DOI: 10.1038/ng1292-340. A locus for familial early–onset Alzhelmer's disease on the long arm of chromosome 14, proximal to the α1

A locus for familial early–onset Alzhelmer's disease on the long arm of chromosome 14, proximal to the α1–antichymotrypsin gene

10.1038/ng1292-340

Crossref journal-article

Springer Science and Business Media LLC

Nature Genetics (297)

Bibliography

Mullan, M., Houlden, H., Windelspecht, M., Fidani, L., Lombardi, C., Diaz, P., Rossor, M., Crook, R., Hardy, J., Duff, K., & Crawford, F. (1992). A locus for familial earlyâonset Alzhelmerâs disease on the long arm of chromosome 14, proximal to the Î±1âantichymotrypsin gene. Nature Genetics, 2(4), 340â342.

Authors 11

Mike Mullan (first)
Henry Houlden (additional)
Mike Windelspecht (additional)
Liana Fidani (additional)
Chris Lombardi (additional)
Pat Diaz (additional)
Martin Rossor (additional)
Richard Crook (additional)
John Hardy (additional)
Karen Duff (additional)
Fiona Crawford (additional)

References 20 Referenced 206

Masters, C.L. et al. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. natn. Acad. Sci. U.S.A. 82, 4245–4249 (1985). (10.1073/pnas.82.12.4245) / Proc. natn. Acad. Sci. U.S.A. by CL Masters (1985)
Wong, C.W., Quaranta, V. & Glenner, G. Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related. Proc. natn. Acad. Sci. U.S.A. 82, 8729–6732 (1985). (10.1073/pnas.82.24.8729) / Proc. natn. Acad. Sci. U.S.A. by CW Wong (1985)
Goate, A. et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704–706 (1991). (10.1038/349704a0) / Nature by A Goate (1991)
Chartier Harlin, M.C. et al. Early onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene. Nature 353, 844–846 (1991). (10.1038/353844a0) / Nature by MC Chartier Harlin (1991)
Murrell, J., Farlow, M., Ghetti, B. & Benson, M. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254, 97–99 (1991). (10.1126/science.1925564) / Science by J Murrell (1991)
Mullan, M. et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N terminus of β-amyloid. Nature Genet. 1, 345–347 (1992). (10.1038/ng0892-345) / Nature Genet. by M Mullan (1992)
Weitkamp, L.R., Nee, L., Keats, B., Polinsky, R.J. & Guttormsen, S. Alzheimer's disease: Evidence for susceptibility loci on chromosomes 6 and 14. Am. J. hum. Genet. 35, 443–453 (1983). / Am. J. hum. Genet. by LR Weitkamp (1983)
Abraham, C.R., Selkoe, D.J. & Potter, H. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell 52, 487–501 (1988). (10.1016/0092-8674(88)90462-X) / Cell by CR Abraham (1988)
Cox, D., Nakamura, Y. & Gedde-Dahl, T. Jr., Report of the committee on the genetic constitution of chromosome 14. Cytogenet. Cell Genet. 55, 183–188 (1990). (10.1159/000133010) / Cytogenet. Cell Genet. by D Cox (1990)
Wang, Z. & Weber, J. Continuous linkage map of human chromosome 14 short tandem repeat polymorphisms. Genomics 13, 532–536 (1992). (10.1016/0888-7543(92)90121-8) / Genomics by Z Wang (1992)
Ott, J. Analysis of Human Genetic Linkage (Johns Hopkins University Press, Baltimore, 1991). / Analysis of Human Genetic Linkage by J Ott (1991)
Fidani, L. et al. Screen for mutations in the open reading frame and promoter of the beta-amyloid precursor protein gene in familial Alzheimer's disease: Identification of a further family with APP717 Val→lle. Hum. molec. Genet. 1, 165–168 (1992). (10.1093/hmg/1.3.165) / Hum. molec. Genet. by L Fidani (1992)
Schellenberg, G. et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 258, 668–671 (1992). (10.1126/science.1411576) / Science by G Schellenberg (1992)
Glenner, G.G. & Murphy, M.A. Amyloidosis of the nervous system. J. neurol. Sci. 94, 1–28 (1989). (10.1016/0022-510X(89)90214-1) / J. neurol. Sci. by GG Glenner (1989)
Selkoe, D.J. The molecular pathology of Alzheimer's disease. Neuron 6, 487–491 (1991). (10.1016/0896-6273(91)90052-2) / Neuron by DJ Selkoe (1991)
Hardy, J.A. & Higgins, G.A. Alzheimer's disease: The amyloid cascade hypothesis. Science 256, 184–185 (1992). (10.1126/science.1566067) / Science by JA Hardy (1992)
Abe, K., St. George Hyslop, P.H., Tanzi, R.E. & Kogure, K. Induction of the amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells. Neurosci. Letts. 125, 169–171 (1991). (10.1016/0304-3940(91)90019-P) / Neurosci. Letts. by K Abe (1991)
McKhann, G. et al. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34, 939–944 (1984). (10.1212/WNL.34.7.939) / Neurology by G McKhann (1984)
Folstein, M.F., Folstein, S.E. & McHugh, P.R. “Mini Mental State”: A practical method for grading cognitive state of patients for the clinician. J. Psychiatr. Research 12, 189–198 (1975). (10.1016/0022-3956(75)90026-6) / J. Psychiatr. Research by MF Folstein (1975)
Lathrop, G.M. & Ott, J. Analysis of complex diseases under oligogenic models and intrafamilial heterogeneity by the LINKAGE programs. Am. J. hum. Genet. 47, A188 (abstr.) (1990). / Am. J. hum. Genet. by GM Lathrop (1990)

Dates

Type	When
Created	21 years ago (Aug. 18, 2004, 4:50 p.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 6:01 p.m.)
Indexed	2 months, 1 week ago (June 25, 2025, 12:27 a.m.)
Issued	32 years, 9 months ago (Dec. 1, 1992)
Published	32 years, 9 months ago (Dec. 1, 1992)
Published Print	32 years, 9 months ago (Dec. 1, 1992)

Funders 0

None

BibTeX

@article{Mullan_1992, title={A locus for familial early–onset Alzhelmer’s disease on the long arm of chromosome 14, proximal to the α1–antichymotrypsin gene}, volume={2}, ISSN={1546-1718}, url={http://dx.doi.org/10.1038/ng1292-340}, DOI={10.1038/ng1292-340}, number={4}, journal={Nature Genetics}, publisher={Springer Science and Business Media LLC}, author={Mullan, Mike and Houlden, Henry and Windelspecht, Mike and Fidani, Liana and Lombardi, Chris and Diaz, Pat and Rossor, Martin and Crook, Richard and Hardy, John and Duff, Karen and Crawford, Fiona}, year={1992}, month=dec, pages={340–342} }

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