A role for the P-body component GW182 in microRNA function
10.1038/ncb1333
Crossref journal-article
Springer Science and Business Media LLC
Nature Cell Biology (297)
Bibliography

Liu, J., Rivas, F. V., Wohlschlegel, J., Yates, J. R., Parker, R., & Hannon, G. J. (2005). A role for the P-body component GW182 in microRNA function. Nature Cell Biology, 7(12), 1261–1266.

Authors 6
  1. Jidong Liu (first)
  2. Fabiola V. Rivas (additional)
  3. James Wohlschlegel (additional)
  4. John R. Yates (additional)
  5. Roy Parker (additional)
  6. Gregory J. Hannon (additional)
References 30 Referenced 505
  1. Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281–297 (2004). (10.1016/S0092-8674(04)00045-5) / Cell by DP Bartel (2004)
  2. Liu, J., Valencia-Sanchez, M. A., Hannon, G. J. & Parker, R. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nature Cell Biol. 7, 719–723 (2005). (10.1038/ncb1274) / Nature Cell Biol. by J Liu (2005)
  3. Sen, G. L. & Blau, H. M. Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. Nature Cell Biol. 7, 633–636 (2005). (10.1038/ncb1265) / Nature Cell Biol. by GL Sen (2005)
  4. Ambros, V. The functions of animal microRNAs. Nature 431, 350–355 (2004). (10.1038/nature02871) / Nature by V Ambros (2004)
  5. Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. Nature 431, 343–349 (2004). (10.1038/nature02873) / Nature by G Meister (2004)
  6. Liu, J. et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science 305, 1437–1441 (2004). (10.1126/science.1102513) / Science by J Liu (2004)
  7. Meister, G. et al. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol. Cell 15, 185–197 (2004). (10.1016/j.molcel.2004.07.007) / Mol. Cell by G Meister (2004)
  8. Wightman, B., Ha, I. & Ruvkun, G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75, 855–862 (1993). (10.1016/0092-8674(93)90530-4) / Cell by B Wightman (1993)
  9. Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75, 843–854 (1993). (10.1016/0092-8674(93)90529-Y) / Cell by RC Lee (1993)
  10. Lim, L. P. et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433, 769–773 (2005). (10.1038/nature03315) / Nature by LP Lim (2005)
  11. Bagga, S. et al. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122, 553–563 (2005). (10.1016/j.cell.2005.07.031) / Cell by S Bagga (2005)
  12. Kim, J. et al. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc. Natl Acad. Sci. USA 101, 360–365 (2004). (10.1073/pnas.2333854100) / Proc. Natl Acad. Sci. USA by J Kim (2004)
  13. Nelson, P. T., Hatzigeorgiou, A. G. & Mourelatos, Z. miRNP:mRNA association in polyribosomes in a human neuronal cell line. RNA 10, 387–394 (2004). (10.1261/rna.5181104) / RNA by PT Nelson (2004)
  14. Olsen, P. H. & Ambros, V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev. Biol. 216, 671–680 (1999). (10.1006/dbio.1999.9523) / Dev. Biol. by PH Olsen (1999)
  15. Pillai, R. S. et al. Inhibition of translational initiation by Let-7 microRNA in human cells. Science 309, 1573–1576 (2005). (10.1126/science.1115079) / Science by RS Pillai (2005)
  16. Sheth, U. & Parker, R. Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300, 805–808 (2003). (10.1126/science.1082320) / Science by U Sheth (2003)
  17. Andrei, M. A. et al. A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies. RNA 11, 717–727 (2005). (10.1261/rna.2340405) / RNA by MA Andrei (2005)
  18. Teixeira, D., Sheth, U., Valencia-Sanchez, M. A., Brengues, M. & Parker, R. Processing bodies require RNA for assembly and contain nontranslating mRNAs. RNA 11, 371–382 (2005). (10.1261/rna.7258505) / RNA by D Teixeira (2005)
  19. Hammond, S. M., Boettcher, S., Caudy, A. A., Kobayashi, R. & Hannon, G. J. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 293, 1146–1150 (2001). (10.1126/science.1064023) / Science by SM Hammond (2001)
  20. Chendrimada, T. P. et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436, 740–744 (2005). (10.1038/nature03868) / Nature by TP Chendrimada (2005)
  21. Eystathioy, T. et al. A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. Mol. Biol. Cell 13, 1338–1351 (2002). (10.1091/mbc.01-11-0544) / Mol. Biol. Cell by T Eystathioy (2002)
  22. Eystathioy, T. et al. The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies. RNA 9, 1171–1173 (2003). (10.1261/rna.5810203) / RNA by T Eystathioy (2003)
  23. Yang, Z. et al. GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. J. Cell Sci. 117, 5567–5578 (2004). (10.1242/jcs.01477) / J. Cell Sci. by Z Yang (2004)
  24. Doench, J. G., Petersen, C. P. & Sharp, P. A. siRNAs can function as miRNAs. Genes Dev. 17, 438–442 (2003). (10.1101/gad.1064703) / Genes Dev. by JG Doench (2003)
  25. Pillai, R. S., Artus, C. G. & Filipowicz, W. Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis. RNA 10, 1518–1525 (2004). (10.1261/rna.7131604) / RNA by RS Pillai (2004)
  26. Ding, L., Spencer, A., Morita, K. & Han, M. The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans. Mol. Cell 19, 437–447 (2005). (10.1016/j.molcel.2005.07.013) / Mol. Cell by L Ding (2005)
  27. Rehwinkel, J., Behm-Ansmant, I., Gatfield, D. & Izaurralde, E. A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. RNA 11, 1640–1647 (2005). (10.1261/rna.2191905) / RNA by J Rehwinkel (2005)
  28. Coller, J. & Parker, R. General translational repression by activators of mRNA decapping. Cell 122, 875–886 (2005). (10.1016/j.cell.2005.07.012) / Cell by J Coller (2005)
  29. Nakamura, A., Sato, K. & Hanyu-Nakamura, K. Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis. Dev. Cell 6, 69–78 (2004). (10.1016/S1534-5807(03)00400-3) / Dev. Cell by A Nakamura (2004)
  30. Nakamura, A., Amikura, R., Hanyu, K. & Kobayashi, S. Me31B silences translation of oocyte-localizing RNAs through the formation of cytoplasmic RNP complex during Drosophila oogenesis. Development 128, 3233–3242 (2001). (10.1242/dev.128.17.3233) / Development by A Nakamura (2001)
Dates
Type When
Created 19 years, 9 months ago (Nov. 13, 2005, 1:38 p.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 3:27 p.m.)
Indexed 5 days, 11 hours ago (Aug. 23, 2025, 1:01 a.m.)
Issued 19 years, 9 months ago (Nov. 13, 2005)
Published 19 years, 9 months ago (Nov. 13, 2005)
Published Online 19 years, 9 months ago (Nov. 13, 2005)
Published Print 19 years, 8 months ago (Dec. 1, 2005)
Funders 0

None

@article{Liu_2005, title={A role for the P-body component GW182 in microRNA function}, volume={7}, ISSN={1476-4679}, url={http://dx.doi.org/10.1038/ncb1333}, DOI={10.1038/ncb1333}, number={12}, journal={Nature Cell Biology}, publisher={Springer Science and Business Media LLC}, author={Liu, Jidong and Rivas, Fabiola V. and Wohlschlegel, James and Yates, John R. and Parker, Roy and Hannon, Gregory J.}, year={2005}, month=nov, pages={1261–1266} }