Natural killer cell activation in mice and men: different triggers for similar weapons?
10.1038/ni0902-807
Crossref journal-article
Springer Science and Business Media LLC
Nature Immunology (297)
Bibliography

Colucci, F., Di Santo, J. P., & Leibson, P. J. (2002). Natural killer cell activation in mice and men: different triggers for similar weapons? Nature Immunology, 3(9), 807–813.

Authors 3
  1. Francesco Colucci (first)
  2. James P. Di Santo (additional)
  3. Paul J. Leibson (additional)
References 72 Referenced 155
  1. Ravetch, J.V. & Lanier, L.L. Immune inhibitory receptors. Science 290, 84–89 (2000). (10.1126/science.290.5489.84) / Science by JV Ravetch (2000)
  2. Long, E.O. et al. Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158). Immunol. Rev. 181, 223–233 (2001). (10.1034/j.1600-065X.2001.1810119.x) / Immunol. Rev. by EO Long (2001)
  3. Kiessling, R., Klein, E. & Wigzell, H. “Natural” killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur. J. Immunol. 5, 112–117 (1975). (10.1002/eji.1830050208) / Eur. J. Immunol. by R Kiessling (1975)
  4. Herberman, R.B., Nunn, M.E. & Lavrin, D.H. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic acid allogeneic tumors. I. Distribution of reactivity and specificity. Int. J. Cancer 16, 216–229 (1975). (10.1002/ijc.2910160204) / Int. J. Cancer by RB Herberman (1975)
  5. Basse, P.H., Whiteside, T.L., Chambers, W. & Herberman, R.B. Therapeutic activity of NK cells against tumors. Int. Rev. Immunol. 20, 439–501 (2001). (10.3109/08830180109054416) / Int. Rev. Immunol. by PH Basse (2001)
  6. Fehniger, T.A. & Caligiuri, M.A. Ontogeny and expansion of human natural killer cells: clinical implications. Int. Rev. Immunol. 20, 503–534 (2001). (10.3109/08830180109054417) / Int. Rev. Immunol. by TA Fehniger (2001)
  7. Ruggeri, L. et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295, 2097–2100 (2002). (10.1126/science.1068440) / Science by L Ruggeri (2002)
  8. Downward, J. The ins and outs of signalling. Nature 411, 759–762 (2001). (10.1038/35081138) / Nature by J Downward (2001)
  9. Brumbaugh, K.M. et al. Functional role for Syk tyrosine kinase in natural killer cell-mediated natural cytotoxicity. J. Exp. Med. 186, 1965–1974 (1997). (10.1084/jem.186.12.1965) / J. Exp. Med. by KM Brumbaugh (1997)
  10. Colucci, F. et al. Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation. J. Immunol. 163, 1769–1774 (1999). (10.4049/jimmunol.163.4.1769) / J. Immunol. by F Colucci (1999)
  11. Zhang, W. et al. Essential role of LAT in T cell development. Immunity 10, 323–332 (1999). (10.1016/S1074-7613(00)80032-1) / Immunity by W Zhang (1999)
  12. Jevremovic, D. et al. Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. J. Immunol. 162, 2453–2456 (1999). (10.4049/jimmunol.162.5.2453) / J. Immunol. by D Jevremovic (1999)
  13. Lanier, L.L. On guard–activating NK cell receptors. Nature Immunol. 2, 23–27 (2001). (10.1038/83130) / Nature Immunol. by LL Lanier (2001)
  14. Trinchieri, G. Biology of natural killer cells. Adv. Immunol. 47, 187–376 (1989). (10.1016/S0065-2776(08)60664-1) / Adv. Immunol. by G Trinchieri (1989)
  15. Brown, M.G. et al. Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science 292, 934–937 (2001). (10.1126/science.1060042) / Science by MG Brown (2001)
  16. Daniels, K.A. et al. Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49h. J. Exp. Med. 194, 29–44 (2001) (10.1084/jem.194.1.29) / J. Exp. Med. by KA Daniels (2001)
  17. Lee, S.H. et al. Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nature Genet. 28, 42–45 (2001). / Nature Genet. by SH Lee (2001)
  18. Arase, H., Mocarski, E.S., Campbell, A.E., Hill, A.B. & Lanier, L.L. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296, 1323–1326 (2002). (10.1126/science.1070884) / Science by H Arase (2002)
  19. Sutherland, C.L., Chalupny, N.J. & Cosman D. The UL16-binding proteins, a novel family of MHC class I-related ligands for NKG2D, activate natural killer cell functions. Immunol. Rev. 181, 185–192 (2001). (10.1034/j.1600-065X.2001.1810115.x) / Immunol. Rev. by CL Sutherland (2001)
  20. Tortorella, D., Gewurz, B.E., Furman M.H., Schust D.J. & Ploegh, H.L. Viral subversion of the immune system. Annu. Rev. Immunol. 18, 861–926 (2000). (10.1146/annurev.immunol.18.1.861) / Annu. Rev. Immunol. by D Tortorella (2000)
  21. Krmpotic, A. et al. MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo. Nature Immunol. 3, 529–535 (2002). (10.1038/ni799) / Nature Immunol. by A Krmpotic (2002)
  22. Mandelboim, O. et al. Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells. Nature 409, 1055–1060 (2001). (10.1038/35059110) / Nature by O Mandelboim (2001)
  23. Hornung, V. et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168, 4531–4537 (2002). (10.4049/jimmunol.168.9.4531) / J. Immunol. by V Hornung (2002)
  24. Billadeau, D.D. & Leibson, P.J. ITAMs versus ITIMs: striking a balance during cell regulation. J. Clin. Invest. 109, 161–168 (2002). (10.1172/JCI0214843) / J. Clin. Invest. by DD Billadeau (2002)
  25. Lanier, L.L. NK cell receptors. Annu. Rev. Immunol. 16, 359–393 (1998). (10.1146/annurev.immunol.16.1.359) / Annu. Rev. Immunol. by LL Lanier (1998)
  26. Moretta, A. et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19, 197–223 (2001). (10.1146/annurev.immunol.19.1.197) / Annu. Rev. Immunol. by A Moretta (2001)
  27. Leibson, P.J. Signal transduction during natural killer activation: inside the mind of a killer. Immunity 6, 655–661 (1997). (10.1016/S1074-7613(00)80441-0) / Immunity by PJ Leibson (1997)
  28. Takai, T., Li, M., Sylvestre, D., Clynes, R. & Ravetch, J.V. FcRγ chain deletion results in pleiotropic effector cell defects. Cell, 76, 519–529 (1994). (10.1016/0092-8674(94)90115-5) / Cell by T Takai (1994)
  29. van Oers, N.S., Lowin-Kropf, B., Finlay, D., Connolly, K. & Weiss, A. αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity 5, 429–436 (1996). (10.1016/S1074-7613(00)80499-9) / Immunity by NS van Oers (1996)
  30. Chu, D.H. et al. The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J. 15, 6251–6261 (1996). (10.1002/j.1460-2075.1996.tb01015.x) / EMBO J. by DH Chu (1996)
  31. Yamada, H., Kishihara, K., Kong, Y.Y. & Nomoto, K. Enhanced generation of NK cells with intact cytotoxic function in CD45 exon 6-deficient mice. J. Immunol. 157, 1523–1528 (1996). (10.4049/jimmunol.157.4.1523) / J. Immunol. by H Yamada (1996)
  32. Negishi, I. et al. Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376, 435–438 (1995). (10.1038/376435a0) / Nature by I Negishi (1995)
  33. Colucci, F. et al. Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases. Nature Immunol. 3, 288–294 (2002). (10.1038/ni764) / Nature Immunol. by F Colucci (2002)
  34. Ting, A.T., Karnitz, L.M., Schoon, R.A., Abraham, R.T. & Leibson, P.J. Fcγ receptor activation induces the tyrosine phosphorylation of both phospholipase C (PLC)-γ 1 and PLC-γ 2 in natural killer cells. J. Exp. Med. 176, 1751–1755 (1992). (10.1084/jem.176.6.1751) / J. Exp. Med. by AT Ting (1992)
  35. Wang, D. et al. Phospholipase Cg2 is essential in the functions of B cell and several Fc receptors. Immunity 13, 25–35 (2000). (10.1016/S1074-7613(00)00005-4) / Immunity by D Wang (2000)
  36. Billadeau, D.D., Mackie, S.M., Schoon, R.A. & Leibson, P.J. The Rho family guanine nucleotide exchange factor Vav-2 regulates the development of cell-mediated cytotoxicity. J. Exp. Med. 192, 381–392 (2000). (10.1084/jem.192.3.381) / J. Exp. Med. by DD Billadeau (2000)
  37. Colucci, F. et al. Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms. J. Exp. Med. 193, 1413–1424 (2001). (10.1084/jem.193.12.1413) / J. Exp. Med. by F Colucci (2001)
  38. Binstadt, B.A. et al. SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors. J. Biol. Chem. 273, 27518–27523 (1998). (10.1074/jbc.273.42.27518) / J. Biol. Chem. by BA Binstadt (1998)
  39. Clements, J.L. et al. Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 281, 416–419 (1998). (10.1126/science.281.5375.416) / Science by JL Clements (1998)
  40. Smith, K.M., Wu, J., Bakker, A.B., Phillips, J.H. & Lanier, L.L. Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J. Immunol. 161, 7–10 (1998). (10.4049/jimmunol.161.1.7) / J. Immunol. by KM Smith (1998)
  41. Cerwenka, A. & Lanier, L.L. Natural killer cells, viruses and cancer. Nature Rev. Immunol. 1, 41–49 (2001). (10.1038/35095564) / Nature Rev. Immunol. by A Cerwenka (2001)
  42. Perussia, B. Signaling for cytotoxicity. Nature Immunol. 1, 372–374 (2000). (10.1038/80808) / Nature Immunol. by B Perussia (2000)
  43. Bonnema, J.D., Karnitz, L.M., Schoon, R.A., Abraham, R.T. & Leibson, P.J. Fc receptor stimulation of phosphatidylinositol 3-kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated cytotoxicity. J. Exp. Med. 180, 1427–1435 (1994). (10.1084/jem.180.4.1427) / J. Exp. Med. by JD Bonnema (1994)
  44. Jiang, K. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells. Nature Immunol. 1, 419–425 (2000). (10.1038/80859) / Nature Immunol. by K Jiang (2000)
  45. Wu, J. et al. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285, 730–732 (1999). (10.1126/science.285.5428.730) / Science by J Wu (1999)
  46. Boles, K.S., Stepp, S.E., Bennett, M., Kumar, V. & Mathew, P.A. 2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes. Immunol. Rev. 181, 234–249 (2001). (10.1034/j.1600-065X.2001.1810120.x) / Immunol. Rev. by KS Boles (2001)
  47. Tangye, S.G. et al. Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. J. Immunol. 162, 6981–6985 (1999). (10.4049/jimmunol.162.12.6981) / J. Immunol. by SG Tangye (1999)
  48. Sayos, J. et al. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature 395, 462–469 (1998). (10.1038/26683) / Nature by J Sayos (1998)
  49. Chuang, S.S., Kumaresan, P.R. & Mathew, P.A. 2B4 (CD244)-mediated activation of cytotoxicity and IFN-γ release in human NK cells involves distinct pathways. J. Immunol. 167, 6210–6216 (2001). (10.4049/jimmunol.167.11.6210) / J. Immunol. by SS Chuang (2001)
  50. Latour, S. et al. Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nature Immunol. 2, 681–690 (2001). (10.1038/90615) / Nature Immunol. by S Latour (2001)
  51. Mainiero, F. et al. RAC1/P38 MAPK signaling pathway controls β1 integrin-induced interleukin-8 production in human natural killer cells. Immunity 12, 7–16 (2000). (10.1016/S1074-7613(00)80154-5) / Immunity by F Mainiero (2000)
  52. Gismondi, A. et al. Cutting edge: functional role for proline-rich tyrosine kinase 2 in NK cell-mediated natural cytotoxicity. J. Immunol. 164, 2272–2276 (2000). (10.4049/jimmunol.164.5.2272) / J. Immunol. by A Gismondi (2000)
  53. Helander, T.S. et al. ICAM-2 redistributed by ezrin as a target for killer cells. Nature 382, 265–268 (1996). (10.1038/382265a0) / Nature by TS Helander (1996)
  54. Biron, C.A., Nguyen, K.B., Pien, G.C., Cousens, L.P. & Salazar-Mather, T.P. Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu. Rev. Immunol. 17, 189–220 (1999). (10.1146/annurev.immunol.17.1.189) / Annu. Rev. Immunol. by CA Biron (1999)
  55. Williams, N.S. et al. Natural killer cell differentiation: insights from knockout and transgenic mouse models and in vitro systems. Immunol. Rev. 165, 47–61 (1998). (10.1111/j.1600-065X.1998.tb01229.x) / Immunol. Rev. by NS Williams (1998)
  56. Williams, N.S. et al. Differentiation of NK1. 1+, Ly49+ NK cells from flt3+ multipotent marrow progenitor cells. J. Immunol. 163, 2648–2656 (1999). (10.4049/jimmunol.163.5.2648) / J. Immunol. by NS Williams (1999)
  57. Roth, C., Carlyle, J.R., Takizawa, H. & Raulet, D.H. Clonal acquisition of inhibitory Ly49 receptors on developing NK cells is successively restricted and regulated by stromal class I MHC. Immunity 13, 143–153 (2000). (10.1016/S1074-7613(00)00015-7) / Immunity by C Roth (2000)
  58. Fischer, A. et al. Naturally occurring primary deficiencies of the immune system. Annu. Rev. Immunol. 15, 93–124 (1997). (10.1146/annurev.immunol.15.1.93) / Annu. Rev. Immunol. by A Fischer (1997)
  59. Raulet, D.H., Vance, R.E. & McMahon, C.W. Regulation of the natural killer cell receptor repertoire. Annu. Rev. Immunol. 19, 291–330 (2001). (10.1146/annurev.immunol.19.1.291) / Annu. Rev. Immunol. by DH Raulet (2001)
  60. Cooper, M.A. et al. Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset. Blood 97, 3146–3151 (2001). (10.1182/blood.V97.10.3146) / Blood by MA Cooper (2001)
  61. Cooper, M.A., Fehniger, T.A. & Caligiuri, M.A. The biology of human natural killer-cell subsets. Trends Immunol. 22, 633–640 (2001). (10.1016/S1471-4906(01)02060-9) / Trends Immunol. by MA Cooper (2001)
  62. Tay, C.H. & Welsh, R.M. Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells. J. Virol. 71, 267–275 (1997). (10.1128/JVI.71.1.267-275.1997) / J. Virol. by CH Tay (1997)
  63. Ashkar, A.A., Di Santo, J.P. & Croy, B.A. Interferon γ contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy. J. Exp. Med. 192, 259–270 (2000). (10.1084/jem.192.2.259) / J. Exp. Med. by AA Ashkar (2000)
  64. Vilches, C. & Parham, P. KIR: Diverse, rapidly evolving receptors of innate and adaptive immunity. Annu. Rev. Immunol. 20, 217–251 (2002). (10.1146/annurev.immunol.20.092501.134942) / Annu. Rev. Immunol. by C Vilches (2002)
  65. Rajagopalan, S., Fu, J. & Long, E.O. Cutting edge: induction of IFN-γ production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells. J. Immunol. 167, 1877–1881 (2001). (10.4049/jimmunol.167.4.1877) / J. Immunol. by S Rajagopalan (2001)
  66. Yoder, J.A. et al. Immune-type receptor genes in zebrafish share genetic and functional properties with genes encoded by the mammalian leukocyte receptor cluster. Proc. Natl. Acad. Sci. USA. 98, 6771–6776 (2001). (10.1073/pnas.121101598) / Proc. Natl. Acad. Sci. USA. by JA Yoder (2001)
  67. Litman, G.W., Hawke, N.A. & Yoder, J.A. Novel immune-type receptor genes. Immunol. Rev. 181, 250–259 (2001). (10.1034/j.1600-065X.2001.1810121.x) / Immunol. Rev. by GW Litman (2001)
  68. Barten, R., Torkar, M., Haude, A., Trowsdale, J. & Wilson, M.J. Divergent and convergent evolution of NK-cell receptors. Trends Immunol. 22, 52–57 (2001). (10.1016/S1471-4906(00)01802-0) / Trends Immunol. by R Barten (2001)
  69. Hercend, T. & Schmidt, R.E. Characteristics and uses of natural killer cells. Immunol. Today 9, 291–293 (1988). (10.1016/0167-5699(88)91317-5) / Immunol. Today by T Hercend (1988)
  70. Kärre, K. MHC gene control of the natural killer system at the level of the target and the host. Semin. Cancer Biol. 2, 295–309 (1991). / Semin. Cancer Biol. by K Kärre (1991)
  71. Biron, C.A., Byron, K.S. & Sullivan, J.L. Severe herpesvirus infections in an adolescent without natural killer cells. N. Engl. J. Med. 320, 1731–1735 (1989). (10.1056/NEJM198906293202605) / N. Engl. J. Med. by CA Biron (1989)
  72. Kim, S., Iizuka, K., Aguila, H.L., Weissman, I.L. & Yokoyama, W.M. In vivo natural killer cell activity revealed by natural killer cell-deficient mice. Proc. Natl. Acad. Sci. USA. 97, 2731–2736 (2000). (10.1073/pnas.050588297) / Proc. Natl. Acad. Sci. USA. by S Kim (2000)
Dates
Type When
Created 23 years ago (Aug. 30, 2002, 4:49 p.m.)
Deposited 1 year, 7 months ago (Jan. 6, 2024, 2:56 p.m.)
Indexed 5 days, 17 hours ago (Aug. 26, 2025, 3:02 a.m.)
Issued 22 years, 11 months ago (Sept. 1, 2002)
Published 22 years, 11 months ago (Sept. 1, 2002)
Published Print 22 years, 11 months ago (Sept. 1, 2002)
Funders 0

None

@article{Colucci_2002, title={Natural killer cell activation in mice and men: different triggers for similar weapons?}, volume={3}, ISSN={1529-2916}, url={http://dx.doi.org/10.1038/ni0902-807}, DOI={10.1038/ni0902-807}, number={9}, journal={Nature Immunology}, publisher={Springer Science and Business Media LLC}, author={Colucci, Francesco and Di Santo, James P. and Leibson, Paul J.}, year={2002}, month=sep, pages={807–813} }