TOX: an HMG box protein implicated in the regulation of thymocyte selection
10.1038/ni767
Crossref journal-article
Springer Science and Business Media LLC
Nature Immunology (297)
Bibliography

Wilkinson, B., Chen, J. Y.-F., Han, P., Rufner, K. M., Goularte, O. D., & Kaye, J. (2002). TOX: an HMG box protein implicated in the regulation of thymocyte selection. Nature Immunology, 3(3), 272–280.

Authors 6
  1. Beverley Wilkinson (first)
  2. Jeff Y.-F. Chen (additional)
  3. Peggy Han (additional)
  4. Kevin M. Rufner (additional)
  5. Olivia D. Goularte (additional)
  6. Jonathan Kaye (additional)
References 61 Referenced 147
  1. Sebzda, E. et al. Selection of the T cell repertoire. Annu. Rev. Immunol. 17, 829–874 (1999). (10.1146/annurev.immunol.17.1.829) / Annu. Rev. Immunol. by E Sebzda (1999)
  2. Basson, M. A. & Zamoyska, R. The CD4/CD8 lineage decision: integration of signaling pathways. Immunol. Today 21, 509–514 (2000). (10.1016/S0167-5699(00)01711-4) / Immunol. Today by MA Basson (2000)
  3. Shao, H., Wilkinson, B., Lee, B., Han, P. C. & Kaye, J. Slow accumulation of active mitogen-activated protein kinase during thymocyte differentiation regulates the temporal pattern of transcription factor gene expression. J. Immunol. 163, 603–610 (1999). (10.4049/jimmunol.163.2.603) / J. Immunol. by H Shao (1999)
  4. Wilkinson, B. & Kaye, J. Requirement for sustained MAPK signaling in both CD4 and CD8 lineage commitment: a threshold model. Cell. Immunol. 211, 86–95 (2001). (10.1006/cimm.2001.1827) / Cell. Immunol. by B Wilkinson (2001)
  5. Wen, L., Huang, J. K., Johnson, B. H. & Reeck, G. R. A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1. Nucleic Acids Res. 17, 1197–1214 (1989). (10.1093/nar/17.3.1197) / Nucleic Acids Res. by L Wen (1989)
  6. Jantzen, H. M., Admon, A., Bell, S. P. & Tjian, R. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. Nature 344, 830–836 (1990). (10.1038/344830a0) / Nature by HM Jantzen (1990)
  7. Gubbay, J. et al. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature 346, 245–250 (1990). (10.1038/346245a0) / Nature by J Gubbay (1990)
  8. Sinclair, A. H. et al. A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 346, 240–244 (1990). (10.1038/346240a0) / Nature by AH Sinclair (1990)
  9. Soullier, S. et al. Diversification pattern of the HMG and SOX family members during evolution. Mol. Evol. 48, 517–527 (1999). (10.1007/PL00006495) / Mol. Evol. by S Soullier (1999)
  10. Oosterwegel, M. et al. Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor α enhancers. J. Exp. Med. 173, 1133–1142 (1991). (10.1084/jem.173.5.1133) / J. Exp. Med. by M Oosterwegel (1991)
  11. Travis, A., Amsterdam, A., Belanger, C. & Grosschedl, R. LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor α enhancer function. Genes Dev. 5, 880–894 (1991). (10.1101/gad.5.5.880) / Genes Dev. by A Travis (1991)
  12. van de Wetering, M., Oosterwegel, M., Dooijes, D. & Clevers, H. Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. EMBO J. 10, 123–132 (1991). (10.1002/j.1460-2075.1991.tb07928.x) / EMBO J. by M van de Wetering (1991)
  13. Waterman, M. L., Fischer, W. H. & Jones, K. A. A thymus-specific member of the HMG protein family regulates the human T cell receptor C α enhancer. Genes Dev. 5, 656–669 (1991). (10.1101/gad.5.4.656) / Genes Dev. by ML Waterman (1991)
  14. Bianchi, M. E. & Beltrame, M. Flexing DNA: HMG-box proteins and their partners. Am. J. Hum. Genet. 63, 1573–1577 (1998). (10.1086/302170) / Am. J. Hum. Genet. by ME Bianchi (1998)
  15. Iwata, M., Kuwata, T., Mukai, M., Tozawa, Y. & Yokoyama, M. Differential induction of helper and killer T cells from isolated CD4+CD8+ thymocytes in suspension culture. Eur. J. Immunol. 26, 2081–2086 (1996). (10.1002/eji.1830260918) / Eur. J. Immunol. by M Iwata (1996)
  16. Ohoka, Y. et al. In vitro differentiation and commitment of CD4+CD8+ thymocytes to the CD4 lineage without TCR engagement. Int. Immunol. 8, 297–306 (1996). (10.1093/intimm/8.3.297) / Int. Immunol. by Y Ohoka (1996)
  17. Ohaka, Y. et al. Regulation of thymocyte lineage commitment by the level of classical protein kinase C activity. J. Immunol. 158, 5707–5716 (1997). (10.4049/jimmunol.158.12.5707) / J. Immunol. by Y Ohaka (1997)
  18. Takahama, Y. & Nakauchi, H. Phorbol ester and calcium ionophore can replace TCR signals that induce positive selection of CD4 T cells. J. Immunol. 157, 1508–1513 (1996). (10.4049/jimmunol.157.4.1508) / J. Immunol. by Y Takahama (1996)
  19. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. Basic local alignment search tool. J. Mol. Biol. 215, 403–410 (1990). (10.1016/S0022-2836(05)80360-2) / J. Mol. Biol. by SF Altschul (1990)
  20. Madden, T. L., Tatusov, R. L. & Zhang, J. Applications of network BLAST server. Meth. Enzymol. 266, 131–141 (1996). (10.1016/S0076-6879(96)66011-X) / Meth. Enzymol. by TL Madden (1996)
  21. Nagase, T. et al. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 5, 277–286 (1998). (10.1093/dnares/5.5.277) / DNA Res. by T Nagase (1998)
  22. Robbins, J., Dilworth, S. M., Laskey, R. A. & Dingwall, C. Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell 64, 615–623 (1991). (10.1016/0092-8674(91)90245-T) / Cell by J Robbins (1991)
  23. Suzuki, H., Punt, J. A., Granger, L. G. & Singer, A. Asymmetric signaling requirements for thymocyte commitment to the CD4+versus CD8+ T cell lineages: a new perspective on thymic commitment and selection. Immunity 2, 413–425 (1995). (10.1016/1074-7613(95)90149-3) / Immunity by H Suzuki (1995)
  24. Lucas, B. & Germain, R. N. Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4+CD8+ thymocyte differentiation. Immunity 5, 461–477 (1996). (10.1016/S1074-7613(00)80502-6) / Immunity by B Lucas (1996)
  25. Mombaerts, P. et al. Mutations in T cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360, 225–231 (1992). (10.1038/360225a0) / Nature by P Mombaerts (1992)
  26. Kaye, J. et al. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341, 746–749 (1989). (10.1038/341746a0) / Nature by J Kaye (1989)
  27. Sha, W. C. et al. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice. Nature 336, 271–274 (1988). (10.1038/335271a0) / Nature by WC Sha (1988)
  28. Grusby, M. J. et al. Mice lacking major histocompatibility complex class I and class II molecules. Proc. Natl Acad. Sci. USA 90, 3913–3917 (1993). (10.1073/pnas.90.9.3913) / Proc. Natl Acad. Sci. USA by MJ Grusby (1993)
  29. Pérarnau, B. et al. Single H2Kb, H2Db and double H2KbDb knockout mice: peripheral CD8+ T cell repertoire and antilymphocytic choriomeningitis virus cytolytic responses. Eur. J. Immunol. 29, 1243–1252 (1999). (10.1002/(SICI)1521-4141(199904)29:04<1243::AID-IMMU1243>3.0.CO;2-A) / Eur. J. Immunol. by B Pérarnau (1999)
  30. Grusby, M. J., Johnson, R. S., Papaioannou, V. E. & Glimcher, L. H. Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science 253, 1417–1420 (1991). (10.1126/science.1910207) / Science by MJ Grusby (1991)
  31. Yamashita, I., Nagata, T., Tada, T. & Nakayama, T. CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection. Int. Immunol. 5, 1139–1150 (1993). (10.1093/intimm/5.9.1139) / Int. Immunol. by I Yamashita (1993)
  32. Godfrey, D. I., Kennedy, J., Suda, T. & Zlotnik A. A developmental pathway involving four phenotypically and functionally distinct subsets of CD3−CD4−CD8− triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150, 4244–4252 (1993). (10.4049/jimmunol.150.10.4244) / J. Immunol. by DI Godfrey (1993)
  33. Godfrey, D. I., Kennedy, J., Mombaerts, P., Tonegawa, S. & Zlotnik, A. Onset of TCR-β gene rearrangement and role of TCR-β expression during CD3−CD4−CD8− thymocyte differentiation. J. Immunol. 152, 4783–4792 (1994). (10.4049/jimmunol.152.10.4783) / J. Immunol. by DI Godfrey (1994)
  34. Penit, C., Lucas, B. & Vasseur, F. Cell expansion and growth arrest phases during the transition from precursor (CD4−8−) to immature (CD4+8+) thymocytes in normal and genetically modified mice. J. Immunol. 154, 5103–5113 (1995). (10.4049/jimmunol.154.10.5103) / J. Immunol. by C Penit (1995)
  35. Shinkai, Y. et al. RAG-2 deficient mice lack mature lymphocytes owing to inability to initiateV(D)J rearrangement. Cell 68, 855–867 (1992). (10.1016/0092-8674(92)90029-C) / Cell by Y Shinkai (1992)
  36. Shao, H., Kono, D. H., Chen, L-Y., Rubin, E. M. & Kaye, J. Induction of the early growth response (Egr) family of transcription factors during thymic selection. J. Exp. Med. 185, 731–744 (1997). (10.1084/jem.185.4.731) / J. Exp. Med. by H Shao (1997)
  37. Linette, G. P. et al. Bcl-2 is upregulated at the CD4+CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1, 197–205 (1994). (10.1016/1074-7613(94)90098-1) / Immunity by GP Linette (1994)
  38. Tao, W. et al. The T cell receptor repertoire of CD4−CD8+ thymocytes is altered by overexpression of the bcl-2 protooncogene in the thymus. J. Exp. Med. 179, 145–153 (1994). (10.1084/jem.179.1.145) / J. Exp. Med. by W Tao (1994)
  39. Deftos, M. L., He, Y. W., Ojala, E. W. & Bevan, M. J. Correlating notch signaling with thymocyte maturation. Immunity 9, 777–786 (1998). (10.1016/S1074-7613(00)80643-3) / Immunity by ML Deftos (1998)
  40. Jameson, S. C., Kaye, J. & Gascoigne, N. R. A T cell receptor V α region selectively expressed in CD4+ cells. J. Immunol. 145, 1324–1331 (1990). (10.4049/jimmunol.145.5.1324) / J. Immunol. by SC Jameson (1990)
  41. Utsunomiya, Y. et al. Analysis of a monoclonal rat antibody directed to the α-chain variable region (V α 3) of the mouse T cell antigen receptor. J. Immunol. 143, 2602–2608 (1989). (10.4049/jimmunol.143.8.2602) / J. Immunol. by Y Utsunomiya (1989)
  42. Yasutomo, K. et al. The duration of antigen receptor signalling determines CD4+versus CD8+ T-cell lineage fate. Nature 404, 506–510 (2000). (10.1038/35006664) / Nature by K Yasutomo (2000)
  43. Brugnera, E. et al. Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells. Immunity 13, 59–71 (2000). (10.1016/S1074-7613(00)00008-X) / Immunity by E Brugnera (2000)
  44. Tarakhovsky, A., Muller, W. & Rajewsky, K. Lymphocyte populations and immune responses in CD5-deficient mice. Eur. J. Immunol. 24, 1678–1684 (1994). (10.1002/eji.1830240733) / Eur. J. Immunol. by A Tarakhovsky (1994)
  45. Tarakhovsky, A. et al. A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science 269, 535–537 (1995). (10.1126/science.7542801) / Science by A Tarakhovsky (1995)
  46. Pena-Rossi, C. et al. Negative regulation of CD4 lineage development and responses by CD5. J. Immunol. 163, 6494–6501 (1999). (10.4049/jimmunol.163.12.6494) / J. Immunol. by C Pena-Rossi (1999)
  47. Azzam, H. S. et al. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 188, 2301–2311 (1998). (10.1084/jem.188.12.2301) / J. Exp. Med. by HS Azzam (1998)
  48. Azzam, H. S. et al. Fine tuning of TCR signaling by CD5. J. Immunol. 166, 5464–5472 (2001). (10.4049/jimmunol.166.9.5464) / J. Immunol. by HS Azzam (2001)
  49. Shimonkevitz, R., Kappler, J., Marrack, P. & Grey, H. Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing. J. Exp. Med. 158, 303–316 (1983). (10.1084/jem.158.2.303) / J. Exp. Med. by R Shimonkevitz (1983)
  50. Murphy, K. M., Heimberger, A. B. & Loh, D. Y. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250, 1720–1723 (1990). (10.1126/science.2125367) / Science by KM Murphy (1990)
  51. Liu, C. P., Kappler, J. W. & Marrack, P. Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage. J. Exp. Med. 184, 1619–1630 (1996). (10.1084/jem.184.5.1619) / J. Exp. Med. by CP Liu (1996)
  52. Koller, B. H., Marrack, P., Kappler, J. W. & Smithies, O. Normal development of mice deficient in β2m MHC class I proteins and CD8+ T cells. Science 248, 1227–1230 (1990). (10.1126/science.2112266) / Science by BH Koller (1990)
  53. Zijlstra, M. et al. β2-microglobulin deficient mice lack CD4−8+ cytolytic T cells. Nature 344,742–746 (1990). (10.1038/344742a0) / Nature by M Zijlstra (1990)
  54. Kolodrubetz, D. & Burgum, A. Duplicated NHP6 genes of Saccharomyces cerevisiae encode proteins homologous to bovine high mobility group protein 1. J. Biol. Chem. 265, 3234–3239 (1990). (10.1016/S0021-9258(19)39758-3) / J. Biol. Chem. by D Kolodrubetz (1990)
  55. Margolis, R. L. et al. cDNAs with long CAG trinucleotide repeats from human brain. Hum. Genet. 100, 114–122 (1997). (10.1007/s004390050476) / Hum. Genet. by RL Margolis (1997)
  56. Kuo, C. T. & Leiden, J. M. Transcriptional regulation of T lymphocyte development and function. Annu. Rev. Immunol. 17, 149–187 (1999). (10.1146/annurev.immunol.17.1.149) / Annu. Rev. Immunol. by CT Kuo (1999)
  57. Ioannidis, V., Beermann, F., Clevers, H. & Held, W. The β-catenin-TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival. Nature Immunol. 2, 691–697 (2001). (10.1038/90623) / Nature Immunol. by V Ioannidis (2001)
  58. Winandy, S., Wu, L., Wang, J. H. & Georgopoulos, K. Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros. J. Exp. Med. 190, 1039–1048 (1999). (10.1084/jem.190.8.1039) / J. Exp. Med. by S Winandy (1999)
  59. Avitahl, N. et al. Ikaros sets thresholds for T cell activation and regulates chromosome propagation. Immunity 10, 333–343 (1999). (10.1016/S1074-7613(00)80033-3) / Immunity by N Avitahl (1999)
  60. Dutz, J. P., Ong, C. J., Marth, J. & Teh, H. S. Distinct differentiative stages of CD4+CD8+ thymocyte development defined by the lack of coreceptor binding in positive selection. J. Immunol. 154, 2588–2599 (1995). (10.4049/jimmunol.154.6.2588) / J. Immunol. by JP Dutz (1995)
  61. Chaffin, K. E. et al. Dissection of thymocyte signaling pathways by in vivo expression of pertussis toxin ADP-ribosyltransferase. EMBO J. 9, 3821–3829 (1990). (10.1002/j.1460-2075.1990.tb07600.x) / EMBO J. by KE Chaffin (1990)
Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 4:30 a.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 6:50 p.m.)
Indexed 2 months ago (June 30, 2025, 5:23 a.m.)
Issued 23 years, 6 months ago (Feb. 19, 2002)
Published 23 years, 6 months ago (Feb. 19, 2002)
Published Online 23 years, 6 months ago (Feb. 19, 2002)
Published Print 23 years, 6 months ago (March 1, 2002)
Funders 0

None

@article{Wilkinson_2002, title={TOX: an HMG box protein implicated in the regulation of thymocyte selection}, volume={3}, ISSN={1529-2916}, url={http://dx.doi.org/10.1038/ni767}, DOI={10.1038/ni767}, number={3}, journal={Nature Immunology}, publisher={Springer Science and Business Media LLC}, author={Wilkinson, Beverley and Chen, Jeff Y.-F. and Han, Peggy and Rufner, Kevin M. and Goularte, Olivia D. and Kaye, Jonathan}, year={2002}, month=feb, pages={272–280} }