Crossref
journal-article
Springer Science and Business Media LLC
Nature Reviews Cancer (297)
References
139
Referenced
645
-
Bridges, C. B. Current maps of the location of the mutant genes of Drosophila Melanogaster. Proc. Natl Acad. Sci. USA 7, 127–132 (1921).
(
10.1073/pnas.7.4.127
) / Proc. Natl Acad. Sci. USA by CB Bridges (1921) -
Shen, W. F., Krishnan, K., Lawrence, H. J. & Largman, C. The HOX homeodomain proteins block CBP histone acetyltransferase activity. Mol. Cell. Biol. 21, 7509–7522 (2001).
(
10.1128/MCB.21.21.7509-7522.2001
) / Mol. Cell. Biol. by WF Shen (2001) - Dolle, P., Izpisua-Belmonte, J. C., Brown, J., Tickle, C. & Duboule, D. Hox genes and the morphogenesis of the vertebrate limb. Prog. Clin. Biol. Res. 383A, 11–20 (1993). / Prog. Clin. Biol. Res. by P Dolle (1993)
-
Mortlock, D. P. & Innis, J. W. Mutation of HOXA13 in hand-foot-genital syndrome. Nature Genet. 15, 179–180 (1997).
(
10.1038/ng0297-179
) / Nature Genet. by DP Mortlock (1997) -
Perez-Cabrera, A., Kofman-Alfaro, S. & Zenteno, J. C. Mutational analysis of HOXD13 and HOXA13 genes in the triphalangeal thumb-brachyectrodactyly syndrome. J. Orthop. Res. 20, 899–901 (2002).
(
10.1016/S0736-0266(02)00008-6
) / J. Orthop. Res. by A Perez-Cabrera (2002) -
Zacchetti, G., Duboule, D. & Zakany, J. Hox gene function in vertebrate gut morphogenesis: the case of the caecum. Development 134, 3967–3973 (2007).
(
10.1242/dev.010991
) / Development by G Zacchetti (2007) - Cardoso, W. V. Transcription factors and pattern formation in the developing lung. Am. J. Physiol. 269, L429–L442 (1995). / Am. J. Physiol. by WV Cardoso (1995)
-
Simpson, J. L. Genetics of the female reproductive ducts. Am. J. Med. Genet. 89, 224–239 (1999).
(
10.1002/(SICI)1096-8628(19991229)89:4<224::AID-AJMG7>3.0.CO;2-C
) / Am. J. Med. Genet. by JL Simpson (1999) -
Wellik, D. M. Hox genes and vertebrate axial pattern. Curr. Top. Dev. Biol. 88, 257–278 (2009).
(
10.1016/S0070-2153(09)88009-5
) / Curr. Top. Dev. Biol. by DM Wellik (2009) -
Jung, C., Kim, R. S., Lee, S. J., Wang, C. & Jeng, M. H. HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4. Cancer Res. 64, 3046–3051 (2004).
(
10.1158/0008-5472.CAN-03-2614
) / Cancer Res. by C Jung (2004) -
Economides, K. D. & Capecchi, M. R. Hoxb13 is required for normal differentiation and secretory function of the ventral prostate. Development 130, 2061–2069 (2003).
(
10.1242/dev.00432
) / Development by KD Economides (2003) -
Wang, Z. et al. The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer. Clin. Cancer Res. 13, 6327–6334 (2007).
(
10.1158/1078-0432.CCR-07-0310
) / Clin. Cancer Res. by Z Wang (2007) -
Calvo, K. R., Sykes, D. B., Pasillas, M. P. & Kamps, M. P. Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1. Oncogene 21, 4247–4256 (2002).
(
10.1038/sj.onc.1205516
) / Oncogene by KR Calvo (2002) -
Zhang, X. et al. HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells. J. Cell. Mol. Med. 11, 299–306 (2007).
(
10.1111/j.1582-4934.2007.00020.x
) / J. Cell. Mol. Med. by X Zhang (2007) -
Chen, H. et al. HOXA5 acts directly downstream of retinoic acid receptor beta and contributes to retinoic acid-induced apoptosis and growth inhibition. Cancer Res. 67, 8007–8013 (2007).
(
10.1158/0008-5472.CAN-07-1405
) / Cancer Res. by H Chen (2007) -
Miao, J. et al. HOXB13 promotes ovarian cancer progression. Proc. Natl Acad. Sci. USA 104, 17093–17098 (2007).
(
10.1073/pnas.0707938104
) / Proc. Natl Acad. Sci. USA by J Miao (2007) -
Wu, X. et al. HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition. Cancer Res. 66, 9527–9534 (2006).
(
10.1158/0008-5472.CAN-05-4470
) / Cancer Res. by X Wu (2006) -
Zhai, Y. et al. Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. Cancer Res. 67, 10163–10172 (2007).
(
10.1158/0008-5472.CAN-07-2056
) / Cancer Res. by Y Zhai (2007) -
Abate-Shen, C. Deregulated homeobox gene expression in cancer: cause or consequence? Nature Rev. Cancer 2, 777–785 (2002).
(
10.1038/nrc907
) / Nature Rev. Cancer by C Abate-Shen (2002) -
Hershko, A. Y., Kafri, T., Fainsod, A. & Razin, A. Methylation of HoxA5 and HoxB5 and its relevance to expression during mouse development. Gene 302, 65–72 (2003).
(
10.1016/S0378111902010910
) / Gene by AY Hershko (2003) -
Rauch, T. et al. Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay. Proc. Natl Acad. Sci. USA 104, 5527–5532 (2007).
(
10.1073/pnas.0701059104
) / Proc. Natl Acad. Sci. USA by T Rauch (2007) -
Fanti, L. et al. The trithorax group and Pc group proteins are differentially involved in heterochromatin formation in Drosophila. Chromosoma 117, 25–39 (2008).
(
10.1007/s00412-007-0123-7
) / Chromosoma by L Fanti (2008) -
Hanson, R. D. et al. Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc. Natl Acad. Sci. USA 96, 14372–14377 (1999).
(
10.1073/pnas.96.25.14372
) / Proc. Natl Acad. Sci. USA by RD Hanson (1999) -
Krivtsov, A. V. & Armstrong, S. A. MLL translocations, histone modifications and leukaemia stem-cell development. Nature Rev. Cancer 7, 823–833 (2007).
(
10.1038/nrc2253
) / Nature Rev. Cancer by AV Krivtsov (2007) -
Ferrando, A. A. et al. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood 102, 262–268 (2003).
(
10.1182/blood-2002-10-3221
) / Blood by AA Ferrando (2003) -
Armstrong, S. A., Golub, T. R. & Korsmeyer, S. J. MLL-rearranged leukemias: insights from gene expression profiling. Semin. Hematol. 40, 268–273 (2003).
(
10.1016/S0037-1963(03)00196-3
) / Semin. Hematol. by SA Armstrong (2003) -
Golub, T. R. et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531–537 (1999).
(
10.1126/science.286.5439.531
) / Science by TR Golub (1999) -
Faber, J. et al. HOXA9 is required for survival in human MLL-rearranged acute leukemias. Blood 113, 2375–2385 (2009).
(
10.1182/blood-2007-09-113597
) / Blood by J Faber (2009) -
Yekta, S., Tabin, C. J. & Bartel, D. P. MicroRNAs in the Hox network: an apparent link to posterior prevalence. Nature Rev. Genet. 9, 789–796 (2008).
(
10.1038/nrg2400
) / Nature Rev. Genet. by S Yekta (2008) -
Chopra, V. S. & Mishra, R. K. “Mir”acles in hox gene regulation. Bioessays 28, 445–448 (2006).
(
10.1002/bies.20401
) / Bioessays by VS Chopra (2006) -
Stark, A. et al. A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands. Genes Dev. 22, 8–13 (2008).
(
10.1101/gad.1613108
) / Genes Dev. by A Stark (2008) -
Weiss, F. U. et al. Retinoic acid receptor (RAR) antagonists inhibit miR-10a expression and block metastatic behaviour of pancreatic cancer. Gastroenterology 137, 2136–2145 (2009).
(
10.1053/j.gastro.2009.08.065
) / Gastroenterology by FU Weiss (2009) -
Popovic, R. et al. Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization. Blood 113, 3314–3322 (2009).
(
10.1182/blood-2008-04-154310
) / Blood by R Popovic (2009) - Han, L., Witmer, P. D., Casey, E., Valle, D. & Sukumar, S. DNA methylation regulates MicroRNA expression. Cancer Biol. Ther. 6, 1284–1288 (2007). / Cancer Biol. Ther. by L Han (2007)
-
Sessa, L. et al. Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster. RNA 13, 223–239 (2007).
(
10.1261/rna.266707
) / RNA by L Sessa (2007) -
Sasaki, Y. T., Sano, M., Kin, T., Asai, K. & Hirose, T. Coordinated expression of ncRNAs and HOX mRNAs in the human HOXA locus. Biochem. Biophys. Res. Commun. 357, 724–730 (2007).
(
10.1016/j.bbrc.2007.03.200
) / Biochem. Biophys. Res. Commun. by YT Sasaki (2007) -
Petruk, S., Sedkov, Y., Brock, H. W. & Mazo, A. A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos. RNA Biol. 4, 1–6 (2007).
(
10.4161/rna.4.1.4300
) / RNA Biol. by S Petruk (2007) -
Rinn, J. L. et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129, 1311–1323 (2007).
(
10.1016/j.cell.2007.05.022
) / Cell by JL Rinn (2007) -
Gupta, R.A., et al. Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature (in the press). 2010.
(
10.1038/nature08975
) -
Khalil, A. M. et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc. Natl Acad. Sci. USA 106, 11667–11672 (2009).
(
10.1073/pnas.0904715106
) / Proc. Natl Acad. Sci. USA by AM Khalil (2009) - Takahashi, O. et al. Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma. Oncol. Rep. 17, 753–760 (2007). / Oncol. Rep. by O Takahashi (2007)
-
Jung, C. et al. HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. Br. J. Cancer 92, 2233–2239 (2005).
(
10.1038/sj.bjc.6602631
) / Br. J. Cancer by C Jung (2005) -
Ghannam, G. et al. The oncogene Nup98-HOXA9 induces gene transcription in myeloid cells. J. Biol. Chem. 279, 866–875 (2004).
(
10.1074/jbc.M307280200
) / J. Biol. Chem. by G Ghannam (2004) -
Lawrence, H. J. et al. Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood 89, 1922–1930 (1997).
(
10.1182/blood.V89.6.1922
) / Blood by HJ Lawrence (1997) -
Lu, Q. & Kamps, M. P. Heterodimerization of Hox proteins with Pbx1 and oncoprotein E2a-Pbx1 generates unique DNA-binding specifities at nucleotides predicted to contact the N-terminal arm of the Hox homeodomain—demonstration of Hox-dependent targeting of E2a-Pbx1 in vivo. Oncogene 14, 75–83 (1997).
(
10.1038/sj.onc.1200799
) / Oncogene by Q Lu (1997) -
Crijns, A. P. et al. MEIS and PBX homeobox proteins in ovarian cancer. Eur. J. Cancer 43, 2495–2505 (2007).
(
10.1016/j.ejca.2007.08.025
) / Eur. J. Cancer by AP Crijns (2007) -
Kawagoe, H., Humphries, R. K., Blair, A., Sutherland, H. J. & Hogge, D. E. Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells. Leukemia 13, 687–698 (1999).
(
10.1038/sj.leu.2401410
) / Leukemia by H Kawagoe (1999) -
Shimamoto, T., Ohyashiki, K., Toyama, K. & Takeshita, K. Homeobox genes in hematopoiesis and leukemogenesis. Int. J. Hematol. 67, 339–350 (1998).
(
10.1016/S0925-5710(98)00024-3
) / Int. J. Hematol. by T Shimamoto (1998) -
Laurent, A., Bihan, R., Omilli, F., Deschamps, S. & Pellerin, I. PBX proteins: much more than Hox cofactors. Int. J. Dev. Biol. 52, 9–20 (2008).
(
10.1387/ijdb.072304al
) / Int. J. Dev. Biol. by A Laurent (2008) -
Myers, C., Charboneau, A., Cheung, I., Hanks, D. & Boudreau, N. Sustained expression of homeobox D10 inhibits angiogenesis. Am. J. Pathol. 161, 2099–2109 (2002).
(
10.1016/S0002-9440(10)64488-4
) / Am. J. Pathol. by C Myers (2002) -
Hansen, S. L., Dosanjh, A., Young, D. M., Boudreau, N. & Hoffman, W. Y. Hemangiomas and homeobox gene expression. J. Craniofac Surg. 17, 767–771 (2006).
(
10.1097/00001665-200607000-00031
) / J. Craniofac Surg. by SL Hansen (2006) -
Myers, C., Charboneau, A. & Boudreau, N. Homeobox B3 promotes capillary morphogenesis and angiogenesis. J. Cell Biol. 148, 343–351 (2000).
(
10.1083/jcb.148.2.343
) / J. Cell Biol. by C Myers (2000) -
Huang, L., Pu, Y., Hepps, D., Danielpour, D. & Prins, G. S. Posterior Hox gene expression and differential androgen regulation in the developing and adult rat prostate lobes. Endocrinology 148, 1235–1245 (2007).
(
10.1210/en.2006-1250
) / Endocrinology by L Huang (2007) -
Trivedi, C. M., Patel, R. C. & Patel, C. V. Homeobox gene HOXA9 inhibits nuclear factor-κB dependent activation of endothelium. Atherosclerosis 195, e50–e60 (2007).
(
10.1016/j.atherosclerosis.2007.04.055
) / Atherosclerosis by CM Trivedi (2007) -
McMullin, R. P., Mutton, L. N. & Bieberich, C. J. Hoxb13 regulatory elements mediate transgene expression during prostate organogenesis and carcinogenesis. Dev. Dyn. 238, 664–672 (2009).
(
10.1002/dvdy.21870
) / Dev. Dyn. by RP McMullin (2009) -
Patel, C. V., Sharangpani, R., Bandyopadhyay, S. & DiCorleto, P. E. Endothelial cells express a novel, tumor necrosis factor-alpha-regulated variant of HOXA9. J. Biol. Chem. 274, 1415–1422 (1999).
(
10.1074/jbc.274.3.1415
) / J. Biol. Chem. by CV Patel (1999) -
Trivedi, C. M., Patel, R. C. & Patel, C. V. Differential regulation of HOXA9 expression by nuclear factor kappa B (NF-κB) and HOXA9. Gene 408, 187–195 (2008).
(
10.1016/j.gene.2007.11.001
) / Gene by CM Trivedi (2008) -
Park, J. R., Eggert, A. & Caron, H. Neuroblastoma: biology, prognosis, and treatment. Pediatr. Clin. North Am. 55, 97–120 (2008).
(
10.1016/j.pcl.2007.10.014
) / Pediatr. Clin. North Am. by JR Park (2008) -
Abbracchio, M. P., Cattabeni, F., Clementi, F. & Sher, E. Adenosine receptors linked to adenylate cyclase activity in human neuroblastoma cells: modulation during cell differentiation. Neuroscience 30, 819–825 (1989).
(
10.1016/0306-4522(89)90173-5
) / Neuroscience by MP Abbracchio (1989) -
Horii, Y. et al. Differential expression of N-myc and c-src proto-oncogenes during neuronal and schwannian differentiation of human neuroblastoma cells. Int. J. Cancer 43, 305–309 (1989).
(
10.1002/ijc.2910430224
) / Int. J. Cancer by Y Horii (1989) -
Manohar, C. F., Salwen, H. R., Furtado, M. R. & Cohn, S. L. Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation. Tumour Biol. 17, 34–47 (1996).
(
10.1159/000217965
) / Tumour Biol. by CF Manohar (1996) -
Jung, C., Kim, R. S., Zhang, H. J., Lee, S. J. & Jeng, M. H. HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling. Cancer Res. 64, 9185–9192 (2004).
(
10.1158/0008-5472.CAN-04-1330
) / Cancer Res. by C Jung (2004) - Miller, G. J. et al. Aberrant HOXC expression accompanies the malignant phenotype in human prostate. Cancer Res. 63, 5879–5888 (2003). / Cancer Res. by GJ Miller (2003)
-
Waltregny, D., Alami, Y., Clausse, N., de Leval, J. & Castronovo, V. Overexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation. Prostate 50, 162–169 (2002).
(
10.1002/pros.10045
) / Prostate by D Waltregny (2002) -
Kikugawa, T. et al. PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate cancer proliferation. Prostate 66, 1092–1099 (2006).
(
10.1002/pros.20443
) / Prostate by T Kikugawa (2006) -
Cheng, W., Liu, J., Yoshida, H., Rosen, D. & Naora, H. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nature Med. 11, 531–537 (2005).
(
10.1038/nm1230
) / Nature Med. by W Cheng (2005) -
Dubeau, L. The cell of origin of ovarian epithelial tumors and the ovarian surface epithelium dogma: does the emperor have no clothes? Gynecol. Oncol. 72, 437–442 (1999).
(
10.1006/gyno.1998.5275
) / Gynecol. Oncol. by L Dubeau (1999) -
Lawrence, H. J., Sauvageau, G., Humphries, R. K. & Largman, C. The role of HOX homeobox genes in normal and leukemic hematopoiesis. Stem Cells 14, 281–291 (1996).
(
10.1002/stem.140281
) / Stem Cells by HJ Lawrence (1996) -
Bijl, J. et al. Expression of HOXC4, HOXC5, and HOXC6 in human lymphoid cell lines, leukemias, and benign and malignant lymphoid tissue. Blood 87, 1737–1745 (1996).
(
10.1182/blood.V87.5.1737.1737
) / Blood by J Bijl (1996) -
Armstrong, S. A. et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nature Genet. 30, 41–47 (2002).
(
10.1038/ng765
) / Nature Genet. by SA Armstrong (2002) -
Ayton, P. M. & Cleary, M. L. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev. 17, 2298–2307 (2003).
(
10.1101/gad.1111603
) / Genes Dev. by PM Ayton (2003) -
Rubin, E. et al. A role for the HOXB7 homeodomain protein in DNA repair. Cancer Res. 67, 1527–1535 (2007).
(
10.1158/0008-5472.CAN-06-4283
) / Cancer Res. by E Rubin (2007) -
Chen, H. et al. Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis. Cancer Res. 68, 3637–3644 (2008).
(
10.1158/0008-5472.CAN-07-2926
) / Cancer Res. by H Chen (2008) -
Chirnomas, D. et al. Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway. Mol. Cancer Ther. 5, 952–961 (2006).
(
10.1158/1535-7163.MCT-05-0493
) / Mol. Cancer Ther. by D Chirnomas (2006) -
Ma, X. J. et al. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell 5, 607–616 (2004).
(
10.1016/j.ccr.2004.05.015
) / Cancer Cell by XJ Ma (2004) -
Jerevall, P. L. et al. Exploring the two-gene ratio in breast cancer—independent roles for HOXB13 and IL17BR in prediction of clinical outcome. Breast Cancer Res. Treat 107, 225–234 (2008).
(
10.1007/s10549-007-9541-8
) / Breast Cancer Res. Treat by PL Jerevall (2008) -
Ma, X. J. et al. Gene expression profiles of human breast cancer progression. Proc. Natl Acad. Sci. USA 100, 5974–5979 (2003).
(
10.1073/pnas.0931261100
) / Proc. Natl Acad. Sci. USA by XJ Ma (2003) -
Raman, V. et al. Compromised HOXA5 function can limit p53 expression in human breast tumours. Nature 405, 974–978 (2000).
(
10.1038/35016125
) / Nature by V Raman (2000) -
Chen, H., Chung, S. & Sukumar, S. HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8. Mol. Cell. Biol. 24, 924–935 (2004).
(
10.1128/MCB.24.2.924-935.2004
) / Mol. Cell. Biol. by H Chen (2004) -
Gendronneau, G. et al. Influence of Hoxa5 on p53 tumorigenic outcome in mice. Am. J. Pathol. 176(2), 995–1005 (2010)
(
10.2353/ajpath.2010.090499
) / Am. J. Pathol. by G Gendronneau (2010) -
Chu, M. C., Selam, F. B. & Taylor, H. S. HOXA10 regulates p53 expression and matrigel invasion in human breast cancer cells. Cancer Biol. Ther. 3, 568–572 (2004).
(
10.4161/cbt.3.6.848
) / Cancer Biol. Ther. by MC Chu (2004) -
Plowright, L., Harrington, K. J., Pandha, H. S. & Morgan, R. HOX transcription factors are potential therapeutic targets in non-small-cell lung cancer (targeting HOX genes in lung cancer). Br. J. Cancer 100, 470–475 (2009).
(
10.1038/sj.bjc.6604857
) / Br. J. Cancer by L Plowright (2009) -
Morgan, R. et al. Antagonism of HOX/PBX dimer formation blocks the in vivo proliferation of melanoma. Cancer Res. 67, 5806–5813 (2007).
(
10.1158/0008-5472.CAN-06-4231
) / Cancer Res. by R Morgan (2007) -
Kasibhatla, S. et al. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-κB and AP-1. Mol. Cell 1, 543–551 (1998).
(
10.1016/S1097-2765(00)80054-4
) / Mol. Cell by S Kasibhatla (1998) -
Argiropoulos, B. & Humphries, R. K. Hox genes in hematopoiesis and leukemogenesis. Oncogene 26, 6766–6776 (2007).
(
10.1038/sj.onc.1210760
) / Oncogene by B Argiropoulos (2007) -
Lawrence, H. J. & Largman, C. Homeobox genes in normal hematopoiesis and leukemia. Blood 80, 2445–2453 (1992).
(
10.1182/blood.V80.10.2445.2445
) / Blood by HJ Lawrence (1992) -
Hu, Y. L., Fong, S., Ferrell, C., Largman, C. & Shen, W. F. HOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis. Mol. Cell. Biol. 29, 5181–5192 (2009).
(
10.1128/MCB.00545-09
) / Mol. Cell. Biol. by YL Hu (2009) -
Whelan, J. T., Ludwig, D. L. & Bertrand, F. E. HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia. Leukemia 22, 1161–1169 (2008).
(
10.1038/leu.2008.57
) / Leukemia by JT Whelan (2008) -
Carrio, M., Arderiu, G., Myers, C. & Boudreau, N. J. Homeobox D10 induces phenotypic reversion of breast tumor cells in a three-dimensional culture model. Cancer Res. 65, 7177–7185 (2005).
(
10.1158/0008-5472.CAN-04-1717
) / Cancer Res. by M Carrio (2005) -
Daftary, G. S. & Taylor, H. S. Endocrine regulation of HOX genes. Endocr. Rev. 27, 331–355 (2006).
(
10.1210/er.2005-0018
) / Endocr. Rev. by GS Daftary (2006) -
Loi, S. et al. Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer. BMC Med. Genomics 2, 37 (2009).
(
10.1186/1755-8794-2-37
) / BMC Med. Genomics by S Loi (2009) -
Qiu, Y. et al. Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth. Am. J. Pathol. 170, 152–159 (2007).
(
10.2353/ajpath.2007.060722
) / Am. J. Pathol. by Y Qiu (2007) -
Crickmore, M. A., Ranade, V. & Mann, R. S. Regulation of Ubx expression by epigenetic enhancer silencing in response to Ubx levels and genetic variation. PLoS Genet. 5, e1000633 (2009).
(
10.1371/journal.pgen.1000633
) / PLoS Genet. by MA Crickmore (2009) -
Kannan, R., Berger, C., Myneni, S., Technau, G. M. & Shashidhara, L. S. Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system. Mech. Dev. 127, 137–145 (2009).
(
10.1016/j.mod.2009.09.008
) / Mech. Dev. by R Kannan (2009) -
Leucht, P. et al. Embryonic origin and Hox status determine progenitor cell fate during adult bone regeneration. Development 135, 2845–2854 (2008).
(
10.1242/dev.023788
) / Development by P Leucht (2008) -
Karnoub, A. E. et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449, 557–563 (2007).
(
10.1038/nature06188
) / Nature by AE Karnoub (2007) -
Korkaya, H. & Wicha, M. S. HER-2, notch, and breast cancer stem cells: targeting an axis of evil. Clin. Cancer Res. 15, 1845–1847 (2009).
(
10.1158/1078-0432.CCR-08-3087
) / Clin. Cancer Res. by H Korkaya (2009) -
Wang, G. G., Cai, L., Pasillas, M. P. & Kamps, M. P. NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. Nature Cell Biol. 9, 804–812 (2007).
(
10.1038/ncb1608
) / Nature Cell Biol. by GG Wang (2007) -
Yang, Y. C. et al. A tumorigenic homeobox (HOX) gene expressing human gastric cell line derived from putative gastric stem cell. Eur. J. Gastroenterol. Hepatol 21, 1016–1023 (2009).
(
10.1097/MEG.0b013e32831d7b9c
) / Eur. J. Gastroenterol. Hepatol by YC Yang (2009) -
Palmqvist, L., Pineault, N., Wasslavik, C. & Humphries, R. K. Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes. PLoS ONE 2, e768 (2007).
(
10.1371/journal.pone.0000768
) / PLoS ONE by L Palmqvist (2007) -
Wong, P., Iwasaki, M., Somervaille, T. C., So, C. W. & Cleary, M. L. Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev. 21, 2762–2774 (2007).
(
10.1101/gad.1602107
) / Genes Dev. by P Wong (2007) -
Chou, W. C. et al. Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients. Leukemia 23, 1303–1310 (2009).
(
10.1038/leu.2009.25
) / Leukemia by WC Chou (2009) -
Goetz, M. P. et al. A two-gene expression ratio of homeoBOX 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. Clin. Cancer Res. 12, 2080–2087 (2006).
(
10.1158/1078-0432.CCR-05-1263
) / Clin. Cancer Res. by MP Goetz (2006) -
Jansen, M. P. et al. HOXB13-to-IL17BR expression ratio is related with tumor aggressiveness and response to tamoxifen of recurrent breast cancer: a retrospective study. J. Clin. Oncol. 25, 662–668 (2007).
(
10.1200/JCO.2006.07.3676
) / J. Clin. Oncol. by MP Jansen (2007) -
Zaremba, T. & Curtin, N. J. PARP inhibitor development for systemic cancer targeting. Anticancer Agents Med. Chem. 7, 515–523 (2007).
(
10.2174/187152007781668715
) / Anticancer Agents Med. Chem. by T Zaremba (2007) -
Kmita, M. et al. Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function. Nature 435, 1113–1116 (2005).
(
10.1038/nature03648
) / Nature by M Kmita (2005) -
Dhanasekaran, S. M. et al. Molecular profiling of human prostate tissues: insights into gene expression patterns of prostate development during puberty. FASEB J. 19, 243–245 (2005).
(
10.1096/fj.04-2415fje
) / FASEB J. by SM Dhanasekaran (2005) -
Yahagi, N. et al. Position-specific expression of Hox genes along the gastrointestinal tract. Congenit Anom (Kyoto) 44, 18–26 (2004).
(
10.1111/j.1741-4520.2003.00004.x
) / Congenit Anom (Kyoto) by N Yahagi (2004) -
Volpe, M. V. et al. Aberrant cell adhesion molecule expression in human bronchopulmonary sequestration and congenital cystic adenomatoid malformation. Am. J. Physiol. Lung Cell. Mol. Physiol. 297, L143–L152 (2009).
(
10.1152/ajplung.90618.2008
) / Am. J. Physiol. Lung Cell. Mol. Physiol. by MV Volpe (2009) -
Goodman, F. R. Limb malformations and the human HOX genes. Am. J. Med. Genet. 112, 256–265 (2002).
(
10.1002/ajmg.10776
) / Am. J. Med. Genet. by FR Goodman (2002) -
Maeda, Y., Dave, V. & Whitsett, J. A. Transcriptional control of lung morphogenesis. Physiol. Rev. 87, 219–244 (2007).
(
10.1152/physrev.00028.2006
) / Physiol. Rev. by Y Maeda (2007) -
Abramovich, C., Pineault, N., Ohta, H. & Humphries, R. K. Hox genes: from leukemia to hematopoietic stem cell expansion. Ann. NY Acad. Sci. 1044, 109–116 (2005).
(
10.1196/annals.1349.014
) / Ann. NY Acad. Sci. by C Abramovich (2005) -
Lawrence, H. J. et al. Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells. Blood 106, 3988–3994 (2005).
(
10.1182/blood-2005-05-2003
) / Blood by HJ Lawrence (2005) -
Thorsteinsdottir, U., Sauvageau, G. & Humphries, R. K. Hox homeobox genes as regulators of normal and leukemic hematopoiesis. Hematol. Oncol. Clin. North Am. 11, 1221–1237 (1997).
(
10.1016/S0889-8588(05)70491-3
) / Hematol. Oncol. Clin. North Am. by U Thorsteinsdottir (1997) -
Yu, J. et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917–1920 (2007).
(
10.1126/science.1151526
) / Science by J Yu (2007) -
Nakagawa, M. et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nature Biotechnol. 26, 101–106 (2008).
(
10.1038/nbt1374
) / Nature Biotechnol. by M Nakagawa (2008) -
Atkinson, S. P. et al. Epigenetic marking prepares the human HOXA cluster for activation during differentiation of pluripotent cells. Stem Cells 26, 1174–1185 (2008).
(
10.1634/stemcells.2007-0497
) / Stem Cells by SP Atkinson (2008) -
Gouti, M. & Gavalas, A. Hoxb1 controls cell fate specification and proliferative capacity of neural stem and progenitor cells. Stem Cells 26, 1985–1997 (2008).
(
10.1634/stemcells.2008-0182
) / Stem Cells by M Gouti (2008) -
Abramovich, C. & Humphries, R. K. Hox regulation of normal and leukemic hematopoietic stem cells. Curr. Opin. Hematol. 12, 210–216 (2005).
(
10.1097/01.moh.0000160737.52349.aa
) / Curr. Opin. Hematol. by C Abramovich (2005) -
Naguibneva, I. et al. The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation. Nature Cell Biol. 8, 278–284 (2006).
(
10.1038/ncb1373
) / Nature Cell Biol. by I Naguibneva (2006) -
Charboneau, A., East, L., Mulholland, N., Rohde, M. & Boudreau, N. Pbx1 is required for Hox D3-mediated angiogenesis. Angiogenesis 8, 289–296 (2005).
(
10.1007/s10456-005-9016-7
) / Angiogenesis by A Charboneau (2005) -
Shen, W., Chrobak, D., Krishnan, K., Lawrence, H. J. & Largman, C. HOXB6 protein is bound to CREB-binding protein and represses globin expression in a DNA binding-dependent, PBX interaction-independent process. J. Biol. Chem. 279, 39895–39904 (2004).
(
10.1074/jbc.M404132200
) / J. Biol. Chem. by W Shen (2004) -
Li, X., Nie, S., Chang, C., Qiu, T. & Cao, X. Smads oppose Hox transcriptional activities. Exp. Cell Res. 312, 854–864 (2006).
(
10.1016/j.yexcr.2005.12.002
) / Exp. Cell Res. by X Li (2006) - Abe, M. et al. Disordered expression of HOX genes in human non-small cell lung cancer. Oncol. Rep. 15, 797–802 (2006). / Oncol. Rep. by M Abe (2006)
-
Alami, Y., Castronovo, V., Belotti, D., Flagiello, D. & Clausse, N. HOXC5 and HOXC8 expression are selectively turned on in human cervical cancer cells compared to normal keratinocytes. Biochem. Biophys. Res. Commun. 257, 738–745 (1999).
(
10.1006/bbrc.1999.0516
) / Biochem. Biophys. Res. Commun. by Y Alami (1999) -
Lewis, E. B. Pseudoallelism and gene evolution. Cold Spring Harb. Symp. Quant. Biol. 16, 159–174 (1951).
(
10.1101/SQB.1951.016.01.014
) / Cold Spring Harb. Symp. Quant. Biol. by EB Lewis (1951) -
Lewis, E. B. A gene complex controlling segmentation in Drosophila. Nature 276, 565–570 (1978).
(
10.1038/276565a0
) / Nature by EB Lewis (1978) -
Kaufman, T. C., Lewis, R. & Wakimoto, B. Cytogenetic Analysis of Chromosome 3 in DROSOPHILA MELANOGASTER: The Homoeotic Gene Complex in Polytene Chromosome Interval 84a-B. Genetics 94, 115–133 (1980).
(
10.1093/genetics/94.1.115
) / Genetics by TC Kaufman (1980) -
Scott, M. P. et al. The molecular organization of the Antennapedia locus of Drosophila. Cell 35, 763–776 (1983).
(
10.1016/0092-8674(83)90109-5
) / Cell by MP Scott (1983) -
Garber, R. L., Kuroiwa, A. & Gehring, W. J. Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila. EMBO J. 2, 2027–2036 (1983).
(
10.1002/j.1460-2075.1983.tb01696.x
) / EMBO J. by RL Garber (1983) -
Duboule, D., Baron, A., Mahl, P. & Galliot, B. A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus. EMBO J. 5, 1973–1980 (1986).
(
10.1002/j.1460-2075.1986.tb04452.x
) / EMBO J. by D Duboule (1986) -
Hart, C. P., Awgulewitsch, A., Fainsod, A., McGinnis, W. & Ruddle, F. H. Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell 43, 9–18 (1985).
(
10.1016/0092-8674(85)90007-8
) / Cell by CP Hart (1985) -
Lonai, P., Arman, E., Czosnek, H., Ruddle, F. H. & Blatt, C. New murine homeoboxes: structure, chromosomal assignment, and differential expression in adult erythropoiesis. DNA 6, 409–418 (1987).
(
10.1089/dna.1987.6.409
) / DNA by P Lonai (1987) -
Kongsuwan, K., Webb, E., Housiaux, P. & Adams, J. M. Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages. EMBO J. 7, 2131–2138 (1988).
(
10.1002/j.1460-2075.1988.tb03052.x
) / EMBO J. by K Kongsuwan (1988) -
Kamps, M. P., Murre, C., Sun, X. H. & Baltimore, D. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 60, 547–555 (1990).
(
10.1016/0092-8674(90)90658-2
) / Cell by MP Kamps (1990) -
Nourse, J. et al. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 60, 535–545 (1990).
(
10.1016/0092-8674(90)90657-Z
) / Cell by J Nourse (1990) -
Zeltser, L., Desplan, C. & Heintz, N. Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. Development 122, 2475–2484 (1996).
(
10.1242/dev.122.8.2475
) / Development by L Zeltser (1996) -
Biondi, A., Cimino, G., Pieters, R. & Pui, C. H. Biological and therapeutic aspects of infant leukemia. Blood 96, 24–33 (2000).
(
10.1182/blood.V96.1.24
) / Blood by A Biondi (2000) -
Yekta, S., Shih, I. H. & Bartel, D. P. MicroRNA-directed cleavage of HOXB8 mRNA. Science 304, 594–596 (2004).
(
10.1126/science.1097434
) / Science by S Yekta (2004)
Dates
Type | When |
---|---|
Created | 15 years, 4 months ago (April 1, 2010, 1:14 a.m.) |
Deposited | 2 years, 2 months ago (May 31, 2023, 1:48 p.m.) |
Indexed | 8 minutes ago (Aug. 29, 2025, 12:04 a.m.) |
Issued | 15 years, 4 months ago (April 1, 2010) |
Published | 15 years, 4 months ago (April 1, 2010) |
Published Online | 15 years, 4 months ago (April 1, 2010) |
Published Print | 15 years, 3 months ago (May 1, 2010) |
@article{Shah_2010, title={The Hox genes and their roles in oncogenesis}, volume={10}, ISSN={1474-1768}, url={http://dx.doi.org/10.1038/nrc2826}, DOI={10.1038/nrc2826}, number={5}, journal={Nature Reviews Cancer}, publisher={Springer Science and Business Media LLC}, author={Shah, Nilay and Sukumar, Saraswati}, year={2010}, month=apr, pages={361–371} }