DOI: 10.1038/ng837. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

10.1038/ng837

Crossref journal-article

Springer Science and Business Media LLC

Nature Genetics (297)

Bibliography

Yarden, R. I., Pardo-Reoyo, S., Sgagias, M., Cowan, K. H., & Brody, L. C. (2002). BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nature Genetics, 30(3), 285â289.

Authors 5

Ronit I. Yarden (first)
Sherly Pardo-Reoyo (additional)
Magda Sgagias (additional)
Kenneth H. Cowan (additional)
Lawrence C. Brody (additional)

References 25 Referenced 362

Bork, P. et al. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 11, 68–76 (1997). (10.1096/fasebj.11.1.9034168) / FASEB J. by P Bork (1997)
Cortez, D., Wang, Y., Qin, J. & Elledge, S.J. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 286, 1162–1166 (1999). (10.1126/science.286.5442.1162) / Science by D Cortez (1999)
Tibbetts, R.S. et al. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 14, 2989–3002 (2000). (10.1101/gad.851000) / Genes Dev. by RS Tibbetts (2000)
Lee, J.S., Collins, K.M., Brown, A.L., Lee, C.H. & Chung, J.H. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404, 201–204 (2000). (10.1038/35004614) / Nature by JS Lee (2000)
Chen, J. Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. Cancer Res. 60, 5037–5039 (2000). / Cancer Res. by J Chen (2000)
Lopez-Girona, A., Furnari, B., Mondesert, O. & Russell, P. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature 397, 172–175 (1999). (10.1038/16488) / Nature by A Lopez-Girona (1999)
Tomlinson, G.E. et al. Characterization of a breast cancer cell line derived from a germ-line BRCA1 mutation carrier. Cancer Res. 58, 3237–3242 (1998). / Cancer Res. by GE Tomlinson (1998)
Scully, R. et al. Genetic analysis of BRCA1 function in a defined tumor cell line. Mol. Cell 4, 1093–1099 (1999). (10.1016/S1097-2765(00)80238-5) / Mol. Cell by R Scully (1999)
Foray, N. et al. Γ-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2. Oncogene 18, 7334–7342 (1999). (10.1038/sj.onc.1203165) / Oncogene by N Foray (1999)
Xu, B., Kim, S. & Kastan, M.B. Involvement of BRCA1 in S-phase and G2-phase checkpoints after ionizing irradiation. Mol. Cell. Biol. 21, 3445–3450 (2001). (10.1128/MCB.21.10.3445-3450.2001) / Mol. Cell. Biol. by B Xu (2001)
Zhong, Q. et al. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. Science 285, 747–750 (1999). (10.1126/science.285.5428.747) / Science by Q Zhong (1999)
MacLachlan, T.K. et al. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression. J. Biol. Chem. 275, 2777–2785 (2000). (10.1074/jbc.275.4.2777) / J. Biol. Chem. by TK MacLachlan (2000)
O'Connor, P.M. et al. G2 delay induced by nitrogen mustard in human cells affects cyclin A/Cdk2 and cyclin B1/Cdc2-kinase complexes differently. J. Biol. Chem. 268, 8298–8308 (1993). (10.1016/S0021-9258(18)53096-9) / J. Biol. Chem. by PM O'Connor (1993)
Rhind, N., Furnari, B. & Russell, P. Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast. Genes Dev. 11, 504–511 (1997). (10.1101/gad.11.4.504) / Genes Dev. by N Rhind (1997)
Lee, M.S. et al. Cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2. Mol. Biol. Cell 3, 73–84 (1992). (10.1091/mbc.3.1.73) / Mol. Biol. Cell by MS Lee (1992)
Ogg, S., Gabrielli, B. & Piwnica-Worms, H. Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216. J. Biol. Chem. 269, 30461–30469 (1994). (10.1016/S0021-9258(18)43836-7) / J. Biol. Chem. by S Ogg (1994)
Furnari, B., Rhind, N. & Russell, P. Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase. Science 277, 1495–1497 (1997). (10.1126/science.277.5331.1495) / Science by B Furnari (1997)
Sanchez, Y. et al. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277, 1497–1501 (1997). (10.1126/science.277.5331.1497) / Science by Y Sanchez (1997)
Peng, C.Y. et al. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277, 1501–1505 (1997). (10.1126/science.277.5331.1501) / Science by CY Peng (1997)
Hermeking, H. et al. 14-3-3σ is a p53-regulated inhibitor of G2/M progression. Mol. Cell 1, 3–11 (1997). (10.1016/S1097-2765(00)80002-7) / Mol. Cell by H Hermeking (1997)
Matsuoka, S., Huang, M. & Elledge, S.J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282, 1893–1897 (1998). (10.1126/science.282.5395.1893) / Science by S Matsuoka (1998)
Xu, X. et al. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell 3, 389–395 (1999). (10.1016/S1097-2765(00)80466-9) / Mol. Cell by X Xu (1999)
Xu, X. et al. Genetic interactions between tumor suppressors BRCA1 and TP53 in apoptosis, cell cycle and tumorigenesis. Nature Genet. 28, 266–271 (2001). (10.1038/90108) / Nature Genet. by X Xu (2001)
van den Heuvel, S. & Harlow, E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262, 2050–2054 (1993). (10.1126/science.8266103) / Science by S van den Heuvel (1993)
Yarden, R.I. & Brody, L.C. BRCA1 interacts with components of the histone deacetylase complex. Proc. Natl Acad. Sci. USA 96, 4983–4988 (1999). (10.1073/pnas.96.9.4983) / Proc. Natl Acad. Sci. USA by RI Yarden (1999)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 4:30 a.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 6:16 p.m.)
Indexed	4 weeks, 1 day ago (Aug. 5, 2025, 8:16 a.m.)
Issued	23 years, 6 months ago (Feb. 11, 2002)
Published	23 years, 6 months ago (Feb. 11, 2002)
Published Online	23 years, 6 months ago (Feb. 11, 2002)
Published Print	23 years, 6 months ago (March 1, 2002)

Funders 0

None

BibTeX

@article{Yarden_2002, title={BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage}, volume={30}, ISSN={1546-1718}, url={http://dx.doi.org/10.1038/ng837}, DOI={10.1038/ng837}, number={3}, journal={Nature Genetics}, publisher={Springer Science and Business Media LLC}, author={Yarden, Ronit I. and Pardo-Reoyo, Sherly and Sgagias, Magda and Cowan, Kenneth H. and Brody, Lawrence C.}, year={2002}, month=feb, pages={285–289} }

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