Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis. Nature Med. 5, 828–831 (1999).
(
10.1038/10552
) / Nature Med. by RJ Moore (1999) -
Pilaro, A. M. et al. TNF-alpha is a principal cytokine involved in the recruitment of NK cells to liver parenchyma. J. Immunol. 153, 333–342 (1994).
(
10.4049/jimmunol.153.1.333
) / J. Immunol. by AM Pilaro (1994) -
Kasaian, M. T. et al. IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity. Immunity 16, 559–569 (2002).
(
10.1016/S1074-7613(02)00295-9
) / Immunity by MT Kasaian (2002) -
Campbell, J. J. et al. Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J. Immunol. 166, 6477–6482 (2001).
(
10.4049/jimmunol.166.11.6477
) / J. Immunol. by JJ Campbell (2001) -
Inngjerdingen, M., Damaj, B. & Maghazachi, A. A. Expression and regulation of chemokine receptors in human natural killer cells. Blood 97, 367–375 (2001).
(
10.1182/blood.V97.2.367
) / Blood by M Inngjerdingen (2001) -
Yoneda, O. et al. Fractalkine-mediated endothelial cell injury by NK cells. J. Immunol. 164, 4055–4062 (2000).
(
10.4049/jimmunol.164.8.4055
) / J. Immunol. by O Yoneda (2000) -
Nishimura, M. et al. Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression. J. Immunol. 168, 6173–6180 (2002).
(
10.4049/jimmunol.168.12.6173
) / J. Immunol. by M Nishimura (2002) -
Piccioli, D., Sbrana, S., Melandri, E. & Valiante, N. M. Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells. J. Exp. Med. 195, 335–341 (2002).
(
10.1084/jem.20010934
) / J. Exp. Med. by D Piccioli (2002) -
Ferlazzo, G. et al. Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J. Exp. Med. 195, 343–351 (2002).
(
10.1084/jem.20011149
) / J. Exp. Med. by G Ferlazzo (2002) -
Gerosa, F. et al. Reciprocal activating interaction between natural killer cells and dendritic cells. J. Exp. Med. 195, 327–333 (2002).
(
10.1084/jem.20010938
) / J. Exp. Med. by F Gerosa (2002) -
Maki, G. et al. Induction of sensitivity to NK mediated cytotoxicity by TNF-alpha treatment: possible roles of ICAM-3 and CD44. Leukemia 12, 1565–1572 (1998).
(
10.1038/sj.leu.2401145
) / Leukemia by G Maki (1998) -
Costello, R. T. et al. Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia. Blood 15, 3661–3667 (2002).
(
10.1182/blood.V99.10.3661
) / Blood by RT Costello (2002) -
Maraninchi, D. et al. A phase II study of interleukin-2 in 49 patients with relapsed or refractory acute leukemia. Leuk Lymphoma 31, 343–349 (1998).
(
10.3109/10428199809059227
) / Leuk Lymphoma by D Maraninchi (1998) -
Chang, E. & Rosenberg, S. A. Patients with melanoma metastases at cutaneous and subcutaneous sites are highly susceptible to interleukin-2-based therapy. J. Immunother. 24, 88–90 (2001).
(
10.1097/00002371-200101000-00010
) / J. Immunother. by E Chang (2001) -
Mulatero, C. W. et al. A phase II study of combined intravenous and subcutaneous interleukin-2 in malignant pleural mesothelioma. Lung Cancer 31, 67–72 (2001).
(
10.1016/S0169-5002(00)00157-4
) / Lung Cancer by CW Mulatero (2001) - Benyunes, M. C. et al. Interleukin-2 with or without lymphokine-activated killer cells as consolidative immunotherapy after autologous bone marrow transplantation for acute myelogenous leukemia. Bone Marrow Transplant. 12, 159–163 (1993). / Bone Marrow Transplant. by MC Benyunes (1993)
-
Hayes, R. L. et al. Improved long term survival after intracavitary interleukin-2 and lymphokine-activated killer cells for adults with recurrent malignant glioma. Cancer 76, 840–852 (1995).
(
10.1002/1097-0142(19950901)76:5<840::AID-CNCR2820760519>3.0.CO;2-R
) / Cancer by RL Hayes (1995) -
Rosenberg, S. A. et al. Prospective randomized trial of high-dose interleukin-2 alone or in conjunction with lymphokine-activated killer cells for the treatment of patients with advanced cancer. J. Natl Cancer Inst. 85, 622–632 (1993).
(
10.1093/jnci/85.8.622
) / J. Natl Cancer Inst. by SA Rosenberg (1993) - Margolin, K. A. Interleukin-2 in the treatment of renal cancer. Semin. Oncol. 27, 194–203 (2000). / Semin. Oncol. by KA Margolin (2000)
- Semino, C. et al. Adoptive immunotherapy of advanced solid tumors: an eight year clinical experience. Anticancer Res. 19, 5645–5649 (1999). / Anticancer Res. by C Semino (1999)
-
Burns, L. J. et al. Enhancement of the anti-tumor activity of a peripheral blood progenitor cell graft by mobilization with interleukin 2 plus granulocyte colony-stimulating factor in patients with advanced breast cancer. Exp. Hematol. 28, 96–103 (2000).
(
10.1016/S0301-472X(99)00129-0
) / Exp. Hematol. by LJ Burns (2000) -
Caligiuri, M. A. et al. Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors. J. Exp. Med. 171, 1509–1526 (1990).
(
10.1084/jem.171.5.1509
) / J. Exp. Med. by MA Caligiuri (1990) -
Buzio, C. et al. Long-term immunotherapy with low-dose interleukin-2 and interferon-alpha in the treatment of patients with advanced renal cell carcinoma. Cancer 92, 2286–2296 (2001).
(
10.1002/1097-0142(20011101)92:9<2286::AID-CNCR1575>3.0.CO;2-I
) / Cancer by C Buzio (2001) -
Carson, W. E. et al. Interleukin-2 enhances the natural killer cell response to Herceptin-coated Her2/neu-positive breast cancer cells. Eur. J. Immunol. 31, 3016–3025 (2001).
(
10.1002/1521-4141(2001010)31:10<3016::AID-IMMU3016>3.0.CO;2-J
) / Eur. J. Immunol. by WE Carson (2001) - Kossman, S. E., Scheinberg, D. A., Jurcic, J. G., Jimenez, J. & Caron, P. C. A phase I trial of humanized monoclonal antibody HuM195 (anti-CD33) with low-dose interleukin 2 in acute myelogenous leukemia. Clin. Cancer Res. 5, 2748–2755 (1999). / Clin. Cancer Res. by SE Kossman (1999)
-
da Costa, L., Renner, C., Hartmann, F. & Pfreundschuh, M. Immune recruitment by bispecific antibodies for the treatment of Hodgkin disease. Cancer Chemother. Pharmacol. 46, S33–S36 (2000).
(
10.1007/PL00014047
) / Cancer Chemother. Pharmacol. by L da Costa (2000) -
Renner, C. et al. Initiation of humoral and cellular immune responses in patients with refractory Hodgkin's disease by treatment with an anti-CD16/CD30 bispecific antibody. Cancer Immunol. Immunother. 49, 173–180 (2000).
(
10.1007/s002620050617
) / Cancer Immunol. Immunother. by C Renner (2000) - Gong, J. H., Maki, G. & Klingemann, H. G. Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells. Leukemia 8, 652–658 (1994). / Leukemia by JH Gong (1994)
- Yan, Y. et al. Antileukemia activity of a natural killer cell line against human leukemias. Clin. Cancer Res. 4, 2859–2868 (1998). / Clin. Cancer Res. by Y Yan (1998)
-
Tonn, T., Becker, S., Esser, R., Schwabe, D. & Seifried, E. Cellular immunotherapy of malignancies using the clonal natural killer cell line NK-92. J. Hematother. Stem Cell Res. 10, 535–544 (2001).
(
10.1089/15258160152509145
) / J. Hematother. Stem Cell Res. by T Tonn (2001) -
Ruggeri, L. et al. Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood 94, 333–339 (1999).
(
10.1182/blood.V94.1.333.413a31_333_339
) / Blood by L Ruggeri (1999) -
Davies, S. M. et al. An evaluation of KIR ligand incompatability in mismatched unrelated donor hematopoietic transplants. Blood 5 Jul 2002 [epub ahead of print].
(
10.1182/blood-2002-04-1197
) -
Groh, V. et al. Tumour-derived soluble MC ligands impair expression of NKG2D and T-cell activation. Nature 419, 734–738 (2002).
(
10.1038/nature01112
) / Nature by V Groh (2002)
Dates
Type | When |
---|---|
Created | 22 years, 9 months ago (Nov. 1, 2002, 11:37 a.m.) |
Deposited | 2 years, 4 months ago (April 25, 2023, 1:23 a.m.) |
Indexed | 1 day, 2 hours ago (Aug. 26, 2025, 2:32 a.m.) |
Issued | 22 years, 9 months ago (Nov. 1, 2002) |
Published | 22 years, 9 months ago (Nov. 1, 2002) |
Published Print | 22 years, 9 months ago (Nov. 1, 2002) |
@article{Smyth_2002, title={New aspects of natural-killer-cell surveillance and therapy of cancer}, volume={2}, ISSN={1474-1768}, url={http://dx.doi.org/10.1038/nrc928}, DOI={10.1038/nrc928}, number={11}, journal={Nature Reviews Cancer}, publisher={Springer Science and Business Media LLC}, author={Smyth, Mark J. and Hayakawa, Yoshihiro and Takeda, Kazuyoshi and Yagita, Hideo}, year={2002}, month=nov, pages={850–861} }