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References
48
Referenced
351
-
Akira, S., Uematsu, S. & Takeuchi, O. Pathogen recognition and innate immunity. Cell 124, 783–801 (2006).
(
10.1016/j.cell.2006.02.015
) / Cell by S Akira (2006) -
Janeway, C.A., Jr. & Medzhitov, R. Innate immune recognition. Annu. Rev. Immunol. 20, 197–216 (2002).
(
10.1146/annurev.immunol.20.083001.084359
) / Annu. Rev. Immunol. by CA Janeway Jr. (2002) -
Beutler, B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430, 257–263 (2004).
(
10.1038/nature02761
) / Nature by B Beutler (2004) -
Adachi, O. et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9, 143–150 (1998).
(
10.1016/S1074-7613(00)80596-8
) / Immunity by O Adachi (1998) -
Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115–122 (1999).
(
10.1016/S1074-7613(00)80086-2
) / Immunity by T Kawai (1999) -
Fitzgerald, K.A. et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78–83 (2001).
(
10.1038/35092578
) / Nature by KA Fitzgerald (2001) -
Horng, T., Barton, G.M. & Medzhitov, R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2, 835–841 (2001).
(
10.1038/ni0901-835
) / Nat. Immunol. by T Horng (2001) -
Horng, T., Barton, G.M., Flavell, R.A. & Medzhitov, R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420, 329–333 (2002).
(
10.1038/nature01180
) / Nature by T Horng (2002) -
Yamamoto, M. et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420, 324–329 (2002).
(
10.1038/nature01182
) / Nature by M Yamamoto (2002) -
Hoebe, K. et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424, 743–748 (2003).
(
10.1038/nature01889
) / Nature by K Hoebe (2003) -
Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T. & Seya, T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-β induction. Nat. Immunol. 4, 161–167 (2003).
(
10.1038/ni886
) / Nat. Immunol. by H Oshiumi (2003) -
Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640–643 (2003).
(
10.1126/science.1087262
) / Science by M Yamamoto (2003) -
Kagan, J.C. et al. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β. Nat. Immunol. 9, 361–368 (2008).
(
10.1038/ni1569
) / Nat. Immunol. by JC Kagan (2008) -
Fitzgerald, K.A. et al. LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the toll adapters TRAM and TRIF. J. Exp. Med. 198, 1043–1055 (2003).
(
10.1084/jem.20031023
) / J. Exp. Med. by KA Fitzgerald (2003) -
Yamamoto, M. et al. TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway. Nat. Immunol. 4, 1144–1150 (2003).
(
10.1038/ni986
) / Nat. Immunol. by M Yamamoto (2003) -
Janssens, S. & Beyaert, R. Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol. Cell 11, 293–302 (2003).
(
10.1016/S1097-2765(03)00053-4
) / Mol. Cell by S Janssens (2003) -
Suzuki, N. et al. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416, 750–756 (2002).
(
10.1038/nature736
) / Nature by N Suzuki (2002) -
Suzuki, N. et al. IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC. J. Immunol. 171, 6065–6071 (2003).
(
10.4049/jimmunol.171.11.6065
) / J. Immunol. by N Suzuki (2003) -
Honda, K. et al. Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc. Natl. Acad. Sci. USA 101, 15416–15421 (2004).
(
10.1073/pnas.0406933101
) / Proc. Natl. Acad. Sci. USA by K Honda (2004) -
Koziczak-Holbro, M. et al. IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression. J. Biol. Chem. 282, 13552–13560 (2007).
(
10.1074/jbc.M700548200
) / J. Biol. Chem. by M Koziczak-Holbro (2007) -
Kim, T.W. et al. A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J. Exp. Med. 204, 1025–1036 (2007).
(
10.1084/jem.20061825
) / J. Exp. Med. by TW Kim (2007) -
Kawagoe, T. et al. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J. Exp. Med. 204, 1013–1024 (2007).
(
10.1084/jem.20061523
) / J. Exp. Med. by T Kawagoe (2007) -
Picard, C. et al. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 299, 2076–2079 (2003).
(
10.1126/science.1081902
) / Science by C Picard (2003) -
Medvedev, A.E. et al. Cutting edge: expression of IL-1 receptor-associated kinase-4 (IRAK-4) proteins with mutations identified in a patient with recurrent bacterial infections alters normal IRAK-4 interaction with components of the IL-1 receptor complex. J. Immunol. 174, 6587–6591 (2005).
(
10.4049/jimmunol.174.11.6587
) / J. Immunol. by AE Medvedev (2005) -
Yang, K. et al. Human TLR-7-, -8-, and -9-mediated induction of IFN-α/β and -λ is IRAK-4 dependent and redundant for protective immunity to viruses. Immunity 23, 465–478 (2005).
(
10.1016/j.immuni.2005.09.016
) / Immunity by K Yang (2005) -
Ku, C.L. et al. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J. Exp. Med. 204, 2407–2422 (2007).
(
10.1084/jem.20070628
) / J. Exp. Med. by CL Ku (2007) -
Kobayashi, K. et al. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110, 191–202 (2002).
(
10.1016/S0092-8674(02)00827-9
) / Cell by K Kobayashi (2002) -
Croston, G.E., Cao, Z. & Goeddel, D.V. NF-κB activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity. J. Biol. Chem. 270, 16514–16517 (1995).
(
10.1074/jbc.270.28.16514
) / J. Biol. Chem. by GE Croston (1995) -
Kanakaraj, P. et al. Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production. J. Exp. Med. 187, 2073–2079 (1998).
(
10.1084/jem.187.12.2073
) / J. Exp. Med. by P Kanakaraj (1998) -
Thomas, J.A. et al. Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J. Immunol. 163, 978–984 (1999).
(
10.4049/jimmunol.163.2.978
) / J. Immunol. by JA Thomas (1999) -
Uematsu, S. et al. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction. J. Exp. Med. 201, 915–923 (2005).
(
10.1084/jem.20042372
) / J. Exp. Med. by S Uematsu (2005) -
Muzio, M., Ni, J., Feng, P. & Dixit, V.M. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278, 1612–1615 (1997).
(
10.1126/science.278.5343.1612
) / Science by M Muzio (1997) -
Hardy, M.P. & O'Neill, L.A. The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory. J. Biol. Chem. 279, 27699–27708 (2004).
(
10.1074/jbc.M403068200
) / J. Biol. Chem. by MP Hardy (2004) -
Keating, S.E., Maloney, G.M., Moran, E.M. & Bowie, A.G. IRAK-2 participates in multiple toll-like receptor signaling pathways to NFκB via activation of TRAF6 ubiquitination. J. Biol. Chem. 282, 33435–33443 (2007).
(
10.1074/jbc.M705266200
) / J. Biol. Chem. by SE Keating (2007) -
Wesche, H. et al. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 274, 19403–19410 (1999).
(
10.1074/jbc.274.27.19403
) / J. Biol. Chem. by H Wesche (1999) -
Yamin, T.T. & Miller, D.K. The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation. J. Biol. Chem. 272, 21540–21547 (1997).
(
10.1074/jbc.272.34.21540
) / J. Biol. Chem. by TT Yamin (1997) -
Li, X. et al. Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase. Mol. Cell. Biol. 19, 4643–4652 (1999).
(
10.1128/MCB.19.7.4643
) / Mol. Cell. Biol. by X Li (1999) -
Swantek, J.L., Tsen, M.F., Cobb, M.H. & Thomas, J.A. IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. J. Immunol. 164, 4301–4306 (2000).
(
10.4049/jimmunol.164.8.4301
) / J. Immunol. by JL Swantek (2000) -
Li, S., Strelow, A., Fontana, E.J. & Wesche, H. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc. Natl. Acad. Sci. USA 99, 5567–5572 (2002).
(
10.1073/pnas.082100399
) / Proc. Natl. Acad. Sci. USA by S Li (2002) -
Knop, J. & Martin, M.U. Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity. FEBS Lett. 448, 81–85 (1999).
(
10.1016/S0014-5793(99)00322-1
) / FEBS Lett. by J Knop (1999) -
Maschera, B., Ray, K., Burns, K. & Volpe, F. Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-κB. Biochem. J. 339, 227–231 (1999).
(
10.1042/bj3390227
) / Biochem. J. by B Maschera (1999) -
Li, X., Commane, M., Jiang, Z. & Stark, G.R. IL-1-induced NFκB and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK). Proc. Natl. Acad. Sci. USA 98, 4461–4465 (2001).
(
10.1073/pnas.071054198
) / Proc. Natl. Acad. Sci. USA by X Li (2001) -
Jensen, L.E. & Whitehead, A.S. IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. J. Biol. Chem. 276, 29037–29044 (2001).
(
10.1074/jbc.M103815200
) / J. Biol. Chem. by LE Jensen (2001) -
Rechsteiner, M. & Rogers, S.W. PEST sequences and regulation by proteolysis. Trends Biochem. Sci. 21, 267–271 (1996).
(
10.1016/S0968-0004(96)10031-1
) / Trends Biochem. Sci. by M Rechsteiner (1996) -
Takeuchi, O. et al. Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J. Immunol. 164, 554–557 (2000).
(
10.4049/jimmunol.164.2.554
) / J. Immunol. by O Takeuchi (2000) -
Hemmi, H. et al. Toll-like receptor recognizes bacterial DNA. Nature 408, 740–745 (2000).
(
10.1038/35047123
) / Nature by H Hemmi (2000) -
Sato, S. et al. A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways. Int. Immunol. 14, 783–791 (2002).
(
10.1093/intimm/dxf046
) / Int. Immunol. by S Sato (2002) -
Barton, G.M., Kagan, J.C. & Medzhitov, R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol. 7, 49–56 (2006).
(
10.1038/ni1280
) / Nat. Immunol. by GM Barton (2006)
Dates
Type | When |
---|---|
Created | 17 years, 3 months ago (April 27, 2008, 2:50 p.m.) |
Deposited | 2 years, 3 months ago (May 18, 2023, 7:35 p.m.) |
Indexed | 2 days ago (Aug. 20, 2025, 8:38 a.m.) |
Issued | 17 years, 3 months ago (April 27, 2008) |
Published | 17 years, 3 months ago (April 27, 2008) |
Published Online | 17 years, 3 months ago (April 27, 2008) |
Published Print | 17 years, 2 months ago (June 1, 2008) |
@article{Kawagoe_2008, title={Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2}, volume={9}, ISSN={1529-2916}, url={http://dx.doi.org/10.1038/ni.1606}, DOI={10.1038/ni.1606}, number={6}, journal={Nature Immunology}, publisher={Springer Science and Business Media LLC}, author={Kawagoe, Tatsukata and Sato, Shintaro and Matsushita, Kazufumi and Kato, Hiroki and Matsui, Kosuke and Kumagai, Yutaro and Saitoh, Tatsuya and Kawai, Taro and Takeuchi, Osamu and Akira, Shizuo}, year={2008}, month=apr, pages={684–691} }