Increasing organismal healthspan by enhancing mitochondrial protein quality control
10.1038/ncb1893
Crossref journal-article
Springer Science and Business Media LLC
Nature Cell Biology (297)
Bibliography

Luce, K., & Osiewacz, H. D. (2009). Increasing organismal healthspan by enhancing mitochondrial protein quality control. Nature Cell Biology, 11(7), 852–858.

Authors 2
  1. Karin Luce (first)
  2. Heinz D. Osiewacz (additional)
References 38 Referenced 114
  1. Osiewacz, H. D. & Hermanns, J. The role of mitochondrial DNA rearrangements in aging and human diseases. Aging (Milano.) 4, 273–286 (1992). / Aging (Milano.) by HD Osiewacz (1992)
  2. Wallace, D. C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 39, 359–407 (2005). (10.1146/annurev.genet.39.110304.095751) / Annu. Rev. Genet. by DC Wallace (2005)
  3. Harman, D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11, 298–300 (1956). (10.1093/geronj/11.3.298) / J. Gerontol. by D Harman (1956)
  4. Finkel, T. & Holbrook, N. J. Oxidants, oxidative stress and the biology of ageing. Nature 408, 239–247 (2000). (10.1038/35041687) / Nature by T Finkel (2000)
  5. Gredilla, R., Grief, J. & Osiewacz, H. D. Mitochondrial free radical generation and lifespan control in the fungal aging model Podospora anserina. Exp. Gerontol. 41, 439–447 (2006). (10.1016/j.exger.2006.01.010) / Exp. Gerontol. by R Gredilla (2006)
  6. Schriner, S. E. et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308, 1909–1911 (2005). (10.1126/science.1106653) / Science by SE Schriner (2005)
  7. Lu, B. et al. Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance. J. Biol. Chem. 282, 17363–17374 (2007). (10.1074/jbc.M611540200) / J. Biol. Chem. by B Lu (2007)
  8. Suzuki, C. K., Suda, K., Wang, N. & Schatz, G. Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration. Science 264, 891 (1994). (10.1126/science.8178144) / Science by CK Suzuki (1994)
  9. Bota, D. A., Ngo, J. K. & Davies, K. J. Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death. Free Radic. Biol. Med. 38, 665–677 (2005). (10.1016/j.freeradbiomed.2004.11.017) / Free Radic. Biol. Med. by DA Bota (2005)
  10. Osiewacz, H. D. Genes, mitochondria and aging in filamentous fungi. Ageing Res. Rev. 1, 425–442 (2002). (10.1016/S1568-1637(02)00010-7) / Ageing Res. Rev. by HD Osiewacz (2002)
  11. Bulteau, A. L., Szweda, L. I. & Friguet, B. Mitochondrial protein oxidation and degradation in response to oxidative stress and aging. Exp. Gerontol. 41, 653–657 (2006). (10.1016/j.exger.2006.03.013) / Exp. Gerontol. by AL Bulteau (2006)
  12. Osiewacz, H. D., Skaletz, A. & Esser, K. Integrative transformation of the ascomycete Podospora anserina: identification of the mating-type locus on chromosome VII of electrophoretically separated chromosomes. Appl. Microbiol. Biotechnol. 35, 38–45 (1991). (10.1007/BF00180633) / Appl. Microbiol. Biotechnol. by HD Osiewacz (1991)
  13. Scheckhuber, C. Q. et al. Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nature Cell Biol. 9, 99–105 (2007). (10.1038/ncb1524) / Nature Cell Biol. by CQ Scheckhuber (2007)
  14. Ikeda, K. et al. N (epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reaction. Biochemistry 35, 8075–8083 (1996). (10.1021/bi9530550) / Biochemistry by K Ikeda (1996)
  15. Bakala, H. et al. Changes in rat liver mitochondria with aging. Lon protease-like reactivity and N(epsilon)-carboxymethyllysine accumulation in the matrix. Eur. J. Biochem. 270, 2295–2302 (2003). (10.1046/j.1432-1033.2003.03598.x) / Eur. J. Biochem. by H Bakala (2003)
  16. Bota, D. A. & Davies, K. J. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nature Cell Biol. 4, 674–680 (2002). (10.1038/ncb836) / Nature Cell Biol. by DA Bota (2002)
  17. Reverter-Branch, Cabiscol, E., Tamarit, J. & Ros, J. Oxidative damage to specific proteins in replicative and chronological-aged Saccharomyces cerevisiae: common targets and prevention by calorie restriction. J. Biol. Chem. 279, 31983–31989 (2004). (10.1074/jbc.M404849200) / J. Biol. Chem. by Reverter-Branch (2004)
  18. Scheckhuber, C. Q., Rödel, E. & Wüstehube, J. Regulation of mitochondrial dynamics--characterization of fusion and fission genes in the ascomycete Podospora anserina. Biotechnol. J. 3, 781–790 (2008). (10.1002/biot.200800010) / Biotechnol. J. by CQ Scheckhuber (2008)
  19. Osiewacz, H. D. & Borghouts, C. Mitochondrial oxidative stress and aging in the filamentous fungus Podospora anserina. Ann. NYAcad. Sci. 908, 31–39 (2000). (10.1111/j.1749-6632.2000.tb06633.x) / Ann. NYAcad. Sci. by HD Osiewacz (2000)
  20. Borghouts, C., Kimpel, E. & Osiewacz, H. D. Mitochondrial DNA rearrangements of Podospora anserina are under the control of the nuclear gene grisea. Proc. Natl. Acad. Sci. U SA 94, 10768–10773 (1997). (10.1073/pnas.94.20.10768) / Proc. Natl. Acad. Sci. U SA by C Borghouts (1997)
  21. Dufour, E., Boulay, J., Rincheval, V. & Sainsard-Chanet, A. A causal link between respiration and senescence in Podospora anserina. Proc. Natl. Acad. Sci. USA 97, 4138–4143 (2000). (10.1073/pnas.070501997) / Proc. Natl. Acad. Sci. USA by E Dufour (2000)
  22. Stumpferl, S. W., Stephan, O. & Osiewacz, H. D. Impact of a disruption of a pathway delivering copper to mitochondria on Podospora anserina metabolism and life span. Eukaryot. Cell 3, 200–211 (2004). (10.1128/EC.3.1.200-211.2004) / Eukaryot. Cell by SW Stumpferl (2004)
  23. van Dyck L., Neupert, W. & Langer, T. The ATP-dependent PIM1 protease is required for the expression of intron-containing genes in mitochondria. Genes Dev. 12, 1515–1524 (1998). (10.1101/gad.12.10.1515) / Genes Dev. by L van Dyck (1998)
  24. Esser, K. Podospora anserina. Handbook of Genetics (ed. R. C. King) 531–551 (Plenum Press, 1974). / Handbook of Genetics by K Esser (1974)
  25. Kück, U. et al. The onset of senescence is affected by DNA rearrangements of a discontinuous mitochondrial gene in Podospora anserina. Curr. Genet. 9, 373–382 (1985). (10.1007/BF00421608) / Curr. Genet. by U Kück (1985)
  26. Kunstmann, B. & Osiewacz, H. D. Over-expression of an S-adenosylmethionine-dependent methyltransferase leads to an extended lifespan of Podospora anserina without impairments in vital functions. Aging Cell 7, 651–662 (2008). (10.1111/j.1474-9726.2008.00412.x) / Aging Cell by B Kunstmann (2008)
  27. Hamann, A., Krause, K., Werner, A. & Osiewacz, H. D. A two-step protocol for efficient deletion of genes in the filamentous ascomycete Podospora anserina. Curr. Genet. 48, 270–275 (2005). (10.1007/s00294-005-0018-1) / Curr. Genet. by A Hamann (2005)
  28. Chaveroche, M. K., Ghigo, J. M. & d'Enfert, C. A rapid method for efficient gene replacement in the filamentous fungus Aspergillus nidulans. Nucleic Acids Res. 28, E97 (2000). (10.1093/nar/28.22.e97) / Nucleic Acids Res. by MK Chaveroche (2000)
  29. Osiewacz, H. D. A versatile shuttle cosmid vector for the efficient construction of genomic libraries and for the cloning of fungal genes. Curr. Genet. 26, 87–90 (1994). (10.1007/BF00326309) / Curr. Genet. by HD Osiewacz (1994)
  30. Pfaffl, M. W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45 (2001). (10.1093/nar/29.9.e45) / Nucleic Acids Res. by MW Pfaffl (2001)
  31. Borghouts, C., Werner, A., Elthon, T. & Osiewacz, H. D. Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina. Mol. Cell Biol. 21, 390–399 (2001). (10.1128/MCB.21.2.390-399.2001) / Mol. Cell Biol. by C Borghouts (2001)
  32. Levine, R. L., Williams, J. A., Stadtman, E. R. & Shacter, E. Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol. 233, 346–357 (1994). (10.1016/S0076-6879(94)33040-9) / Methods Enzymol. by RL Levine (1994)
  33. Nulton-Persson, A. C. & Szweda, L. I. Modulation of mitochondrial function by hydrogen peroxide. J. Biol. Chem. 276, 23357–23361 (2001). (10.1074/jbc.M100320200) / J. Biol. Chem. by AC Nulton-Persson (2001)
  34. Hamann, A., Brust, D. & Osiewacz, H. D. Deletion of putative apoptosis factors leads to lifespan extension in the fungal ageing model Podospora anserina. Mol. Microbiol. 65, 948–958 (2007). (10.1111/j.1365-2958.2007.05839.x) / Mol. Microbiol. by A Hamann (2007)
  35. Schägger, H. & Pfeiffer, K. Supercomplexes in the respiratory chains of yeast and mammalian mitochondria. EMBO J. 19, 1777–1783 (2000). (10.1093/emboj/19.8.1777) / EMBO J. by H Schägger (2000)
  36. Krause, F. et al. Supramolecular organization of cytochrome c oxidase- and alternative oxidase-dependent respiratory chains in the filamentous fungus Podospora anserina. J. Biol. Chem. 279, 26453–26461 (2004). (10.1074/jbc.M402756200) / J. Biol. Chem. by F Krause (2004)
  37. Jung, C., Higgins, C. M. & Xu, Z. Measuring the quantity and activity of mitochondrial electron transport chain complexes in tissues of central nervous system using blue native polyacrylamide gel electrophoresis. Anal. Biochem. 286, 214–223 (2000). (10.1006/abio.2000.4813) / Anal. Biochem. by C Jung (2000)
  38. Nijtmans, L. G., Henderson, N. S. & Holt, I. J. Blue Native electrophoresis to study mitochondrial and other protein complexes. Methods 26, 327–334 (2002). (10.1016/S1046-2023(02)00038-5) / Methods by LG Nijtmans (2002)
Dates
Type When
Created 16 years, 2 months ago (June 21, 2009, 1:15 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 3:32 p.m.)
Indexed 1 month ago (July 25, 2025, 6:37 a.m.)
Issued 16 years, 2 months ago (June 21, 2009)
Published 16 years, 2 months ago (June 21, 2009)
Published Online 16 years, 2 months ago (June 21, 2009)
Published Print 16 years, 1 month ago (July 1, 2009)
Funders 0

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@article{Luce_2009, title={Increasing organismal healthspan by enhancing mitochondrial protein quality control}, volume={11}, ISSN={1476-4679}, url={http://dx.doi.org/10.1038/ncb1893}, DOI={10.1038/ncb1893}, number={7}, journal={Nature Cell Biology}, publisher={Springer Science and Business Media LLC}, author={Luce, Karin and Osiewacz, Heinz D.}, year={2009}, month=jun, pages={852–858} }