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Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005). IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nature Immunology, 6(10), 981–988.

Authors 9
  1. Taro Kawai (first)
  2. Ken Takahashi (additional)
  3. Shintaro Sato (additional)
  4. Cevayir Coban (additional)
  5. Himanshu Kumar (additional)
  6. Hiroki Kato (additional)
  7. Ken J Ishii (additional)
  8. Osamu Takeuchi (additional)
  9. Shizuo Akira (additional)
References 38 Referenced 2,143
  1. Janeway, C.A. Jr. & Medzhitov, R. Innate immune recognition. Annu. Rev. Immunol. 20, 197–216 (2002). (10.1146/annurev.immunol.20.083001.084359) / Annu. Rev. Immunol. by CA Janeway Jr. (2002)
  2. Takeda, K., Kaisho, T. & Akira, S. Toll-like receptors. Annu. Rev. Immunol. 21, 335–376 (2003). (10.1146/annurev.immunol.21.120601.141126) / Annu. Rev. Immunol. by K Takeda (2003)
  3. Akira, S. & Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499–511 (2004). (10.1038/nri1391) / Nat. Rev. Immunol. by S Akira (2004)
  4. Alexopoulou, L., Holt, A.C., Medzhitov, R. & Flavell, R.A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413, 732–738 (2001). (10.1038/35099560) / Nature by L Alexopoulou (2001)
  5. Yamamoto, M. et al. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling. J. Immunol. 169, 6668–6672 (2002). (10.4049/jimmunol.169.12.6668) / J. Immunol. by M Yamamoto (2002)
  6. Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T. & Seya, T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-β induction. Nat. Immunol. 4, 161–167 (2003). (10.1038/ni886) / Nat. Immunol. by H Oshiumi (2003)
  7. Sharma, S. et al. Triggering the interferon antiviral response through an IKK-related pathway. Science 300, 1148–1151 (2003). (10.1126/science.1081315) / Science by S Sharma (2003)
  8. Fitzgerald, K.A. et al. IKKε and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491–496 (2003). (10.1038/ni921) / Nat. Immunol. by KA Fitzgerald (2003)
  9. Sato, S. et al. Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-κB and IFN-regulatory factor-3, in the Toll-like receptor signaling. J. Immunol. 171, 4304–4310 (2003). (10.4049/jimmunol.171.8.4304) / J. Immunol. by S Sato (2003)
  10. Meylan, E. et al. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation. Nat. Immunol. 5, 503–507 (2004). (10.1038/ni1061) / Nat. Immunol. by E Meylan (2004)
  11. Heil, F. et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303, 1526–1529 (2004). (10.1126/science.1093620) / Science by F Heil (2004)
  12. Diebold, S.S. et al. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529–1531 (2004). (10.1126/science.1093616) / Science by SS Diebold (2004)
  13. Hemmi, H., Kaisho, T., Takeda, K. & Akira, S. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J. Immunol. 170, 3059–3064 (2003). (10.4049/jimmunol.170.6.3059) / J. Immunol. by H Hemmi (2003)
  14. Hoshino, K., Kaisho, T., Iwabe, T., Takeuchi, O. & Akira, S. Differential involvement of IFN-β in Toll-like receptor-stimulated dendritic cell activation. Int. Immunol. 14, 1225–1231 (2002). (10.1093/intimm/dxf089) / Int. Immunol. by K Hoshino (2002)
  15. Kawai, T. et al. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5, 1061–1068 (2004). (10.1038/ni1118) / Nat. Immunol. by T Kawai (2004)
  16. Honda, K. et al. Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc. Natl. Acad. Sci. USA 101, 15416–15421 (2004). (10.1073/pnas.0406933101) / Proc. Natl. Acad. Sci. USA by K Honda (2004)
  17. Uematsu, S. et al. Interleukin-1 receptor-associated kinase-1 (IRAK-1) plays an essential role for TLR7- and TLR9-mediated interferon-α induction. J. Exp. Med. 201, 915–923 (2005). (10.1084/jem.20042372) / J. Exp. Med. by S Uematsu (2005)
  18. Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640–643 (2003). (10.1126/science.1087262) / Science by M Yamamoto (2003)
  19. Hoebe, K. et al. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat. Immunol. 4, 1223–1229 (2003). (10.1038/ni1010) / Nat. Immunol. by K Hoebe (2003)
  20. Hemmi, H. et al. The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199, 1641–1650 (2004). (10.1084/jem.20040520) / J. Exp. Med. by H Hemmi (2004)
  21. Perry, A.K., Chow, E.K., Goodnough, J.B., Yeh, W.C. & Cheng, G. Differential requirement for TANK-binding kinase-1 in type I interferon responses to Toll-like receptor activation and viral infection. J. Exp. Med. 199, 1651–1658 (2004). (10.1084/jem.20040528) / J. Exp. Med. by AK Perry (2004)
  22. McWhirter, S.M. et al. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc. Natl. Acad. Sci. USA 101, 233–238 (2004). (10.1073/pnas.2237236100) / Proc. Natl. Acad. Sci. USA by SM McWhirter (2004)
  23. Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5, 730–737 (2004). (10.1038/ni1087) / Nat. Immunol. by M Yoneyama (2004)
  24. Kato, H. et al. Cell type specific involvement of RIG-I in antiviral response. Immunity 23, 19–28 (2005). (10.1016/j.immuni.2005.04.010) / Immunity by H Kato (2005)
  25. Kovacsovics, M. et al. Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. Curr. Biol. 12, 838–843 (2002). (10.1016/S0960-9822(02)00842-4) / Curr. Biol. by M Kovacsovics (2002)
  26. Andrejeva, J. et al. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc. Natl. Acad. Sci. USA 101, 17264–17269 (2004). (10.1073/pnas.0407639101) / Proc. Natl. Acad. Sci. USA by J Andrejeva (2004)
  27. Balachandran, S., Thomas, E. & Barber, G.N. A FADD-dependent innate immune mechanism in mammalian cells. Nature 432, 401–405 (2004). (10.1038/nature03124) / Nature by S Balachandran (2004)
  28. Matsuda, A. et al. Large-scale identification and characterization of human genes that activate NF-κB and MAPK signaling pathways. Oncogene 22, 3307–3318 (2003). (10.1038/sj.onc.1206406) / Oncogene by A Matsuda (2003)
  29. Jayakar, H.R. & Whitt, M.A. Identification of two additional translation products from the matrix (M) gene that contribute to vesicular stomatitis virus cytopathology. J. Virol. 76, 8011–8018 (2002). (10.1128/JVI.76.16.8011-8018.2002) / J. Virol. by HR Jayakar (2002)
  30. Pomerantz, J.L. & Baltimore, D. NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J. 18, 6694–6704 (1999). (10.1093/emboj/18.23.6694) / EMBO J. by JL Pomerantz (1999)
  31. Nomura, F., Kawai, T., Nakanishi, K. & Akira, S. NF-κB activation through IKK-i-dependent I-TRAF/TANK phosphorylation. Genes Cells 5, 191–202 (2000). (10.1046/j.1365-2443.2000.00315.x) / Genes Cells by F Nomura (2000)
  32. Sasai, M. et al. NF-κB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation. J. Immunol. 174, 27–30 (2005). (10.4049/jimmunol.174.1.27) / J. Immunol. by M Sasai (2005)
  33. Sumpter, R. Jr. et al. Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J. Virol. 79, 2689–2699 (2005). (10.1128/JVI.79.5.2689-2699.2005) / J. Virol. by R Sumpter Jr. (2005)
  34. Breiman, A. et al. Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKε. J. Virol. 79, 3969–3978 (2005). (10.1128/JVI.79.7.3969-3978.2005) / J. Virol. by A Breiman (2005)
  35. Stockinger, S. et al. IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism. J. Immunol. 173, 7416–7425 (2004). (10.4049/jimmunol.173.12.7416) / J. Immunol. by S Stockinger (2004)
  36. O'Connell, R.M. et al. Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF-κB kinase-binding kinase 1. J. Immunol. 174, 1602–1607 (2005). (10.4049/jimmunol.174.3.1602) / J. Immunol. by RM O'Connell (2005)
  37. Pomerantz, J.L., Denny, E.M. & Baltimore, D. CARD11 mediates factor-specific activation of NF-κB by the T cell receptor complex. EMBO J. 21, 5184–5194 (2002). (10.1093/emboj/cdf505) / EMBO J. by JL Pomerantz (2002)
  38. Sugiyama, T. et al. CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+CD11c+ monocytes. J. Immunol. 174, 2273–2279 (2005). (10.4049/jimmunol.174.4.2273) / J. Immunol. by T Sugiyama (2005)
Dates
Type When
Created 19 years, 11 months ago (Aug. 28, 2005, 1:33 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 6:44 p.m.)
Indexed 23 hours, 42 minutes ago (Aug. 26, 2025, 2:58 a.m.)
Issued 19 years, 11 months ago (Aug. 28, 2005)
Published 19 years, 11 months ago (Aug. 28, 2005)
Published Online 19 years, 11 months ago (Aug. 28, 2005)
Published Print 19 years, 10 months ago (Oct. 1, 2005)
Funders 0

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@article{Kawai_2005, title={IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction}, volume={6}, ISSN={1529-2916}, url={http://dx.doi.org/10.1038/ni1243}, DOI={10.1038/ni1243}, number={10}, journal={Nature Immunology}, publisher={Springer Science and Business Media LLC}, author={Kawai, Taro and Takahashi, Ken and Sato, Shintaro and Coban, Cevayir and Kumar, Himanshu and Kato, Hiroki and Ishii, Ken J and Takeuchi, Osamu and Akira, Shizuo}, year={2005}, month=aug, pages={981–988} }