Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity
10.1038/ncpendmet0716
Crossref journal-article
Springer Science and Business Media LLC
Nature Clinical Practice Endocrinology & Metabolism (297)
Bibliography

Adams, J. S., & Hewison, M. (2008). Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nature Clinical Practice Endocrinology & Metabolism, 4(2), 80–90.

Authors 2
  1. John S Adams (first)
  2. Martin Hewison (additional)
References 87 Referenced 598
  1. Barbour GL et al. (1981) Hypercalcemia in an anephric patient with sarcoidosis: evidence for extrarenal generation of 1,25-dihydroxyvitamin D. N Engl J Med 305: 440–443 (10.1056/NEJM198108203050807) / N Engl J Med by GL Barbour (1981)
  2. Adams JS et al. (1983) Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. J Clin Invest 72: 1856–1860 (10.1172/JCI111147) / J Clin Invest by JS Adams (1983)
  3. Deluca HF and Cantorna MT (2001) Vitamin D: its role and uses in immunology. FASEB J 15: 2579–2585 (10.1096/fj.01-0433rev) / FASEB J by HF Deluca (2001)
  4. Eelen G et al. (2007) Mechanism and potential of the growth-inhibitory actions of vitamin D and analogs. Curr Med Chem 14: 1893–1910 (10.2174/092986707781058823) / Curr Med Chem by G Eelen (2007)
  5. Bouillon R et al. (1995) Structure-function relationships in the vitamin D endocrine system. Endocr Rev 16: 200–257 / Endocr Rev by R Bouillon (1995)
  6. Johnson CS et al. (2006) The antitumor efficacy of calcitriol: preclinical studies. Anticancer Res 26: 2543–2549 / Anticancer Res by CS Johnson (2006)
  7. Mathieu C and Adorini L (2002) The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents. Trends Mol Med 8: 174–179 (10.1016/S1471-4914(02)02294-3) / Trends Mol Med by C Mathieu (2002)
  8. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357: 266–281 (10.1056/NEJMra070553) / N Engl J Med by MF Holick (2007)
  9. Rook GA et al. (1986) Vitamin D3, γ interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 57: 159–163 / Immunology by GA Rook (1986)
  10. Wang TT et al. (2004) Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 173: 2909–2912 (10.4049/jimmunol.173.5.2909) / J Immunol by TT Wang (2004)
  11. Gombart AF et al. (2005) Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J 19: 1067–1077 (10.1096/fj.04-3284com) / FASEB J by AF Gombart (2005)
  12. Yim S et al. (2007) Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D(3). J Cyst Fibros 6: 403–410 (10.1016/j.jcf.2007.03.003) / J Cyst Fibros by S Yim (2007)
  13. Weber G et al. (2005) Vitamin D induces the antimicrobial protein hCAP18 in human skin. J Invest Dermatol 124: 1080–1082 (10.1111/j.0022-202X.2005.23687.x) / J Invest Dermatol by G Weber (2005)
  14. Trinchieri G and Sher A (2007) Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 7: 179–190 (10.1038/nri2038) / Nat Rev Immunol by G Trinchieri (2007)
  15. Liu PT et al. (2006) Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311: 1770–1773 (10.1126/science.1123933) / Science by PT Liu (2006)
  16. Martineau AR et al. (2007) IFN-γ- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37. J Immunol 178: 7190–7198 (10.4049/jimmunol.178.11.7190) / J Immunol by AR Martineau (2007)
  17. Liu PT et al. (2007) Cutting Edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol 179: 2060–2063 (10.4049/jimmunol.179.4.2060) / J Immunol by PT Liu (2007)
  18. Reichel H et al. (1987) 25-Hydroxyvitamin D3 metabolism by lipopolysaccharide-stimulated normal human macrophages. J Clin Endocrinol Metab 64: 1–9 (10.1210/jcem-64-1-1) / J Clin Endocrinol Metab by H Reichel (1987)
  19. Islam D et al. (2001) Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med 7: 180–185 (10.1038/84627) / Nat Med by D Islam (2001)
  20. Sadeghi K et al. (2006) Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol 36: 361–370 (10.1002/eji.200425995) / Eur J Immunol by K Sadeghi (2006)
  21. Sakaki T et al. (2005) Metabolism of vitamin D3 by cytochromes P450. Front Biosci 10: 119–134 (10.2741/1514) / Front Biosci by T Sakaki (2005)
  22. Ren S et al. (2005) Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis. J Biol Chem 280: 20604–20611 (10.1074/jbc.M414522200) / J Biol Chem by S Ren (2005)
  23. Schauber J et al. (2007) Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest 117: 803–811 (10.1172/JCI30142) / J Clin Invest by J Schauber (2007)
  24. Schauber J et al. (2006) Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli. Immunology 118: 509–519 (10.1111/j.1365-2567.2006.02399.x) / Immunology by J Schauber (2006)
  25. Bikle DD and Pillai S (1993) Vitamin D, calcium, and epidermal differentiation. Endocr Rev 14: 3–19 / Endocr Rev by DD Bikle (1993)
  26. Provvedini DM et al. (1983) 1,25-Dihydroxyvitamin D3 receptors in human leukocytes. Science 221: 1181–1183 (10.1126/science.6310748) / Science by DM Provvedini (1983)
  27. Bhalla AK et al. (1983) Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J Clin Endocrinol Metab 57: 1308–1310 (10.1210/jcem-57-6-1308) / J Clin Endocrinol Metab by AK Bhalla (1983)
  28. Provvedini DM et al. (1986) 1 α,25-Dihydroxyvitamin D3-binding macromolecules in human B lymphocytes: effects on immunoglobulin production. J Immunol 136: 2734–2740 (10.4049/jimmunol.136.8.2734) / J Immunol by DM Provvedini (1986)
  29. Lemire JM et al. (1984) 1 α,25-Dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells. J Clin Invest 74: 657–661 (10.1172/JCI111465) / J Clin Invest by JM Lemire (1984)
  30. Chen S et al. (2007) Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 179: 1634–1647 (10.4049/jimmunol.179.3.1634) / J Immunol by S Chen (2007)
  31. Rigby WF et al. (1984) Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). J Clin Invest 74: 1451–1455 (10.1172/JCI111557) / J Clin Invest by WF Rigby (1984)
  32. Lemire JM et al. (1985) 1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro. J Immunol 134: 3032–3035 (10.4049/jimmunol.134.5.3032) / J Immunol by JM Lemire (1985)
  33. Abbas AK et al. (1996) Functional diversity of helper T lymphocytes. Nature 383: 787–793 (10.1038/383787a0) / Nature by AK Abbas (1996)
  34. Romagnani S (2006) Regulation of the T cell response. Clin Exp Allergy 36: 1357–1366 (10.1111/j.1365-2222.2006.02606.x) / Clin Exp Allergy by S Romagnani (2006)
  35. Lemire JM et al. (1995) Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions. J Nutr 125: 1704S–1708S / J Nutr by JM Lemire (1995)
  36. Boonstra A et al. (2001) 1α,25-Dihydroxyvitamin D3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol 167: 4974–4980 (10.4049/jimmunol.167.9.4974) / J Immunol by A Boonstra (2001)
  37. Piemonti L et al. (2000) Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells. J Immunol 164: 4443–4451 (10.4049/jimmunol.164.9.4443) / J Immunol by L Piemonti (2000)
  38. Overbergh L et al. (2000) 1α,25-Dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543). Diabetes 49: 1301–1307 (10.2337/diabetes.49.8.1301) / Diabetes by L Overbergh (2000)
  39. Barrat FJ et al. (2002) In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 195: 603–616 (10.1084/jem.20011629) / J Exp Med by FJ Barrat (2002)
  40. Gregori S et al. (2001) Regulatory T cells induced by 1 α,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol 167: 1945–1953 (10.4049/jimmunol.167.4.1945) / J Immunol by S Gregori (2001)
  41. Penna G and Adorini L (2000) 1 α,25-Dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 164: 2405–2411 (10.4049/jimmunol.164.5.2405) / J Immunol by G Penna (2000)
  42. Penna G et al. (2007) 1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. J Immunol 178: 145–153 (10.4049/jimmunol.178.1.145) / J Immunol by G Penna (2007)
  43. Penna G et al. (2006) Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol. J Immunol 177: 8504–8511 (10.4049/jimmunol.177.12.8504) / J Immunol by G Penna (2006)
  44. Sigmundsdottir H et al. (2007) DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27. Nat Immunol 8: 285–293 (10.1038/ni1433) / Nat Immunol by H Sigmundsdottir (2007)
  45. Kreutz M et al. (1993) 1,25-Dihydroxyvitamin D3 production and vitamin D3 receptor expression are developmentally regulated during differentiation of human monocytes into macrophages. Blood 82: 1300–1307 (10.1182/blood.V82.4.1300.1300) / Blood by M Kreutz (1993)
  46. Hewison M et al. (2003) Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells. J Immunol 170: 5382–5390 (10.4049/jimmunol.170.11.5382) / J Immunol by M Hewison (2003)
  47. Jones G et al. (1998) Current understanding of the molecular actions of vitamin D. Physiol Rev 78: 1193–1231 (10.1152/physrev.1998.78.4.1193) / Physiol Rev by G Jones (1998)
  48. DeLuca HF (2004) Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 80: 1689S–1696S (10.1093/ajcn/80.6.1689S) / Am J Clin Nutr by HF DeLuca (2004)
  49. Townsend K et al. (2005) Biological actions of extra-renal 25-hydroxyvitamin D-1α-hydroxylase and implications for chemoprevention and treatment. J Steroid Biochem Mol Biol 97: 103–109 (10.1016/j.jsbmb.2005.06.004) / J Steroid Biochem Mol Biol by K Townsend (2005)
  50. Townsend K et al. (2005) Autocrine metabolism of vitamin D in normal and malignant breast tissue. Clin Cancer Res 11: 3579–3586 (10.1158/1078-0432.CCR-04-2359) / Clin Cancer Res by K Townsend (2005)
  51. Bises G et al. (2004) 25-Hydroxyvitamin D3-1α-hydroxylase expression in normal and malignant human colon. J Histochem Cytochem 52: 985–989 (10.1369/jhc.4B6271.2004) / J Histochem Cytochem by G Bises (2004)
  52. Bland R et al. (2004) Expression of 25-hydroxyvitamin D3-1α-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol 89–90: 121–125 (10.1016/j.jsbmb.2004.03.115) / J Steroid Biochem Mol Biol by R Bland (2004)
  53. Schwartz GG et al. (1998) Human prostate cells synthesize 1,25-dihydroxyvitamin D3 from 25-hydroxyvitamin D3. Cancer Epidemiol Biomarkers Prev 7: 391–395 / Cancer Epidemiol Biomarkers Prev by GG Schwartz (1998)
  54. Schwartz GG et al. (2004) Pancreatic cancer cells express 25-hydroxyvitamin D-1 α-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3. Carcinogenesis 25: 1015–1026 (10.1093/carcin/bgh086) / Carcinogenesis by GG Schwartz (2004)
  55. Whitlatch LW et al. (2002) 25-Hydroxyvitamin D-1α-hydroxylase activity is diminished in human prostate cancer cells and is enhanced by gene transfer. J Steroid Biochem Mol Biol 81: 135–140 (10.1016/S0960-0760(02)00053-5) / J Steroid Biochem Mol Biol by LW Whitlatch (2002)
  56. Giovannucci E et al. (2006) Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 98: 451–459 (10.1093/jnci/djj101) / J Natl Cancer Inst by E Giovannucci (2006)
  57. Ahonen MH et al. (2000) Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). Cancer Causes Control 11: 847–852 (10.1023/A:1008923802001) / Cancer Causes Control by MH Ahonen (2000)
  58. Feskanich D et al. (2004) Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev 13: 1502–1508 (10.1158/1055-9965.1502.13.9) / Cancer Epidemiol Biomarkers Prev by D Feskanich (2004)
  59. Garland CF et al. (2006) The role of vitamin D in cancer prevention. Am J Public Health 96: 252–261 (10.2105/AJPH.2004.045260) / Am J Public Health by CF Garland (2006)
  60. Grant WB (2002) An estimate of premature cancer mortality in the U.S. due to inadequate doses of solar ultraviolet-B radiation. Cancer 94: 1867–1875 (10.1002/cncr.10427) / Cancer by WB Grant (2002)
  61. Eyles DW et al. (2005) Distribution of the vitamin D receptor and 1 α-hydroxylase in human brain. J Chem Neuroanat 29: 21–30 (10.1016/j.jchemneu.2004.08.006) / J Chem Neuroanat by DW Eyles (2005)
  62. O'Loan J et al. (2007) Vitamin D deficiency during various stages of pregnancy in the rat; its impact on development and behaviour in adult offspring. Psychoneuroendocrinology 32: 227–234 (10.1016/j.psyneuen.2006.12.006) / Psychoneuroendocrinology by J O'Loan (2007)
  63. McGrath J et al. (2002) Long-term trends in sunshine duration and its association with schizophrenia birth rates and age at first registration—data from Australia and the Netherlands. Schizophr Res 54: 199–212 (10.1016/S0920-9964(01)00259-6) / Schizophr Res by J McGrath (2002)
  64. Gloth FM III et al. (1999) Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder. J Nutr Health Aging 3: 5–7 / J Nutr Health Aging by FM Gloth III (1999)
  65. Zittermann A (2006) Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol 92: 39–48 (10.1016/j.pbiomolbio.2006.02.001) / Prog Biophys Mol Biol by A Zittermann (2006)
  66. Zittermann A et al. (2003) Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J Am Coll Cardiol 41: 105–112 (10.1016/S0735-1097(02)02624-4) / J Am Coll Cardiol by A Zittermann (2003)
  67. Dawson-Hughes B et al. (2005) Estimates of optimal vitamin D status. Osteoporos Int 16: 713–716 (10.1007/s00198-005-1867-7) / Osteoporos Int by B Dawson-Hughes (2005)
  68. Chapuy MC et al. (1997) Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 7: 439–443 (10.1007/s001980050030) / Osteoporos Int by MC Chapuy (1997)
  69. Norman AW et al. (2007) 13th Workshop consensus for vitamin D nutritional guidelines. J Steroid Biochem Mol Biol 103: 204–205 (10.1016/j.jsbmb.2006.12.071) / J Steroid Biochem Mol Biol by AW Norman (2007)
  70. Martineau AR et al. (2007) A single dose of vitamin D enhances immunity to mycobacteria. Am J Respir Crit Care Med 176: 208–213 (10.1164/rccm.200701-007OC) / Am J Respir Crit Care Med by AR Martineau (2007)
  71. Nursyam EW et al. (2006) The effect of vitamin D as supplementary treatment in patients with moderately advanced pulmonary tuberculous lesion. Acta Med Indones 38: 3–5 / Acta Med Indones by EW Nursyam (2006)
  72. Cannell JJ et al. (2006) Epidemic influenza and vitamin D. Epidemiol Infect 134: 1129–1140 (10.1017/S0950268806007175) / Epidemiol Infect by JJ Cannell (2006)
  73. Aloia JF and Li-Ng M (2007) Correspondence. Epidemiol Infect 135: 1095–1098 (10.1017/S0950268807008308) / Epidemiol Infect by JF Aloia (2007)
  74. Bergman P et al (2007) The antimicrobial peptide LL-37 inhibits HIV-1 replication. Curr HIV Res 5: 410-415 (10.2174/157016207781023947)
  75. Ponsonby AL et al. (2005) UVR, vitamin D and three autoimmune diseases—multiple sclerosis, type 1 diabetes, rheumatoid arthritis. Photochem Photobiol 81: 1267–1275 (10.1562/2005-02-15-IR-441) / Photochem Photobiol by AL Ponsonby (2005)
  76. Ponsonby AL et al. (2002) Ultraviolet radiation and autoimmune disease: insights from epidemiological research. Toxicology 181–182: 71–78 (10.1016/S0300-483X(02)00257-3) / Toxicology by AL Ponsonby (2002)
  77. Munger KL et al. (2006) Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 296: 2832–2838 (10.1001/jama.296.23.2832) / JAMA by KL Munger (2006)
  78. Merlino LA et al. (2004) Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum 50: 72–77 (10.1002/art.11434) / Arthritis Rheum by LA Merlino (2004)
  79. Harris SS (2005) Vitamin D in type 1 diabetes prevention. J Nutr 135: 323–325 (10.1093/jn/135.2.323) / J Nutr by SS Harris (2005)
  80. Hypponen E et al. (2001) Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 358: 1500–1503 (10.1016/S0140-6736(01)06580-1) / Lancet by E Hypponen (2001)
  81. Gregori S et al. (2002) A 1α,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 51: 1367–1374 (10.2337/diabetes.51.5.1367) / Diabetes by S Gregori (2002)
  82. Giulietti A et al. (2004) Vitamin D deficiency in early life accelerates type 1 diabetes in non-obese diabetic mice. Diabetologia 47: 451–462 (10.1007/s00125-004-1329-3) / Diabetologia by A Giulietti (2004)
  83. Pike JW et al. (1980) Biochemical evidence for 1,25-dihydroxyvitamin D receptor macromolecules in parathyroid, pancreatic, pituitary, and placental tissues. Life Sci 26: 407–414 (10.1016/0024-3205(80)90158-7) / Life Sci by JW Pike (1980)
  84. Need AG et al. (2005) Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women. Clin Endocrinol (Oxf) 62: 738–741 (10.1111/j.1365-2265.2005.02288.x) / Clin Endocrinol (Oxf) by AG Need (2005)
  85. Ramos-Lopez E et al. (2006) Protection from type 1 diabetes by vitamin D receptor haplotypes. Ann N Y Acad Sci 1079: 327–334 (10.1196/annals.1375.050) / Ann N Y Acad Sci by E Ramos-Lopez (2006)
  86. Bailey R et al. (2007) Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes 56: 2616–2621 (10.2337/db07-0652) / Diabetes by R Bailey (2007)
  87. Autier P and Gandini S (2007) Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 167: 1730–1737 (10.1001/archinte.167.16.1730) / Arch Intern Med by P Autier (2007)
Dates
Type When
Created 17 years, 7 months ago (Jan. 23, 2008, 6:03 a.m.)
Deposited 1 year, 6 months ago (Feb. 21, 2024, 10:50 a.m.)
Indexed 4 days ago (Aug. 26, 2025, 3:16 a.m.)
Issued 17 years, 6 months ago (Feb. 1, 2008)
Published 17 years, 6 months ago (Feb. 1, 2008)
Published Print 17 years, 6 months ago (Feb. 1, 2008)
Funders 0

None

@article{Adams_2008, title={Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity}, volume={4}, ISSN={1745-8374}, url={http://dx.doi.org/10.1038/ncpendmet0716}, DOI={10.1038/ncpendmet0716}, number={2}, journal={Nature Clinical Practice Endocrinology & Metabolism}, publisher={Springer Science and Business Media LLC}, author={Adams, John S and Hewison, Martin}, year={2008}, month=feb, pages={80–90} }