Lack of the bone morphogenetic protein BMP6 induces massive iron overload
10.1038/ng.320
Crossref journal-article
Springer Science and Business Media LLC
Nature Genetics (297)
Bibliography

Meynard, D., Kautz, L., Darnaud, V., Canonne-Hergaux, F., Coppin, H., & Roth, M.-P. (2009). Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nature Genetics, 41(4), 478–481.

Authors 6
  1. Delphine Meynard (first)
  2. Léon Kautz (additional)
  3. Valérie Darnaud (additional)
  4. François Canonne-Hergaux (additional)
  5. Hélène Coppin (additional)
  6. Marie-Paule Roth (additional)
References 26 Referenced 490
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  2. Truksa, J., Peng, H., Lee, P. & Beutler, E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc. Natl. Acad. Sci. USA 103, 10289–10293 (2006). (10.1073/pnas.0603124103) / Proc. Natl. Acad. Sci. USA by J Truksa (2006)
  3. Kautz, L. et al. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112, 1503–1509 (2008). (10.1182/blood-2008-03-143354) / Blood by L Kautz (2008)
  4. Nemeth, E. et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306, 2090–2093 (2004). (10.1126/science.1104742) / Science by E Nemeth (2004)
  5. Nemeth, E., Roetto, A., Garozzo, G., Ganz, T. & Camaschella, C. Hepcidin is decreased in TFR2 hemochromatosis. Blood 105, 1803–1806 (2005). (10.1182/blood-2004-08-3042) / Blood by E Nemeth (2005)
  6. Papanikolaou, G. et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat. Genet. 36, 77–82 (2004). (10.1038/ng1274) / Nat. Genet. by G Papanikolaou (2004)
  7. Piperno, A. et al. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood 110, 4096–4100 (2007). (10.1182/blood-2007-06-096503) / Blood by A Piperno (2007)
  8. Roetto, A. et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat. Genet. 33, 21–22 (2003). (10.1038/ng1053) / Nat. Genet. by A Roetto (2003)
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  12. Solloway, M.J. et al. Mice lacking Bmp6 function. Dev. Genet. 22, 321–339 (1998). (10.1002/(SICI)1520-6408(1998)22:4<321::AID-DVG3>3.0.CO;2-8) / Dev. Genet. by MJ Solloway (1998)
  13. Huang, F.W., Pinkus, J.L., Pinkus, G.S., Fleming, M.D. & Andrews, N.C. A mouse model of juvenile hemochromatosis. J. Clin. Invest. 115, 2187–2191 (2005). (10.1172/JCI25049) / J. Clin. Invest. by FW Huang (2005)
  14. Niederkofler, V., Salie, R. & Arber, S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J. Clin. Invest. 115, 2180–2186 (2005). (10.1172/JCI25683) / J. Clin. Invest. by V Niederkofler (2005)
  15. Lesbordes-Brion, J.C. et al. Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood 108, 1402–1405 (2006). (10.1182/blood-2006-02-003376) / Blood by JC Lesbordes-Brion (2006)
  16. Cox, T.M. & Halsall, D.J. Hemochromatosis—neonatal and young subjects. Blood Cells Mol. Dis. 29, 411–417 (2002). (10.1006/bcmd.2002.0580) / Blood Cells Mol. Dis. by TM Cox (2002)
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Dates
Type When
Created 16 years, 6 months ago (March 1, 2009, 1:11 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 5:04 p.m.)
Indexed 13 hours, 47 minutes ago (Sept. 6, 2025, 3:32 p.m.)
Issued 16 years, 6 months ago (March 1, 2009)
Published 16 years, 6 months ago (March 1, 2009)
Published Online 16 years, 6 months ago (March 1, 2009)
Published Print 16 years, 5 months ago (April 1, 2009)
Funders 0

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@article{Meynard_2009, title={Lack of the bone morphogenetic protein BMP6 induces massive iron overload}, volume={41}, ISSN={1546-1718}, url={http://dx.doi.org/10.1038/ng.320}, DOI={10.1038/ng.320}, number={4}, journal={Nature Genetics}, publisher={Springer Science and Business Media LLC}, author={Meynard, Delphine and Kautz, Léon and Darnaud, Valérie and Canonne-Hergaux, François and Coppin, Hélène and Roth, Marie-Paule}, year={2009}, month=mar, pages={478–481} }