Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery
10.1038/nm739
Crossref journal-article
Springer Science and Business Media LLC
Nature Medicine (297)
Bibliography

Hoshijima, M., Ikeda, Y., Iwanaga, Y., Minamisawa, S., Date, M., Gu, Y., Iwatate, M., Li, M., Wang, L., Wilson, J. M., Wang, Y., Ross, J., & Chien, K. R. (2002). Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nature Medicine, 8(8), 864–871.

Authors 13
  1. Masahiko Hoshijima (first)
  2. Yasuhiro Ikeda (additional)
  3. Yoshitaka Iwanaga (additional)
  4. Susumu Minamisawa (additional)
  5. Moto-o Date (additional)
  6. Yusu Gu (additional)
  7. Mitsuo Iwatate (additional)
  8. Manxiang Li (additional)
  9. Lili Wang (additional)
  10. James M. Wilson (additional)
  11. Yibin Wang (additional)
  12. John Ross (additional)
  13. Kenneth R. Chien (additional)
References 38 Referenced 301
  1. Chien, K.R. Stress pathways and heart failure. Cell 98, 555–558 (1999). (10.1016/S0092-8674(00)80043-4) / Cell by KR Chien (1999)
  2. Hunter, J.J. & Chien, K.R. Signaling pathways for cardiac hypertrophy and failure. N. Engl. J. Med. 341, 1276–1283 (1999). (10.1056/NEJM199910213411706) / N. Engl. J. Med. by JJ Hunter (1999)
  3. Hoshijima, M. & Chien, K.R. Mixed signals in heart failure: cancer rules. J. Clin. Invest. 109, 849–855 (2002). (10.1172/JCI0215380) / J. Clin. Invest. by M Hoshijima (2002)
  4. Minamisawa, S. et al. Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell 99, 313–322 (1999). (10.1016/S0092-8674(00)81662-1) / Cell by S Minamisawa (1999)
  5. Arber, S. et al. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell 88, 393–403 (1997). (10.1016/S0092-8674(00)81878-4) / Cell by S Arber (1997)
  6. Sato, Y. et al. Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation. J. Biol. Chem. 276, 9392–9399 (2001). (10.1074/jbc.M006889200) / J. Biol. Chem. by Y Sato (2001)
  7. Freeman, K. et al. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. J. Clin. Invest. 107, 967–74 (2001). (10.1172/JCI12083) / J. Clin. Invest. by K Freeman (2001)
  8. Miyamoto, M.I. et al. Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc. Natl. Acad. Sci. USA 97, 793–798 (2000). (10.1073/pnas.97.2.793) / Proc. Natl. Acad. Sci. USA by MI Miyamoto (2000)
  9. del Monte, F. et al. Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure. Circulation 104, 1424–1429 (2001). (10.1161/hc3601.095574) / Circulation by F del Monte (2001)
  10. White, D.C. et al. Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. Proc. Natl. Acad. Sci USA 97, 5428–5433 (2000). (10.1073/pnas.090091197) / Proc. Natl. Acad. Sci USA by DC White (2000)
  11. Shah, A.S. et al. In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation 103, 1311–1316 (2001). (10.1161/01.CIR.103.9.1311) / Circulation by AS Shah (2001)
  12. Ikeda, Y. et al. Altered membrane proteins and permeability correlate with cardiac dysfunction in cardiomyopathic hamsters. Am. J. Physiol. Heart Circ. Physiol. 278, H1362–1370 (2000). (10.1152/ajpheart.2000.278.4.H1362) / Am. J. Physiol. Heart Circ. Physiol. by Y Ikeda (2000)
  13. Straub, V. & Campbell, K.P. Muscular dystrophies and the dystrophin-glycoprotein complex. Curr. Opin. Neurol. 10, 168–75 (1997). (10.1097/00019052-199704000-00016) / Curr. Opin. Neurol. by V Straub (1997)
  14. Ikeda, Y. et al. Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer. Circulation 105, 502–8 (2002). (10.1161/hc0402.102953) / Circulation by Y Ikeda (2002)
  15. Tada, M. & Toyofuku, T. Cardiac sarcoplasmic reticulum Ca2+-ATPase. in Handbook of Physiology, Section 2, The Cardiovascular system, Volume 1: The Heart ed. Berne, R.M. 301–334 (Oxford University Press, 2001). / Handbook of Physiology by M Tada (2001)
  16. Simmerman, H.K. & Jones, L.R. Phospholamban: Protein structure, mechanism of action, and role in cardiac function. Physiol. Rev. 78, 921–947 (1998). (10.1152/physrev.1998.78.4.921) / Physiol. Rev. by HK Simmerman (1998)
  17. Antos, C.L. et al. Dilated cardiomyopathy and sudden death resulting from constitutive activation of protein kinase a. Circ. Res. 89, 997–1004 (2001). (10.1161/hh2301.100003) / Circ. Res. by CL Antos (2001)
  18. Ryoke, T. et al. Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibition. Circulation 100, 1734–1743 (1999). (10.1161/01.CIR.100.16.1734) / Circulation by T Ryoke (1999)
  19. Lai, N.C. et al. Intracoronary delivery of adenovirus encoding adenylyl cyclase VI increases left ventricular function and cAMP-generating capacity. Circulation 102, 2396–2401 (2000). (10.1161/01.CIR.102.19.2396) / Circulation by NC Lai (2000)
  20. Logeart, D. et al. Highly efficient adenovirus-mediated gene transfer to cardiac myocytes after single-pass coronary delivery. Hum. Gene Ther. 11, 1015–1022 (2000). (10.1089/10430340050015329) / Hum. Gene Ther. by D Logeart (2000)
  21. Brauner, R. et al. Intracoronary adenovirus-mediated transfer of immunosuppressive cytokine genes prolongs allograft survival. J. Thorac. Cardiovasc. Surg. 114, 923–933 (1997). (10.1016/S0022-5223(97)70006-0) / J. Thorac. Cardiovasc. Surg. by R Brauner (1997)
  22. Svensson, E.C. et al. Efficient and stable transduction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated virus vectors. Circulation 99, 201–205 (1999). (10.1161/01.CIR.99.2.201) / Circulation by EC Svensson (1999)
  23. Kawada, T. et al. Rescue of hereditary form of dilated cardiomyopathy by rAAV-mediated somatic gene therapy: Amelioration of morphological findings, sarcolemmal permeability, cardiac performances, and the prognosis of TO- 2 hamsters. Proc. Natl. Acad. Sci. USA 99, 901–906 (2002). (10.1073/pnas.022641799) / Proc. Natl. Acad. Sci. USA by T Kawada (2002)
  24. Melo, L.G. et al. Gene therapy strategy for long-term myocardial protection using adeno- associated virus-mediated delivery of heme oxygenase gene. Circulation 105, 602–607 (2002). (10.1161/hc0502.103363) / Circulation by LG Melo (2002)
  25. Xiao, X., Li, J. & Samulski, R.J. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J. Virol. 70, 8098–8108 (1996). (10.1128/JVI.70.11.8098-8108.1996) / J. Virol. by X Xiao (1996)
  26. Kessler, P.D. et al. Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein. Proc. Natl. Acad. Sci. USA 93, 14082–14087 (1996). (10.1073/pnas.93.24.14082) / Proc. Natl. Acad. Sci. USA by PD Kessler (1996)
  27. Kay, M.A. et al. Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector. Nature Genet. 24, 257–261 (2000). (10.1038/73464) / Nature Genet. by MA Kay (2000)
  28. Summerford, C. & Samulski, R.J. Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J. Virol. 72, 1438–1445 (1998). (10.1128/JVI.72.2.1438-1445.1998) / J. Virol. by C Summerford (1998)
  29. Pruchnic, R. et al. The use of adeno-associated virus to circumvent the maturation- dependent viral transduction of muscle fibers. Hum. Gene Ther. 11, 521–536 (2000). (10.1089/10430340050015716) / Hum. Gene Ther. by R Pruchnic (2000)
  30. Asundi, V.K., Keister, B.F., Stahl, R.C. & Carey, D.J. Developmental and cell-type-specific expression of cell surface heparan sulfate proteoglycans in the rat heart. Exp. Cell Res. 230, 145–153 (1997). (10.1006/excr.1996.3400) / Exp. Cell Res. by VK Asundi (1997)
  31. Snyder, R.O. et al. Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors. Nature Genet. 16, 270–276 (1997). (10.1038/ng0797-270) / Nature Genet. by RO Snyder (1997)
  32. Nakai, H. et al. Adeno-associated viral vector-mediated gene transfer of human blood coagulation factor IX into mouse liver. Blood 91, 4600–4607 (1998). (10.1182/blood.V91.12.4600) / Blood by H Nakai (1998)
  33. Coral-Vazquez, R. et al. Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. Cell 98, 465–474 (1999). (10.1016/S0092-8674(00)81975-3) / Cell by R Coral-Vazquez (1999)
  34. Xiao, X., Li, J. & Samulski, R.J. Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J. Virol. 72, 2224–2232 (1998). (10.1128/JVI.72.3.2224-2232.1998) / J. Virol. by X Xiao (1998)
  35. Auricchio, A., Hildinger, M., O'Connor, E., Gao, G.P. & Wilson, J.M. Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column. Hum. Gene Ther. 12, 71–76 (2001). (10.1089/104303401450988) / Hum. Gene Ther. by A Auricchio (2001)
  36. Frank, K., Tilgmann, C., Shannon, T.R., Bers, D.M. & Kranias, E.G. Regulatory role of phospholamban in the efficiency of cardiac sarcoplasmic reticulum Ca2+ transport. Biochemistry 39, 14176–14182 (2000). (10.1021/bi001049k) / Biochemistry by K Frank (2000)
  37. Jackson, W.A. & Colyer, J. Translation of Ser16 and Thr17 phosphorylation of phospholamban into Ca2+-pump stimulation. Biochem. J. 316, 201–207 (1996). (10.1042/bj3160201) / Biochem. J. by WA Jackson (1996)
  38. Christensen, G., Minamisawa, S., Gruber, P.J., Wang, Y. & Chien, K.R. High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates. Circulation 101, 178–184 (2000). (10.1161/01.CIR.101.2.178) / Circulation by G Christensen (2000)
Dates
Type When
Created 23 years, 1 month ago (July 28, 2002, 5:36 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 6:32 p.m.)
Indexed 2 weeks, 5 days ago (Aug. 19, 2025, 5:56 a.m.)
Issued 23 years, 1 month ago (July 22, 2002)
Published 23 years, 1 month ago (July 22, 2002)
Published Online 23 years, 1 month ago (July 22, 2002)
Published Print 23 years, 1 month ago (Aug. 1, 2002)
Funders 0

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@article{Hoshijima_2002, title={Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery}, volume={8}, ISSN={1546-170X}, url={http://dx.doi.org/10.1038/nm739}, DOI={10.1038/nm739}, number={8}, journal={Nature Medicine}, publisher={Springer Science and Business Media LLC}, author={Hoshijima, Masahiko and Ikeda, Yasuhiro and Iwanaga, Yoshitaka and Minamisawa, Susumu and Date, Moto-o and Gu, Yusu and Iwatate, Mitsuo and Li, Manxiang and Wang, Lili and Wilson, James M. and Wang, Yibin and Ross, John and Chien, Kenneth R.}, year={2002}, month=jul, pages={864–871} }