Crossref journal-article
Springer Science and Business Media LLC
Nature Cell Biology (297)
Bibliography

Zhou, B. P., Liao, Y., Xia, W., Zou, Y., Spohn, B., & Hung, M.-C. (2001). HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nature Cell Biology, 3(11), 973–982.

Authors 6
  1. Binhua P. Zhou (first)
  2. Yong Liao (additional)
  3. Weiya Xia (additional)
  4. Yiyu Zou (additional)
  5. Bill Spohn (additional)
  6. Mien-Chie Hung (additional)
References 36 Referenced 708
  1. Slamon, D. J. et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235, 177–182 (1987). (10.1126/science.3798106) / Science by DJ Slamon (1987)
  2. Slamon, D. J. et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244, 707–712 (1989). (10.1126/science.2470152) / Science by DJ Slamon (1989)
  3. Yu, D. & Hung, M.-C. in DNA Alterations in Cancer (ed. Ehrlich, M.) Ch. 21 (Eaton, Natick, Massachusetts, 2000). / DNA Alterations in Cancer by D Yu (2000)
  4. Zhou, B. P. et al. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-κB pathways. J. Biol. Chem. 275, 8027–8031 (2000). (10.1074/jbc.275.11.8027) / J. Biol. Chem. by BP Zhou (2000)
  5. Zhou, B. P. et al. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nature Cell Biol. 3, 245–252 (2001). (10.1038/35060032) / Nature Cell Biol. by BP Zhou (2001)
  6. Downward, J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell Biol. 10, 262–267 (1998). (10.1016/S0955-0674(98)80149-X) / Curr. Opin. Cell Biol. by J Downward (1998)
  7. Datta, S. R., Brunet, A. & Greenberg, M. E. Cellular survival: a play in three Akts. Genes Dev. 13, 2905–2927 (1999). (10.1101/gad.13.22.2905) / Genes Dev. by SR Datta (1999)
  8. Peso, L. D., Gonzalez-Garcia, M., Page, C., Herrera, R. & Nunez, G. Interleukin-3-induced phosphorylation of bad through the protein kinase Akt. Science 278, 687–689 (1997). (10.1126/science.278.5338.687) / Science by LD Peso (1997)
  9. Cardone, M. H. et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 282, 1318–1321 (1998). (10.1126/science.282.5392.1318) / Science by MH Cardone (1998)
  10. Brunet, A. et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96, 857–868 (1999). (10.1016/S0092-8674(00)80595-4) / Cell by A Brunet (1999)
  11. Kops, G. J. P. L. et al. Direct control of the forkhead transcription factor AFX by protein kinase B. Nature 398, 630–634 (1999). (10.1038/19328) / Nature by GJPL Kops (1999)
  12. Ozes, O. N. et al. NF-κB activation by tumor necrosis factor requires the Akt serine–threonine kinase. Nature 401, 82–85 (1999). (10.1038/43466) / Nature by ON Ozes (1999)
  13. Sabbatini, P. & McCormick, F. Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis. J. Biol. Chem. 274, 24263–24269 (1999). (10.1074/jbc.274.34.24263) / J. Biol. Chem. by P Sabbatini (1999)
  14. Woods, D. B. & Vousden, K. H. Regulation of p53 function. Exp. Cell Res. 264, 56–66 (2001). (10.1006/excr.2000.5141) / Exp. Cell Res. by DB Woods (2001)
  15. Sherr, C. J. & Weber, J. D. The ARF/p53 pathway. Curr. Opin. Genet. Dev. 10, 94–99 (2000). (10.1016/S0959-437X(99)00038-6) / Curr. Opin. Genet. Dev. by CJ Sherr (2000)
  16. Vousden, K. H. p53: death star. Cell 103, 691–694 (2000). (10.1016/S0092-8674(00)00171-9) / Cell by KH Vousden (2000)
  17. Vogelstein, B., Lane, D. & Levine, A. J. Surfing the p53 network. Nature 408, 307–310 (2000). (10.1038/35042675) / Nature by B Vogelstein (2000)
  18. Hupp, T. R., Lane, D. P. & Ball, K. L. Strategies for manipulating the p53 pathway in the treatment of human cancer. Biochem. J. 352, 1–17 (2000). (10.1042/bj3520001) / Biochem. J. by TR Hupp (2000)
  19. Caspari, T. Checkpoints: how to activate p53. Curr. Biol. 10, R315–R317 (2000). (10.1016/S0960-9822(00)00439-5) / Curr. Biol. by T Caspari (2000)
  20. Momand, J., Wu, H.-H. & Dasgupta, G. MDM2—master regulator of the p53 tumor suppressor protein. Gene 242, 15–29 (2000). (10.1016/S0378-1119(99)00487-4) / Gene by J Momand (2000)
  21. Colman, M. S., Afshari, C. A. & Barrett, J. C. Regulation of p53 stability and activity in response to genotoxic stress. Mut. Res. 462, 179–188 (2000). (10.1016/S1383-5742(00)00035-1) / Mut. Res. by MS Colman (2000)
  22. Lill, N. L., Grossman, S. R., Ginsberg, D., DeCaprio, J. & Livingston, D. M. Binding and modulation of p53 by p300/CBP coactivators. Nature 387, 823–827 (1997). (10.1038/42981) / Nature by NL Lill (1997)
  23. Grossman, S. R. et al. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol. Cell 2, 405–415 (1998). (10.1016/S1097-2765(00)80140-9) / Mol. Cell by SR Grossman (1998)
  24. Pomerantz, J. et al. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and nuetralizes MDM2's inhibition of p53. Cell 92, 713–723 (1998). (10.1016/S0092-8674(00)81400-2) / Cell by J Pomerantz (1998)
  25. Zhang, Y., Xiong, Y. & Yarbrough, W. G. ARF promotes MDM2 degradation and stabilizes p53: ARF-Ink4a locus deletion impairs both Rb and p53 tumor suppressor pathways. Cell 92, 725–734 (1998). (10.1016/S0092-8674(00)81401-4) / Cell by Y Zhang (1998)
  26. Sherr, C. J. The Pezcoller Lecture: cancer cell cycles revisited. Cancer Res. 60, 3689–3695 (2000). / Cancer Res. by CJ Sherr (2000)
  27. Honda, R. & Yasuda, H. Association of p19ARF with MDM2 inhibits ubiquitin ligase activity of MDM2 for tumor suppressor p53. EMBO J. 18, 22–27 (1999). (10.1093/emboj/18.1.22) / EMBO J. by R Honda (1999)
  28. Weber, J. D., Taylor, L. J., Roussel, M. F., Sherr, C. J. & Bar-Sagi, D. Nucleolar Arf sequesters Mdm2 and activates p53. Nature Cell Biol. 1, 20–26 (1999). (10.1038/8991) / Nature Cell Biol. by JD Weber (1999)
  29. Zhang, Y. & Xiong, Y. Mutation in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol. Cell 3, 579–591 (1999). (10.1016/S1097-2765(00)80351-2) / Mol. Cell by Y Zhang (1999)
  30. Yu, D. & Hung, M.-C. Role of erbB2 in breast cancer chemosensitivity. BioEssays 22, 673–680 (2000). (10.1002/1521-1878(200007)22:7<673::AID-BIES10>3.0.CO;2-A) / BioEssays by D Yu (2000)
  31. Tsai, C. M. et al. Enhanced chemoresistance by elevation of p185 levels in HER-2/neu-transfected human lung cancer cells. J. Natl Cancer Inst. 87, 682–684 (1995). (10.1093/jnci/87.9.682) / J. Natl Cancer Inst. by CM Tsai (1995)
  32. Zhou, B.-B. S. & Elledge, S. J. The DNA damage response: putting checkings in perspective. Nature 408, 433–439 (2000). (10.1038/35044005) / Nature by B-BS Zhou (2000)
  33. Freedman, D. A. & Levine, A. J. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6. Mol. Cell. Biol. 18, 7288–7293 (1998). (10.1128/MCB.18.12.7288) / Mol. Cell. Biol. by DA Freedman (1998)
  34. Khosravi, R. et al. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc. Natl Acad. Sci. USA 96, 14973–14977 (1999). (10.1073/pnas.96.26.14973) / Proc. Natl Acad. Sci. USA by R Khosravi (1999)
  35. Lianos, S., Clark, P. A., Rowe, J. & Peters, G. Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus. Nature Cell Biol. 3, 445–452 (2001). (10.1038/35074506) / Nature Cell Biol. by S Lianos (2001)
  36. Mayo, L. D. & Donner, D. B. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl Acad. Sci. USA 98, 11598–11603 (2001). (10.1073/pnas.181181198) / Proc. Natl Acad. Sci. USA by LD Mayo (2001)
Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 4:34 a.m.)
Deposited 2 years, 3 months ago (May 18, 2023, 3:22 p.m.)
Indexed 1 week, 5 days ago (Aug. 19, 2025, 6:24 a.m.)
Issued 23 years, 10 months ago (Oct. 8, 2001)
Published 23 years, 10 months ago (Oct. 8, 2001)
Published Online 23 years, 10 months ago (Oct. 8, 2001)
Published Print 23 years, 9 months ago (Nov. 1, 2001)
Funders 0

None

@article{Zhou_2001, title={HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation}, volume={3}, ISSN={1476-4679}, url={http://dx.doi.org/10.1038/ncb1101-973}, DOI={10.1038/ncb1101-973}, number={11}, journal={Nature Cell Biology}, publisher={Springer Science and Business Media LLC}, author={Zhou, Binhua P. and Liao, Yong and Xia, Weiya and Zou, Yiyu and Spohn, Bill and Hung, Mien-Chie}, year={2001}, month=oct, pages={973–982} }