DOI: 10.1038/ng1467. Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes

Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes

10.1038/ng1467

Crossref journal-article

Springer Science and Business Media LLC

Nature Genetics (297)

Bibliography

Umlauf, D., Goto, Y., Cao, R., Cerqueira, F., Wagschal, A., Zhang, Y., & Feil, R. (2004). Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nature Genetics, 36(12), 1296â1300.

Authors 7

David Umlauf (first)
Yuji Goto (additional)
Ru Cao (additional)
Frédérique Cerqueira (additional)
Alexandre Wagschal (additional)
Yi Zhang (additional)
Robert Feil (additional)

References 30 Referenced 343

Ferguson-Smith, A.C. & Surani, M.A. Imprinting and the epigenetic asymmetry between parental genomes. Science 293, 1086–1089 (2001). (10.1126/science.1064020) / Science by AC Ferguson-Smith (2001)
Sleutels, S., Barlow, D.S. & Lyle, R. The uniqueness of the imprinting mechanism. Curr. Opin. Genet. Dev. 10, 229–233 (2000). (10.1016/S0959-437X(00)00062-9) / Curr. Opin. Genet. Dev. by S Sleutels (2000)
Delaval, K. & Feil, R. Epigenetic regulation of mammalian genomic imprinting. Curr. Opin. Genet. Dev. 14, 188–195 (2004). (10.1016/j.gde.2004.01.005) / Curr. Opin. Genet. Dev. by K Delaval (2004)
Li, E., Beard, C. & Jaenisch, R. Role of DNA methylation in genomic imprinting. Nature 366, 362–365 (1993). (10.1038/366362a0) / Nature by E Li (1993)
Fitzpatrick, G.V., Soloway, P.D. & Higgins, M.J. Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat. Genet. 32, 426–431 (2002). (10.1038/ng988) / Nat. Genet. by GV Fitzpatrick (2002)
Mancini-DiNardo, D., Steele, S.J.S., Ingram, R.S. & Tilghman, S.M. A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencer. Hum. Mol. Genet. 12, 283–294 (2003). (10.1093/hmg/ddg024) / Hum. Mol. Genet. by D Mancini-DiNardo (2003)
Caspary, T., Cleary, M.A., Baker, C., Guan, X-J. & Tilghman, S.M. Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster. Mol. Cell Biol. 18, 3466–3474 (1998). (10.1128/MCB.18.6.3466) / Mol. Cell Biol. by T Caspary (1998)
Tanaka, M. et al. Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation. Mech. Dev. 87, 129–142 (1999). (10.1016/S0925-4773(99)00158-6) / Mech. Dev. by M Tanaka (1999)
Yatsuki, H. et al. Domain regulation of imprinting cluster in Kip2/lit1 subdomain on mouse chromosome 7F4/F5: Large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region. Genome Res. 12, 1860–1870 (2002). (10.1101/gr.110702) / Genome Res. by H Yatsuki (2002)
Higashimoto, K. et al. Characterization and imprinting status of OBPH1/Obph1 gene: Implications for an extended imprinting domain. Genomics 80, 575–584 (2002). (10.1006/geno.2002.7006) / Genomics by K Higashimoto (2002)
Engemann, S. et al. Sequence and functional comparison in the Beckwith-Wiedemann region: implication for a novel imprinting centre and extended imprinting. Hum. Mol. Genet. 9, 2691–2706 (2000). (10.1093/hmg/9.18.2691) / Hum. Mol. Genet. by S Engemann (2000)
Paulsen, M. et al. Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse. Hum. Mol. Genet. 9, 1829–1841 (2000). (10.1093/hmg/9.12.1829) / Hum. Mol. Genet. by M Paulsen (2000)
Peters, A.H.F.M. et al. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol. Cell 12, 1577–1589 (2003). (10.1016/S1097-2765(03)00477-5) / Mol. Cell by AHFM Peters (2003)
Cao, R. et al. Role of H3 lysine 27 methylation in Polycomb-group silencing. Science 298, 1039–1043 (2002). (10.1126/science.1076997) / Science by R Cao (2002)
Kouzarides, T. Histone methylation in transcriptional control. Curr. Opin. Genet. Dev. 12, 198–209 (2002). (10.1016/S0959-437X(02)00287-3) / Curr. Opin. Genet. Dev. by T Kouzarides (2002)
Dean, W. et al. Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes. Development 125, 2273–2282 (1998). (10.1242/dev.125.12.2273) / Development by W Dean (1998)
Erhardt, S. et al. Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 130, 4235–4248 (2003). (10.1242/dev.00625) / Development by S Erhardt (2003)
Cao, R. & Zhang, Y. The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr. Opin. Genet. Dev. 14, 155–164 (2004). (10.1016/j.gde.2004.02.001) / Curr. Opin. Genet. Dev. by R Cao (2004)
Cao, R. & Zhang, Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 15, 57–67 (2004). (10.1016/j.molcel.2004.06.020) / Mol. Cell by R Cao (2004)
Mager, J., Montgomery, N.D., Pardo-Manuel de Villena, F. & Magnuson, T. Genome imprinting regulated by the mouse polycomb group protein Eed. Nat. Genet. 33, 502–507 (2003). (10.1038/ng1125) / Nat. Genet. by J Mager (2003)
Fournier, C. et al. Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes. EMBO J. 21, 6560–6570 (2002). (10.1093/emboj/cdf655) / EMBO J. by C Fournier (2002)
Lewis, A. et al. Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat. Genet. advance online publication, 31 October 2004 (doi:10.1038/ng1468). (10.1038/ng1468)
Silva, J. et al. Establishment of histone H3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb-group complexes. Dev. Cell 4, 481–495 (2003). (10.1016/S1534-5807(03)00068-6) / Dev. Cell by J Silva (2003)
Zwart, R. et al. Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes. Genes Dev. 15, 2361–2366 (2001). (10.1101/gad.206201) / Genes Dev. by R Zwart (2001)
Mann, M.R. et al. Selective loss of imprinting in the placenta following preimplantation development in culture. Development 131, 3727–3735 (2004). (10.1242/dev.01241) / Development by MR Mann (2004)
Wang, J. et al. Imprinted X inactivation maintained by a mouse Polycomb group gene. Nat. Genet. 28, 371–375 (2001). (10.1038/ng574) / Nat. Genet. by J Wang (2001)
Plath, K. et al. Role of histone lysine 27 methylation in X-inactivation. Science 300, 131–135 (2003). (10.1126/science.1084274) / Science by K Plath (2003)
Okamoto, I. et al. Epigenetic dynamics of imprinted X inactivation during early mouse development. Science 303, 644–649 (2004). (10.1126/science.1092727) / Science by I Okamoto (2004)
Mak, W. et al. Reactivation of the paternal X chromosome in early mouse embryos. Science 303, 666–669 (2004). (10.1126/science.1092674) / Science by W Mak (2004)
Huynh, K.D. & Lee, J.T. Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature 426, 857–862 (2004). (10.1038/nature02222) / Nature by KD Huynh (2004)

Dates

Type	When
Created	20 years, 9 months ago (Oct. 31, 2004, 1:46 p.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 6:07 p.m.)
Indexed	3 weeks, 1 day ago (Aug. 6, 2025, 9:36 a.m.)
Issued	20 years, 9 months ago (Oct. 31, 2004)
Published	20 years, 9 months ago (Oct. 31, 2004)
Published Online	20 years, 9 months ago (Oct. 31, 2004)
Published Print	20 years, 8 months ago (Dec. 1, 2004)

Funders 0

None

BibTeX

@article{Umlauf_2004, title={Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes}, volume={36}, ISSN={1546-1718}, url={http://dx.doi.org/10.1038/ng1467}, DOI={10.1038/ng1467}, number={12}, journal={Nature Genetics}, publisher={Springer Science and Business Media LLC}, author={Umlauf, David and Goto, Yuji and Cao, Ru and Cerqueira, Frédérique and Wagschal, Alexandre and Zhang, Yi and Feil, Robert}, year={2004}, month=oct, pages={1296–1300} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        6
      ]
    ],
    "date-time": "2025-08-06T13:36:58Z",
    "timestamp": 1754487418210
  },
  "reference-count": 30,
  "publisher": "Springer Science and Business Media LLC",
  "issue": "12",
  "license": [
    {
      "start": {
        "date-parts": [
          [
            2004,
            10,
            31
          ]
        ],
        "date-time": "2004-10-31T00:00:00Z",
        "timestamp": 1099180800000
      },
      "content-version": "tdm",
      "delay-in-days": 0,
      "URL": "http://www.springer.com/tdm"
    }
  ],
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        2004,
        12
      ]
    ]
  },
  "DOI": "10.1038/ng1467",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2004,
        10,
        31
      ]
    ],
    "date-time": "2004-10-31T18:46:53Z",
    "timestamp": 1099248413000
  },
  "page": "1296-1300",
  "source": "Crossref",
  "is-referenced-by-count": 343,
  "title": "Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes",
  "prefix": "10.1038",
  "volume": "36",
  "author": [
    {
      "given": "David",
      "family": "Umlauf",
      "sequence": "first",
      "affiliation": []
    },
    {
      "given": "Yuji",
      "family": "Goto",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Ru",
      "family": "Cao",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Fr\u00e9d\u00e9rique",
      "family": "Cerqueira",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Alexandre",
      "family": "Wagschal",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Yi",
      "family": "Zhang",
      "sequence": "additional",
      "affiliation": []
    },
    {
      "given": "Robert",
      "family": "Feil",
      "sequence": "additional",
      "affiliation": []
    }
  ],
  "member": "297",
  "published-online": {
    "date-parts": [
      [
        2004,
        10,
        31
      ]
    ]
  },
  "reference": [
    {
      "key": "BFng1467_CR1",
      "doi-asserted-by": "publisher",
      "first-page": "1086",
      "DOI": "10.1126/science.1064020",
      "volume": "293",
      "author": "AC Ferguson-Smith",
      "year": "2001",
      "unstructured": "Ferguson-Smith, A.C. & Surani, M.A. Imprinting and the epigenetic asymmetry between parental genomes. Science 293, 1086\u20131089 (2001).",
      "journal-title": "Science"
    },
    {
      "key": "BFng1467_CR2",
      "doi-asserted-by": "publisher",
      "first-page": "229",
      "DOI": "10.1016/S0959-437X(00)00062-9",
      "volume": "10",
      "author": "S Sleutels",
      "year": "2000",
      "unstructured": "Sleutels, S., Barlow, D.S. & Lyle, R. The uniqueness of the imprinting mechanism. Curr. Opin. Genet. Dev. 10, 229\u2013233 (2000).",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "BFng1467_CR3",
      "doi-asserted-by": "publisher",
      "first-page": "188",
      "DOI": "10.1016/j.gde.2004.01.005",
      "volume": "14",
      "author": "K Delaval",
      "year": "2004",
      "unstructured": "Delaval, K. & Feil, R. Epigenetic regulation of mammalian genomic imprinting. Curr. Opin. Genet. Dev. 14, 188\u2013195 (2004).",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "BFng1467_CR4",
      "doi-asserted-by": "publisher",
      "first-page": "362",
      "DOI": "10.1038/366362a0",
      "volume": "366",
      "author": "E Li",
      "year": "1993",
      "unstructured": "Li, E., Beard, C. & Jaenisch, R. Role of DNA methylation in genomic imprinting. Nature 366, 362\u2013365 (1993).",
      "journal-title": "Nature"
    },
    {
      "key": "BFng1467_CR5",
      "doi-asserted-by": "publisher",
      "first-page": "426",
      "DOI": "10.1038/ng988",
      "volume": "32",
      "author": "GV Fitzpatrick",
      "year": "2002",
      "unstructured": "Fitzpatrick, G.V., Soloway, P.D. & Higgins, M.J. Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat. Genet. 32, 426\u2013431 (2002).",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "BFng1467_CR6",
      "doi-asserted-by": "publisher",
      "first-page": "283",
      "DOI": "10.1093/hmg/ddg024",
      "volume": "12",
      "author": "D Mancini-DiNardo",
      "year": "2003",
      "unstructured": "Mancini-DiNardo, D., Steele, S.J.S., Ingram, R.S. & Tilghman, S.M. A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencer. Hum. Mol. Genet. 12, 283\u2013294 (2003).",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "BFng1467_CR7",
      "doi-asserted-by": "publisher",
      "first-page": "3466",
      "DOI": "10.1128/MCB.18.6.3466",
      "volume": "18",
      "author": "T Caspary",
      "year": "1998",
      "unstructured": "Caspary, T., Cleary, M.A., Baker, C., Guan, X-J. & Tilghman, S.M. Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster. Mol. Cell Biol. 18, 3466\u20133474 (1998).",
      "journal-title": "Mol. Cell Biol."
    },
    {
      "key": "BFng1467_CR8",
      "doi-asserted-by": "publisher",
      "first-page": "129",
      "DOI": "10.1016/S0925-4773(99)00158-6",
      "volume": "87",
      "author": "M Tanaka",
      "year": "1999",
      "unstructured": "Tanaka, M. et al. Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation. Mech. Dev. 87, 129\u2013142 (1999).",
      "journal-title": "Mech. Dev."
    },
    {
      "key": "BFng1467_CR9",
      "doi-asserted-by": "publisher",
      "first-page": "1860",
      "DOI": "10.1101/gr.110702",
      "volume": "12",
      "author": "H Yatsuki",
      "year": "2002",
      "unstructured": "Yatsuki, H. et al. Domain regulation of imprinting cluster in Kip2/lit1 subdomain on mouse chromosome 7F4/F5: Large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region. Genome Res. 12, 1860\u20131870 (2002).",
      "journal-title": "Genome Res."
    },
    {
      "key": "BFng1467_CR10",
      "doi-asserted-by": "publisher",
      "first-page": "575",
      "DOI": "10.1006/geno.2002.7006",
      "volume": "80",
      "author": "K Higashimoto",
      "year": "2002",
      "unstructured": "Higashimoto, K. et al. Characterization and imprinting status of OBPH1/Obph1 gene: Implications for an extended imprinting domain. Genomics 80, 575\u2013584 (2002).",
      "journal-title": "Genomics"
    },
    {
      "key": "BFng1467_CR11",
      "doi-asserted-by": "publisher",
      "first-page": "2691",
      "DOI": "10.1093/hmg/9.18.2691",
      "volume": "9",
      "author": "S Engemann",
      "year": "2000",
      "unstructured": "Engemann, S. et al. Sequence and functional comparison in the Beckwith-Wiedemann region: implication for a novel imprinting centre and extended imprinting. Hum. Mol. Genet. 9, 2691\u20132706 (2000).",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "BFng1467_CR12",
      "doi-asserted-by": "publisher",
      "first-page": "1829",
      "DOI": "10.1093/hmg/9.12.1829",
      "volume": "9",
      "author": "M Paulsen",
      "year": "2000",
      "unstructured": "Paulsen, M. et al. Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse. Hum. Mol. Genet. 9, 1829\u20131841 (2000).",
      "journal-title": "Hum. Mol. Genet."
    },
    {
      "key": "BFng1467_CR13",
      "doi-asserted-by": "publisher",
      "first-page": "1577",
      "DOI": "10.1016/S1097-2765(03)00477-5",
      "volume": "12",
      "author": "AHFM Peters",
      "year": "2003",
      "unstructured": "Peters, A.H.F.M. et al. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol. Cell 12, 1577\u20131589 (2003).",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "BFng1467_CR14",
      "doi-asserted-by": "publisher",
      "first-page": "1039",
      "DOI": "10.1126/science.1076997",
      "volume": "298",
      "author": "R Cao",
      "year": "2002",
      "unstructured": "Cao, R. et al. Role of H3 lysine 27 methylation in Polycomb-group silencing. Science 298, 1039\u20131043 (2002).",
      "journal-title": "Science"
    },
    {
      "key": "BFng1467_CR15",
      "doi-asserted-by": "publisher",
      "first-page": "198",
      "DOI": "10.1016/S0959-437X(02)00287-3",
      "volume": "12",
      "author": "T Kouzarides",
      "year": "2002",
      "unstructured": "Kouzarides, T. Histone methylation in transcriptional control. Curr. Opin. Genet. Dev. 12, 198\u2013209 (2002).",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "BFng1467_CR16",
      "doi-asserted-by": "crossref",
      "first-page": "2273",
      "DOI": "10.1242/dev.125.12.2273",
      "volume": "125",
      "author": "W Dean",
      "year": "1998",
      "unstructured": "Dean, W. et al. Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes. Development 125, 2273\u20132282 (1998).",
      "journal-title": "Development"
    },
    {
      "key": "BFng1467_CR17",
      "doi-asserted-by": "publisher",
      "first-page": "4235",
      "DOI": "10.1242/dev.00625",
      "volume": "130",
      "author": "S Erhardt",
      "year": "2003",
      "unstructured": "Erhardt, S. et al. Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development 130, 4235\u20134248 (2003).",
      "journal-title": "Development"
    },
    {
      "key": "BFng1467_CR18",
      "doi-asserted-by": "publisher",
      "first-page": "155",
      "DOI": "10.1016/j.gde.2004.02.001",
      "volume": "14",
      "author": "R Cao",
      "year": "2004",
      "unstructured": "Cao, R. & Zhang, Y. The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. Curr. Opin. Genet. Dev. 14, 155\u2013164 (2004).",
      "journal-title": "Curr. Opin. Genet. Dev."
    },
    {
      "key": "BFng1467_CR19",
      "doi-asserted-by": "publisher",
      "first-page": "57",
      "DOI": "10.1016/j.molcel.2004.06.020",
      "volume": "15",
      "author": "R Cao",
      "year": "2004",
      "unstructured": "Cao, R. & Zhang, Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 15, 57\u201367 (2004).",
      "journal-title": "Mol. Cell"
    },
    {
      "key": "BFng1467_CR20",
      "doi-asserted-by": "publisher",
      "first-page": "502",
      "DOI": "10.1038/ng1125",
      "volume": "33",
      "author": "J Mager",
      "year": "2003",
      "unstructured": "Mager, J., Montgomery, N.D., Pardo-Manuel de Villena, F. & Magnuson, T. Genome imprinting regulated by the mouse polycomb group protein Eed. Nat. Genet. 33, 502\u2013507 (2003).",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "BFng1467_CR21",
      "doi-asserted-by": "publisher",
      "first-page": "6560",
      "DOI": "10.1093/emboj/cdf655",
      "volume": "21",
      "author": "C Fournier",
      "year": "2002",
      "unstructured": "Fournier, C. et al. Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes. EMBO J. 21, 6560\u20136570 (2002).",
      "journal-title": "EMBO J."
    },
    {
      "key": "BFng1467_CR22",
      "doi-asserted-by": "crossref",
      "unstructured": "Lewis, A. et al. Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation. Nat. Genet. advance online publication, 31 October 2004 (doi:10.1038/ng1468).",
      "DOI": "10.1038/ng1468"
    },
    {
      "key": "BFng1467_CR23",
      "doi-asserted-by": "publisher",
      "first-page": "481",
      "DOI": "10.1016/S1534-5807(03)00068-6",
      "volume": "4",
      "author": "J Silva",
      "year": "2003",
      "unstructured": "Silva, J. et al. Establishment of histone H3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb-group complexes. Dev. Cell 4, 481\u2013495 (2003).",
      "journal-title": "Dev. Cell"
    },
    {
      "key": "BFng1467_CR24",
      "doi-asserted-by": "publisher",
      "first-page": "2361",
      "DOI": "10.1101/gad.206201",
      "volume": "15",
      "author": "R Zwart",
      "year": "2001",
      "unstructured": "Zwart, R. et al. Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes. Genes Dev. 15, 2361\u20132366 (2001).",
      "journal-title": "Genes Dev."
    },
    {
      "key": "BFng1467_CR25",
      "doi-asserted-by": "publisher",
      "first-page": "3727",
      "DOI": "10.1242/dev.01241",
      "volume": "131",
      "author": "MR Mann",
      "year": "2004",
      "unstructured": "Mann, M.R. et al. Selective loss of imprinting in the placenta following preimplantation development in culture. Development 131, 3727\u20133735 (2004).",
      "journal-title": "Development"
    },
    {
      "key": "BFng1467_CR26",
      "doi-asserted-by": "publisher",
      "first-page": "371",
      "DOI": "10.1038/ng574",
      "volume": "28",
      "author": "J Wang",
      "year": "2001",
      "unstructured": "Wang, J. et al. Imprinted X inactivation maintained by a mouse Polycomb group gene. Nat. Genet. 28, 371\u2013375 (2001).",
      "journal-title": "Nat. Genet."
    },
    {
      "key": "BFng1467_CR27",
      "doi-asserted-by": "publisher",
      "first-page": "131",
      "DOI": "10.1126/science.1084274",
      "volume": "300",
      "author": "K Plath",
      "year": "2003",
      "unstructured": "Plath, K. et al. Role of histone lysine 27 methylation in X-inactivation. Science 300, 131\u2013135 (2003).",
      "journal-title": "Science"
    },
    {
      "key": "BFng1467_CR28",
      "doi-asserted-by": "publisher",
      "first-page": "644",
      "DOI": "10.1126/science.1092727",
      "volume": "303",
      "author": "I Okamoto",
      "year": "2004",
      "unstructured": "Okamoto, I. et al. Epigenetic dynamics of imprinted X inactivation during early mouse development. Science 303, 644\u2013649 (2004).",
      "journal-title": "Science"
    },
    {
      "key": "BFng1467_CR29",
      "doi-asserted-by": "publisher",
      "first-page": "666",
      "DOI": "10.1126/science.1092674",
      "volume": "303",
      "author": "W Mak",
      "year": "2004",
      "unstructured": "Mak, W. et al. Reactivation of the paternal X chromosome in early mouse embryos. Science 303, 666\u2013669 (2004).",
      "journal-title": "Science"
    },
    {
      "key": "BFng1467_CR30",
      "doi-asserted-by": "publisher",
      "first-page": "857",
      "DOI": "10.1038/nature02222",
      "volume": "426",
      "author": "KD Huynh",
      "year": "2004",
      "unstructured": "Huynh, K.D. & Lee, J.T. Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature 426, 857\u2013862 (2004).",
      "journal-title": "Nature"
    }
  ],
  "container-title": "Nature Genetics",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "http://www.nature.com/articles/ng1467.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/ng1467",
      "content-type": "text/html",
      "content-version": "vor",
      "intended-application": "text-mining"
    },
    {
      "URL": "http://www.nature.com/articles/ng1467.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        5,
        18
      ]
    ],
    "date-time": "2023-05-18T22:07:44Z",
    "timestamp": 1684447664000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.nature.com/articles/ng1467"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2004,
        10,
        31
      ]
    ]
  },
  "references-count": 30,
  "journal-issue": {
    "issue": "12",
    "published-print": {
      "date-parts": [
        [
          2004,
          12
        ]
      ]
    }
  },
  "alternative-id": [
    "BFng1467"
  ],
  "URL": "http://dx.doi.org/10.1038/ng1467",
  "relation": {},
  "ISSN": [
    "1061-4036",
    "1546-1718"
  ],
  "subject": [],
  "container-title-short": "Nat Genet",
  "published": {
    "date-parts": [
      [
        2004,
        10,
        31
      ]
    ]
  }
}