DOI: 10.1038/ni904. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

10.1038/ni904

Crossref journal-article

Springer Science and Business Media LLC

Nature Immunology (297)

Bibliography

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003). Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nature Immunology, 4(4), 330â336.

Authors 3

Jason D. Fontenot (first)
Marc A. Gavin (additional)
Alexander Y. Rudensky (additional)

References 26 Referenced 6,068

Sakaguchi, S. et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182, 18–32 (2001). (10.1034/j.1600-065X.2001.1820102.x) / Immunol. Rev. by S Sakaguchi (2001)
Shevach, E.M. CD4+ CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2, 389–400 (2002). (10.1038/nri821) / Nat. Rev. Immunol. by EM Shevach (2002)
Maloy, K.J. & Powrie, F. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2, 816–822 (2001). (10.1038/ni0901-816) / Nat. Immunol. by KJ Maloy (2001)
Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 1151–1164 (1995). (10.4049/jimmunol.155.3.1151) / J. Immunol. by S Sakaguchi (1995)
Gavin, M.A., Clarke, S.R., Negrou, E., Gallegos, A. & Rudensky, A. Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat. Immunol. 3, 33–41 (2002). (10.1038/ni743) / Nat. Immunol. by MA Gavin (2002)
Brunkow, M.E. et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27, 68–73 (2001). (10.1038/83784) / Nat. Genet. by ME Brunkow (2001)
Lyon, M.F., Peters, J., Glenister, P.H., Ball, S. & Wright, E. The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome. Proc. Natl. Acad. Sci. USA 87, 2433–2437 (1990). (10.1073/pnas.87.7.2433) / Proc. Natl. Acad. Sci. USA by MF Lyon (1990)
Kanangat, S. et al. Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genes. Eur. J. Immunol. 26, 161–165 (1996). (10.1002/eji.1830260125) / Eur. J. Immunol. by S Kanangat (1996)
Blair, P.J. et al. CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse. J. Immunol. 153, 3764–3774 (1994). (10.4049/jimmunol.153.8.3764) / J. Immunol. by PJ Blair (1994)
Clark, L.B. et al. Cellular and molecular characterization of the scurfy mouse mutant. J. Immunol. 162, 2546–2554 (1999). (10.4049/jimmunol.162.5.2546) / J. Immunol. by LB Clark (1999)
Chatila, T.A. et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J. Clin. Invest. 106, R75–81 (2000). (10.1172/JCI11679) / J. Clin. Invest. by TA Chatila (2000)
Bennett, C.L. et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27, 20–21 (2001). (10.1038/83713) / Nat. Genet. by CL Bennett (2001)
Wildin, R.S. et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 27, 18–20 (2001). (10.1038/83707) / Nat. Genet. by RS Wildin (2001)
Tommasini, A. et al. X-chromosome inactivation analysis in a female carrier of FOXP3 mutation. Clin. Exp. Immunol. 130, 127–130 (2002). (10.1046/j.1365-2249.2002.01940.x) / Clin. Exp. Immunol. by A Tommasini (2002)
Schubert, L.A., Jeffery, E., Zhang, Y., Ramsdell, F. & Ziegler, S.F. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem. 276, 37672–37679 (2001). (10.1074/jbc.M104521200) / J. Biol. Chem. by LA Schubert (2001)
Murakami, M., Sakamoto, A., Bender, J., Kappler, J. & Marrack, P. CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proc. Natl. Acad. Sci. USA 99, 8832–8837 (2002). (10.1073/pnas.132254399) / Proc. Natl. Acad. Sci. USA by M Murakami (2002)
Asseman, C., Mauze, S., Leach, M.W., Coffman, R.L. & Powrie, F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190, 995–1004 (1999). (10.1084/jem.190.7.995) / J. Exp. Med. by C Asseman (1999)
Powrie, F., Leach, M.W., Mauze, S., Caddle, L.B. & Coffman, R.L. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int. Immunol. 5, 1461–1471 (1993). (10.1093/intimm/5.11.1461) / Int. Immunol. by F Powrie (1993)
Malek, T.R., Yu, A., Vincek, V., Scibelli, P. & Kong, L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17, 167–178 (2002). (10.1016/S1074-7613(02)00367-9) / Immunity by TR Malek (2002)
Almeida, A.R., Legrand, N., Papiernik, M. & Freitas, A.A. Homeostasis of peripheral CD4+ T cells: IL-2R α and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J. Immunol. 169, 4850–4860 (2002). (10.4049/jimmunol.169.9.4850) / J. Immunol. by AR Almeida (2002)
Jordan, M.S. et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2, 301–306 (2001). (10.1038/86302) / Nat. Immunol. by MS Jordan (2001)
Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3, 756–763 (2002). (10.1038/ni816) / Nat. Immunol. by I Apostolou (2002)
Grubin, C.E., Kovats, S., deRoos, P. & Rudensky, A.Y. Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity 7, 197–208 (1997). (10.1016/S1074-7613(00)80523-3) / Immunity by CE Grubin (1997)
Barton, G.M. & Rudensky, A.Y. Requirement for diverse, low-abundance peptides in positive selection of T cells. Science 283, 67–70 (1999). (10.1126/science.283.5398.67) / Science by GM Barton (1999)
Farley, F.W., Soriano, P., Steffen, L.S. & Dymecki, S.M. Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28, 106–110 (2000). (10.1002/1526-968X(200011/12)28:3/4<106::AID-GENE30>3.0.CO;2-T) / Genesis by FW Farley (2000)
Deftos, M.L., He, Y.W., Ojala, E.W. & Bevan, M.J. Correlating notch signaling with thymocyte maturation. Immunity 9, 777–786 (1998). (10.1016/S1074-7613(00)80643-3) / Immunity by ML Deftos (1998)

Dates

Type	When
Created	22 years, 5 months ago (March 26, 2003, 5:48 p.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 6:53 p.m.)
Indexed	2 hours, 5 minutes ago (Sept. 4, 2025, 9:13 a.m.)
Issued	22 years, 6 months ago (March 3, 2003)
Published	22 years, 6 months ago (March 3, 2003)
Published Online	22 years, 6 months ago (March 3, 2003)
Published Print	22 years, 5 months ago (April 1, 2003)

Funders 0

None

BibTeX

@article{Fontenot_2003, title={Foxp3 programs the development and function of CD4+CD25+ regulatory T cells}, volume={4}, ISSN={1529-2916}, url={http://dx.doi.org/10.1038/ni904}, DOI={10.1038/ni904}, number={4}, journal={Nature Immunology}, publisher={Springer Science and Business Media LLC}, author={Fontenot, Jason D. and Gavin, Marc A. and Rudensky, Alexander Y.}, year={2003}, month=mar, pages={330–336} }

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