Bibliography
Okamoto, S., Pouladi, M. A., Talantova, M., Yao, D., Xia, P., Ehrnhoefer, D. E., Zaidi, R., Clemente, A., Kaul, M., Graham, R. K., Zhang, D., Vincent Chen, H.-S., Tong, G., Hayden, M. R., & Lipton, S. A. (2009). Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nature Medicine, 15(12), 1407â1413.
Authors
15
- Shu-ichi Okamoto (first)
- Mahmoud A Pouladi (additional)
- Maria Talantova (additional)
- Dongdong Yao (additional)
- Peng Xia (additional)
- Dagmar E Ehrnhoefer (additional)
- Rameez Zaidi (additional)
- Arjay Clemente (additional)
- Marcus Kaul (additional)
- Rona K Graham (additional)
- Dongxian Zhang (additional)
- H-S Vincent Chen (additional)
- Gary Tong (additional)
- Michael R Hayden (additional)
- Stuart A Lipton (additional)
References
43
Referenced
358
-
The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72, 971–983 (1993).
(
10.1016/0092-8674(93)90585-E
) / Cell by M MACDONALD (1993) -
DiFiglia, M. et al. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277, 1990–1993 (1997).
(
10.1126/science.277.5334.1990
) / Science by M DiFiglia (1997) -
Ciechanover, A. & Brundin, P. The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron 40, 427–446 (2003).
(
10.1016/S0896-6273(03)00606-8
) / Neuron by A Ciechanover (2003) -
Beal, M.F. et al. Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Nature 321, 168–171 (1986).
(
10.1038/321168a0
) / Nature by MF Beal (1986) -
Ferrante, R.J. et al. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J. Neurosci. 22, 1592–1599 (2002).
(
10.1523/JNEUROSCI.22-05-01592.2002
) / J. Neurosci. by RJ Ferrante (2002) -
Zeron, M.M. et al. Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron 33, 849–860 (2002).
(
10.1016/S0896-6273(02)00615-3
) / Neuron by MM Zeron (2002) -
Heng, M.Y., Detloff, P.J., Wang, P.L., Tsien, J.Z. & Albin, R.L. In vivo evidence for NMDA receptor–mediated excitotoxicity in a murine genetic model of Huntington disease. J. Neurosci. 29, 3200–3205 (2009).
(
10.1523/JNEUROSCI.5599-08.2009
) / J. Neurosci. by MY Heng (2009) -
Slow, E.J. et al. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Hum. Mol. Genet. 12, 1555–1567 (2003).
(
10.1093/hmg/ddg169
) / Hum. Mol. Genet. by EJ Slow (2003) -
Lipton, S.A. Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat. Rev. Drug Discov. 5, 160–170 (2006).
(
10.1038/nrd1958
) / Nat. Rev. Drug Discov. by SA Lipton (2006) -
Lipton, S.A. Pathologically activated therapeutics for neuroprotection. Nat. Rev. Neurosci. 8, 803–808 (2007).
(
10.1038/nrn2229
) / Nat. Rev. Neurosci. by SA Lipton (2007) -
Hardingham, G.E., Fukunaga, Y. & Bading, H. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat. Neurosci. 5, 405–414 (2002).
(
10.1038/nn835
) / Nat. Neurosci. by GE Hardingham (2002) -
Li, L., Murphy, T.H., Hayden, M.R. & Raymond, L.A. Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor–mediated synaptic currents in a mouse model of Huntington disease. J. Neurophysiol. 92, 2738–2746 (2004).
(
10.1152/jn.00308.2004
) / J. Neurophysiol. by L Li (2004) -
Pickett, J. Folding away the bad guys. Nat. Rev. Neurosci. 7, 832–833 (2006).
(
10.1038/nrn2034
) / Nat. Rev. Neurosci. by J Pickett (2006) -
Tam, S., Geller, R., Spiess, C. & Frydman, J. The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions. Nat. Cell Biol. 8, 1155–1162 (2006).
(
10.1038/ncb1477
) / Nat. Cell Biol. by S Tam (2006) -
Melville, M.W., McClellan, A.J., Meyer, A.S., Darveau, A. & Frydman, J. The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex. Mol. Cell. Biol. 23, 3141–3151 (2003).
(
10.1128/MCB.23.9.3141-3151.2003
) / Mol. Cell. Biol. by MW Melville (2003) -
Behrends, C. et al. TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. Mol. Cell 23, 887–897 (2006).
(
10.1016/j.molcel.2006.08.017
) / Mol. Cell by C Behrends (2006) -
Kitamura, A. et al. Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state. Nat. Cell Biol. 8, 1163–1170 (2006).
(
10.1038/ncb1478
) / Nat. Cell Biol. by A Kitamura (2006) -
King, M.A. et al. Cytoplasmic inclusions of Htt exon1 containing an expanded polyglutamine tract suppress execution of apoptosis in sympathetic neurons. J. Neurosci. 28, 14401–14415 (2008).
(
10.1523/JNEUROSCI.4751-08.2008
) / J. Neurosci. by MA King (2008) -
Davies, S.W. et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90, 537–548 (1997).
(
10.1016/S0092-8674(00)80513-9
) / Cell by SW Davies (1997) -
Saudou, F., Finkbeiner, S., Devys, D. & Greenberg, M.E. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 95, 55–66 (1998).
(
10.1016/S0092-8674(00)81782-1
) / Cell by F Saudou (1998) -
Tsai, J., Grutzendler, J., Duff, K. & Gan, W.B. Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat. Neurosci. 7, 1181–1183 (2004).
(
10.1038/nn1335
) / Nat. Neurosci. by J Tsai (2004) -
Arrasate, M., Mitra, S., Schweitzer, E.S., Segal, M.R. & Finkbeiner, S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431, 805–810 (2004).
(
10.1038/nature02998
) / Nature by M Arrasate (2004) -
Sánchez, I., Mahlke, C. & Yuan, J. Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature 421, 373–379 (2003).
(
10.1038/nature01301
) / Nature by I Sánchez (2003) -
Friedlander, R.M. Apoptosis and caspases in neurodegenerative diseases. N. Engl. J. Med. 348, 1365–1375 (2003).
(
10.1056/NEJMra022366
) / N. Engl. J. Med. by RM Friedlander (2003) -
Tovar, K.R. & Westbrook, G.L. The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J. Neurosci. 19, 4180–4188 (1999).
(
10.1523/JNEUROSCI.19-10-04180.1999
) / J. Neurosci. by KR Tovar (1999) -
Lipton, S.A. & Rosenberg, P.A. Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613–622 (1994).
(
10.1056/NEJM199403033300907
) / N. Engl. J. Med. by SA Lipton (1994) -
Fellin, T. et al. Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. Neuron 43, 729–743 (2004).
(
10.1016/j.neuron.2004.08.011
) / Neuron by T Fellin (2004) -
Tian, G.F. et al. An astrocytic basis of epilepsy. Nat. Med. 11, 973–981 (2005).
(
10.1038/nm1277
) / Nat. Med. by GF Tian (2005) -
Subramaniam, S., Sixt, K.M., Barrow, R. & Snyder, S.H. Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science 324, 1327–1330 (2009).
(
10.1126/science.1172871
) / Science by S Subramaniam (2009) -
Nucifora, F.C., Jr. et al. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science 291, 2423–2428 (2001).
(
10.1126/science.1056784
) / Science by FC Nucifora Jr. (2001) -
McGill, J.K. & Beal, M.F. PGC-1α, a new therapeutic target in Huntington's disease? Cell 127, 465–468 (2006).
(
10.1016/j.cell.2006.10.023
) / Cell by JK McGill (2006) -
Chen, H.S. et al. Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J. Neurosci. 12, 4427–4436 (1992).
(
10.1523/JNEUROSCI.12-11-04427.1992
) / J. Neurosci. by HS Chen (1992) -
Hesselink, M.B., De Boer, B.G., Breimer, D.D. & Danysz, W. Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine: a quantitative microdialysis study. Pharm. Res. 16, 637–642 (1999).
(
10.1023/A:1018856020583
) / Pharm. Res. by MB Hesselink (1999) -
Parsons, C.G., Stöffler, A. & Danysz, W. Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system—too little activation is bad, too much is even worse. Neuropharmacology 53, 699–723 (2007).
(
10.1016/j.neuropharm.2007.07.013
) / Neuropharmacology by CG Parsons (2007) -
Gutekunst, C.A. et al. Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology. J. Neurosci. 19, 2522–2534 (1999).
(
10.1523/JNEUROSCI.19-07-02522.1999
) / J. Neurosci. by CA Gutekunst (1999) -
Vonsattel, J.P. et al. Neuropathological classification of Huntington's disease. J. Neuropathol. Exp. Neurol. 44, 559–577 (1985).
(
10.1097/00005072-198511000-00003
) / J. Neuropathol. Exp. Neurol. by JP Vonsattel (1985) -
Cui, L. et al. Transcriptional repression of PGC-1α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell 127, 59–69 (2006).
(
10.1016/j.cell.2006.09.015
) / Cell by L Cui (2006) -
Papadia, S., Stevenson, P., Hardingham, N.R., Bading, H. & Hardingham, G.E. Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection. J. Neurosci. 25, 4279–4287 (2005).
(
10.1523/JNEUROSCI.5019-04.2005
) / J. Neurosci. by S Papadia (2005) -
Soriano, F.X. et al. Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. J. Neurosci. 26, 4509–4518 (2006).
(
10.1523/JNEUROSCI.0455-06.2006
) / J. Neurosci. by FX Soriano (2006) -
Beister, A. et al. The N-methyl-D-aspartate antagonist memantine retards progression of Huntington's disease. J. Neural Transm. Suppl. 68, 117–122 (2004).
(
10.1007/978-3-7091-0579-5_14
) / J. Neural Transm. Suppl. by A Beister (2004) -
Okamoto, S.-i. et al. Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proc. Natl. Acad. Sci. USA 99, 3974–3979 (2002).
(
10.1073/pnas.022036399
) / Proc. Natl. Acad. Sci. USA by S-i Okamoto (2002) -
Lei, S.Z. et al. Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron 8, 1087–1099 (1992).
(
10.1016/0896-6273(92)90130-6
) / Neuron by SZ Lei (1992) -
Van Raamsdonk, J.M. et al. Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease. J. Neurosci. 25, 4169–4180 (2005).
(
10.1523/JNEUROSCI.0590-05.2005
) / J. Neurosci. by JM Van Raamsdonk (2005)
Dates
Type | When |
---|---|
Created | 15 years, 8 months ago (Dec. 4, 2009, 2:09 p.m.) |
Deposited | 2 years, 3 months ago (May 18, 2023, 6:24 p.m.) |
Indexed | 2 days, 5 hours ago (Aug. 30, 2025, 1:13 p.m.) |
Issued | 15 years, 9 months ago (Nov. 15, 2009) |
Published | 15 years, 9 months ago (Nov. 15, 2009) |
Published Online | 15 years, 9 months ago (Nov. 15, 2009) |
Published Print | 15 years, 9 months ago (Dec. 1, 2009) |
@article{Okamoto_2009, title={Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin}, volume={15}, ISSN={1546-170X}, url={http://dx.doi.org/10.1038/nm.2056}, DOI={10.1038/nm.2056}, number={12}, journal={Nature Medicine}, publisher={Springer Science and Business Media LLC}, author={Okamoto, Shu-ichi and Pouladi, Mahmoud A and Talantova, Maria and Yao, Dongdong and Xia, Peng and Ehrnhoefer, Dagmar E and Zaidi, Rameez and Clemente, Arjay and Kaul, Marcus and Graham, Rona K and Zhang, Dongxian and Vincent Chen, H-S and Tong, Gary and Hayden, Michael R and Lipton, Stuart A}, year={2009}, month=nov, pages={1407–1413} }