DOI: 10.1038/ncb866. BID regulation by p53 contributes to chemosensitivity

BID regulation by p53 contributes to chemosensitivity

10.1038/ncb866

Crossref journal-article

Springer Science and Business Media LLC

Nature Cell Biology (297)

Bibliography

Sax, J. K., Fei, P., Murphy, M. E., Bernhard, E., Korsmeyer, S. J., & El-Deiry, W. S. (2002). BID regulation by p53 contributes to chemosensitivity. Nature Cell Biology, 4(11), 842â849.

Authors 6

Joanna K. Sax (first)
Peiwen Fei (additional)
Maureen E. Murphy (additional)
Eric Bernhard (additional)
Stanley J. Korsmeyer (additional)
Wafik S. El-Deiry (additional)

References 50 Referenced 328

Ryan, K. M., Phillips, A. C. & Vousden, K. H. Regulation and function of the p53 tumor suppressor protein. Curr. Opin. Cell Biol. 13, 332–337 (2001). (10.1016/S0955-0674(00)00216-7) / Curr. Opin. Cell Biol. by KM Ryan (2001)
El-Deiry, W. S. Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling. Cell Death Differ. 8, 1066–1075 (2001). (10.1038/sj.cdd.4400943) / Cell Death Differ. by WS El-Deiry (2001)
El-Deiry, W. S. et al. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817–825 (1993). (10.1016/0092-8674(93)90500-P) / Cell by WS El-Deiry (1993)
Attardi, L. D. et al. PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev. 14, 704–718 (2000). (10.1101/gad.14.6.704) / Genes Dev. by LD Attardi (2000)
Lin, Y., Ma, W. & Benchimol, S. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. Nature Genet. 26, 122–127 (2000). (10.1038/79102) / Nature Genet. by Y Lin (2000)
Miyashita, T. & Reed, J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293–299 (1995). (10.1016/0092-8674(95)90513-8) / Cell by T Miyashita (1995)
Nakano, K. & Vousden, K. H. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7, 683–694 (2001). (10.1016/S1097-2765(01)00214-3) / Mol. Cell by K Nakano (2001)
Oda, E. et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288, 1053–1058 (2000). (10.1126/science.288.5468.1053) / Science by E Oda (2000)
Yu, J., Zhang, L., Hwang, P. M., Kinzler, K. W. & Vogelstein, B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7, 673–682 (2001). (10.1016/S1097-2765(01)00213-1) / Mol. Cell by J Yu (2001)
Wu, G. S. et al. KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nature Genet. 17, 141–143 (1997). (10.1038/ng1097-141) / Nature Genet. by GS Wu (1997)
Wu, G. S., Burns, T. F., Zhan, Y., Alnemri, E. S. & El-Deiry, W. S. Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res. 59, 2770–2775 (1999). / Cancer Res. by GS Wu (1999)
Muller, M. et al. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J. Exp. Med. 188, 2033–2045 (1998). (10.1084/jem.188.11.2033) / J. Exp. Med. by M Muller (1998)
Murphy, M. et al. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev. 13, 2490–2501 (1999). (10.1101/gad.13.19.2490) / Genes Dev. by M Murphy (1999)
Hoffman, W. H., Biade, S., Zilfou, J. T., Chen, J. & Murphy, M. Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J. Biol. Chem. 277, 3247–3257 (2002). (10.1074/jbc.M106643200) / J. Biol. Chem. by WH Hoffman (2002)
Adams, J. M. & Cory, S. The Bcl-2 protein family: arbiters of cell survival. Science 281, 1322–1326 (1998). (10.1126/science.281.5381.1322) / Science by JM Adams (1998)
Wang, K., Yin, X. M., Chao, D. T., Milliman, C. L. & Korsmeyer, S. J. BID: a novel BH3 domain-only death agonist. Genes Dev. 10, 2859–2869 (1996). (10.1101/gad.10.22.2859) / Genes Dev. by K Wang (1996)
Li, H., Zhu, H., Xu, C. J. & Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94, 491–501 (1998). (10.1016/S0092-8674(00)81590-1) / Cell by H Li (1998)
Luo, X., Budihardjo, I., Zou, H., Slaughter, C. & Wang, X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94, 481–490 (1998). (10.1016/S0092-8674(00)81589-5) / Cell by X Luo (1998)
Zha, J., Weiler, S., Oh, K. J., Wei, M. C. & Korsmeyer, S. J. Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science 290, 1761–1765 (2000). (10.1126/science.290.5497.1761) / Science by J Zha (2000)
Wei, M. C. et al. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14, 2060–2071 (2000). (10.1101/gad.14.16.2060) / Genes Dev. by MC Wei (2000)
Wei, M. C. et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727–730 (2001). (10.1126/science.1059108) / Science by MC Wei (2001)
Gross, A. et al. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J. Biol. Chem. 274, 1156–1163 (1999). (10.1074/jbc.274.2.1156) / J. Biol. Chem. by A Gross (1999)
Yin, X. M. et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400, 886–891 (1999). (10.1038/23730) / Nature by XM Yin (1999)
Scaffidi, C. et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17, 1675–1687 (1998). (10.1093/emboj/17.6.1675) / EMBO J. by C Scaffidi (1998)
Scorrano, L. et al. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev. Cell 2, 55–67 (2002). (10.1016/S1534-5807(01)00116-2) / Dev. Cell by L Scorrano (2002)
Harvey, D. M. & Levine, A. J. p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Genes Dev. 5, 2375–2385 (1991). (10.1101/gad.5.12b.2375) / Genes Dev. by DM Harvey (1991)
Chen, J., Wu, X., Lin, J. & Levine, A. J. mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol. 16, 2445–2452 (1996). (10.1128/MCB.16.5.2445) / Mol. Cell. Biol. by J Chen (1996)
Wang, Y. et al. Reconstitution of wild-type p53 expression triggers apoptosis in a p53-negative v-myc retrovirus-induced T-cell lymphoma line. Cell Growth Differ. 4, 467–473 (1993). / Cell Growth Differ. by Y Wang (1993)
Pritchard, D. M., Potten, C. S., Korsmeyer, S. J., Roberts, S. & Hickman, J. A. Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. Oncogene 18, 7287–7293 (1999). (10.1038/sj.onc.1203150) / Oncogene by DM Pritchard (1999)
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A. & Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847–849 (1993). (10.1038/362847a0) / Nature by SW Lowe (1993)
Midgley, C. A. et al. Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo. J. Cell Sci. 108, 1843–1848 (1995). (10.1242/jcs.108.5.1843) / J. Cell Sci. by CA Midgley (1995)
Burns, T. F., Bernhard, E. J. & El-Deiry, W. S. Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Oncogene 20, 4601–4612 (2001). (10.1038/sj.onc.1204484) / Oncogene by TF Burns (2001)
Wang, K. et al. BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11. Genomics 53, 235–238 (1998). (10.1006/geno.1998.5489) / Genomics by K Wang (1998)
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W. & Vogelstein, B. Definition of a consensus binding site for p53. Nature Genet. 1, 45–49 (1992). (10.1038/ng0492-45) / Nature Genet. by WS El-Deiry (1992)
Vousden, K. H. & Lu, X. Live or let die: the cell's response to p53. Nature Rev. Cancer 2, 594–604 (2002). (10.1038/nrc864) / Nature Rev. Cancer by KH Vousden (2002)
Kaeser, M. D. & Iggo, R. D. From the cover: chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc. Natl Acad. Sci. USA 99, 95–100 (2002). (10.1073/pnas.012283399) / Proc. Natl Acad. Sci. USA by MD Kaeser (2002)
Oda, K. et al. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102, 849–862 (2000). (10.1016/S0092-8674(00)00073-8) / Cell by K Oda (2000)
Costanzo, A. et al. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol. Cell 9, 175–186 (2002). (10.1016/S1097-2765(02)00431-8) / Mol. Cell by A Costanzo (2002)
Bunz, F. et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J. Clin. Invest. 104, 263–269 (1999). (10.1172/JCI6863) / J. Clin. Invest. by F Bunz (1999)
MacLachlan, T. K. & El-Deiry, W. S. Apoptotic threshold is lowered by p53 transactivation of caspase-6. Proc. Natl Acad. Sci. USA 99, 9492–9497 (2002). (10.1073/pnas.132241599) / Proc. Natl Acad. Sci. USA by TK MacLachlan (2002)
Moroni, M. C. et al. Apaf-1 is a transcriptional target for E2F and p53. Nature Cell Biol. 3, 552–558 (2001). (10.1038/35078527) / Nature Cell Biol. by MC Moroni (2001)
Zeng, Y. X. & El-Deiry, W. S. Regulation of p21WAF1/CIP1 expression by p53-independent pathways. Oncogene 12, 1557–1564 (1996). / Oncogene by YX Zeng (1996)
Sax, J. K., Dash, B. C., Hong, R., Dicker, D. T. & El-Deiry, W. S. The cyclin-dependent kinase inhibitor butyrolactone is a potent inhibitor of p21(WAF1/CIP1) expression. Cell Cycle 1, 90–96 (2002). / Cell Cycle by JK Sax (2002)
Kadkol, S., Juang, J. & Wu, T. C. in Tumor Suppressor Genes: Regulations, Functions and Medicinal Applications Vol. 2 (ed. El-Deiry, W. S.) (Humana Press, Totowa, NJ, 2003). / Tumor Suppressor Genes: Regulations, Functions and Medicinal Applications by S Kadkol (2003)
Somasundaram, K. et al. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CIP1. Nature 389, 187–190 (1997). (10.1038/38291) / Nature by K Somasundaram (1997)
MacLachlan, T. K. et al. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression. J. Biol. Chem. 275, 2777–2785 (2000). (10.1074/jbc.275.4.2777) / J. Biol. Chem. by TK MacLachlan (2000)
Pietenpol, J. A. et al. Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc. Natl Acad. Sci. USA 91, 1998–2002 (1994). (10.1073/pnas.91.6.1998) / Proc. Natl Acad. Sci. USA by JA Pietenpol (1994)
Zeng, Y. X., Somasundaram, K., Prabhu, N. S., Krishnadasan, R. & El-Deiry, W. S. Detection and analysis of living, growth-inhibited mammalian cells following transfection. Biotechniques 23, 88–94 (1997). (10.2144/97231bm19) / Biotechniques by YX Zeng (1997)
Takimoto, R. & El-Deiry, W. S. Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site. Oncogene 19, 1735–1743 (2000). (10.1038/sj.onc.1203489) / Oncogene by R Takimoto (2000)
Szak, S. T., Mays, D. & Pietenpol, J. A. Kinetics of p53 binding to promoter sites in vivo. Mol. Cell. Biol. 21, 3375–3386 (2001). (10.1128/MCB.21.10.3375-3386.2001) / Mol. Cell. Biol. by ST Szak (2001)

Dates

Type	When
Created	22 years, 9 months ago (Nov. 2, 2002, 1:02 p.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 3:52 p.m.)
Indexed	1 month, 3 weeks ago (June 30, 2025, 7:26 a.m.)
Issued	22 years, 9 months ago (Oct. 28, 2002)
Published	22 years, 9 months ago (Oct. 28, 2002)
Published Online	22 years, 9 months ago (Oct. 28, 2002)
Published Print	22 years, 9 months ago (Nov. 1, 2002)

Funders 0

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BibTeX

@article{Sax_2002, title={BID regulation by p53 contributes to chemosensitivity}, volume={4}, ISSN={1476-4679}, url={http://dx.doi.org/10.1038/ncb866}, DOI={10.1038/ncb866}, number={11}, journal={Nature Cell Biology}, publisher={Springer Science and Business Media LLC}, author={Sax, Joanna K. and Fei, Peiwen and Murphy, Maureen E. and Bernhard, Eric and Korsmeyer, Stanley J. and El-Deiry, Wafik S.}, year={2002}, month=oct, pages={842–849} }

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