Extreme multifunctional proteins identified from a human protein interaction network
10.1038/ncomms8412
Crossref journal-article
Springer Science and Business Media LLC
Nature Communications (297)
Abstract

AbstractMoonlighting proteins are a subclass of multifunctional proteins whose functions are unrelated. Although they may play important roles in cells, there has been no large-scale method to identify them, nor any effort to characterize them as a group. Here, we propose the first method for the identification of ‘extreme multifunctional’ proteins from an interactome as a first step to characterize moonlighting proteins. By combining network topological information with protein annotations, we identify 430 extreme multifunctional proteins (3% of the human interactome). We show that the candidates form a distinct sub-group of proteins, characterized by specific features, which form a signature of extreme multifunctionality. Overall, extreme multifunctional proteins are enriched in linear motifs and less intrinsically disordered than network hubs. We also provide MoonDB, a database containing information on all the candidates identified in the analysis and a set of manually curated human moonlighting proteins.

Bibliography

Chapple, C. E., Robisson, B., Spinelli, L., Guien, C., Becker, E., & Brun, C. (2015). Extreme multifunctional proteins identified from a human protein interaction network. Nature Communications, 6(1).

Authors 6
  1. Charles E. Chapple (first)
  2. Benoit Robisson (additional)
  3. Lionel Spinelli (additional)
  4. Céline Guien (additional)
  5. Emmanuelle Becker (additional)
  6. Christine Brun (additional)
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Dates
Type When
Created 10 years, 2 months ago (June 9, 2015, 11:51 a.m.)
Deposited 2 years, 8 months ago (Jan. 5, 2023, 6:22 a.m.)
Indexed 1 week, 6 days ago (Aug. 23, 2025, 9:17 p.m.)
Issued 10 years, 2 months ago (June 9, 2015)
Published 10 years, 2 months ago (June 9, 2015)
Published Online 10 years, 2 months ago (June 9, 2015)
Funders 0

None

@article{Chapple_2015, title={Extreme multifunctional proteins identified from a human protein interaction network}, volume={6}, ISSN={2041-1723}, url={http://dx.doi.org/10.1038/ncomms8412}, DOI={10.1038/ncomms8412}, number={1}, journal={Nature Communications}, publisher={Springer Science and Business Media LLC}, author={Chapple, Charles E. and Robisson, Benoit and Spinelli, Lionel and Guien, Céline and Becker, Emmanuelle and Brun, Christine}, year={2015}, month=jun }