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Feng, B. Y., & Shoichet, B. K. (2006). A detergent-based assay for the detection of promiscuous inhibitors. Nature Protocols, 1(2), 550–553.

Authors 2
  1. Brian Y Feng (first)
  2. Brian K Shoichet (additional)
References 13 Referenced 396
  1. Hajduk, P.J., Huth, J.R. & Fesik, S.W. Druggability indices for protein targets derived from NMR-based screening data. J. Med. Chem. 48, 2518–2525 (2005). (10.1021/jm049131r) / J. Med. Chem. by PJ Hajduk (2005)
  2. Rishton, G.M. Reactive compounds and in vitro false positives in HTS. Drug Discov. Today 2, 382–384 (1997). (10.1016/S1359-6446(97)01083-0) / Drug Discov. Today by GM Rishton (1997)
  3. Walters, W.P. & Namchuk, M. Designing screens: how to make your hits a hit. Nat. Rev. Drug Discov. 2, 259–266 (2003). (10.1038/nrd1063) / Nat. Rev. Drug Discov. by WP Walters (2003)
  4. Feng, B. & Shoichet, B.K. Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures. J. Med. Chem. 49, 2151–2154 (2006). (10.1021/jm060029z) / J. Med. Chem. by B Feng (2006)
  5. Feng, B.Y. et al. High-throughput assays for promiscuous inhibitors. Nat. Chem. Biol. 1, 146–148 (2005). (10.1038/nchembio718) / Nat. Chem. Biol. by BY Feng (2005)
  6. McGovern, S.L., Caselli, E., Grigorieff, N. & Shoichet, B.K. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J. Med. Chem. 45, 1712–1722 (2002). (10.1021/jm010533y) / J. Med. Chem. by SL McGovern (2002)
  7. McGovern, S.L., Helfand, B.T., Feng, B.Y. & Shoichet, B.K. A specific mechanism of nonspecific inhibition. J. Med. Chem. 46, 4265–4272 (2003). (10.1021/jm030266r) / J. Med. Chem. by SL McGovern (2003)
  8. McGovern, S.L. & Shoichet, B.K. Kinase inhibitors: not just for kinases anymore. J. Med. Chem. 46, 1478–1483 (2003). (10.1021/jm020427b) / J. Med. Chem. by SL McGovern (2003)
  9. Seidler, J., McGovern, S.L., Doman, T. & Shoichet, B.K. Identification and prediction of promiscuous aggregating inhibitors among known drugs. J. Med. Chem. 46, 4477–4486 (2003). (10.1021/jm030191r) / J. Med. Chem. by J Seidler (2003)
  10. Seidler, J., McGovern, S.L., Doman, T.N. & Shoichet, B.K. Identification and prediction of promiscuous drugs. J. Med. Chem. 46, 4477–4486 (2003). (10.1021/jm030191r) / J. Med. Chem. by J Seidler (2003)
  11. Weston, G.S., Blazquez, J., Baquero, F. & Shoichet, B.K. Structure-based enhancement of boronic acid-based inhibitors of AmpC β-lactamase. J. Med. Chem. 41, 4577–4586 (1998). (10.1021/jm980343w) / J. Med. Chem. by GS Weston (1998)
  12. Ryan, A.J., Gray, N.M., Lowe, P.N. & Chung, C. Effect of detergent on 'promiscuous' inhibitors. J. Med. Chem. 46, 3448–3451 (2003). (10.1021/jm0340896) / J. Med. Chem. by AJ Ryan (2003)
  13. Straus, O.H. & Goldstein, A. Zone behavior of enzymes: illustrated by the effect of dissociation constant and dilution on the system cholinesterase–physostigmine. J. Gen. Physiol. 26, 559–585 (1943). (10.1085/jgp.26.6.559) / J. Gen. Physiol. by OH Straus (1943)
Dates
Type When
Created 19 years, 1 month ago (June 29, 2006, 9:57 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 8:04 p.m.)
Indexed 1 day, 20 hours ago (Aug. 27, 2025, 12:36 p.m.)
Issued 19 years, 2 months ago (June 27, 2006)
Published 19 years, 2 months ago (June 27, 2006)
Published Online 19 years, 2 months ago (June 27, 2006)
Published Print 19 years ago (Aug. 1, 2006)
Funders 0

None

@article{Feng_2006, title={A detergent-based assay for the detection of promiscuous inhibitors}, volume={1}, ISSN={1750-2799}, url={http://dx.doi.org/10.1038/nprot.2006.77}, DOI={10.1038/nprot.2006.77}, number={2}, journal={Nature Protocols}, publisher={Springer Science and Business Media LLC}, author={Feng, Brian Y and Shoichet, Brian K}, year={2006}, month=jun, pages={550–553} }