DOI: 10.1038/ng1197-298. Trinucleotide repeats affect DNA replication in vivo

Trinucleotide repeats affect DNA replication in vivo

10.1038/ng1197-298

Crossref journal-article

Springer Science and Business Media LLC

Nature Genetics (297)

Authors 3

George M. Samadashwily (first)
Gordana Raca (additional)
Sergei M. Mirkin (additional)

References 50 Referenced 257

Ashley, C. Jr. & Warren, S.T. Trinucleotide repeat expansion and human disease. Annu. Rev. Genet. 29, 703–728 (1995). (10.1146/annurev.ge.29.120195.003415) / Annu. Rev. Genet. by C Ashley Jr. (1995)
McMurray, C.T. Mechanisms of DNA expansion. Chromosoma 104, 2–13 (1995). / Chromosoma by CT McMurray (1995)
Wells, R.D. Molecular basis of genetic instability of triplet repeats. J. Biot. Chem. 271, 2875–2878 (1996). (10.1074/jbc.271.6.2875) / J. Biot. Chem. by RD Wells (1996)
Bates, G. & Lehrach, H. Trinucleotide repeat expansions and human genetic disease. Bioessays 16, 277–284 (1994). (10.1002/bies.950160411) / Bioessays by G Bates (1994)
Caskey, C.T., Pizzuti, A., Fu, Y.-H., Fenwick, R.G., & Nelson, D.L. Triplet repeat mutations in human disease. Science 256, 784–789 (1992). (10.1126/science.1589758) / Science by CT Caskey (1992)
Cox, R. & Mirkin, S.M. Characteristic enrichment of DNA repeats in different genomes. Proc. Natl. Acad. Sci. USA 94, 5237–5242 (1997). (10.1073/pnas.94.10.5237) / Proc. Natl. Acad. Sci. USA by R Cox (1997)
Kohwi, Y., Wang, H. & Kohwi-Shigematsu, T. A single trinucleotide, 5′AGC3′/5′GCT3′, of the triplet-repeat disease genes confers metal ion-induced non-B DNA structure. Nucleic Acids Res. 21, 5651–5655 (1993). (10.1093/nar/21.24.5651) / Nucleic Acids Res. by Y Kohwi (1993)
Bacolla, A. et al. Flexible DNA: genetically unstable CTG CAG and CGG CCG from human hereditary neuromuscular disease genes. J. Biol. Chem. 272, 16783–16792 (1997). (10.1074/jbc.272.27.16783) / J. Biol. Chem. by A Bacolla (1997)
Mitchell, J.E., Newbury, S.F. & McClellan, J.A. Compact structures of d(CNG)n oligonucleotides in solution and their possible relevance to fragile X and related human genetic diseases. Nucleic Acids Res. 23, 1876–1881 (1995). (10.1093/nar/23.11.1876) / Nucleic Acids Res. by JE Mitchell (1995)
Petruska, J., Arnheim, N. & Goodman, M.F. Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseases. Nucleic Adds Res. 24, 1992–1998 (1996). (10.1093/nar/24.11.1992) / Nucleic Adds Res. by J Petruska (1996)
Yu, A. et al. The trinucleotide repeat sequence d(GTC)l5 adopts a hairpin conformation. Nucleic Acids Res. 23, 2706–2714 (1995). (10.1093/nar/23.14.2706) / Nucleic Acids Res. by A Yu (1995)
Yu, A. et al. At physiological pH, d(CCG)15 forms a hairpin containing protonated cytosines and a distorted helix. Biochemistry 36, 3687–3699 (1997). (10.1021/bi9625410) / Biochemistry by A Yu (1997)
Zheng, M., Huang, X., Smith, G.K., Yang, X. & Gao, X. Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding: an NMR and UV spectroscopic study. J. Mol. Biol. 264, 323–336 (1996). (10.1006/jmbi.1996.0643) / J. Mol. Biol. by M Zheng (1996)
Gacy, A.M., Goellner, G., Juranic, N., Macura, S. & McMurray, C.T. Trinucleotide repeats that expand in human disease form hairpin structures in vitro. Cell 81, 533–540 (1995). (10.1016/0092-8674(95)90074-8) / Cell by AM Gacy (1995)
Chen, X. et al. Hairpins are formed by the single DNA strands of the fragile X triplet repeats: structure and biological implications. Proc. Natl. Acad. Sci. USA 92, 5199–5203 (1995). (10.1073/pnas.92.11.5199) / Proc. Natl. Acad. Sci. USA by X Chen (1995)
Fry, M. & Loeb, L.A. The fragile X syndrome d(CGG)n nucleotide repeats form a stable tetrahelical structure. Proc. Natl. Acad. Sci. USA 91, 4950–4954 (1994). (10.1073/pnas.91.11.4950) / Proc. Natl. Acad. Sci. USA by M Fry (1994)
Kettani, A., Kumar, R.A. & Patel, D.J. Solution structure of a DNA quadruplex containing the fragile X syndrome triplet repeat. J. Mol. Biol. 254, 638–656 (1995). (10.1006/jmbi.1995.0644) / J. Mol. Biol. by A Kettani (1995)
Kuryavyi, V.V. & Jovin, T.M. Triad-DNA: a model for trinucleotide repeats. Nature Genet. 9, 339–341 (1995). (10.1038/ng0495-339) / Nature Genet. by VV Kuryavyi (1995)
Reiss, A.L. et al. Frequency and stability of the fragile X premutation. Hum. Mol. Genet. 3, 393–398 (1994). (10.1093/hmg/3.3.393) / Hum. Mol. Genet. by AL Reiss (1994)
Kunst, C.B. & Warrren, S.T. Cryptic and polar variation of the fragile X repeat could result in predisposing normal alleles. Cell 77, 853–861 (1994). (10.1016/0092-8674(94)90134-1) / Cell by CB Kunst (1994)
Snow, K., Tester, D.J., Kruckeberg, K.E., Schaid, D.J. & Thibodeau, S.N. Sequence analysis of the fragile X trinucleotide repeat: implications for the origin of the fragile X mutation. Hum. Mol. Genet. 3, 1543–1551 (1994). (10.1093/hmg/3.9.1543) / Hum. Mol. Genet. by K Snow (1994)
Jodice, C. et al. Effect of trinucleotide repeat length and parental sex on phenotypic variation in spinocerebellar ataxia I. Am. J. Hum. Genet. 54, 959–965 (1994). / Am. J. Hum. Genet. by C Jodice (1994)
Trinh, T.Q. & Sinden, R.R. Preferential DNA secondary structure mutagenesis in the lagging strand of replication in E. coli. Nature 352, 544–547 (1991). (10.1038/352544a0) / Nature by TQ Trinh (1991)
Kang, S., Ohshima, K., Shimizu, M., Amirhaeri, S. & Wells, R.D. Pausing of DNA synthesis in vitro at specific loci in CTG and CGG triplet repeats from human hereditary disease genes. J. Biol. Chem. 270, 27014–27021 (1995). (10.1074/jbc.270.45.27014) / J. Biol. Chem. by S Kang (1995)
Ohshima, K. & Wells, R.D. Hairpin formation during DNA synthesis primer realignment in vitro in triplet repeat sequences from human hereditary disease genes. J. Biol. Chem. 272, 16798–16806 (1997). (10.1074/jbc.272.27.16798) / J. Biol. Chem. by K Ohshima (1997)
Usdin, K. & Woodford, K.J. CGG repeats associated with DNA instability and chromosome fragility from structures that block DNA synthesis in vitro. Nucleic Acids Res. 23, 4202–4209 (1995). (10.1093/nar/23.20.4202) / Nucleic Acids Res. by K Usdin (1995)
Kang, S., Ohshima, K., Jaworski, A. & Wells, R.D. CTG triplet repeats from the myotonic dystrophy gene are expanded in Escherichia coli distal to the replication origin as a single large event. J. Mol. Biol. 258, 543–547 (1996). / Escherichia coli distal to the replication origin as a single large event by S Kang (1996)
Kang, S., Jaworski, A., Ohshima, K. & Wells, R.D. Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli. Nature Genet. 10, 213–218 (1995). (10.1038/ng0695-213) / Nature Genet. by S Kang (1995)
Bowater, R.P., Rosche, W.A., Jaworski, A., Sinden, R.R. & Wells, R.D. Relationship between Escherichia coli growth and deletions of CTG. CAG triplet repeats in plasmids. J. Mol. Biol. 264, 82–96 (1996). (10.1006/jmbi.1996.0625) / J. Mol. Biol. by RP Bowater (1996)
Ohshima, K., Kang, S. & Wells, R.D. CTG triplet repeats from human hereditary diseases are dominant genetic expansion products in Escherichia coli. J. Biol. Chem. 271, 1853–1856 (1996). / Escherichia coli by K Ohshima (1996)
Shimizu, M., Gellibolian, R., Oostra, B.A. & Wells, R.D., Cloning, characterization and properties of plasmids containing CGG triplet repeats from the FMR-1 gene. J. Mol. Biol. 258, 614–626 (1996). (10.1006/jmbi.1996.0273) / J. Mol. Biol. by M Shimizu (1996)
Webb, T. Delayed replication of Xq27 in individuals with the fragile X syndrome. Am. J. Med. Genet. 43, 1057–1062 (1992). (10.1002/ajmg.1320430633) / Am. J. Med. Genet. by T Webb (1992)
Hansen, R.S., Canfield, T.K., Lamb, M.M., Gartler, S.M. & Laird, C.D. Association of fragile X syndrome with delayed replication of the FMR1 gene. Cell 73, 1403–1409 (1993). (10.1016/0092-8674(93)90365-W) / Cell by RS Hansen (1993)
Subramanian, P.S., Nelson, D.L. & Chinault, A.C. Large domains of apparent delayed replication timing associated with triplet repeat expansion at FRAXA and FRAXE. Am. J. Hum. Genet. 59, 407–416 (1996). / Am. J. Hum. Genet. by PS Subramanian (1996)
Brewer, B.J. & Fangman, W.L. The localization of replication origins on ARS plasmids in S. cerevisiae. Cell 51, 463–471 (1987). (10.1016/0092-8674(87)90642-8) / Cell by BJ Brewer (1987)
Kornberg, A. & Baker, T. DNA Replication, 2nd ed.(W.H. Freeman & Co., New York, (1992). / DNA Replication, 2nd ed by A Kornberg (1992)
Amann, E., Ochs, B. & Abel, K.J. Tightly regulated tac promoter vectors useful for the expression of unfused and fused proteins in Escherichia coli. Gene 69, 301–315 (1988). (10.1016/0378-1119(88)90440-4) / Gene by E Amann (1988)
Martin-Parras, L., Hernandez, P., Martinez-Robles, M. & Schvartzman, J.B. Unidirectional replication as visualised by two-dimensional agarose gel electrophoresis. J. Mol. Biol. 220, 843–855 (1991). (10.1016/0022-2836(91)90357-C) / J. Mol. Biol. by L Martin-Parras (1991)
Clewell, D.B. Nature of Col E1 plasmid replication in Escherichia coli in the presence of chloramphenicol. J. Bacteriol. 110, 667–676 (1972). (10.1128/JB.110.2.667-676.1972) / J. Bacteriol. by DB Clewell (1972)
Balbas, P. et al. Plasmid vector pBR322 and its special-purpose derivatives—a review. Gene 50, 3–40 (1986). (10.1016/0378-1119(86)90307-0) / Gene by P Balbas (1986)
Friedman, K.L. & Brewer, B.J. Analysis of replication intermediates by two-dimensional agarose gel electrophoresis. Methods Enzymol. 262, 613–627 (1995). (10.1016/0076-6879(95)62048-6) / Methods Enzymol. by KL Friedman (1995)
Reaban, M.E., Lebowitz, J. & Griffin, J.A. Transcription induces the formation of a stable RNA-DNA hybrid in the immunoglobulin α switch region. J. Biol. Chem. 269, 21850–21857 (1994). (10.1016/S0021-9258(17)31881-1) / J. Biol. Chem. by ME Reaban (1994)
Reaban, M.E. & Griffin, J.A. Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region. Nature 348, 342–344 (1990). (10.1038/348342a0) / Nature by ME Reaban (1990)
Strand, M., Prolla, T.A., Liskay, R.M. & Petes, T.D. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365, 274–276 (1993). (10.1038/365274a0) / Nature by M Strand (1993)
Jaworski, A. et al. Mismatch repair in Escherichia coli enhances instability of (CTG)n triplet repeats from human hereditary diseases. Proc. Natl. Acad. Sci. USA 92, 11019–11023 (1995). / Escherichia coli enhances instability of (CTG)n triplet repeats from human hereditary diseases by A Jaworski (1995)
Hacker, K.J. & Alberts, B.M. The rapid dissociation of the T4 DNA polymerase holoenzyme when stopped by a DNA hairpin helix: a model for polymerase release following the termination of each Okazaki fragment. J. Biol. Chem. 269, 24221–24228 (1994). (10.1016/S0021-9258(19)51071-7) / J. Biol. Chem. by KJ Hacker (1994)
Krasilnikov, A.S. et al. Mechanisms of triplex-caused polymerization arrest. Nucleic Acids Res. 25, 1339–1346 (1997). (10.1093/nar/25.7.1339) / Nucleic Acids Res. by AS Krasilnikov (1997)
Gordenin, D.A., Kunkel, T.A. & Resnick, M.A. Repeat expansion—all in a flap? Nature Genet. 16, 116–118 (1997). (10.1038/ng0697-116) / Nature Genet. by DA Gordenin (1997)
Tishkoff, D.X., Filosi, N., Gaida, G.M. & Kolodner, R.D. A novel mutation avoidance mechanism dependent on S.cerevisiae RAD27 is distinct from DNA mismatch repair. Cell 88, 253–263 (1997). (10.1016/S0092-8674(00)81846-2) / Cell by DX Tishkoff (1997)
Samadashwily, G.M., Dayn, A. & Mirkin, S.M. Suicidal nucleotide sequences for DNA polymerization. EMBO J. 12, 4975–4983 (1993). (10.1002/j.1460-2075.1993.tb06191.x) / EMBO J. by GM Samadashwily (1993)

Dates

Type	When
Created	19 years, 1 month ago (July 21, 2006, 7:17 a.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 5:20 p.m.)
Indexed	1 week, 3 days ago (Aug. 27, 2025, 12:08 p.m.)
Issued	27 years, 10 months ago (Nov. 1, 1997)
Published	27 years, 10 months ago (Nov. 1, 1997)
Published Print	27 years, 10 months ago (Nov. 1, 1997)

Funders 0

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BibTeX

@article{Samadashwily_1997, title={Trinucleotide repeats affect DNA replication in vivo}, volume={17}, ISSN={1546-1718}, url={http://dx.doi.org/10.1038/ng1197-298}, DOI={10.1038/ng1197-298}, number={3}, journal={Nature Genetics}, publisher={Springer Science and Business Media LLC}, author={Samadashwily, George M. and Raca, Gordana and Mirkin, Sergei M.}, year={1997}, month=nov, pages={298–304} }

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