DOI: 10.1038/ncb748. α-Synuclein is phosphorylated in synucleinopathy lesions

α-Synuclein is phosphorylated in synucleinopathy lesions

10.1038/ncb748

Crossref journal-article

Springer Science and Business Media LLC

Nature Cell Biology (297)

Bibliography

Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., & Iwatsubo, T. (2002). Î±-Synuclein is phosphorylated in synucleinopathy lesions. Nature Cell Biology, 4(2), 160â164.

Authors 9

Hideo Fujiwara (first)
Masato Hasegawa (additional)
Naoshi Dohmae (additional)
Akiko Kawashima (additional)
Eliezer Masliah (additional)
Matthew S. Goldberg (additional)
Jie Shen (additional)
Koji Takio (additional)
Takeshi Iwatsubo (additional)

References 25 Referenced 1,628

Spillantini, M. G. et al. Nature 388, 839–840 (1997). (10.1038/42166) / Nature by MG Spillantini (1997)
Baba, M. et al. Am. J. Pathol. 152, 879–884 (1998). / Am. J. Pathol. by M Baba (1998)
Polymeropoulos, M. H. et al. Science 276, 2045–2047 (1997). (10.1126/science.276.5321.2045) / Science by MH Polymeropoulos (1997)
Jakes, R. et al. Neurosci. Lett. 269, 13–16 (1999). (10.1016/S0304-3940(99)00411-5) / Neurosci. Lett. by R Jakes (1999)
Culvenor, J. G. et al. Am. J. Pathol. 155, 1173–1181 (1999). (10.1016/S0002-9440(10)65220-0) / Am. J. Pathol. by JG Culvenor (1999)
Masliah, E. et al. Science 287, 1265–1269 (2000). (10.1126/science.287.5456.1265) / Science by E Masliah (2000)
Sharon, R. et al. Proc. Natl Acad. Sci. USA 98, 9110–9115 (2001). (10.1073/pnas.171300598) / Proc. Natl Acad. Sci. USA by R Sharon (2001)
Okochi, M. et al. J. Biol. Chem. 275, 390–397 (2000). (10.1074/jbc.275.1.390) / J. Biol. Chem. by M Okochi (2000)
Pronin, A. N., Morris, A. J., Surgunchov, A. & Benovic, J. L. J. Biol. Chem. 275, 26515–26522 (2000). (10.1074/jbc.M003542200) / J. Biol. Chem. by AN Pronin (2000)
Lee, V. M.-Y., Balin, B. J., Otvos, L. Jr & Trojanowski, J. Q. Science 251, 675–678 (1991). (10.1126/science.1899488) / Science by VM-Y Lee (1991)
Goedert, M. Nature 399, 739–740 (1999). (10.1038/21550) / Nature by M Goedert (1999)
Goldberg M. S. & Lansbury P. T. Jr Nature Cell Biol. 2, E115–E119 (2000). (10.1038/35017124) / Nature Cell Biol. by MS Goldberg (2000)
Conway, K. A. et al. Proc. Natl Acad. Sci. USA 97, 571–576 (2000). (10.1073/pnas.97.2.571) / Proc. Natl Acad. Sci. USA by KA Conway (2000)
Giasson, B. I. et al. Science 290, 985–989 (2000). (10.1126/science.290.5493.985) / Science by BI Giasson (2000)
Shimura, H. et al. Science 293, 263–269 (2001). (10.1126/science.1060627) / Science by H Shimura (2001)
Hasegawa, M. et al. J. Biol. Chem. 267, 17047–17054 (1992). (10.1016/S0021-9258(18)41890-X) / J. Biol. Chem. by M Hasegawa (1992)
Pandey, A. & Mann, M. Nature 405, 837–846 (2000). (10.1038/35015709) / Nature by A Pandey (2000)
Morishima-Kawashima, M. et al. J. Biol. Chem. 270, 823–829 (1995). (10.1074/jbc.270.2.823) / J. Biol. Chem. by M Morishima-Kawashima (1995)
Tu, P.-H. et al. Ann. Neurol. 44, 415–422 (1998). (10.1002/ana.410440324) / Ann. Neurol. by P-H Tu (1998)
Iwatsubo, T., Hasegawa, M. & Ihara, Y. Acta Neuropathol. 88, 129–136 (1994). (10.1007/BF00294505) / Acta Neuropathol. by T Iwatsubo (1994)
Biere, A. L. et al. J. Biol. Chem. 275, 34574–34579 (2000). (10.1074/jbc.M005514200) / J. Biol. Chem. by AL Biere (2000)
Giasson, B. I., Murray, I. V., Trojanowski, J. Q. & Lee, V. M.-Y. J. Biol. Chem. 276, 2380–2386 (2001). (10.1074/jbc.M008919200) / J. Biol. Chem. by BI Giasson (2001)
Crowther, R. A., Jakes, R., Spillantini, M. G. & Goedert, M. FEBS Lett. 436, 309–312 (1998). (10.1016/S0014-5793(98)01146-6) / FEBS Lett. by RA Crowther (1998)
Rochet, J.-C., Conway, K. A. & Lansbury, P. T. Jr Biochemistry 39, 10619–10626 (2000). (10.1021/bi001315u) / Biochemistry by J-C Rochet (2000)
Volles, M. J. et al. Biochemistry 40, 7812–7819 (2001).¶ (10.1021/bi0102398) / Biochemistry by MJ Volles (2001)

Dates

Type	When
Created	7 years, 9 months ago (Nov. 28, 2017, 3:10 a.m.)
Deposited	2 years, 3 months ago (May 18, 2023, 3:50 p.m.)
Indexed	24 minutes ago (Aug. 28, 2025, 4:58 a.m.)
Issued	23 years, 7 months ago (Jan. 28, 2002)
Published	23 years, 7 months ago (Jan. 28, 2002)
Published Online	23 years, 7 months ago (Jan. 28, 2002)
Published Print	23 years, 6 months ago (Feb. 1, 2002)

Funders 0

None

BibTeX

@article{Fujiwara_2002, title={α-Synuclein is phosphorylated in synucleinopathy lesions}, volume={4}, ISSN={1476-4679}, url={http://dx.doi.org/10.1038/ncb748}, DOI={10.1038/ncb748}, number={2}, journal={Nature Cell Biology}, publisher={Springer Science and Business Media LLC}, author={Fujiwara, Hideo and Hasegawa, Masato and Dohmae, Naoshi and Kawashima, Akiko and Masliah, Eliezer and Goldberg, Matthew S. and Shen, Jie and Takio, Koji and Iwatsubo, Takeshi}, year={2002}, month=jan, pages={160–164} }

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