Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration
10.1038/nm987
Crossref journal-article
Springer Science and Business Media LLC
Nature Medicine (297)
Bibliography

Heikenwalder, M., Polymenidou, M., Junt, T., Sigurdson, C., Wagner, H., Akira, S., Zinkernagel, R., & Aguzzi, A. (2004). Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nature Medicine, 10(2), 187–192.

Authors 8
  1. Mathias Heikenwalder (first)
  2. Magdalini Polymenidou (additional)
  3. Tobias Junt (additional)
  4. Christina Sigurdson (additional)
  5. Hermann Wagner (additional)
  6. Shizuo Akira (additional)
  7. Rolf Zinkernagel (additional)
  8. Adriano Aguzzi (additional)
References 30 Referenced 372
  1. Krieg, A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20, 709–760 (2002). (10.1146/annurev.immunol.20.100301.064842) / Annu. Rev. Immunol. by AM Krieg (2002)
  2. Hemmi, H. et al. A Toll-like receptor recognizes bacterial DNA. Nature 408, 740–745 (2000). (10.1038/35047123) / Nature by H Hemmi (2000)
  3. Sethi, S., Lipford, G., Wagner, H. & Kretzschmar, H. Postexposure prophylaxis against prion disease with a stimulator of innate immunity. Lancet 360, 229–230 (2002). (10.1016/S0140-6736(02)09513-2) / Lancet by S Sethi (2002)
  4. Klein, M.A. et al. A crucial role for B cells in neuroinvasive scrapie. Nature 390, 687–690 (1997). (10.1038/37789) / Nature by MA Klein (1997)
  5. Aucouturier, P. et al. Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie. J. Clin. Invest. 108, 703–708 (2001). (10.1172/JCI200113155) / J. Clin. Invest. by P Aucouturier (2001)
  6. Adachi, O. et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL- 18-mediated function. Immunity 9, 143–150 (1998). (10.1016/S1074-7613(00)80596-8) / Immunity by O Adachi (1998)
  7. Hacker, H. et al. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 192, 595–600 (2000). (10.1084/jem.192.4.595) / J. Exp. Med. by H Hacker (2000)
  8. Prinz, M. et al. Prion pathogenesis in the absence of Toll-like receptor signalling. EMBO Rep. 4, 195–199 (2003). (10.1038/sj.embor.embor731) / EMBO Rep. by M Prinz (2003)
  9. Montrasio, F. et al. Impaired prion replication in spleens of mice lacking functional follicular dendritic cells. Science 288, 1257–1259 (2000). (10.1126/science.288.5469.1257) / Science by F Montrasio (2000)
  10. Aguzzi, A., Montrasio, F. & Kaeser, P.S. Prions: health scare and biological challenge. Nat. Rev. Mol. Cell. Biol. 2, 118–126 (2001). (10.1038/35052063) / Nat. Rev. Mol. Cell. Biol. by A Aguzzi (2001)
  11. Sparwasser, T. et al. Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis. J. Immunol. 162, 2368–2374 (1999). (10.4049/jimmunol.162.4.2368) / J. Immunol. by T Sparwasser (1999)
  12. Davila, E., Velez, M.G., Heppelmann, C.J. & Celis, E. Creating space: an antigen-independent, CpG-induced peripheral expansion of naive and memory T lymphocytes in a full T-cell compartment. Blood 100, 2537–2545 (2002). (10.1182/blood-2002-02-0401) / Blood by E Davila (2002)
  13. Schmidt, U., Wagner, H. & Miethke, T. CpG-DNA upregulates the major acute-phase proteins SAA and SAP. Cell. Microbiol. 1, 61–67 (1999). (10.1046/j.1462-5822.1999.00007.x) / Cell. Microbiol. by U Schmidt (1999)
  14. Rothe, J. et al. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364, 798–802 (1993). (10.1038/364798a0) / Nature by J Rothe (1993)
  15. Muller, U. et al. Functional role of type I and type II interferons in antiviral defense. Science 264, 1918–1921 (1994). (10.1126/science.8009221) / Science by U Muller (1994)
  16. Alexopoulou, L., Holt, A.C., Medzhitov, R. & Flavell, R.A. Recognition of double-stranded RNA and activation of NF-κB by Toll- like receptor 3. Nature 413, 732–738 (2001). (10.1038/35099560) / Nature by L Alexopoulou (2001)
  17. Gilch, S. et al. Polyclonal anti-PrP auto-antibodies induced with dimeric PrP interfere efficiently with PrPSc propagation in prion-infected cells. J. Biol. Chem. 278, 18524–18531 (2003). (10.1074/jbc.M210723200) / J. Biol. Chem. by S Gilch (2003)
  18. Ochsenbein, A.F. et al. Control of early viral and bacterial distribution and disease by natural antibodies. Science 286, 2156–2159 (1999). (10.1126/science.286.5447.2156) / Science by AF Ochsenbein (1999)
  19. Oxenius, A., Martinic, M.M., Hengartner, H. & Klenerman, P. CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines. J. Virol. 73, 4120–4126 (1999). (10.1128/JVI.73.5.4120-4126.1999) / J. Virol. by A Oxenius (1999)
  20. Vabulas, R.M., Pircher, H., Lipford, G.B., Hacker, H. & Wagner, H. CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses. J. Immunol. 164, 2372–2378 (2000). (10.4049/jimmunol.164.5.2372) / J. Immunol. by RM Vabulas (2000)
  21. Binder, D., Fehr, J., Hengartner, H. & Zinkernagel, R.M. Virus-induced transient bone marrow aplasia: major role of interferon-α/β during acute infection with the noncytopathic lymphocytic choriomeningitis virus. J. Exp. Med. 185, 517–530 (1997). (10.1084/jem.185.3.517) / J. Exp. Med. by D Binder (1997)
  22. Riviere, Y., Gresser, I., Guillon, J.C. & Tovey, M.G. Inhibition by anti-interferon serum of lymphocytic choriomeningitis virus disease in suckling mice. Proc. Natl. Acad. Sci. USA 74, 2135–2139 (1977). (10.1073/pnas.74.5.2135) / Proc. Natl. Acad. Sci. USA by Y Riviere (1977)
  23. Odermatt, B., Eppler, M., Leist, T.P., Hengartner, H. & Zinkernagel, R.M. Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. Proc. Natl. Acad. Sci. USA 88, 8252–8256 (1991). (10.1073/pnas.88.18.8252) / Proc. Natl. Acad. Sci. USA by B Odermatt (1991)
  24. Davila, E. & Celis, E. Repeated administration of cytosine-phosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity. J. Immunol. 165, 539–547 (2000). (10.4049/jimmunol.165.1.539) / J. Immunol. by E Davila (2000)
  25. Martin, F., Oliver, A.M. & Kearney, J.F. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 14, 617–629 (2001). (10.1016/S1074-7613(01)00129-7) / Immunity by F Martin (2001)
  26. Fehr, T. et al. Correlation of anti-viral B cell responses and splenic morphology with expression of B cell-specific molecules. Int. Immunol. 12, 1275–1284 (2000). (10.1093/intimm/12.9.1275) / Int. Immunol. by T Fehr (2000)
  27. Storni, T. et al. Critical role for activation of antigen-presenting cells in priming of cytotoxic T cell responses after vaccination with virus-like particles. J. Immunol. 168, 2880–2886 (2002). (10.4049/jimmunol.168.6.2880) / J. Immunol. by T Storni (2002)
  28. Karrer, U. et al. Antiviral B cell memory in the absence of mature follicular dendritic cell networks and classical germinal centers in TNFR1−/− mice. J. Immunol. 164, 768–778 (2000). (10.4049/jimmunol.164.2.768) / J. Immunol. by U Karrer (2000)
  29. Prinz, M. et al. Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion. Nature 425, 957–962 (2003). (10.1038/nature02072) / Nature by M Prinz (2003)
  30. Heppner, F.L. et al. Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science 294, 178–182 (2001). (10.1126/science.1063093) / Science by FL Heppner (2001)
Dates
Type When
Created 21 years, 7 months ago (Jan. 26, 2004, 10:48 a.m.)
Deposited 1 year, 7 months ago (Jan. 11, 2024, 8 p.m.)
Indexed 1 month ago (July 26, 2025, 5:07 a.m.)
Issued 21 years, 7 months ago (Jan. 25, 2004)
Published 21 years, 7 months ago (Jan. 25, 2004)
Published Online 21 years, 7 months ago (Jan. 25, 2004)
Published Print 21 years, 6 months ago (Feb. 1, 2004)
Funders 0

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@article{Heikenwalder_2004, title={Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration}, volume={10}, ISSN={1546-170X}, url={http://dx.doi.org/10.1038/nm987}, DOI={10.1038/nm987}, number={2}, journal={Nature Medicine}, publisher={Springer Science and Business Media LLC}, author={Heikenwalder, Mathias and Polymenidou, Magdalini and Junt, Tobias and Sigurdson, Christina and Wagner, Hermann and Akira, Shizuo and Zinkernagel, Rolf and Aguzzi, Adriano}, year={2004}, month=jan, pages={187–192} }